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https://www.readbyqxmd.com/read/28293419/cilia-before-and-after
#1
REVIEW
Peter Satir
This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although sensory and primary cilia were well described, research was largely focused on motile cilia, their structure, movement, and biogenesis. After IFT and the link to PKD, although work on motile cilia has continued to progress, research on primary cilia has exploded, leading to new insights into the role of cilia in cell signaling and development...
2017: Cilia
https://www.readbyqxmd.com/read/28192563/evaluation-of-evidence-of-statistical-support-and-corroboration-of-subgroup-claims-in-randomized-clinical-trials
#2
Joshua D Wallach, Patrick G Sullivan, John F Trepanowski, Kristin L Sainani, Ewout W Steyerberg, John P A Ioannidis
Importance: Many published randomized clinical trials (RCTs) make claims for subgroup differences. Objective: To evaluate how often subgroup claims reported in the abstracts of RCTs are actually supported by statistical evidence (P < .05 from an interaction test) and corroborated by subsequent RCTs and meta-analyses. Data Sources: This meta-epidemiological survey examines data sets of trials with at least 1 subgroup claim, including Subgroup Analysis of Trials Is Rarely Easy (SATIRE) articles and Discontinuation of Randomized Trials (DISCO) articles...
February 13, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28184908/satir-the-interventionist-a-response-to-lee-and-rovers
#3
Christopher J Wretman
No abstract text is available yet for this article.
February 10, 2017: Social Work
https://www.readbyqxmd.com/read/28152196/a-meta-analysis-of-the-relation-between-therapeutic-alliance-and-treatment-outcome-in-eating-disorders
#4
REVIEW
Tiffany A Graves, Nassim Tabri, Heather Thompson-Brenner, Debra L Franko, Kamryn T Eddy, Stephanie Bourion-Bedes, Amy Brown, Michael J Constantino, Christoph Flückiger, Sarah Forsberg, Leanna Isserlin, Jennifer Couturier, Gunilla Paulson Karlsson, Johannes Mander, Martin Teufel, James E Mitchell, Ross D Crosby, Claudia Prestano, Dana A Satir, Susan Simpson, Richard Sly, J Hubert Lacey, Colleen Stiles-Shields, Giorgio A Tasca, Glenn Waller, Shannon L Zaitsoff, Renee Rienecke, Daniel Le Grange, Jennifer J Thomas
The therapeutic alliance has demonstrated an association with favorable psychotherapeutic outcomes in the treatment of eating disorders (EDs). However, questions remain about the inter-relationships between early alliance, early symptom improvement, and treatment outcome. We conducted a meta-analysis on the relations among these constructs, and possible moderators of these relations, in psychosocial treatments for EDs. Twenty studies met inclusion criteria and supplied sufficient supplementary data. Results revealed small-to-moderate effect sizes, βs = 0...
February 2, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/27928903/lessons-intended-and-learned-from-satire
#5
Mark R Tonelli
No abstract text is available yet for this article.
February 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27873404/the-show-must-go-on-patients-props-and-pedagogy-in-the-theatre-of-the-osce
#6
Gerard J Gormley, Brian D Hodges, Nancy McNaughton, Jennifer L Johnston
 According to Shakespeare, all the world's a stage, and all the men and women merely players. The objective structured clinical examination (OSCE), that most ubiquitous form of assessment in health professions education, offers us a particular instance of this maxim. Comprising at first glance a world of psychometric data, detailed checklists and global rating scales, the OSCE sets out to facilitate the assessment of a candidate's competence in a highly standardised and objective fashion. Despite this clear intention, OSCEs also offer a rich vein of (often unacknowledged) social and cultural processes...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27821520/chirality-of-the-cytoskeleton-in-the-origins-of-cellular-asymmetry
#7
REVIEW
Peter Satir
Self-assembly of two important components of the cytoskeleton of eukaryotic cells, actin microfilaments and microtubules (MTs) results in polar filaments of one chirality. As is true for bacterial flagella, in actin microfilaments, screw direction is important for assembly processes and motility. For MTs, polar orientation within the cell is paramount. The alignment of these elements in the cell cytoplasm gives rise to emergent properties, including the potential for cell differentiation and specialization...
December 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27514923/clem-methods-for-studying-primary-cilia
#8
Frank P Macaluso, Geoffrey S Perumal, Johan Kolstrup, Peter Satir
CLEM (correlated light and electron microscope) imaging is a highly useful technique for examining primary cilia. With CLEM, it is possible to determine the distribution of tagged proteins along the ciliary membrane and axoneme with high precision. Scanning electron microscopy (SEM) permits measurement of ciliary length and orientation in relation to nearby cellular structures in a 3D image; in optimal cases, this can be combined with superresolution microscopy of selected ciliary components as they enter or leave the cilium...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27514915/methods-to-study-interactions-between-ciliogenesis-and-autophagy
#9
Birgit Hegner Satir, Olatz Pampliega
Autophagy is a catabolic pathway for the degradation and recycling of intracellular components, contributing to maintain cell homeostasis. Changes in autophagy activity can be monitored by a variety of biochemical and functional assays that should be used in combination. Recently, it has been described that signaling from the primary cilium modulates autophagy. This novel and reciprocal interaction will impact diverse aspects of the cell biology in healthy and pathophysiological conditions. Here, we describe methods to monitor autophagy activity in cilia mutants, as well as the use of autophagy mutants to monitor ciliogenesis...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27475878/the-room-where-it-happens-a-skeptic-s-analysis-of-the-new-heart-failure-guidelines
#10
Milton Packer
New heart failure guidelines have been issued during the past several months, both in the United States and in Europe, in response to recent advances in and the approval of new drugs for the treatment of heart failure. Although guidelines documents are often viewed as authoritative and purely evidence-based, there are replete with meaningful (and inexplicable) inconsistencies, which derive from a review of the same body of scientific data by different groups. This satirical review highlights several examples of the entertaining foolishness of recent guideline documents in the good-natured hope that physicians will understand what the guidelines are, and more importantly, what they are not...
September 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27383650/amyloid-precursor-protein-expression-and-processing-are-differentially-regulated-during-cortical-neuron-differentiation
#11
Petra Bergström, Lotta Agholme, Faisal Hayat Nazir, Tugce Munise Satir, Jamie Toombs, Henrietta Wellington, Joakim Strandberg, Thomas Olsson Bontell, Hlin Kvartsberg, Maria Holmström, Cecilia Boreström, Stina Simonsson, Tilo Kunath, Anders Lindahl, Kaj Blennow, Eric Hanse, Erik Portelius, Selina Wray, Henrik Zetterberg
Amyloid precursor protein (APP) and its cleavage product amyloid β (Aβ) have been thoroughly studied in Alzheimer's disease. However, APP also appears to be important for neuronal development. Differentiation of induced pluripotent stem cells (iPSCs) towards cortical neurons enables in vitro mechanistic studies on human neuronal development. Here, we investigated expression and proteolytic processing of APP during differentiation of human iPSCs towards cortical neurons over a 100-day period. APP expression remained stable during neuronal differentiation, whereas APP processing changed...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27299636/satire-corporations-sans-humor
#12
Raymond G Bunge
No abstract text is available yet for this article.
June 14, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27148156/microm%C3%A3-gas-altered-body-environment-scaling-in-literary-fiction
#13
REVIEW
Sebastian Dieguez
Architectonic embodiment postulates a bidirectional link between bodily awareness and the architectural environment. The standard size and features of the human body, for instance, are thought to influence the structure of interiors and buildings, as well as their perception and appreciation. Whereas architectural practice and theory, the visual arts and more recently the cognitive sciences have explored this relationship of humans with their crafted environments, many fictional literary works have long experimented with alterations of body-environment scaling...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27116737/phase-and-amplitude-modulation-methods-for-nonlinear-ultrasound-imaging-with-cmuts
#14
Sarp Satir, F Levent Degertekin
Conventional amplitude and phase modulated pulse sequences for selective imaging of nonlinear tissue and ultrasound contrast agents are designed for piezoelectric transducers that behave linearly. Inherent nonlinearity of capacitive micromachined ultrasonic transducers (CMUTs), especially during large-signal operation, renders these methods inapplicable. In this paper, we present different pulse sequences for nonlinear imaging that are valid for small- and large-signal CMUT operations. For small-signal operation, two-pulse amplitude and phase modulation methods for microbubble and tissue harmonic imaging are presented, where CMUT nonlinearity is compensated via subharmonic excitation...
August 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27096212/-report-on-the-vd%C3%A3-pc-fellowship
#15
COMPARATIVE STUDY
E Sarantopoulos
"Orandum est ut sit mens sana in corpore sano" ("You should pray for a healthy mind in a healthy body"). This phrase is a shortened citation from the satirical work of the Roman poet Juvenal. It highlights the significant role of physical as well as mental health. Aesthetic ideals have existed since the Archaic age, but they are not necessarily the same in different continents. Being familiar with aesthetic ideals in different cultures might help to accommodate patients' needs and wishes in today's globalised world...
April 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/27059618/generating-a-social-movement-online-community-through-an-online-discourse-the-case-of-myalgic-encephalomyelitis
#16
Olaug S Lian, Jan Grue
Online communities, created and sustained by people sharing and discussing texts on the internet, play an increasingly important role in social health movements. In this essay, we explore a collective mobilization in miniature through an in-depth analysis of two satiric texts from an online community for people with myalgic encephalomyelitis (ME). By blending a sociological analysis with a rhetorical exploration of these texts, our aim is to grasp the discursive generation of a social movement online community set up by sufferers themselves to negotiate and contest the dominating biomedical perception of their condition...
April 8, 2016: Journal of Medical Humanities
https://www.readbyqxmd.com/read/26955066/a-structural-basis-for-how-motile-cilia-beat
#17
Peter Satir, Thomas Heuser, Winfield S Sale
The motile cilium is a mechanical wonder, a cellular nanomachine that produces a high-speed beat based on a cycle of bends that move along an axoneme made of 9+2 microtubules. The molecular motors, dyneins, power the ciliary beat. The dyneins are compacted into inner and outer dynein arms, whose activity is highly regulated to produce microtubule sliding and axonemal bending. The switch point hypothesis was developed long ago to account for how sliding in the presence of axonemal radial spoke-central pair interactions causes the ciliary beat...
December 1, 2014: Bioscience
https://www.readbyqxmd.com/read/26949209/lydgate-s-danse-macabre-and-the-trauma-of-the-hundred-years-war
#18
R D Perry
This essay argues that the foundational traumatic lacuna behind John Lydgate's Danse Macabre is the social agon between those who wage the Hundred Years War and those who fight in it. Drawing from the insights of trauma theory to discuss the poem's form, the essay uncovers Lydgate's persistent concern with the damage caused by the war and the concomitant political unrest it causes. It argues further that Lydgate theorized this agon using the emergent genre of tragedy, which is beginning to be practiced anew in late-medieval England...
2015: Literature and Medicine
https://www.readbyqxmd.com/read/26932094/study-of-electron-current-extraction-from-a-radio-frequency-plasma-cathode-designed-as-a-neutralizer-for-ion-source-applications
#19
Sina Jahanbakhsh, Mert Satir, Murat Celik
Plasma cathodes are insert free devices that are developed to be employed as electron sources in electric propulsion and ion source applications as practical alternatives to more commonly used hollow cathodes. Inductively coupled plasma cathodes, or Radio Frequency (RF) plasma cathodes, are introduced in recent years. Because of its compact geometry, and simple and efficient plasma generation, RF plasma source is considered to be suitable for plasma cathode applications. In this study, numerous RF plasma cathodes have been designed and manufactured...
February 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/26898000/saving-satir-contemporary-perspectives-on-the-change-process-model
#20
Christopher J Wretman
Virginia Satir continues to be a highly influential figure in family therapy. The summation of her decades of work with families, the Satir growth model (SGM), remains a relevant therapeutic approach that is still practiced by many. This narrative review sought to examine (a) the core therapeutic methods developed by Satir for working with families, and (b) the empirical evidence to support the use of such methods. The author reviewed both firsthand and secondhand accounts of Satir's model of therapy, as well as extant research...
January 2016: Social Work
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