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water and progression of renal disease

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https://www.readbyqxmd.com/read/29743334/randomised-controlled-trial-of-high-versus-ad-libitum-water-intake-in-patients-with-autosomal-dominant-polycystic-kidney-disease-rationale-and-design-of-the-drink-feasibility-trial
#1
Ragada El-Damanawi, Michael Lee, Tess Harris, Laura B Mader, Simon Bond, Holly Pavey, Richard N Sandford, Ian B Wilkinson, Alison Burrows, Przemyslaw Woznowski, Yoav Ben-Shlomo, Fiona E Karet Frankl, Thomas F Hiemstra
INTRODUCTION: Vasopressin stimulates cyst growth in autosomal dominant polycystic kidney disease (ADPKD) leading to enlarged kidneys, hypertension and renal failure. Vasopressin receptor blockade slows disease progression. Physiological suppression of vasopressin secretion through high water (HW) intake could achieve a similar effect, necessitating a definitive large-scale trial of HW intake in ADPKD. The objective of the DRINK trial is to answer the key design and feasibility questions required to deliver a successful definitive water intake trial...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29674410/a-large-intraperitoneal-residual-volume-hampers-adequate-volumetric-assessment-of-osmotic-onductance-to-glucose
#2
Anne-Lorraine Clause, Mehdi Keddar, Ralph Crott, Tom Darius, Catherine Fillée, Eric Goffin, Johann Morelle
BACKGROUND: In end-stage renal disease patients treated with peritoneal dialysis (PD), the osmotic conductance to glucose (OCG) represents the intrinsic ability of the membrane to transport water in response to a crystalloid osmotic gradient. A progressive loss of OCG in long-term PD patients indicates the development of fibrosis in the peritoneal interstitium, and helps identify patients at risk for encapsulating peritoneal sclerosis. The double mini-peritoneal equilibration test (PET) has been proposed as a simple method to assess OCG using the difference in initial ultrafiltration rates generated by 2 successive dwells using 1...
April 19, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29573172/quantification-of-urinary-protein-biomarkers-of-autosomal-dominant-polycystic-kidney-disease-by-parallel-reaction-monitoring
#3
Navin Rauniyar, Xiaoqing Yu, Jennifer Cantley, Edward Voss, Justin Belcher, Chris Colangelo, Kathryn Stone, Neera Dahl, Chirag Parikh, TuKiet T Lam, Lloyd G Cantley
PURPOSE: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a life-long disease in which the genes responsible are known, but the pathogenesis of cyst formation and cyst growth are not understood. Cyst growth ultimately leads to end stage renal failure in most patients. Analysis of the urinary proteome offers the potential to identify proteins that indicate the presence of cysts (and thus provides diagnosis) as well as the rates of cyst growth (providing prognostic information). EXPERIMENTAL DESIGN: We performed scheduled Parallel Reaction Monitoring (sPRM) assay on urine samples from 14 patients and 18 normal controls...
March 23, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29571452/lipids-inflammation-and-chronic-kidney-disease-a-sharp-perspective
#4
David D Waters, Liffert Vogt
Accumulating evidence indicates that inflammation plays a role in the initiation and progression of chronic kidney disease. In the Study of Heart and Renal Protection (SHARP) trial, higher baseline C-reactive protein and higher baseline low-density lipoprotein cholesterol levels were both associated with a higher risk of cardiovascular events, but higher baseline C-reactive protein levels were also associated with a higher risk of nonvascular events. Simvastatin/ezetimibe reduced cardiovascular events independent of baseline C-reactive protein levels...
April 2018: Kidney International
https://www.readbyqxmd.com/read/29553830/medullary-thick-ascending-limb-impairment-in-the-gla-tm-tg-cag-a4galt-fabry-model-mice
#5
Hiroki Maruyama, Atsumi Taguchi, Yuji Nishikawa, Chu Guili, Mariko Mikame, Masaaki Nameta, Yutaka Yamaguchi, Mitsuhiro Ueno, Naofumi Imai, Yumi Ito, Takahiko Nakagawa, Ichiei Narita, Satoshi Ishii
A main feature of Fabry disease is nephropathy, with polyuria an early manifestation; however, the mechanism that underlies polyuria and affected tubules is unknown. To increase globotriaosylceramide (Gb3) levels, we previously crossbred asymptomatic Glatm mice with transgenic mice that expressed human Gb3 synthase (A4GALT) and generated the Glatm Tg(CAG-A4GALT) symptomatic Fabry model mice. Additional analyses revealed that these mice exhibit polyuria and renal dysfunction without remarkable glomerular damage...
March 19, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29550811/gum-acacia-improves-renal-function-and-ameliorates-systemic-inflammation-oxidative-and-nitrosative-stress-in-streptozotocin-induced-diabetes-in-rats-with-adenine-induced-chronic-kidney-disease
#6
Mohammed Al Za'abi, Suhail Al Salam, Yousuf Al Suleimani, Priyadarsini Manoj, Abderrahim Nemmar, Badreldin H Ali
BACKGROUND/AIMS: The effect of treatment with gum acacia (GA), a prebiotic shown previously to ameliorate chronic kidney disease (CKD), in diabetic and non - diabetic rats with adenine - induced CKD has been investigated using several conventional and novel physiological, biochemical, and histopathological parameters. METHODS: Diabetes mellitus was induced in rats by a single injection of streptozotocin (STZ). Diabetic and non - diabetic rats were randomly divided into several groups, and given either normal food or food mixed with adenine (0...
March 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29511302/nlrp3-inflammasome-inhibition-ameliorates-tubulointerstitial-injury-in-the-remnant-kidney-model
#7
Orestes Foresto-Neto, Victor Ferreira Ávila, Simone Costa Alarcon Arias, Fernanda Florencia Fregnan Zambom, Lisienny Campoli Tono Rempel, Viviane Dias Faustino, Flavia Gomes Machado, Denise Maria Avancini Costa Malheiros, Hugo Abensur, Niels Olsen Saraiva Camara, Roberto Zatz, Clarice Kazue Fujihara
Recent studies suggest that NLRP3 inflammasome activation is involved in the pathogenesis of chronic kidney disease (CKD). Allopurinol (ALLO) inhibits xanthine oxidase (XOD) activity, and, consequently, reduces the production of uric acid (UA) and reactive oxygen species (ROS), both of which can activate the NLRP3 pathway. Thus, ALLO can contribute to slow the progression of CKD. We investigated whether inhibition of XOD by ALLO reduces NLRP3 activation and renal injury in the 5/6 renal ablation (Nx) model...
March 6, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29471458/pro-the-rationale-for-dietary-therapy-for-patients-with-advanced-chronic-kidney-disease
#8
Joel D Kopple, Denis Fouque
Dietary treatment offers many benefits to patients with advanced chronic kidney disease (CKD) who are approaching the need for renal replacement therapy. A large number of these benefits are independent of whether diets slow the rate of progression of CKD. These diets are low in protein and many minerals, and provide adequate energy for the CKD patient. The diets can reduce accumulation of potentially toxic metabolic products derived from protein and amino acid degradation, maintain a healthier balance of body water, sodium, potassium, phosphorus, calcium and other minerals, and prevent or improve protein-energy wasting...
March 1, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29436846/effect-of-dimethyl-fumarate-on-renal-disease-progression-in-a-genetic-ortholog-of-nephronophthisis
#9
Oliver Oey, Padmashree Rao, Magdalena Luciuk, Carly Mannix, Natasha M Rogers, Priyanka Sagar, Annette Wong, Gopala Rangan
Dimethyl fumarate is an FDA-approved oral immunomodulatory drug with anti-inflammatory properties that induces the upregulation of the anti-oxidant transcription factor, nuclear factor erythroid-derived factor 2. The aim of this study was to determine the efficacy of dimethyl fumarate on interstitial inflammation and renal cyst growth in a preclinical model of nephronophthisis. Four-week-old female Lewis polycystic kidney disease (a genetic ortholog of human nephronophthisis-9) rats received vehicle (V), 10 mg/kg (D10) or 30 mg/kg (D30) ( n = 8-9 each) dimethyl fumarate in drinking water for eight weeks...
March 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29398135/activation-of-podocyte-notch-mediates-early-wt1-glomerulopathy
#10
Rowan I Asfahani, Mona M Tahoun, Eve V Miller-Hodges, Jack Bellerby, Alex K Virasami, Robert D Sampson, Dale Moulding, Neil J Sebire, Peter Hohenstein, Peter J Scambler, Aoife M Waters
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of scar tissue within glomeruli, the mechanisms of which are poorly understood. Here, we used a tamoxifen-based CRE-LoxP system to induce deletion of Wt1 in adult mice to investigate the mechanisms underlying evolution of glomerulosclerosis. Podocyte apoptosis was evident as early as the fourth day post-induction and increased during disease progression, supporting a role for Wt1 in mature podocyte survival...
April 2018: Kidney International
https://www.readbyqxmd.com/read/29395014/-hev-and-transfusion-recipient-risk
#11
REVIEW
J Izopet
HEV infections are mainly food- and water-borne but transfusion-transmission has occurred in both developing and developed countries. The infection is usually asymptomatic but it can lead to fulminant hepatitis in patients with underlying liver disease and pregnant women living in developing countries. It also causes chronic hepatitis E, with progressive fibrosis and cirrhosis, in approximately 60 % of immunocompromised patients infected with HEV genotype 3. Extra-hepatic manifestations such as neurological and renal manifestations have been reported...
March 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29383015/protective-effects-of-hydrogen-sulfide-on-chronic-kidney-disease-by-reducing-oxidative-stress-inflammation-and-apoptosis
#12
Hassan Askari, Behjat Seifi, Mehri Kadkhodaee, Nima Sanadgol, Mohammed Elshiekh, Mina Ranjbaran, Parisa Ahghari
The current study aimed to examine the renoprotective effects of long-term treatment with sodium hydrosulfide (NaHS), a prominent hydrogen sulfide donor, in 5/6 nephrectomy animal model. Twenty-four rats were randomly divided into 3 groups including sham-operated group (Sham), 5/6-nephrectomized group (5/6 Nx), and NaHS-treated group (5/6Nx+NaHS). NaHS (30 micromol/l) was added twice daily into the drinking water and renal failure was induced by 5/6 nephrectomy. Twelve weeks after surgical procedure, blood pressure, creatinine clearance (CCr), urine concentration of neutrophil gelatinase associated lipocalin (NGAL) and tissue concentration of malondialdehyde (MDA), superoxide dismutase (SOD), as well as renal morphological changes, apoptosis (cleaved caspase-3) and inflammation (p-NF-κB) were measured...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29358433/randomised-controlled-trial-to-determine-the-efficacy-and-safety-of-prescribed-water-intake-to-prevent-kidney-failure-due-to-autosomal-dominant-polycystic-kidney-disease-prevent-adpkd
#13
Annette T Y Wong, Carly Mannix, Jared J Grantham, Margaret Allman-Farinelli, Sunil V Badve, Neil Boudville, Karen Byth, Jessie Chan, Susan Coulshed, Marie E Edwards, Bradley J Erickson, Mangalee Fernando, Sheryl Foster, Imad Haloob, David C H Harris, Carmel M Hawley, Julie Hill, Kirsten Howard, Martin Howell, Simon H Jiang, David W Johnson, Timothy L Kline, Karthik Kumar, Vincent W Lee, Maureen Lonergan, Jun Mai, Philip McCloud, Anthony Peduto, Anna Rangan, Simon D Roger, Kamal Sud, Vincent Torres, Eswari Vliayuri, Gopala K Rangan
INTRODUCTION: Maintaining fluid intake sufficient to reduce arginine vasopressin (AVP) secretion has been hypothesised to slow kidney cyst growth in autosomal dominant polycystic kidney disease (ADPKD). However, evidence to support this as a clinical practice recommendation is of poor quality. The aim of the present study is to determine the long-term efficacy and safety of prescribed water intake to prevent the progression of height-adjusted total kidney volume (ht-TKV) in patients with chronic kidney disease (stages 1-3) due to ADPKD...
January 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29357442/characterization-of-urinary-exosomal-release-of-aquaporin-1-and-2-after-renal-ischemia-reperfusion-in-rats
#14
Siree Asvapromtada, Hiroko Sonoda, Minami Kinouchi, Sayaka Oshikawa, Saki Takahashi, Yuya Hoshino, Thitaporn Sinlapadeelerdkul, Naoko Yokota-Ikeda, Toshiyuki Matsuzaki, Masahiro Ikeda
Acute kidney injury (AKI) is an important risk factor for the development of chronic kidney disease (CKD), and an alteration in renal water handling has been observed during the transition of AKI to CKD. Urinary exosomal release of aquaporin-1 (AQP1) and AQP2, important proteins for renal water handling, has recently been reported to predict their levels of renal expression. Therefore, we examined the patterns of urinary exosomal release of AQP1 and AQP2, and the exosomal marker proteins tumor susceptibility 101 protein (TSG101) and ALG-2 interacting protein X (Alix), in the acute and chronic phases following induction of AKI by renal bilateral ischemia/reperfusion (I/R) in rats...
April 1, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29357410/tamm-horsfall-protein-uromodulin-deficiency-elicits-tubular-compensatory-responses-leading-to-hypertension-and-hyperuricemia
#15
Yan Liu, David Goldfarb, Tarek M El-Achkar, John C Lieske, Xue-Ru Wu
Expression of Tamm-Horsfall protein (THP or uromodulin) is highly restricted to the kidneys' thick ascending limb (TAL) of loop of Henle. Despite the unique location and recent association of THP gene mutations with hereditary uromodulin-associated kidney disease and THP single nucleotide polymorphisms with chronic kidney disease and hypertension, the physiological function(s) of THP and its pathological involvement remain incompletely understood. By studying age-dependent changes of THP knockout (KO) mice, we show here that young KO mice had significant salt and water wasting but were partially responsive to furosemide, due to decreased luminal translocation of Na-K-Cl cotransporter 2 (NKCC2) in the TAL...
January 10, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29353796/associations-between-arsenic-in-drinking-water-and-occurrence-of-end-stage-renal-disease-with-modifications-by-comorbidities-a-nationwide-population-based-study-in-taiwan
#16
Ya-Yun Cheng, Yu-Tzu Chang, Hong-Lin Cheng, Kun-Hung Shen, Junne-Ming Sung, How-Ran Guo
Arsenic may affect the function of proximal convoluted tubules and glomeruli, but epidemiological data on the association between arsenic ingestion and end-stage renal disease (ESRD) are limited. Therefore, we conducted a nationwide population-based study in Taiwan, where the incidence of ESRD is the highest in the world, to study the potential association. Using the National Health Insurance Database in Taiwan, we constructed a cohort of 362,505 members with age≥40years in 1998. We identified patients of ESRD newly diagnosed between January 1, 1998 and December 31, 2010 and performed Cox proportional hazard regressions to identify risk factors for ESRD and evaluate their effects...
June 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29344814/nutritional-therapy-in-autosomal-dominant-polycystic-kidney-disease
#17
REVIEW
Biagio R Di Iorio, Adamasco Cupisti, Claudia D'Alessandro, Antonio Bellasi, Vincenzo Barbera, Luca Di Lullo
CKD-related nutritional therapy (NT) is a crucial cornerstone of CKD patients' treatment, but the role of NT has not been clearly investigated in autosomal dominant polycystic kidney disease (ADPKD). Several clinical studies have focused on new pharmacological approaches to delay cystic disease progression, but there are no data on dietary interventions in ADPKD patients. The aim of this paper is to analyze the evidence from the literature on the impact of five nutritional aspects (water, sodium, phosphorus, protein intake, and net acid load) in CKD-related ADPKD extrapolating-where information is unavailable-from what occurs in CKD non-ADPKD patients Sodium intake restriction could be useful in decreasing the growth rate of cysts...
January 17, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29229166/holding-water-congenital-anomalies-of-the-kidney-and-urinary-tract-ckd-and-the-ongoing-role-of-excellence-in-plumbing
#18
REVIEW
Lars J Cisek
Congenital anomalies of the kidneys and urinary tracts can result in diminished natal kidney function, possibly through common embryologic pathway disruption or as a result of development taking place in the face of disordered 'post-renal' drainage. Impaired conduit and reservoir function present potential for an ongoing assault leading to further deterioration and progression of chronic kidney disease, a risk that extends to adults with these conditions, even after "correction". The drainage and storage aspects of the urinary system that can impact kidney function are reviewed with attention to correctable or manageable problems including: Bladder dysfunction wherein the low pressure storage of urine is compromised requiring the kidney to work against a pressure gradient, the classic post renal failure problem...
November 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29146141/the-myth-of-water-and-salt-from-aquaretics-to-tenapanor
#19
REVIEW
Luca Visconti, Valeria Cernaro, Sebastiano Calimeri, Antonio Lacquaniti, Francesca De Gregorio, Carlo Alberto Ricciardi, Viviana Lacava, Domenico Santoro, Michele Buemi
The impact of water intake has been studied in several renal diseases. For example, increasing water intake is useful to prevent primary and secondary nephrolithiasis. In autosomal dominant polycystic kidney disease, arginine vasopressin (AVP) is involved in the progression of the disease, and water intake could play a therapeutic role by inhibiting the synthesis of AVP, but its efficacy is still controversial. Conversely, the use of aquaretics, which are antagonists of AVP V2 receptors, results in the reduction of the increase rate of total kidney volume with a slower decline of glomerular filtration rate...
March 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28910788/uremia-retention-molecules-and-clinical-outcomes
#20
Fellype Carvalho Barreto, Daniela Veit Barreto, Maria Eugênia Fernandes Canziani
Chronic kidney disease is characterized by the accumulation of organic compounds in the bloodstream that may exert a variety of toxic effects in the body. These compounds, collectively known as uremic toxins, may be classified according to their physicochemical properties as free water-soluble low molecular weight molecules, middle molecules or protein-bound uremic toxins. Most of these retention molecules, due to either their size and/or binding to protein, constitute a complex therapeutic challenge to the nephrologist, particularly in end-stage renal disease, because of their limited removal by conventional dialysis therapies...
2017: Contributions to Nephrology
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