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Rosa Campopiano, Larisa Ryskalin, Emiliano Giardina, Stefania Zampatti, Carla L Busceti, Francesca Biagioni, Rosangela Ferese, Marianna Storto, Stefano Gambardella, Francesco Fornai
Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease clinically characterized by upper and lower motor neuron dysfunction resulting in rapidly progressive paralysis and death from respiratory failure. Most cases appear to be sporadic, but 5-10 % of cases have a family history of the disease, and over the last decade, identification of mutations in about 20 genes predisposing to these disorders has provided the means to better understand their pathogenesis. Next Generation sequencing (NGS) is an advanced high-throughput DNA sequencing technology which have rapidly contributed to an acceleration in the discovery of genetic risk factors for both familial and sporadic neurological and neurodegenerative diseases...
December 1, 2017: Archives Italiennes de Biologie
Elena Serena, Elisa Cimetta, Susi Zatti, Tania Zaglia, Monica Zagallo, Gordon Keller, Nicola Elvassore
INTRODUCTION: The heart is one of the least regenerative organs in the body and any major insult can result in a significant loss of heart cells. The development of an in vitro-based cardiac tissue could be of paramount importance for many aspects of the cardiology research. In this context, we developed an in vitro assay based on human cardiomyocytes (hCMs) and ad hoc micro-technologies, suitable for several applications: from pharmacological analysis to physio-phatological studies on transplantable hCMs...
2012: PloS One
V N Buriak, A S Serhyenko
Analysis features of clinical manifestation and pathogenetic mechanisms of development of meningococcal infection is introduced. It is emphasized that in most cases mentioned infection is characterized by mild course as nasopharyngitidis. However relatively seldom developing generalize form put this phatology on third place after intestinal infections and septicemia in structure of child mortality from infection deseases. Occurence of generalize forms of meningococcal infection depend on peculiarity of immune response is followed by release of endotoxin and exotoxin in blood stream...
July 2011: Likars'ka Sprava
N M Anichkov, V A Pechenikova, D F Kostiuchek
Adenomyosis, ovarian endometriosis and extragenital endometriosis are clinico-pathologic types of one nosologic form as endometrioid disease (ED). ED's clinical presentations are various, but they are essentially characterized by a pain syndrome and disorder of menstrual cycle. The comparative clinico-pathologic analysis of adenomyosis, ovarian endometriosis, and extragenital endometriosis affords to suppose that theirs clinical course, the intensity and character of symptoms, as well as morphogenetic processes are generally determined by the organ localization...
July 2011: Arkhiv Patologii
M Fiducia, R Lauretta, R Lunghi, S Kyanvash, S Pallotti
AIM: Aim of the study is a prospective evaluation of the simultaneous presence of antinuclear antibodies (ANA) in patients with Hashimoto's thyroiditis as a sign of a possible occurrence of another autoimmune disease. METHODS: Thirty two patients with Hashimoto's thyroiditis have been selected. No other immunological parameters have been used for the selection. All the patients have been submitted to ANA research and to thyroid colour-Doppler ultrasonography. Moreover, subgroups of patients have been submitted to the research of other autoimmunity parameters: 25 patients to AMA (anti-mitochondrial antibodies), ASMA (anti-smooth muscle antibodies), ENA (extractable nuclear antigens) and anti-double stranded-DNA; 7 patients to anti-gastric mucosa; 8 patients to ACA (anti-cardiolipin antibodies) IgM and IgG; 12 patients to rheuma-screen...
April 2007: Minerva Medica
B Cánovas, M A Morlán, C Familiar, J Sastre, A Marco, J López
Chylous fistula after neck dissection is a well-described complication. This pHatology can lead to serious respiratory and nutritional complications. Therapeutical options for chylous fistula remains controversial. On last reviews, there are an agreement on the conservative management. Within of this management, low long-chain triglycerides fat diet is an essential part.
November 2005: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
M A Rubio
Three decades ago, the observations of Trowell and Burkitt gave rise to the "fibre theory", in which it was contended that there was a link between the consumption of a diet rich in fibre and non-processed carbohydrates and the level of protection against many of the "first world diseases" such as constipation, diverticulosis, cancer of the colon, diabetes, obesity and cardiovascular disease. Since that time, numerous studies have been presented to analyze the relationship between fibre and disorders of the gastrointestinal tract and other processes with severe health implications...
2002: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
G Ponce, J L Romero, G Hernández, A Padrón, E Cabrera, C Abad
INTRODUCTION: Morbidity and mortality in elective valve surgery is still significant. The main cause of death in these patients is cardiogenic shock, of which the most frequent etiology is acute myocardial infarction (AMI) with Q wave in the ECG. However, there are patients with cardiogenic shock without Q wave in the ECG and with rises in CK-MB enzyme that makes us suspect non-Q wave AMI. OBJECTIVE: To analyze the use of the determination of cardiac troponin-I, a more specific marker of AMI than CK-MB after cardiac surgery, to detect perioperative non-Q wave AMI, and to establish its clinical significance...
October 2001: Revista Española de Cardiología
A Taccola, D Mino
334 subjects all with anamnesis indicating a vascular acrosyndrome (mostly due to their working conditions) were studied using the pulsoplethysmographic method to evaluate whether a relationship exists between the absence of increases to physiological acral posture and the presence of Raynaud's disease successively induced by Cold Test. The results obtained showed marked correlation (which for some of the subgroups examined was also statistically significant) between the lack of postural regolation and abnormal or frankly phatological plethysmographic findings following the Cold Test...
April 2000: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
M Trignano, I Pisano, G P Mastino, G Sini, V Bresadola, D De Anna, F Tanda, P Cossu-Rocca, L Canu, E Tolu
The aim of the experimental study was to evaluate the possibility of performing an end-to-end anastomosis by using fibrin adhesive as the only means of suture. To this end, 24 Wistar rats were used, of which 16 underwent ilear resection and 8 underwent colotomy, and they were divided respectively into two groups. On the rats of the first group the anastomosis was performed by using only fibrin adhesive; on the rats of the second group operated the anastomosis was performed by using fibrin adhesive in association with non adsorbable suture material, while on those operated of colectomy the anastomosis was performed by fibrin adhesive and adsorbable suture material...
May 1996: Annali Italiani di Chirurgia
A F Holstein
Aging of the testis is a normal physiological process, which gradually proceeds with increasing age. Under normal conditions, an abrupt breaking off the spermatogenetic and hormonal functions of the testis does not occur. Already in the testis of every adult fertile man single degenerating germ cells are recognizable, the occurrence of which is understood as physiological germ cell loss. In men, older than 65 years, further degenerative changes of the germ cells and of the germinal epithelium regularly can be found, which have negative effects on the spermatogenetic activity of the germinal epithelium...
May 1986: Der Urologe. Ausg. A
A Keilani, D Boulieu, D Raudrant, M Carraz, P Quenin
The study was carried out on 175 patients who underwent laparoscopy together with search for chlamydia in the peritoneal fluid when they were having investigations for sterility or for pelvic pain. These patients are classified into three groups according to the clinical and laparoscopic features: 50 cases of acute salpingitis. 104 cases of tubal sterility and 21 control cases who were normal on laparoscopy. The mean age was 25.7 years for acute salpingitis and 30.4 years for tubal sterility. The purpose of this study was to work out the role played by chlamydia trachomatis in tubal phatology and two techniques were used at the same time: The identification of chlamydia trachomatis in 175 samples of peritoneal fluid taken during a laparoscopy; Research for anti-chlamydia antibodies in serum using an indirect micro-immunofluorescent technique...
1989: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
A Giovinetto, P Rinella, O Russo, F Basile, T Bianca
The Authors briefly describe two cases of diaphragmatic relaxatio that they have seen and studied; then they make a revision of the literature about this uncommon disease. They speak about embryogenesis of the diaphragm and about nosology, etiopathogenesis, frequency (ages and sex) and phatological anatomy of this disease. In conclusion the Authors discuss in detail signs and symptoms, diagnosis and surgical treatment of diaphragmatic relaxatio.
August 1979: Chirurgia Italiana
M Meves, H G Beger
A method is described (isotope gastro-diagram) in which a radio-active labelled standard meal is used under physiological and phatological conditions; in this way the half-value time of gastric emptying can be used as an objective measure of gastric motor function, and which can be easily reproduced. This has become of clinical interest, particularly since the introduction of hypotonic and double contrast methods in radiological diagnosis. The clinical value of this method has been elucidated amongst surgical patients on whom pre- and post-operative measurements were carried out following selective vagotomies, combined with various types of pyloroplastry for the treatment of gastric and duodenal ulcers...
April 1976: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
A L Costa, A Amato, A Loteta, A Valenti
According to the higher frequency of isolation of bacterial strains belonging to the genus Pseudomonas from various human phatologic materials, in was seemed interesting to study the biological characteristics of these bacteria, which are the most virulent and pathogenic Gram-microorganism. In the present work the results of cultural, biochemical, cytochemical and immunological tests are reported. In vivo tests were also carried out, using rabbits inoculated with whole cells or their products.
January 1979: Giornale di Batteriologia, Virologia Ed Immunologia
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