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Sara Hägglund, Krister Blodörn, Katarina Näslund, Karin Vargmar, Sara Bergström Lind, Jia Mi, Mariluz Araínga, Sabine Riffault, Geraldine Taylor, John Pringle, Jean François Valarcher
Human and bovine respiratory syncytial viruses (HRSV/BRSV) are major causes of severe lower respiratory tract infections in children and calves, respectively. Shared epidemiological, clinical, pathological and genetic characteristics of these viruses make comparative research highly relevant. To characterise the host response against BRSV infection, bronchoalveolar lavage supernatant (BAL) from i) non-vaccinated, BRSV-infected ii) vaccinated, BRSV-infected and iii) non-infected calves was analysed by tandem mass spectrometry...
2017: PloS One
Jun Lu, Jin-Huan Wei, Zi-Hao Feng, Zhen-Hua Chen, Yong-Qian Wang, Yong Huang, Yong Fang, Yan-Ping Liang, Jun-Jie Cen, Yi-Hui Pan, Bing Liao, Wen-Fang Chen, Wei Chen, Jun-Hang Luo
PURPOSE: To examine the role of miR-106b-5p in regulating the cancer stem-cell-like phenotype in clear cell renal cell carcinomas (ccRCC). EXPERIMENTAL DESIGN: Real-time PCR was performed to evaluate miR-106b-5p levels in ccRCC cell lines and patients specimens. A series of in vivo and in vitro assays were performed to confirm the effect of miR-106b-5p on ccRCC stemness phenotype. RESULTS: ccRCC cells and tissues expressed more miR-106b-5p than normal controls...
March 28, 2017: Oncotarget
Ping Liu, Fei Yang, Yu Zhuang, Qingyang Xiao, Huabin Cao, Caiying Zhang, Tiancheng Wang, Huayuan Lin, Xiaoquan Guo, Guoliang Hu
Ascites syndrome (AS), also known as pulmonary artery hypertension, remains a challenging disease that severely affects both humans and broiler chickens. Pulmonary artery remodeling presents a key step in the development of AS. In this study, we obtained pulmonary artery tissues from broilers with and without AS to perform miRNA sequencing analysis, miRNA-mRNA association analysis and pathological examinations. 29 significantly differentially expressed miRNAs were found both in known and novel miRNAs with 18 up-regulated and 11 down-regulated miRNAs...
January 10, 2017: Oncotarget
Jamaji C Nwanaji-Enwerem, Elena Colicino, Letizia Trevisi, Itai Kloog, Allan C Just, Jincheng Shen, Kasey Brennan, Alexandra Dereix, Lifang Hou, Pantel Vokonas, Joel Schwartz, Andrea A Baccarelli
BACKGROUND: Ambient particles have been shown to exacerbate measures of biological aging; yet, no studies have examined their relationships with DNA methylation age (DNAm-age), an epigenome-wide DNA methylation based predictor of chronological age. OBJECTIVE: We examined the relationship of DNAm-age with fine particulate matter (PM2.5 ), a measure of total inhalable particle mass, and black carbon (BC), a measure of particles from vehicular traffic. METHODS: We used validated spatiotemporal models to generate 1-year PM2...
April 2016: Environmental Epigenetics
Jiangsong Jiang, Kanyarat Promchan, Hong Jiang, Parirokh Awasthi, Heather Marshall, Adam Harned, Ven Natarajan
Bardet-Biedl syndrome (BBS) is a heterogeneous disease characterized by deficiencies in various organs that are caused by defects in genes involved in the genesis, structural maintenance, and protein trafficking of cilia. Leucine zipper transcription factor-like 1 (LZTFL1) has been identified as a BBS protein (BBS17), because patients with mutations in this gene exhibit the common BBS phenotypes. In this study, we generated a knockout mouse model to investigate the effects of LZTFL1 depletion. Lztfl1 knockout mice were born with low birth weight, reached similar weight to those of wild-type mice at 10 weeks of age, and later gained more weight than their wild-type counterparts...
June 20, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
Hong Jiang, Kanyarat Promchan, Bor-Ruei Lin, Stephen Lockett, De Chen, Heather Marshall, Yunden Badralmaa, Ven Natarajan
Retinoic acids, which are metabolites of vitamin A, have been shown to be involved in multiple T cell effector responses through their binding to the retinoic acid receptor, a ligand-activated transcription factor. Because the molecular mechanism of regulation by retinoic acid is still not fully uncovered, we investigated the gene expression profile of all-trans retinoic acid (ATRA)-treated human CD4(+) T cells. Leucine zipper transcription factor-like 1 (LZTFL1) was upregulated by ATRA in a dose- and time-dependent manner...
February 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Q Wei, Z-H Chen, L Wang, T Zhang, L Duan, C Behrens, I I Wistuba, J D Minna, B Gao, J-H Luo, Z P Liu
Lung cancer is the leading cause of cancer-related death in the United States, and metastatic behavior is largely responsible for this mortality. Mutations in multiple 'driver' oncogenes and tumor suppressors are known to contribute to the lung tumorigenesis and in some cases represent therapeutic targets. Leucine Zipper Transcription Factor-like 1 (LZTFL1) is located in the chromosome region 3p21.3 where allelic loss and genetic alterations occur early and frequently in lung cancers. Previously, we found that LZTFL1 is downregulated in epithelial tumors, including lung cancer, and functions as a tumor suppressor in gastric cancers...
May 19, 2016: Oncogene
Poppy Datta, Chantal Allamargot, Joseph S Hudson, Emily K Andersen, Sajag Bhattarai, Arlene V Drack, Val C Sheffield, Seongjin Seo
Compartmentalization and polarized protein trafficking are essential for many cellular functions. The photoreceptor outer segment (OS) is a sensory compartment specialized for phototransduction, and it shares many features with primary cilia. As expected, mutations disrupting protein trafficking to cilia often disrupt protein trafficking to the OS and cause photoreceptor degeneration. Bardet-Biedl syndrome (BBS) is one of the ciliopathies associated with defective ciliary trafficking and photoreceptor degeneration...
August 11, 2015: Proceedings of the National Academy of Sciences of the United States of America
Thibaut Eguether, Jovenal T San Agustin, Brian T Keady, Julie A Jonassen, Yinwen Liang, Richard Francis, Kimimasa Tobita, Colin A Johnson, Zakia A Abdelhamed, Cecilia W Lo, Gregory J Pazour
Vertebrate hedgehog signaling is coordinated by the differential localization of the receptors patched-1 and Smoothened in the primary cilium. Cilia assembly is mediated by intraflagellar transport (IFT), and cilia defects disrupt hedgehog signaling, causing many structural birth defects. We generated Ift25 and Ift27 knockout mice and show that they have structural birth defects indicative of hedgehog signaling dysfunction. Surprisingly, ciliary assembly is not affected, but abnormal hedgehog signaling is observed in conjunction with ciliary accumulation of patched-1 and Smoothened...
November 10, 2014: Developmental Cell
Linbo Wang, Jufeng Guo, Qinchuan Wang, Jichun Zhou, Chenpu Xu, Rongyue Teng, Yongxia Chen, Qun Wei, Zhi-Ping Liu
PURPOSE: Our previous work identified leucine zipper transcription factor-like 1 (LZTFL1) as a novel tumor suppressor gene, with its expression correlated with survival outcome in gastric cancer (GC) patients. This study focuses on the role of LZTFL1 in GC aggression and metastasis as well as its underlying molecular mechanisms. METHOD: LZTFL1 immunohistochemical (IHC) staining on 311 paired normal/cancer tissue arrays were used to reconfirm the clinical significance of LZTFL1 expression...
December 2014: Journal of Cancer Research and Clinical Oncology
E Schaefer, J Lauer, M Durand, V Pelletier, C Obringer, A Claussmann, J-J Braun, C Redin, C Mathis, J Muller, C Schmidt-Mutter, E Flori, V Marion, C Stoetzel, H Dollfus
Ciliopathies are heterogeneous disorders sharing different clinical signs due to a defect at the level of the primary cilia/centrosome complex. Postaxial polydactyly is frequently reported in ciliopathies, especially in Bardet-Biedl syndrome (BBS). Clinical features and genetic results observed in a pair of dizygotic twins with BBS are reported. The following manifestations were present: retinitis pigmentosa, bilateral insertional polydactyly, cognitive impairment and renal dysfunction. X-rays of the hands confirmed the presence of a 4th mesoaxial extra-digit with Y-shaped metacarpal bones...
May 2014: Clinical Genetics
Vincent Marion, Fanny Stutzmann, Marion Gérard, Charlie De Melo, Elise Schaefer, Aurélie Claussmann, Sophie Hellé, Valérie Delague, Eric Souied, Catherine Barrey, Alain Verloes, Corinne Stoetzel, Hélène Dollfus
BACKGROUND: Bardet--Biedl Syndrome (BBS) is an emblematic recessive genetically highly heterogeneous ciliopathy characterised mainly by polydactyly, retinitis pigmentosa, obesity, cognitive impairment, and kidney dysfunction. The 16 BBS genes known to date are implied in the primary cilia related cellular pathways. METHODS AND RESULTS: Single nucleotide polymorphism (SNP) array analysis followed by exome sequencing was performed in a consanguineous family diagnosed with BBS with unusual developmental features, namely situs inversus and insertional polydactyly...
May 2012: Journal of Medical Genetics
Takuya Sakurai, Junetsu Ogasawara, Takako Kizaki, Yoshinaga Ishibashi, Tomonori Fujiwara, Kimio Akagawa, Tetsuya Izawa, Shuji Oh-ishi, Shukoh Haga, Hideki Ohno
It is well known that exercise prevents and reduces cognitive impairment. In the present study, we focused on exercise training as a tool to prevent cognitive impairment, and searched for novel molecules that may relate to the prevention of cognitive impairment in the hippocampus. Two-month-old senescence-accelerated mouse prone-8 (SAMP8) mice were subjected to voluntary exercise training by running on a wheel for 4 months, and were then assigned a conditioned fear memory test. Moreover, various mRNA levels in the hippocampus were examined by DNA array analysis and real-time PCR...
December 9, 2011: Biochemical and Biophysical Research Communications
Seongjin Seo, Qihong Zhang, Kevin Bugge, David K Breslow, Charles C Searby, Maxence V Nachury, Val C Sheffield
Many signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including differentiation, proliferation, organogenesis, and tumorigenesis. Bardet-Biedl Syndrome (BBS) proteins are involved in maintaining ciliary function by mediating protein trafficking to the cilia. However, the mechanisms governing ciliary trafficking by BBS proteins are not well understood. Here, we show that a novel protein, Leucine-zipper transcription factor-like 1 (LZTFL1), interacts with a BBS protein complex known as the BBSome and regulates ciliary trafficking of this complex...
November 2011: PLoS Genetics
Qun Wei, Wen Zhou, Weining Wang, Boning Gao, Linbo Wang, Jiang Cao, Zhi-Ping Liu
Human leucine zipper transcription factor-like 1 (LZTFL1) is a novel gene with unknown biological functions. It is located in the chromosome region 3p21.3, a hotspot for tumor suppressor genes. To understand the biological functions of LZTFL1, we surveyed the expression level of LZTFL1 in tumor and normal samples in tissue microarrays and a clinical archive of 84 gastric cancer specimens using immunohistochemistry. We found that LZTFL1 is expressed highly in the epithelial cells of normal tissues and is significantly downregulated in the corresponding tumor samples...
April 1, 2010: Cancer Research
H Kiss, D Kedra, C Kiss, M Kost-Alimova, Y Yang, G Klein, S Imreh, J P Dumanski
Deletions on 3p have been described in a large number of human tumors, suggesting the presence of a tumor suppressor gene(s). Using the elimination test, we previously defined a 1-Mb segment from human 3p21.3 (C3CER1). Genomic sequencing allowed us to construct a transcription map covering 250 kb containing five genes. We have characterized a human leucine zipper containing gene, leucine zipper transcription factor-like 1 (LZTFL1), and its mouse orthologue (Lztfl1), which was also mapped to mouse chromosome 9F...
April 1, 2001: Genomics
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