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JOURNAL ARTICLE
Warren D Backman, Michael V DiCaro, Xintong Zuo, Adelqui Peralta, Ariela R Orkaby
BACKGROUND: Patients ≥80 with implantable cardioverter-defibrillators (ICDs) have high rates of hospitalization and mortality, yet few have documented advance directives. We sought to determine the prevalence of advance directives in adults ≥80 years with ICDs, focusing on those with frailty and cognitive impairment. METHODS: Prospective cohort study (July 2016-May 2019) in an electrophysiology clinic. Presence of advance directives (health care proxies [HCP] and living wills [LW], or medical orders for life-sustaining treatment [MOLST]) was determined by medical record review...
April 10, 2024: Pacing and Clinical Electrophysiology: PACE
#22
JOURNAL ARTICLE
Alida L P Caforio, Juan P Kaski, Juan R Gimeno, Perry M Elliott, Cecile Laroche, Luigi Tavazzi, Michal Tendera, Michael Fu, Simone Sala, Petar M Seferovic, Tiina Heliö, Leonardo Calò, Olga Blagova, Ahmad Amin, Ingrid Kindermann, Gianfranco Sinagra, Andrea Frustaci, Daniel Bonnet, Philippe Charron, Aldo P Maggioni
BACKGROUND AND AIMS: Contemporary multicentre data on clinical and diagnostic spectrum and outcome in myocarditis are limited. Study aims were to describe baseline features, 1-year follow-up, and baseline predictors of outcome in clinically suspected or biopsy-proven myocarditis (2013 European Society of Cardiology criteria) in adult and paediatric patients from the EURObservational Research Programme Cardiomyopathy and Myocarditis Long-Term Registry. METHODS: Five hundred eighty-one (68...
April 10, 2024: European Heart Journal
#23
REVIEW
Syed Bukhari, Syed Zamrak Khan, Mohamed Ghoweba, Bilal Khan, Zubair Bashir
Cardiac amyloidosis is caused by amyloid fibrils that deposit in the myocardial interstitium, causing restrictive cardiomyopathy and eventually death. The electromechanical, inflammatory, and autonomic changes due to amyloid deposition result in arrhythmias. Atrial fibrillation is by far the most common arrhythmia. The rate control strategy is generally poorly tolerated due to restrictive filling physiology and heart rate dependance, favoring adoption of the rhythm control strategy. Anticoagulation for stroke prophylaxis is warranted, irrespective of CHA2 DS2 -VASc score in patients with a favorable bleeding profile; data on left appendage closure devices are still insufficient...
February 25, 2024: Journal of Clinical Medicine
#24
JOURNAL ARTICLE
Anna van Veelen, Tom E Verstraelen, Yvemarie B O Somsen, Joëlle Elias, Ivo M van Dongen, Peter Paul H M Delnoy, Marcoen F Scholten, Lucas V A Boersma, Alexander H Maass, Sipke Strikwerda, Mehran Firouzi, Cornelis P Allaart, Kevin Vernooy, Robert W Grauss, Raymond Tukkie, Paul Knaapen, Aeilko H Zwinderman, Marcel G W Dijkgraaf, Bimmer E P M Claessen, Marit van Barreveld, Arthur A M Wilde, José P S Henriques
BACKGROUND: Chronic total coronary occlusions (CTO) substantially increase the risk for sudden cardiac death. Among patients with chronic ischemic heart disease at risk for sudden cardiac death, an implantable cardioverter defibrillator (ICD) is the favored therapy for primary prevention of sudden cardiac death. This study sought to investigate the impact of CTOs on the risk for appropriate ICD shocks and mortality within a nationwide prospective cohort. METHODS AND RESULTS: This is a subanalysis of the nationwide Dutch-Outcome in ICD Therapy (DO-IT) registry of primary prevention ICD recipients in The Netherlands between September 2014 and June 2016 (n=1442)...
April 9, 2024: Journal of the American Heart Association
#25
JOURNAL ARTICLE
Avani Lamba, Thomas M Roston, Puck J Peltenburg, Dania Kallas, Sonia Franciosi, Krystien V V Lieve, Prince J Kannankeril, Minoru Horie, Seiko Ohno, Ramon Brugada, Takeshi Aiba, Peter Fischbach, Linda Knight, Jan Till, Sit-Yee Kwok, Vincent Probst, David Backhoff, Martin J LaPage, Anjan S Batra, Fabrizio Drago, Kristina Haugaa, Andrew D Krahn, Tomas Robyns, Heikki Swan, Terezia Tavacova, Joseph Atallah, Martin Borggrefe, Boris Rudic, Georgia Sarquella-Brugada, Ehud Chorin, Allison Hill, Janneke Kammeraad, Anna Kamp, Ian Law, James Perry, Jason D Roberts, Svjetlana Tisma-Dupanovic, Christopher Semsarian, Jonathan R Skinner, Jacob Tfelt-Hansen, Isabelle Denjoy, Antoine Leenhardt, Peter J Schwartz, Michael J Ackerman, Arthur A M Wilde, Christian van der Werf, Shubhayan Sanatani
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) may cause sudden cardiac death (SCD) despite medical therapy. Therefore, implantable cardioverter defibrillators (ICDs) are commonly advised. However, there are limited data on the outcomes of ICD use in children. OBJECTIVE: To compare the risk of arrhythmic events in pediatric CPVT patients with and without ICDs. METHODS: We compared the risk of SCD in RYR2 variant and phenotype positive symptomatic CPVT patients with and without ICDs, who were <19 years of age and had no history of sudden cardiac arrest (SCA) at phenotype diagnosis...
April 6, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#26
JOURNAL ARTICLE
Sonia Chabrak, Abdeddayem Haggui, Emna Allouche, Sana Ouali, Afef Ben Halima, Slim Kacem, Salma Krichen, Sonia Marrakchi, Wafa Fehri, Mohamed Sami Mourali, Zeineb Jabbari, Manel Ben Halima, Elyes Neffati, Aymen Heraiech, Mehdi Slim, Salem Kachboura, Habib Gamra, Majed Hassine, Sondes Kraiem, Sofien Kammoun, Leila Bezdah, Gouider Jridi, Hatem Bouraoui, Samir Kammoun, Rania Hammami, Rafik Chettaoui, Youssef Ben Ameur, Fares Azaiez, Rami Tlili, Kais Battikh, Hedi Ben Slima, Rim Chrigui, Samia Fazaa, Islem Sanaa, Yassine Ellouz, Mohamed Mosrati, Sami Milouchi, Soumaya Jarmouni, Wacef Ayadi, Malek Akrout, Rabie Razgallah, Wissal Neffati, Meriem Drissa, Selma Charfeddine, Salem Abdessalem, Leila Abid, Lilia Zakhama
BACKGROUND: In Tunisia, the number of cardiac implantable electronic devices (CIEDs) is increasing, owing to the increase in patient life expectancy and expanding indications. Despite their life-saving potential and a significant reduction in population morbidity and mortality, their increased numbers have been associated with the development of multiple early and late complications related to vascular access, pockets, leads, or patient characteristics. OBJECTIVE: The study aims to identify the rate, type, and predictors of complications occurring within the first year after CIED implantation...
April 8, 2024: JMIR Research Protocols
#27
JOURNAL ARTICLE
Richárd Masszi, Előd-János Zsigmond, Réka Ehrenberger, Caner Turan, Péter Fehérvári, Brigitta Teutsch, Zsolt Molnár, Zsófia Drobni, Hajnalka Vágó, Péter Hegyi, Béla Merkely, Annamária Kosztin
AIMS: Late gadolinium enhancement (LGE) assessed by cardiovascular magnetic resonance (CMR) can evaluate myocardial scar associated with a higher risk of sudden cardiac death (SCD), which can guide the selection between cardiac resynchronization therapy with or without a defibrillator (CRT-P/CRT-D). Our aim was to investigate the association between LGE and SCD risk in patients with CRT using the LGE-CMR technique. METHODS AND RESULTS: We performed a systematic literature search using four databases...
April 8, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#28
JOURNAL ARTICLE
Anmol Johal, Ndausung Udongwo, Steven Imburgio, Anton Mararenko, Hira Akhlaq, Sowmya Dandu, Temidayo Abe, Jesus Almendral, Joseph Heaton, Riple Hansalia
INTRODUCTION: COVID-19 drastically impacted the landscape of the United States' medical system. Limited data is available on the nationwide implantation trends in Cardiac Resynchronization Therapy Defibrillator (CRT-D) devices before and during the pandemic. We aimed to explore the impact of the COVID-19 pandemic on CRT-D insertion rates and adverse outcomes related to delays in care. METHODS AND RESULTS: We conducted a retrospective cross-sectional analysis using the National Inpatient Sample database between 2017 and 2020...
April 2024: Journal of Arrhythmia
#29
JOURNAL ARTICLE
Kenta Tsutsui, Yoshitaka Terazaki, Risa Kanai, Masako Ishii, Seika Ohno, Yoko Sasaki, Akira Kitamura, Daisuke Kudo, Wataru Sasaki, Naomichi Tanaka, Masataka Narita, Kazuhisa Matsumoto, Hitoshi Mori, Yoshifumi Ikeda, Takahide Arai, Shintaro Nakano, Ritsushi Kato
OBJECTIVE: Postoperative pain is a major issue with subcutaneous implantable cardioverter defibrillators (S-ICD). In 2020, we introduced intravenous patient-controlled analgesia (IV-PCA) in addition to the conventional, request-based analgesia for postoperative pain control in S-ICD. To determine the effect and safety, we quantitatively assessed the effect of IV-PCA after S-ICD surgery over conventional methods. METHODS: During the study period, a total of 113 consecutive patients (age, 50...
April 2024: Journal of Arrhythmia
#30
Santiago Luna-Alcala, Mauricio Garcia-Cardenas, Enrique C Guerra, Pavel Martinez-Dominguez, Aldo Cabello-Ganem, Leonardo Proaño-Bernal, Cristian A Chava-Ponte, Arturo Hernandez-Pacherres, Nilda Espinola-Zavaleta
Arrhythmogenic cardiomyopathy is a biventricular disease in which the effect on the left ventricle can be either equivalent to or more severe than that on the right ventricle. It is a rare disease due to its low reported prevalence and typically becomes clinically evident during the second to fourth decade of life. It represents 4% of sudden cardiac death cases referred for autopsy and 10% of cases of unexplained cardiac arrest. We present a challenging case report of a 68-year-old man who arrived at the emergency room with chest discomfort, palpitations, and light-headedness before a syncopal episode with urinary incontinence...
June 2024: Radiology Case Reports
#31
Deepti Ranganathan, Eduardo Sanhueza Gonzalez, Maria Terricabras, Christopher C Cheung
A young man presented following successful cardiac resuscitation after an out-of-hospital cardiac arrest. During his admission, he had multiple runs of short-coupled ventricular fibrillation with a similar morphology premature ventricular complex (PVC) trigger. He was brought to the electrophysiology laboratory, and, with a high dose of isoprenaline, the PVC was localised to the moderator band. Ablation induced short runs of ventricular tachycardia before elimination of the PVC. He subsequently underwent subcutaneous implantable cardiac defibrillator implantation before his discharge...
March 2024: Journal of Innovations in Cardiac Rhythm Management
#32
JOURNAL ARTICLE
Radosław Lenarczyk, Katja Zeppenfeld, Jacob Tfelt-Hansen, Frank R Heinzel, Thomas Deneke, Elena Ene, Christian Meyer, Arthur Wilde, Elena Arbelo, Ewa Jędrzejczyk-Patej, Avi Sabbag, Markus Stühlinger, Luigi di Biase, Marmar Vaseghi, Ohad Ziv, William-Fernando Bautista-Vargas, Saurabh Kumar, Narayanan Namboodiri, Benhur Davi Henz, Jose Montero-Cabezas, Nikolaos Dagres, Petr Peichl, Antonio Frontera, Stylianos Tzeis, Jose Luis Merino, Kyoko Soejima, Christian de Chillou, Roderick Tung, Lars Eckardt, Philippe Maury, Peter Hlivak, Larisa G Tereshchenko, Pipin Kojodjojo, Jacob Atié
Electrical storm (ES) is a state of electrical instability, manifesting as recurrent ventricular arrhythmias (VAs) over a short period of time (three or more episodes of sustained VA within 24 h, separated by at least 5 min, requiring termination by an intervention). The clinical presentation can vary, but ES is usually a cardiac emergency. Electrical storm mainly affects patients with structural or primary electrical heart disease, often with an implantable cardioverter-defibrillator (ICD). Management of ES requires a multi-faceted approach and the involvement of multi-disciplinary teams, but despite advanced treatment and often invasive procedures, it is associated with high morbidity and mortality...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#33
JOURNAL ARTICLE
Marco Schiavone, Alessio Gasperetti, Paolo Compagnucci, Julia Vogler, Mikael Laredo, Elisabetta Montemerlo, Simone Gulletta, Alexander Breitenstein, Matteo Ziacchi, Martin Martinek, Michela Casella, Pietro Palmisano, Lukas Kaiser, Carlo Lavalle, Leonardo Calò, Sebastian Seidl, Ardan M Saguner, Giovanni Rovaris, Jürgen Kuschyk, Mauro Biffi, Luigi Di Biase, Antonio Dello Russo, Claudio Tondo, Paolo Della Bella, Roland Tilz, Giovanni B Forleo
AIMS: Catheter ablation (CA) of ventricular tachycardia (VT) has become an important tool to improve clinical outcomes in patients with appropriate transvenous implantable cardioverter defibrillator (ICD) shocks. The aim of our analysis was to test whether VT ablation (VTA) impacts long-term clinical outcomes even in subcutaneous ICD (S-ICD) carriers. METHODS AND RESULTS: International Subcutaneous Implantable Cardioverter Defibrillator (iSUSI) registry patients who experienced either an ICD shock or a hospitalization for monomorphic VT were included in this analysis...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#34
MULTICENTER STUDY
Atul Verma, Vidal Essebag, Petr Neuzil, Katia Dyrda, Jippe Balt, Borislav Dinov, Angeliki Darma, Arash Arya, Frederic Sacher, Vivek Y Reddy, Lucas Boersma, Ilya Grigorov, Tom De Potter
AIMS: The ultra-low-temperature cryoablation (ULTC) ablation system using -196°C N2 cryogen has been reported to create lesions with freeze duration-dependent depth titratable to over 10 mm with minimum attenuation by scar. Cryocure-VT (NCT04893317) was a first-in-human clinical trial evaluating the safety and efficacy of a novel, purpose-built ULTC catheter in endocardial ablation of scar-dependent ventricular tachycardias (VTs). METHODS AND RESULTS: This prospective, multi-centre study enrolled patients referred for de novo or second ablations of recurrent monomorphic VT of both ischaemic and non-ischaemic aetiologies...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#35
JOURNAL ARTICLE
Cristina Gómez González, Iván Del Campo Cano, Ana Isabel Fernández-Avila, Maria Paz Suárez-Mier, María José Sagastizábal, Reyes Álvarez García-Rovés, Irene Méndez Fernández, Silvia Vilches, Miriam Centeno Jiménez, Ana Siles Sánchez-Manjavacas, Ana Usano Carrasco, Emiliano Gonzalez-Vioque, Juan Pablo Ochoa, Constancio Medrano, Esther González López, Pablo García-Pavía, Javier Bermejo, María Angeles Espinosa Castro
Biallelic variants in PPA2 gene cause a rare but lethal mitochondrial disorder. We describe the first four cases reported in Spain of PPA2 disease in two unrelated families. We have conducted a revision of the clinical history, necropsies, and postmortem genetic testing from probands, and clinical evaluation, genetic testing and blood transcript analysis in family members. All the cases harbored biallelic PPA2 variants in compound heterozygous status. Two brothers from family 1 suffered sudden death after a small first intake of alcohol in 2013 and 2022...
April 4, 2024: Gene
#36
JOURNAL ARTICLE
Shreyas Singireddy, Samuel Edusa
Rationale Sarcoidosis with cardiac involvement can be associated with serious life-threatening arrhythmias and an increased risk of sudden cardiac death. Implantable cardiac defibrillators (ICDs) have been used for primary and secondary prevention of sudden death in patients with cardiac sarcoidosis (CS). Post-ICD placement complications have been shown to be higher in patients with CS. However, data comparing postoperative ICD complications among sarcoidosis patients with the general population is limited...
March 2024: Curēus
#37
JOURNAL ARTICLE
Menno T Maris, Ayca Koçar, Dick L Willems, Jeannette Pols, Hanno L Tan, Georg L Lindinger, Marieke A R Bak
BACKGROUND: The emergence of artificial intelligence (AI) in medicine has prompted the development of numerous ethical guidelines, while the involvement of patients in the creation of these documents lags behind. As part of the European PROFID project we explore patient perspectives on the ethical implications of AI in care for patients at increased risk of sudden cardiac death (SCD). AIM: Explore perspectives of patients on the ethical use of AI, particularly in clinical decision-making regarding the implantation of an implantable cardioverter-defibrillator (ICD)...
April 4, 2024: BMC Medical Ethics
#38
JOURNAL ARTICLE
Sabine Ammann, Arnaud Dominati, Philippe Meyer, Etienne Pruvot, Camillo Ribi, Jörg Seebach
The diagnosis of cardiac sarcoidosis, particularly in its isolated cardiac form, represents a major challenge due to non-specific symptoms and the limited sensitivity and specificity of basic cardiac investigations. MRI and metabolic PET-CT are important elements in the diagnostic process. Corticosteroids remain the cornerstone for the treatment of the inflammatory phase, in association with biological agents and steroid-sparing therapies. The goal is to limit the progression of fibrosis, which is a source of malignant arrhythmias and heart failure...
April 3, 2024: Revue Médicale Suisse
#39
JOURNAL ARTICLE
E Doğan, F Ergin, M B Beyter, G Kayan Kaşıkçı, O Ay, R E Levent, Ç Engin, Z Ülger
OBJECTIVE: Pediatric heart failure is an important cause of morbidity and mortality in childhood. Left ventricular assist devices (L-VAD) are used for bridging to transplantation in patients with indications for heart transplantation. PATIENTS AND METHODS: The children included in the study were patients who underwent implantation of an L-VAD due to advanced heart failure at Ege University Faculty of Medicine Hospital between January 2009 and January 2023. RESULTS: Of the 33 patients who underwent L-VAD implantation, 16 (48...
March 2024: European Review for Medical and Pharmacological Sciences
#40
JOURNAL ARTICLE
Hui Sun, Xin Liu, Jin Fu, Yin Song, Xiaoxiao Qin, Haiyin Wang
OBJECTIVES: Implantable cardioverter defibrillator (ICDs) for primary prevention (PP) of sudden cardiac arrest (SCA) is underutilized in developing countries. The Improve SCA study has identified a subset of 1.5 primary prevention (1.5PP) patients with a higher risk of SCA and a significant mortality benefit from ICD therapy. From the perspective of China's healthcare system, we evaluated the cost-effectiveness of ICD therapy vs. no ICD therapy among1.5PP patients with a view of informing clinical and policy decisions...
April 3, 2024: Journal of Medical Economics
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