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JOURNAL ARTICLE
John A Stauffer, David Hyman, Gina Porrazzo, Mary Tice, Zhuo Li, Tariq Almerey
BACKGROUND: Laparoscopic pancreaticoduodenectomy has been found safe and associated with advantages over open pancreaticoduodenectomy in prior studies. We compared outcomes of laparoscopic pancreaticoduodenectomy versus open pancreaticoduodenectomy at a single institution after applying technical aspects and perioperative care learned from laparoscopic pancreaticoduodenectomy to the open pancreaticoduodenectomy practice. METHODS: From January 2010 to December 2020, all patients undergoing pancreaticoduodenectomy were identified, and information was collected in a prospective fashion...
April 2024: Surgery
#22
JOURNAL ARTICLE
Joseline Haizel-Cobbina, Ama Eli Boumi, Erica Chung, James Sobboh, Jonathan M Rose, Esther Mwangi, Rebecca Johnson, Richard B Oni, Danushka Wanduragala, William M Stauffer Iii
No abstract text is available yet for this article.
February 2, 2024: Journal of Travel Medicine
#23
JOURNAL ARTICLE
Kevin Barley, Anshuman Parekh, Syed Pervez Salam, Damodara Rao Mendu, Ravi Prakash Shukla, Deepa Vatti, Daniel Verina, Chanan Stauffer, Christian Salib, Siraj El Jamal, Julie Teruya-Feldstein, Amy S Duffield, Violetta V Leshchenko, Sundar Jagannath, Manisha Balwani, Samir Parekh
No abstract text is available yet for this article.
January 29, 2024: Blood Advances
#24
REVIEW
Emily J Luo, Albert T Anastasio, Taylor Stauffer, Caitlin Grant, Christine J Wu, Kevin A Wu, Samantha Kaplan, Brian C Lau
Background: Jones fracture, or proximal fifth metatarsal fracture, is a common injury in National Football League (NFL)-caliber athletes. Combine draft performance can greatly impact the long-term success of these athletes, and substantial emphasis has been placed on early return to play (RTP) and the minimization of post-operative complications after Jones fracture in these athletes. To date, no study has specifically described the treatment and outcomes of this injury specifically in NFL-caliber players, considering factors relevant to this unique population...
December 25, 2023: Sports
#25
REVIEW
Henry Madsen, Jay Richard Stauffer
Parasites are very diverse and common in both natural populations and in stocks kept in aquacultural facilities. For most cultured species, there are important bacteria and viruses causing diseases, but eukaryotic parasites are also very important. We review the various combinations of aquacultured species and eukaryotic parasitic groups and discuss other problems associated with aquaculture such as eutrophication, zoonotic species, and invasive species, and we conclude that further development of aquaculture in a sustainable manner must include a holistic approach (One Health) where many factors (e...
January 11, 2024: Biology
#26
JOURNAL ARTICLE
Adrianus F Konings, Torin A Miller, Jay R Stauffer Jr
Pseudotropheus Regan had been a catch-all genus for many of the rock-dwelling cichlids of Lake Malai, known as mbuna, for over half a century. Although many of the species previously assigned to this genus have since been allocated to other genera there are still about a dozen species in the genus that do not appear to be closely related to its type species, P. williamsi, but for which no better placement could be found. Pseudotropheus livingstonii (Boulenger) is one such species and the new species described herein appears to be closely related and has for that reason been temporarily assigned to Pseudotropheus...
January 11, 2024: Zootaxa
#27
JOURNAL ARTICLE
Caitlin Grant, Taylor P Stauffer, Thorsten M Seyler, Christine J Wu, Zoe W Hinton
BACKGROUND: Historically, orthopaedic surgery has had low female representation, with <6% of practicing surgeons identifying as female. Although prior literature has illustrated gender disparities in first and last authorship as well as changes in gender representation over time, less attention has been paid to middle authorship. We hypothesized that trends in female authorship would reflect increasing female participation in orthopaedic surgery and orthopaedic subspecialties coinciding with an overall increase in female authorship...
January 9, 2024: Journal of Bone and Joint Surgery. American Volume
#28
JOURNAL ARTICLE
Andrea Accogli, Saurabh Shakya, Taewoo Yang, Christine Insinna, Soo Yeon Kim, David Bell, Kirill R Butov, Mariasavina Severino, Marcello Niceta, Marcello Scala, Hyun Sik Lee, Taekyeong Yoo, Jimmy Stauffer, Huijie Zhao, Chiara Fiorillo, Marina Pedemonte, Maria C Diana, Simona Baldassari, Viktoria Zakharova, Anna Shcherbina, Yulia Rodina, Christina Fagerberg, Laura Sønderberg Roos, Jolanta Wierzba, Artur Dobosz, Amanda Gerard, Lorraine Potocki, Jill A Rosenfeld, Seema R Lalani, Tiana M Scott, Daryl Scott, Mahshid S Azamian, Raymond Louie, Hannah W Moore, Neena L Champaigne, Grace Hollingsworth, Annalaura Torella, Vincenzo Nigro, Rafal Ploski, Vincenzo Salpietro, Federico Zara, Simone Pizzi, Giovanni Chillemi, Marzia Ognibene, Erin Cooney, Jenny Do, Anders Linnemann, Martin J Larsen, Suzanne Specht, Kylie J Walters, Hee-Jung Choi, Murim Choi, Marco Tartaglia, Phillippe Youkharibache, Jong-Hee Chae, Valeria Capra, Sung-Gyoo Park, Christopher J Westlake
WDR44 prevents ciliogenesis initiation by regulating RAB11-dependent vesicle trafficking. Here, we describe male patients with missense and nonsense variants within the WD40 repeats (WDR) of WDR44, an X-linked gene product, who display ciliopathy-related developmental phenotypes that we can model in zebrafish. The patient phenotypic spectrum includes developmental delay/intellectual disability, hypotonia, distinct craniofacial features and variable presence of brain, renal, cardiac and musculoskeletal abnormalities...
January 8, 2024: Nature Communications
#29
JOURNAL ARTICLE
Hao Luo, David Mahon, Patrick Wong, Nandakumar Madayiputhiya, Yingchen Chen, Tara Stauffer, Li Tao, Ming Zeng
Protein tyrosine sulfation is a post-translational modification (PTM) that is rarely reported in recombinant therapeutic proteins. However, when sulfation does occur, the additional negative charge from the modification can influence intermolecular interactions and antigen-binding activity, making it a critical quality attribute that necessitates stringent control. In this study, we developed a unique hydrophobic interaction chromatography (HIC) method for the separation and quantification of a therapeutic bispecific antibody with varying degrees of sulfation...
December 22, 2023: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
#30
JOURNAL ARTICLE
Kevin Felt, Madeleine Stauffer, Leslie Salas-Estrada, Peter R Guzzo, Dejian Xie, Jinkun Huang, Marta Filizola, Sudha Chakrapani
Hyperactivity of serotonin 3 receptors (5-HT3 R) underlies pathologies associated with irritable bowel syndrome and chemotherapy-induced nausea and vomiting. Setrons, a class of high-affinity competitive antagonists, are used in the treatment of these conditions. Although generally effective for chemotherapy-induced nausea and vomiting, the use of setrons for treating irritable bowel syndrome has been impaired by adverse side effects. Partial agonists are now being considered as an alternative strategy, with potentially less severe side effects than full antagonists...
January 4, 2024: Nature Structural & Molecular Biology
#31
JOURNAL ARTICLE
Joachim Baech, Simon Husby, Trine Trab, Kristian Kragholm, Peter Brown, Jette S Gørløv, Judit M Jørgensen, Sif Gudbrandsdottir, Marianne Tang Severinsen, Kirsten Grønbaek, Thomas Stauffer Larsen, Tove Wästerlid, Sandra Eloranta, Knut B Smeland, Lasse Hjort Jakobsen, Tarec C El-Galaly
Cardiovascular diseases, especially congestive heart failure (CHF), are known complications of anthracyclines, but the risk for patients undergoing high-dose chemotherapy and autologous stem cell transplant (HDT-ASCT) is not well established. With T-cell therapies emerging as alternatives, studies of long-term complications after HDT-ASCT are warranted. Danish patients treated with HDT-ASCT for aggressive lymphoma between 2001 and 2017 were matched 1:5 on sex, birth year and Charlson comorbidity score to the general population...
December 28, 2023: British Journal of Haematology
#32
JOURNAL ARTICLE
Angelo D'Alessandro, Eric J Earley, Travis Nemkov, Daniel Stephenson, Monika Dzieciatkowska, Kirk C Hansen, Giampaolo Minetti, Benoit Champigneulle, Emeric Stauffer, Aurélien Pichon, Michael Furian, Samuel Verges, Steven Kleinman, Philip J Norris, Michael P Busch, Grier P Page, Lars Kaestner
Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes to physiological human adaptations to hypoxia, a multifaceted process critical to health and disease. To delve into the molecular underpinnings of this phenomenon, first, we performed a multi-omics analysis of RBCs from six lowlanders after exposure to high-altitude hypoxia, with longitudinal sampling at baseline, upon ascent to 5,100 m and descent to sea level. Results highlighted an association between erythrocyte levels of 2,3-bisphosphoglycerate (BPG), an allosteric regulator of hemoglobin that favors oxygen off-loading in the face of hypoxia, and expression levels of the Rhesus blood group RHCE protein...
January 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
#33
JOURNAL ARTICLE
Benoit Champigneulle, Julien V Brugniaux, Emeric Stauffer, Stéphane Doutreleau, Michael Furian, Elisa Perger, Alessandra Pina, Sébastien Baillieul, Blandine Deschamps, Ivan Hancco, Philippe Connes, Paul Robach, Aurélien Pichon, Samuel Verges
Exposure to chronic hypobaric hypoxia imposes a significant physiological burden to more than 80 million humans living above 2500 m throughout the world. Among them, 50 000 live in the world's highest city, La Rinconada, located at 5000-5300 m in southern Peru. Expedition 5300 is the first scientific and medical programme led in La Rinconada to investigate the physiological adaptations and altitude-related health issues in this unique population. Dwellers from La Rinconada have very high haemoglobin concentration (20...
December 26, 2023: Journal of Physiology
#34
JOURNAL ARTICLE
Elliot Marseille, Christopher S Stauffer, Manish Agrawal, Paul Thambi, Kimberly Roddy, Michael Mithoefer, Stefano M Bertozzi, James G Kahn
OBJECTIVE: To compare group and individual psychedelic-assisted therapy in terms of clinician time, costs and patient access. METHODS: Using 2023 data from two group therapy trial sites, one using 3,4-Methylenedioxymethamphetamine (MDMA) to treat posttraumatic stress disorder (PTSD), and one using psilocybin to treat major depressive disorder (MDD), we compared overall variable costs, clinician costs and clinician time required by therapy protocols utilizing groups versus individual patient therapy...
2023: Frontiers in Psychiatry
#35
REVIEW
Genewoo Hong, Alexandra Sideris, Seth Waldman, Joe Stauffer, Christopher L Wu
Federal and state laws in the United States governing the use of cannabis are rapidly evolving. Under federal law, marijuana and its derivatives remain schedule I, defined as substances having no currently accepted medical use and a high potential for abuse. Hemp and its derivatives, in contrast, have been removed from schedule I. At the state level, a majority of states have passed laws legalizing cannabis in some form, although these laws vary from state to state in terms of the extent to which use is permitted, approved medical uses, and the types of regulation placed on commercial activity and quality control...
January 1, 2024: Anesthesia and Analgesia
#36
JOURNAL ARTICLE
Tamara Megan Huete-Stauffer, Ramiro Logares, Mohd Ikram Ansari, Anders Røstad, Maria Lluch Calleja, Xosé Anxelu G Morán
BACKGROUND: The diel vertical migration (DVM) of fish provides an active transport of labile dissolved organic matter (DOM) to the deep ocean, fueling the metabolism of heterotrophic bacteria and archaea. We studied the impact of DVM on the mesopelagic prokaryotic diversity of the Red Sea focusing on the mesopelagic deep scattering layer (DSL) between 450-600 m. RESULTS: Despite the general consensus of homogeneous conditions in the mesopelagic layer, we observed variability in physico-chemical variables (oxygen, inorganic nutrients, DOC) in the depth profiles...
December 14, 2023: Environmental microbiome
#37
JOURNAL ARTICLE
Shuying Wan, Dario B Rodrigues, Janet Kwiatkowski, Omaditya Khanna, Kevin D Judy, Robert C Goldstein, Marty Overbeek Bloem, Yan Yu, Sophia E Rooks, Wenyin Shi, Mark D Hurwitz, Paul R Stauffer
Previous work has reported the design of a novel thermobrachytherapy (TBT) balloon implant to deliver magnetic nanoparticle (MNP) hyperthermia and high-dose-rate (HDR) brachytherapy simultaneously after brain tumor resection, thereby maximizing their synergistic effect. This paper presents an evaluation of the robustness of the balloon device, compatibility of its heat and radiation delivery components, as well as thermal and radiation dosimetry of the TBT balloon. TBT balloon devices with 1 and 3 cm diameter were evaluated when placed in an external magnetic field with a maximal strength of 8...
December 1, 2023: Cancers
#38
JOURNAL ARTICLE
Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Michael Ghijs, Eduardo Dos Santos Schultz, Mina Roudgar, Tamas Vigh, Fanny Stauffer, Ingmar Nopens, Thomas De Beer
In the last few years, twin-screw wet granulation (TSWG) has become one of the key continuous pharmaceutical unit operations. Despite the many studies that have been performed, only little is known about the effect of the starting material properties on the stepwise granule formation along the length of the twin-screw granulator (TSG) barrel. Hence, this study obtained a detailed understanding of the effect of formulation properties (i.e., Active Pharmaceutical Ingredient (API) properties, formulation blend particle size distribution and formulation drug load) and process settings on granule formation in TSWG...
December 6, 2023: International Journal of Pharmaceutics
#39
Catherine Bullock, Dana Amiraian, Tariq Almerey, John Stauffer, Miglena K Komforti, Jordan D LeGout
Ectopic pancreas, or the presence of pancreatic tissue separate from the anatomic pancreas, is rarely reported in locations other than the stomach or duodenum. A 43-year-old female was found to have a large jejunal mesenteric ectopic pancreas causing ectopic pancreatitis during workup for frequent episodes of abdominal pain. We present the imaging findings and postresection pathology findings of a rare jejunal ectopic pancreas and discuss the potential complications of this unique condition.
January 2024: Radiology Case Reports
#40
Monika Ryś, Karolina Piotrowicz, Marcin Chłosta, Mateusz Ostachowski, Barbara Gryglewska, Piotr Chłosta, Jerzy Gąsowski
We describe a case of a 74-year-old patient with recurrent fever of up-to 38.5°C, nocturnal sweating, weight loss of 4 kg, non-characteristic pain, and elevation of liver function tests (LFTs), who was diagnosed with Stauffer's syndrome. The patient successfully underwent laparoscopic heminephrectomy. The histology was clear-cell carcinoma of the right kidney (cT1a). The abnormalities in laboratory tests, such as Erythrocyte Sedimentation Rate, C-reactive protein, LFTs, α2-globulin, and most clinical symptoms abated 2 weeks post-surgery...
2023: Central European Journal of Urology
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