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https://www.readbyqxmd.com/read/28637539/laparoscopic-excision-of-remnant-gallbladder-after-subtotal-cholecystectomy
#1
Levan Tsamalaidze, Tariq Almerey, Lucio Pereira, Samantha Permenter, John A Stauffer
No abstract text is available yet for this article.
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28635124/regular-aerobic-exercise-reduces-endothelin-1-mediated-vasoconstrictor-tone-in-overweight-and-obese-adults
#2
Caitlin A Dow, Brian L Stauffer, Danielle L Brunjes, Jared J Greiner, Christopher A DeSouza
Endothelin (ET)-1-mediated vasoconstrictor tone is elevated in overweight and obese adults, contributing to vasomotor dysfunction and increased cardiovascular disease risk. While the effects of habitual aerobic exercise on endothelium-dependent vasodilation in overweight/obese adults has been studied, little is known regarding ET-1 vasoconstriction. Accordingly, the aims of the present study were to determine: (1) if regular aerobic exercise training reduces ET-1-mediated vasoconstrictor tone in overweight and obese adults; and, if so (2) whether the reduction in ET-1 vasoconstriction contributes to exercise-induced improvement in endothelium-dependent vasodilation in this population...
June 20, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28622455/intestinal-metabolites-are-profoundly-altered-in-the-context-of-hla-b27-expression-and-functionally-modulate-disease-in-a-rat-model-of-spondyloarthropathy
#3
Mark Asquith, Sean Davin, Patrick Stauffer, Claire Michell, Cathleen Janowitz, Phoebe Lin, Joe Ensign-Lewis, Jason M Kinchen, Dennis R Koop, Jim Rosenbaum
Objective HLA-B27 associated spondyloarthropathies are associated with an altered intestinal microbiota and bowel inflammation. Therefore, we sought to identify B27-dependent changes in both host and microbial metabolites in the HLA-B27/β2m rat and whether microbiota-derived metabolites could impact disease in this major model of spondyloarthropathy. Methods Cecal contents were collected from 6wk (pre-diseased) and 16wk (diseased) Fischer 344 HLA-B27/β2m transgenic rats and WT controls. Metabolomic profiling was performed by high-throughput gas- and liquid-chromatography-based mass spectrometry...
June 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28617445/acquired-cross-linker-resistance-associated-with-a-novel-spliced-brca2-protein-variant-for-molecular-phenotyping-of-brca2-disruption
#4
Stefan Meyer, Adam Stevens, Roberto Paredes, Marion Schneider, Michael J Walker, Andrew J K Williamson, Maria-Belen Gonzalez-Sanchez, Stephanie Smetsers, Vineet Dalal, Hsiang Ying Teng, Daniel J White, Sam Taylor, Joanne Muter, Andrew Pierce, Chiara de Leonibus, Davy A P Rockx, Martin A Rooimans, Elaine Spooncer, Stacey Stauffer, Kajal Biswas, Barbara Godthelp, Josephine Dorsman, Peter E Clayton, Shyam K Sharan, Anthony D Whetton
BRCA2 encodes a protein with a fundamental role in homologous recombination that is essential for normal development. Carrier status of mutations in BRCA2 is associated with familial breast and ovarian cancer, while bi-allelic BRCA2 mutations can cause Fanconi anemia (FA), a cancer predisposition syndrome with cellular cross-linker hypersensitivity. Cancers associated with BRCA2 mutations can acquire chemo-resistance on relapse. We modeled acquired cross-linker resistance with an FA-derived BRCA2-mutated acute myeloid leukemia (AML) platform...
June 15, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28614121/inguinal-hernia-surgery-updates-in-surgery-series
#5
Verena K Stauffer, Markus M Luedi, Richard P Dutton
No abstract text is available yet for this article.
June 12, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28611937/stauffer-s-syndrome-in-pancreatic-cancer-first-case-report
#6
David Harris, Muhammad W Saif
Stauffer's syndrome is a rare paraneoplastic syndrome classically associated with renal cell carcinoma. It presents as abnormal hepatic panel in the absence of hepatic disease, which improves with treatment of the cancer and worsens with recurrence. Here, we describe a case of hepatic panel abnormalities in a patient with pancreatic cancer with no evidence of metastatic disease to the liver, primary hepatobiliary etiology, or clear offending medications. We believe this to be the first reported case of Stauffer's syndrome in patients with pancreatic cancer...
May 8, 2017: Curēus
https://www.readbyqxmd.com/read/28598569/heart-failure-in-patients-admitted-for-acute-coronary-syndromes-a-report-from-a-large-national-registry
#7
Raban V Jeger, Otmar Pfister, Dragana Radovanovic, Franz R Eberli, Hans Rickli, Philip Urban, Giovanni Pedrazzini, Jean-Christophe Stauffer, Jörg Nossen, Paul Erne
BACKGROUND: Data on temporal trends of heart failure (HF) in acute coronary syndrome (ACS) are scarce. HYPOTHESIS: Improved treatment options may have led to lower case-fatality rates (CFRs) during the last years in ACS complicated by HF. METHODS: Patients of the nationwide Acute Myocardial Infarction in Switzerland (AMIS)-Plus ACS registry were analyzed from 2000 to 2014. RESULTS: Of 36 366 ACS patients, 3376 (9.3%) had acute or chronic HF, 2111 (5...
June 9, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28594741/characterization-and-optimal-management-of-high-risk-pancreatic-anastomoses-during-pancreatoduodenectomy
#8
Brett L Ecker, Matthew T McMillan, Horacio J Asbun, Chad G Ball, Claudio Bassi, Joal D Beane, Stephen W Behrman, Adam C Berger, Euan J Dickson, Mark Bloomston, Mark P Callery, John D Christein, Elijah Dixon, Jeffrey A Drebin, Carlos Fernandez-Del Castillo, William E Fisher, Zhi Ven Fong, Ericka Haverick, Robert H Hollis, Michael G House, Steven J Hughes, Nigel B Jamieson, Ammar A Javed, Tara S Kent, Stacy J Kowalsky, John W Kunstman, Giuseppe Malleo, Katherine E Poruk, Ronald R Salem, Carl R Schmidt, Kevin Soares, John A Stauffer, Vicente Valero, Lavanniya K P Velu, Amarra A Watkins, Christopher L Wolfgang, Amer H Zureikat, Charles M Vollmer
OBJECTIVE: The aim of this study was to identify the optimal fistula mitigation strategy following pancreaticoduodenectomy. BACKGROUND: The utility of technical strategies to prevent clinically relevant postoperative pancreatic fistula (CR-POPF) following pancreatoduodenectomy (PD) may vary by the circumstances of the anastomosis. The Fistula Risk Score (FRS) identifies a distinct high-risk cohort (FRS 7 to 10) that demonstrates substantially worse clinical outcomes...
June 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28592822/bacterial-sphingomyelinase-is-a-state-dependent-inhibitor-of-the-cystic-fibrosis-transmembrane-conductance-regulator-cftr
#9
B B Stauffer, G Cui, K A Cottrill, D T Infield, N A McCarty
Sphingomyelinase C (SMase) inhibits CFTR chloride channel activity in multiple cell systems, an effect that could exacerbate disease in CF and COPD patients. The mechanism by which sphingomyelin catalysis inhibits CFTR is not known but evidence suggests that it occurs independently of CFTR's regulatory "R" domain. In this study we utilized the Xenopus oocyte expression system to shed light on how CFTR channel activity is reduced by SMase. We found that the pathway leading to inhibition is not membrane delimited and that inhibited CFTR channels remain at the cell membrane, indicative of a novel silencing mechanism...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28579819/outcomes-and-prognostic-variables-of-radiofrequency-zygapophyseal-joint-neurotomy-in-utah-workers-compensation-patients
#10
Tyler J Christensen, M Scott DeBerard, Anthony J Wheeler
PURPOSE: The prevalence of radiofrequency zygapophyseal joint neurotomy (RFN) has increased substantially across the past decade. Limited research exists that has examined pre-procedure predictors of RFN outcomes, particularly within workers' compensation populations. The purpose of this study was to determine if pre-procedure biopsychosocial variables are predictive of outcomes in a cohort of compensated Utah patients who have undergone RFN. PATIENTS AND METHODS: This was a retrospective cohort study consisting of a review of pre-procedure medical records and a telephone outcome survey...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28576627/comparison-of-everolimus-and-biolimus-eluting-coronary-stents-with-everolimus-eluting-bioresorbable-vascular-scaffolds-two-year-clinical-outcomes-of-the-everbio-ii-trial
#11
Diego Arroyo, Gregoire Gendre, Sara Schukraft, Zacharenia Kallinikou, Olivier Müller, Gérard Baeriswyl, Jean-Christophe Stauffer, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
BACKGROUND: Data from randomized controlled trials have shown that the ABSORB BVS is non-inferior to Cobalt Chromium everolimus-eluting stents at 2years. METHODS & RESULTS: The EVERBIO II trial (Comparison of Everolimus- and Biolimus-Eluting Coronary Stents with Everolimus-Eluting Bioresorbable Vascular Scaffold) is a single-center, assessor-blind, randomized controlled trial enrolling 240 patients with an allocation ration of 1:1:1 conducted at University and Hospital Fribourg, Switzerland...
May 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28568648/influence-of-sex-on-circulating-endothelial-microparticle-number-and-microrna-expression-in-middle-aged-adults
#12
Tyler D Bammert, Jamie G Hijmans, Philip J Kavlich, Grace M Lincenberg, Whitney R Reiakvam, Ryan T Fay, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
The aims of this study were to determine: 1) if circulating concentrations of endothelial microparticles (EMPs) differ in middle-aged men compared with women; and 2) whether there are sex-related differences in microRNA expression in EMPs. Peripheral blood was collected from 30 sedentary adults: 15 men (52 ± 8 yr) and 15 women (52 ± 8 yr). EMPs were defined by markers of activation (CD62e(+) ) or apoptosis (CD31(+) /CD42b(-) ) by flow cytometry. MicroRNA (miR-34a, 92a, 125a, and 126) expression in activation- and apoptosis-derived EMPs was measured by RT-PCR...
June 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28508434/maternal-arterial-stiffness-and-fetal-cardiovascular-physiology-in-diabetic-pregnancies
#13
Shreya Moodley, Alisa Arunamata, Katie Jo Stauffer, Susan E Nourse, Angela Chen, Amy Quirin, Elif Seda Selamet Tierney
OBJECTIVES: In mothers with pre-gestational or gestational diabetes, abnormal arterial stiffness (stiffer arteries) has been reported. The impact of abnormal maternal arterial stiffness on fetal placental and cardiovascular physiology is unknown. The purpose of the study was to determine the impact of maternal diabetes on maternal arterial stiffness and the association with fetal cardiovascular physiology as measured by fetal echocardiography. METHODS: Between December 2013 and January 2017 we conducted a prospective study on diabetic (otherwise healthy) and non-diabetic, healthy pregnant mothers (at 20-28 gestational weeks and 18-40 years of age) who had a normal fetal cardiac echocardiogram and obstetric ultrasound...
May 15, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28503258/feasibility-of-pancreatectomy-following-high-dose-proton-therapy-for-unresectable-pancreatic-cancer
#14
Kathryn E Hitchcock, R Charles Nichols, Christopher G Morris, Debashish Bose, Steven J Hughes, John A Stauffer, Scott A Celinski, Elizabeth A Johnson, Robert A Zaiden, Nancy P Mendenhall, Michael S Rutenberg
AIM: To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic adenocarcinoma. METHODS: From April 2010 to September 2013, 15 patients with initially unresectable pancreatic cancer were treated with proton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy (RBE) to the gross disease and 1 patient received 50.40 Gy (RBE) to high-risk nodal targets...
April 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28474198/seroprevalence-of-histoplasmosis-in-somali-burmese-and-hmong-refugees-residing-in-thailand-and-kenya
#15
Nathan C Bahr, Deborah Lee, William M Stauffer, Michelle Durkin, Martin S Cetron, L Joseph Wheat, David R Boulware
Histoplasmosis is known to be endemic to the Midwestern United States, but cases have been reported throughout much of the world. Somali, Hmong, and Burmese (ethnically Karen) persons make up some of the largest refugee populations coming the United States in recent years. Yet, information about risk of Histoplasma capsulatum infection amongst these populations is limited. This study used the CDC Migrant Serum Bank to test ~100 samples from each of Somali, Burmese, and Hmong U.S.-bound refugees. Samples were tested by enzyme immunoassay for Histoplasma capsulatum IgG...
May 4, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28471697/pirfenidone-reduces-respiratory-related-hospitalizations-in-idiopathic-pulmonary-fibrosis
#16
Brett Ley, Jeffrey Swigris, Bann-Mo Day, John L Stauffer, Karina Raimundo, Willis Chou, Harold R Collard
RATIONALE: Respiratory-related hospitalizations in patients with idiopathic pulmonary fibrosis (IPF) are more frequent than acute IPF exacerbations and are associated with poor outcomes. OBJECTIVES: To compare the risk of non-elective hospitalization by type (all-cause, respiratory-related, non-respiratory related) and death after hospitalization for pirfenidone versus placebo over 52 weeks from three phase 3 IPF clinical trials. METHODS: Individual patient data was pooled from three phase 3 randomized, placebo-controlled studies of pirfenidone for IPF (CAPACITY and ASCEND) including all patients randomized to pirfenidone 2403 mg/day (n=623) or placebo (n=624)...
May 4, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28470545/relationship-between-adherence-rate-threshold-and-drug-forgiveness
#17
Alan Morrison, Melissa E Stauffer, Anna S Kaufman
The medication adherence rate (A) is the proportion of prescribed drug doses consumed within a given time period. It is often assumed that there is an adherence rate threshold (A th) at or above which the therapeutic effect of the medication is maintained. Drug forgiveness (F) is the number of consecutive doses that can be missed while still maintaining a therapeutic effect. At a given value for A, the therapeutic effect of the drug will be continuously maintained if there is no possibility of >F missed doses...
May 3, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28452837/factors-related-to-self-rated-health-in-older-adults-a-clinical-approach-using-the-international-classification-of-functioning-disability-and-health-icf-model
#18
Chad W Tiernan, Hali A Fleishman, Meghann A Hiscox, Sarah N Shaver, Caitlyn M Stauffer, Patrick A W Thibodeau
BACKGROUND AND PURPOSE: A growing population of older adults will require health care professionals to become increasingly knowledgeable in geriatric care. Patient ratings, functional measures, and emphasis on health and wellness should be part of geriatric physical therapy practice. The purpose of the current study was to examine relationships between self-rated health (SRH) and movement-related variables in older adults using the International Classification of Functioning, Disability, and Health (ICF) as a research framework...
April 27, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28414340/comparison-of-chirped-probe-pulse-and-hybrid-femtosecond-picosecond-coherent-anti-stokes-raman-scattering-for-combustion-thermometry
#19
Daniel R Richardson, Hans U Stauffer, Sukesh Roy, James R Gord
A comparison is made between two ultrashort-pulse coherent anti-Stokes Raman scattering (CARS) thermometry techniques-hybrid femtosecond/picosecond (fs/ps) CARS and chirped-probe-pulse (CPP) fs-CARS-that have become standards for high-repetition-rate thermometry in the combustion diagnostics community. These two variants of fs-CARS differ only in the characteristics of the ps-duration probe pulse; in hybrid fs/ps CARS a spectrally narrow, time-asymmetric probe pulse is used, whereas a highly chirped, spectrally broad probe pulse is used in CPP fs-CARS...
April 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28390863/the-phasic-dopamine-signal-maturing-from-reward-via-behavioural-activation-to-formal-economic-utility
#20
REVIEW
Wolfram Schultz, Wiliam R Stauffer, Armin Lak
The phasic dopamine reward prediction error response is a major brain signal underlying learning, approach and decision making. This dopamine response consists of two components that reflect, initially, stimulus detection from physical impact and, subsequenttly, reward valuation; dopamine activations by punishers reflect physical impact rather than aversiveness. The dopamine reward signal is distinct from earlier reported and recently confirmed phasic changes with behavioural activation. Optogenetic activation of dopamine neurones in monkeys causes value learning and biases economic choices...
April 6, 2017: Current Opinion in Neurobiology
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