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https://www.readbyqxmd.com/read/29148387/incentives-for-bushmeat-consumption-and-importation-among-west-african-immigrants-minnesota-usa
#1
Emily Walz, David Wilson, Jacob C Stauffer, Danushka Wanduragala, William M Stauffer, Dominic A Travis, Jonathan D Alpern
The knowledge, attitudes, and practices surrounding bushmeat consumption and importation in the United States are not well described. Focus groups of West African persons living in Minnesota, USA, found that perceived risks are low and unlikely to deter consumers. Incentives for importation and consumption were multifactorial in this community.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29138755/paraneoplastic-hepatopathy-associated-with-gastrointestinal-carcinoid
#2
Dhruv Mehta, Priyanka Chugh, Lavneet Chawla, Daniela Jodorkovsky
Paraneoplastic hepatopathy has been reported with various malignancies, most commonly with renal cell cancer. This non-metastatic hepatic dysfunction in such malignancies is known as Stauffer syndrome. We describe a 61-year-old man who presented with symptoms of bowel obstruction with marked cholestasis and high levels of alkaline phosphatase and bilirubin. Imaging revealed an unremarkable liver and a mass in the ileocecal valve with mesenteric lymphadenopathy. Biopsies were consistent with a carcinoid tumor...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29122812/nebivolol-but-not-metoprolol-treatment-improves-endothelial-fibrinolytic-capacity-in-adults-with-elevated-blood-pressure
#3
Brian L Stauffer, Caitlin A Dow, Kyle J Diehl, Tyler D Bammert, Jared J Greiner, Christopher A DeSouza
BACKGROUND: Vascular endothelial fibrinolytic function is impaired in adults with prehypertension and hypertension and plays a mechanistic role in the development of atherothrombotic events. The influence of β-blockers on endothelial fibrinolysis is unknown. This study compared the effects of chronic nebivolol and metoprolol treatment on endothelial tissue-type plasminogen activator (t-PA) release in adults with elevated blood pressure (BP). METHODS AND RESULTS: Forty-four middle-aged adults (36% women) with elevated BP completed a 3-month, double-blind, randomized, placebo-controlled trial comparing nebivolol (5 mg/d), metoprolol succinate (100 mg/d), and placebo...
November 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29120204/the-relationship-between-students-counseling-center-contact-and-long-term-educational-outcomes
#4
Brett E Scofield, Ashley L Stauffer, Benjamin D Locke, Jeffrey A Hayes, Ya-Chi Hung, Megan L Nyce, Adam E Christensen, Alexander C Yin
Numerous studies have demonstrated that counseling centers deliver a positive impact on the emotional and social development of college students who receive services. These healthy outcomes, in turn, can lead to increased academic success, such as improved performance, retention, and persistence. While these short-term academic outcomes have been widely investigated, very few studies have explored the relationship between counseling center services and longer-term educational outcomes, such as final grade point average (GPA), time spent at the university, and degree completion...
November 2017: Psychological Services
https://www.readbyqxmd.com/read/29118219/nonhuman-primate-optogenetics-recent-advances-and-future-directions
#5
Adriana Galvan, William R Stauffer, Leah Acker, Yasmine El-Shamayleh, Ken-Ichi Inoue, Shay Ohayon, Michael C Schmid
Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for millisecond resolution control of neural activity. By targeting opsin expression to specific cell types and neuronal pathways, optogenetics can expand our understanding of the neural basis of normal and pathological behavior. To maximize the potential of optogenetics to study human cognition and behavior, optogenetics should be applied to the study of nonhuman primates (NHPs). The homology between NHPs and humans makes these animals the best experimental model for understanding human brain function and dysfunction...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29102747/endoscopic-versus-open-great-saphenous-vein-harvesting-for-femoral-to-popliteal-artery-bypass
#6
Aleem K Mirza, Kendall Stauffer, Mark D Fleming, Randall De Martino, Gustavo Oderich, Manju Kalra, Peter Gloviczki, Thomas Bower
OBJECTIVE: Conflicting data exist on outcomes of open vein harvest (OVH) and endoscopic vein harvest (EVH) for infrainguinal bypass. The purpose of this study was to compare outcomes between OVH and EVH in femoral to popliteal artery bypasses. METHODS: A retrospective review was performed of all patients undergoing common femoral to popliteal artery bypass with great saphenous vein between January 1997 and June 2014. Bypasses using arm or composite vein were excluded, as were those performed for popliteal artery aneurysms or trauma...
November 1, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29076112/reward-and-value-coding-by-dopamine-neurons-in-non-human-primates
#7
REVIEW
Aydin Alikaya, Mackenzie Rack-Wildner, William R Stauffer
Rewards are fundamental to everyday life. They confer pleasure, support learning, and mediate decisions. Dopamine-releasing neurons in the midbrain are critical for reward processing. These neurons receive input from more than 30 brain areas and send widespread projections to the basal ganglia and frontal cortex. Their phasic responses are tuned to rewards. Specifically, dopamine signals code reward prediction error, the difference between received and predicted rewards. Decades of research in awake, behaving non-human primates (NHP), have shown the importance of these neural signals for learning and decision making...
October 26, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29076037/the-adherence-rate-threshold-is-drug-specific
#8
Melissa E Stauffer, Paul Hutson, Anna S Kaufman, Alan Morrison
INTRODUCTION: Patient adherence to a medication regimen is usually expressed as an adherence rate, defined as the proportion of prescribed doses actually taken. An adherence rate threshold, above which the therapeutic effect is maintained, is typically assigned an arbitrary value, commonly 0.8. OBJECTIVE: Here, we determined the value of the adherence rate threshold objectively in different drugs of the same class, using statins as an example. METHODS: We used pharmacokinetic/pharmacodynamic (PK/PD) modeling to predict serum levels of low-density lipoprotein cholesterol (LDL-C) in patients taking simvastatin 20 mg or atorvastatin 5 mg once daily for 30 days...
October 26, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/29056577/is-neurogenic-bladder-a-risk-factor-for-febrile-urinary-tract-infection-after-ureteroscopy-and-if-so-why
#9
Craig E Stauffer, Elizabeth Snyder, Tin C Ngo, Christopher S Elliott
OBJECTIVE: To characterize the rate of febrile urinary tract infections (UTI) after ureteroscopy in patients with neurogenic bladder compared to those with physiologically normal bladders. While generally considered safe and effective, there is a growing body of evidence suggesting that patients with neurogenic bladder are at increased risk of infectious complications following ureteroscopy. MATERIALS AND METHODS: We performed retrospective chart review of those undergoing ureteroscopy in a single academically affiliated hospital system between June 2013 and May 2016...
October 19, 2017: Urology
https://www.readbyqxmd.com/read/29050751/fibrosis-related-gene-expression-in-single-ventricle-heart-disease
#10
Stephanie J Nakano, Austine K Siomos, Anastacia M Garcia, Hieu Nguyen, Megan SooHoo, Csaba Galambos, Karin Nunley, Brian L Stauffer, Carmen C Sucharov, Shelley D Miyamoto
OBJECTIVE: To evaluate fibrosis and fibrosis-related gene expression in the myocardium of pediatric subjects with single ventricle with right ventricular failure. STUDY DESIGN: Real-time quantitative polymerase chain reaction was performed on explanted right ventricular myocardium of pediatric subjects with single ventricle disease and controls with nonfailing heart disease. Subjects were divided into 3 groups: single ventricle failing (right ventricular failure before or after stage I palliation), single ventricle nonfailing (infants listed for primary transplantation with normal right ventricular function), and stage III (Fontan or right ventricular failure after stage III)...
October 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29023087/simulations-of-a-graphene-nanoflake-as-a-nanovector-to-improve-znpc-phototherapy-toxicity-from-vacuum-to-cell-membrane
#11
Eric Duverger, Fabien Picaud, Louise Stauffer, Philippe Sonnet
We propose a new approach to improving photodynamic therapy (PDT) by transporting zinc phthalocyanine (ZnPc) in biological systems via a graphene nanoflake, to increase its targeting. Indeed, by means of time-dependent density functional theory simulations, we show that the ZnPc molecule in interaction with a graphene nanoflake preserves its optical properties not only in a vacuum but also in water. Moreover, molecular dynamic simulations demonstrate that the graphene nanoflake/ZnPc association, as a carrier, permits one to stabilize the ZnPc/graphene nanoflake system on the cellular membrane, which was not possible when using ZnPc alone...
October 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29020146/trends-in-pricing-and-generic-competition-within-the-oral-antibiotic-drug-market-in-the-united-states
#12
Jonathan D Alpern, Lei Zhang, William M Stauffer, Aaron S Kesselheim
Background: In recent years, many older, generic drugs have increased substantially in price, including numerous antibiotics. We sought to analyze recent price changes and extent of generic competition within a cohort of commonly prescribed off-patent oral antibiotics. Methods: We extracted oral antibiotics recommended for common outpatient conditions within the Infectious Disease Society of America Practice Guidelines. We determined all Food and Drug Administration (FDA)-approved manufacturers for each formulation and strength in 2013 and 2016, and the yearly National Average Drug Acquisition Cost (NADAC) price between 2013 to 2016...
July 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016308/absence-of-loa-loa-microfilaremia-among-newly-arrived-congolese-refugees-in-texas
#13
Jessica Montour, Deborah Lee, Cathy Snider, Emily S Jentes, William Stauffer
The Centers for Disease Control and Prevention recommends that refugees at risk of Loa loa infection be tested for microfilaria before treatment with ivermectin. We report observational results of this approach in African refugees in Texas. Daytime blood smears were performed for microfilaria on at-risk African refugees who arrived in Texas from July 1, 2014 through December 30, 2016. Clinics were asked if there were any adverse events reported among those who received ivermectin. Of the 422 persons screened, 346 (82%) were born in L...
September 5, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28993210/telomere-length-sibling-competition-and-development-of-antioxidant-defense-in-wild-house-mice
#14
Janina Stauffer, Bineet Panda, Petteri Ilmonen
Antioxidants and telomere length are potential biomarkers for individuals' exposure and ability to cope with environmental stressors. However, intraspecific variations in antioxidant alterations due to natural, life cycle related stress, have been rarely estimated. We investigated those changes in wild-derived house mice in a longitudinal study with natural sibling competition as a stressor. Blood was used for telomere length measurements at 8-weeks age and for several selected antioxidants at 8-weeks and 6-months age...
October 7, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28979060/diapause-and-overwintering-of-two-spruce-bark-beetle-species
#15
REVIEW
Martin Schebeck, E Matthew Hansen, Axel Schopf, Gregory J Ragland, Christian Stauffer, Barbara J Bentz
Diapause, a strategy to endure unfavourable conditions (e.g. cold winters) is commonly found in ectothermic organisms and is characterized by an arrest of development and reproduction, a reduction of metabolic rate, and an increased resistance to adversity. Diapause, in addition to adaptations for surviving low winter temperatures, significantly influences phenology, voltinism and ultimately population growth. We review the literature on diapause and overwintering behaviour of two bark beetle species that affect spruce-dominated forests in the northern hemisphere, and describe and compare how these strategies can influence population dynamics...
September 2017: Physiological Entomology
https://www.readbyqxmd.com/read/28975236/gene-expression-profiling-and-heterogeneity-of-nonspecific-orbital-inflammation-affecting-the-lacrimal-gland
#16
James T Rosenbaum, Dongseok Choi, Christina A Harrington, David J Wilson, Hans E Grossniklaus, Cailin H Sibley, Sherveen S Salek, John D Ng, Roger A Dailey, Eric A Steele, Brent Hayek, Caroline M Craven, Deepak P Edward, Azza M Y Maktabi, Hailah Al Hussain, Valerie A White, Peter J Dolman, Craig N Czyz, Jill A Foster, Gerald J Harris, Youn-Shen Bee, David T Tse, Chrisfouad R Alabiad, Sander R Dubovy, Michael Kazim, Dinesh Selva, R Patrick Yeatts, Bobby S Korn, Don O Kikkawa, Rona Z Silkiss, Jennifer A Sivak-Callcott, Patrick Stauffer, Stephen R Planck
Importance: Although a variety of well-characterized diseases, such as sarcoidosis and granulomatosis with polyangiitis, affect the lacrimal gland, many patients with dacryoadenitis are diagnosed as having nonspecific orbital inflammation (NSOI) on the basis of histology and systemic disease evaluation. The ability to further classify the disease in these patients should facilitate selection of effective therapies. Objective: To test the a priori hypothesis that gene expression profiles would complement clinical and histopathologic evaluations in identifying well-characterized diseases and in subdividing NSOI into clinically relevant groups...
November 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28973011/zika-beyond-the-americas-travelers-as-sentinels-of-zika-virus-transmission-a-geosentinel-analysis-2012-to-2016
#17
Karin Leder, Martin P Grobusch, Philippe Gautret, Lin H Chen, Susan Kuhn, Poh Lian Lim, Johnnie Yates, Anne E McCarthy, Camilla Rothe, Yasuyuki Kato, Emmanuel Bottieau, Kristina Huber, Eli Schwartz, William Stauffer, Denis Malvy, Marc T M Shaw, Christophe Rapp, Lucille Blumberg, Mogens Jensenius, Perry J J van Genderen, Davidson H Hamer
BACKGROUND: Zika virus (ZIKV) was first isolated in Africa; decades later, caused large outbreaks in the Pacific, and is considered endemic in Asia. We aim to describe ZIKV disease epidemiology outside the Americas, the importance of travelers as sentinels of disease transmission, and discrepancies in travel advisories from major international health organizations. METHODS AND FINDINGS: This descriptive analysis using GeoSentinel Surveillance Network records involves sixty-four travel and tropical medicine clinics in 29 countries...
2017: PloS One
https://www.readbyqxmd.com/read/28957072/mixture-fraction-imaging-at-1%C3%A2-%C3%A2-khz-using-femtosecond-laser-induced-fluorescence-of-krypton
#18
Daniel R Richardson, Naibo Jiang, Hans U Stauffer, Sean P Kearney, Sukesh Roy, James R Gord
Femtosecond, two-photon-absorption laser-induced-fluorescence (TALIF) imaging measurements of krypton (Kr) are demonstrated to study mixing in gaseous flows. A measurement approach is presented in which observed Kr TALIF signals are 7 times stronger than the current state-of-the-art methodology. Fluorescence emission is compared for different gas pressures and excitation wavelengths, and the strongest fluorescence signals were observed when the excitation wavelength was tuned to 212.56 nm. Using this optimized excitation scheme, 1-kHz, single-laser-shot visualizations of unsteady flows and two-dimensional measurements of mixture fraction and scalar dissipation rate of a Kr-seeded jet are demonstrated...
September 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28945148/serological-susceptibility-to-varicella-among-u-s-immigration-and-customs-enforcement-detainees
#19
Aiden K Varan, Edith R Lederman, Shanon S Stous, Diana Elson, Jennifer L Freiman, Mona Marin, Adriana S Lopez, William M Stauffer, Rachael H Joseph, Stephen H Waterman
U.S. Immigration and Customs Enforcement (ICE) is responsible for detaining unauthorized aliens during immigration proceedings. During 2014 to 2015, adult ICE detainees at a California facility were invited to complete a survey concerning self-reported varicella history and risk factors. Participants underwent serological testing for varicella-zoster virus (VZV) IgG; susceptible individuals were offered varicella vaccination. Among 400 detainees with available serology results, 48 (12%) were susceptible to varicella...
January 1, 2017: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/28922180/qualitative-case-studies-of-professional-level-workers-with-traumatic-brain-injuries-a-contextual-approach-to-job-accommodation-and-retention
#20
Richard T Roessler, Phillip D Rumrill, Stuart P Rumrill, Deborah L Minton, Deborah J Hendricks, Elaine Sampson, Callista Stauffer, Marcia J Scherer, Amanda Nardone, Anne Leopold, Karen Jacobs, Eileen Elias
BACKGROUND: Traumatic brain injury (TBI) is a multi-systemic disability that causes a wide range of difficulties with personal and social functioning. METHODS: Four individuals with TBI participated in an evaluation of barriers to their continued employment following graduation from college. A trained interviewer completed the Work Experience Survey (WES) in teleconsultation sessions with each participant. RESULTS: Researchers applied a qualitative case study research design...
September 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
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