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Martin Schebeck, Lukas Feldkirchner, Belen Marín, Susanne Krumböck, Hannes Schuler, Christian Stauffer
Heritable bacterial endosymbionts can alter the biology of numerous arthropods. They can influence the reproductive outcome of infected hosts, thus affecting the ecology and evolution of various arthropod species. The spruce bark beetle Pityogenes chalcographus (L.) (Coleoptera: Curculionidae: Scolytinae) was reported to express partial, unidirectional crossing incompatibilities among certain European populations. Knowledge on the background of these findings is lacking; however, bacterial endosymbionts have been assumed to manipulate the reproduction of this beetle...
May 1, 2018: Journal of Insect Science
Jeanette L Bertron, Hyekyung P Cho, Pedro M Garcia-Barrantes, Joseph D Panarese, James M Salovich, Kellie D Nance, Darren W Engers, Jerri M Rook, Anna L Blobaum, Colleen M Niswender, Shaun R Stauffer, P Jeffrey Conn, Craig W Lindsley
This letter describes the chemical optimization of a new series of M1 positive allosteric modulators (PAMs) based on a novel benzomorpholine core, developed via iterative parallel synthesis, and culminating in the highly utilized rodent in vivo tool compound, VU0486846 (7), devoid of adverse effect liability. This is the first report of the optimization campaign (SAR and DMPK profiling) that led to the discovery of VU0486846 and details all of the challenges faced in allosteric modulator programs (both steep and flat SAR, as well as subtle structural changes affecting CNS penetration and overall physiochemical and DMPK properties)...
May 5, 2018: Bioorganic & Medicinal Chemistry Letters
Emmanuel Gabriel, Enrique Elli, Sanjay Bagaria, Nabil Wasif, Travis Grotz, John Stauffer, Pashtoon M Kasi, Horacio Asbun
BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is an appropriate treatment for select patients with peritoneal carcinomatosis. While most commonly performed through an open incision, the laparoscopic approach has been reported and offers short-term benefits. A robotic-assisted approach for carcinomatosis of gastrointestinal origin, however, has not yet been described. METHODS: We report our approach to robotic-assisted CRS-HIPEC for a patient with a perforated appendiceal mucocele...
May 5, 2018: Journal of Robotic Surgery
Youfeng Zhang, Yunje Oh, Douglas Stauffer, Andreas A Polycarpou
We present a highly sensitive force-displacement transducer capable of performing ultra-shallow nanoindentation and adhesion measurements. The transducer utilizes electrostatic actuation and capacitive sensing combined with microelectromechanical fabrication technologies. Air indentation experiments report a root-mean-square (RMS) force resolution of 1.8 nN and an RMS displacement resolution of 0.019 nm. Nanoindentation experiments on a standard fused quartz sample report a practical RMS force resolution of 5 nN and an RMS displacement resolution of 0...
April 2018: Review of Scientific Instruments
Javier Augusto Arreaza, Levan Tsamalaidze, John Andrew Stauffer
No abstract text is available yet for this article.
April 1, 2018: American Surgeon
Javier Augusto Arreaza, Levan Tsamalaidze, John Andrew Stauffer
No abstract text is available yet for this article.
April 1, 2018: American Surgeon
Florian M Steiner, Sándor Csősz, Bálint Markó, Alexander Gamisch, Lukas Rinnhofer, Clemens Folterbauer, Sarina Hammerle, Christian Stauffer, Wolfgang Arthofer, Birgit C Schlick-Steiner
Seed harvesting ants are ecosystem engineers that shape vegetation, nutrient cycles, and microclimate. Progress in ecological research is, however, slowed down by poor species delimitation. For example, it has not been resolved to date, how many species the European harvester ant Messor "structor" (Latreille, 1798) represents. Since its first description, splitting into additional taxa was often proposed but not accepted later on due to inconsistent support from morphology and ecology. Here, we took an iterative integrative-taxonomy approach - comparing multiple, independent data sets of the same sample - and used traditional morphometrics, Wolbachia symbionts, mitochondrial DNA, amplified fragment length polymorphism, and ecological niche modelling...
April 27, 2018: Molecular Phylogenetics and Evolution
Ning Zhang, Flurin Stauffer, Benjamin R Simona, Feng Zhang, Zhao-Ming Zhang, Ning-Ping Huang, János Vörös
Cardiovascular diseases are a major cause of death around the world underlining the importance of efficient treatments including novel medication. In vitro models of cardiac tissues are highly desired for monitoring electrophysiological response to screen pharmaceutical compounds at an early stage. Here, we report a platinum based 3D pillar electrode platform with cell growth guiding channel, which allows integrated, continuous electrical stimulation and recording of the cardiac tissues. This platform was successfully used to culture beating cardiomyocytes over weeks...
April 19, 2018: Biosensors & Bioelectronics
Jerri M Rook, Jeanette L Bertron, Hyekyung P Cho, Pedro M Garcia-Barrantes, Sean P Moran, James T Maksymetz, Kellie D Nance, Jonathan W Dickerson, Daniel H Remke, Sichen Chang, Joel Harp, Anna L Blobaum, Colleen M Niswender, Carrie K Jones, Shaun R Stauffer, P Jeffrey Conn, Craig W Lindsley
Selective activation of the M1 subtype of muscarinic acetylcholine receptor, via positive allosteric modulation (PAM), is an exciting strategy to improve cognition in schizophrenia and Alzheimer's disease patients. However, highly potent M1 ago-PAMs, such as MK-7622, PF-06764427, and PF-06827443, can engender excessive activation of M1, leading to agonist actions in the prefrontal cortex (PFC) that impairs cognitive function, induces behavioral convulsions, and results in other classic cholinergic adverse events (AEs)...
April 27, 2018: ACS Chemical Neuroscience
Emily G Pieracci, Danielle Stanek, Daniel Koch, Katrin S Kohl, Jesse D Blanton, Terri Harder, Marian O'Brien, Hugo Leon, Pam Colarusso, Brittany Baker, Clive Brown, Kendra E Stauffer, Brett W Petersen, Ryan M Wallace
No abstract text is available yet for this article.
April 27, 2018: MMWR. Morbidity and Mortality Weekly Report
Jay R Jr Stauffer
A new species, Metriaclima koningsi, is described from Likoma and Maingano islands in Lake Malaŵi. The species is distinguished from other congeners, except Metriaclima usisyae Li, Konings Stauffer, by the absence of conspicuous bars along its flank and the presence of a dark submarginal band in the dorsal fin. Males of M. usisyae have gold coloured flanks, while males of M. koningsi have blue flanks.
January 9, 2018: Zootaxa
Roland E Andersson, Dietrich Doll, Verena K Stauffer, Andreas P Vogt, Steven D Boggs, Markus M Luedi
National or international guidelines can help surgeons and anesthesiologists make treatment decisions, but the existence of conflicting recommendations can hinder treatment rather than helping. A case in point is the treatment of pilonidal sinus disease, a chronic subcutaneous infection located in the sacrococcygeal area. Its incidence is rising, reaching almost 100/100,000 inhabitants. Three surgical societies have proposed guidelines for treating the disease, but these guidelines vary greatly in their approach to anesthesia...
April 23, 2018: A&A practice
Levan Tsamalaidze, John A Stauffer
Background: Pancreaticoduodenectomy outcomes improve as surgeon experience increases. We analyzed the outcomes of pancreaticoduodenectomy for any improvements over time to assess the learning curve. Methods: A retrospective study of patients undergoing consecutive pancreaticoduodenectomy by a single surgeon at the beginning of practice was performed. Operative factors and 90-day outcomes were examined and trends over the course of the 4-year time period were analyzed...
2018: Journal of Visualized Surgery
Peter D Mariner, Armin Korst, Anis Karimpour-Fard, Brian L Stauffer, Shelley D Miyamoto, Carmen C Sucharov
BACKGROUND: The measurement of circulating miRNAs has proven to be a powerful biomarker tool for several disease processes. Current protocols for the detection of miRNAs usually involve an RNA extraction step, requiring a substantial volume of patient serum or plasma to obtain sufficient input material. OBJECTIVE: Here, we describe a novel methodology that allows detection of a large number of miRNAs from a small volume of serum or plasma without the need for RNA extraction...
April 16, 2018: MicroRNA
Akke Bakker, Rebecca Holman, Dario B Rodrigues, Hana Dobšíček Trefná, Paul R Stauffer, Geertjan van Tienhoven, Coen R N Rasch, Hans Crezee
PURPOSE: Tumor response and treatment toxicity are related to minimum and maximum tissue temperatures during hyperthermia, respectively. Using a large set of clinical data, we analyzed the number of sensors required to adequately monitor skin temperature during superficial hyperthermia treatment of breast cancer patients. METHODS: Hyperthermia treatments monitored with >60 stationary temperature sensors were selected from a database of patients with recurrent breast cancer treated with re-irradiation (23 × 2 Gy) and hyperthermia using single 434 MHz applicators (effective field size 351-396 cm2 )...
April 27, 2018: International Journal of Hyperthermia
Mário Fontes-Sousa, Helena Magalhães, Fernando Calais da Silva, Maria Joaquina Maurício
BACKGROUND: Stauffer's syndrome corresponds to a set of clinical and analytical changes of paraneoplastic nature firstly recognized more than 50 years ago, in association to renal cell carcinoma. A definitive review including universal diagnostic criteria and updated knowledge since the original description is lacking. BASIC PROCEDURES: The authors conducted a comprehensive bibliographical review and propose updated diagnostic criteria to standardize diagnosis for clinical practice purposes and avoid misclassification...
April 12, 2018: Urologic Oncology
Jamie G Hijmans, Kyle J Diehl, Tyler D Bammert, Philip J Kavlich, Grace M Lincenberg, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
microRNAs (miRNAs) have a key role in regulating inflammation, vascular health and in turn, cardiovascular disease. Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-150 has been linked with the pathogenesis and progression of cardiovascular disease. The aim of this study was to determine whether the circulating profile of these vascular-related miRNAs is disrupted with hypertension. Thirty sedentary, middle-aged adults were studied: 15 normotensive (10M/5F; age: 56 ± 1 year; BP: 113/71 ± 2/1 mmHg) and 15 hypertensive (10M/5F; 56 ± 2 year; 140/87 ± 2/2 mmHg)...
April 4, 2018: Journal of Human Hypertension
Jamie G Hijmans, Kyle J Diehl, Tyler D Bammert, Philip J Kavlich, Grace M Lincenberg, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
BACKGROUND: Increased cardiovascular disease risk and prevalence associated with overweight and obesity is due, in part, to heightened inflammatory burden. The mechanisms underlying adiposity-related amplification of inflammation are not fully understood. Alterations in regulators of inflammatory processes such as microRNAs (miRs), however, is thought to play a pivotal role. OBJECTIVE: The aim of this study was to determine the influence of overweight and obesity, independent of other cardiovascular risk factors, on circulating expression of miR-34a, miR-126, miR-146a, miR-150 and miR-181b...
April 2, 2018: MicroRNA
Nelly Besson, Mie Topholm Bruun, Thomas Stauffer Larsen, Christian Nielsen
Success of peripheral blood stem cell (PBSC) collections depends on patient biological parameters and stable apheresis device performance. We investigated product quality and factors influencing main apheresis procedure outcomes including CD34+ collection efficiency (CE), product volume or platelet CE. We also assessed different CD34+ cell yield prediction algorithms. Autologous PBSC collections by Spectra Optia from myeloma and lymphoma patients were analyzed. Complete blood count (CBC) from patient preprocedure and from collected products were assessed...
March 23, 2018: Journal of Clinical Apheresis
Katerina Nikolouli, Hervé Colinet, David Renault, Thomas Enriquez, Laurence Mouton, Patricia Gibert, Fabiana Sassu, Carlos Cáceres, Christian Stauffer, Rui Pereira, Kostas Bourtzis
Drosophila suzukii , a vinegar fly originated from Southeast Asia, has recently invaded western countries, and it has been recognized as an important threat of a wide variety of several commercial soft fruits. This review summarizes the current information about the biology and dispersal of D. suzukii and discusses the current status and prospects of control methods for the management of this pest. We highlight current knowledge and ongoing research on innovative environmental-friendly control methods with emphasis on the sterile insect technique (SIT) and the incompatible insect technique (IIT)...
2018: Journal of Pest Science
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