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Brij B Agarwal, Nayan Agarwal, Neeraj Dhamija, Chintamani
Success in any profession has no well-defined predictors. Knowledge, skills, training, and talent come in plenty but fail at times to achieve the universal goal of success. Some attribute it to luck. Apart from the tangible ingredients of a successful career, the intangibles like luck or something ill-defined is a real challenge. The intangibles seem like a chasm, an abyss, or a phantom obstacle. Presence of a guiding spirit who can handhold you to overcome these is essential for success. The aim of a professional is to learn, earn, and yearn for creativity...
February 2018: Indian Journal of Surgery
Ari Z Zivotofsky, Hagar Bernad-Elazari, Pnina Grossman, Jeffrey M Hausdorff
Recent studies have shown that gait synchronization during natural walking is not merely anecdotal, but it is a repeatable phenomenon that is quantifiable and is apparently related to available sensory feedback modalities. However, the mechanisms underlying this phase-locking of gait have only recently begun to be investigated. For example, it is not known what role, if any, attention plays. We employed a dual tasking paradigm in order to investigate the role attention plays in gait synchronization. Sixteen pairs of subjects walked under six conditions that manipulated the available sensory feedback and the degree of difficulty of the dual task, i...
March 23, 2018: Human Movement Science
Francesca Sylos-Labini, Andrea d'Avella, Francesco Lacquaniti, Yury Ivanenko
Handholding can naturally occur between two walkers. When people walk side-by-side, either with or without hand contact, they often synchronize their steps. However, despite the importance of haptic interaction in general and the natural use of hand contact between humans during walking, few studies have investigated forces arising from physical interactions. Eight pairs of adult subjects participated in this study. They walked on side-by-side treadmills at 4 km/h independently and with hand contact. Only hand contact-related sensory information was available for unintentional synchronization, while visual and auditory communication was obstructed...
2018: Frontiers in Physiology
Pavel Goldstein, Irit Weissman-Fogel, Guillaume Dumas, Simone G Shamay-Tsoory
The mechanisms underlying analgesia related to social touch are not clear. While recent research highlights the role of the empathy of the observer to pain relief in the target, the contribution of social interaction to analgesia is unknown. The current study examines brain-to-brain coupling during pain with interpersonal touch and tests the involvement of interbrain synchrony in pain alleviation. Romantic partners were assigned the roles of target (pain receiver) and observer (pain observer) under pain-no-pain and touch-no-touch conditions concurrent with EEG recording...
March 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Simon R Hemelaar, Babujhi Saspaanithy, Severin R M L'Hommelet, Felipe P Perona Martinez, Kiran J van der Laan, Romana Schirhagl
Fluorescent nanodiamonds are promising probes for nanoscale magnetic resonance measurements. Their physical properties predict them to have particularly useful applications in intracellular analysis. Before using them in intracellular experiments however, it should be clear whether diamond particles influence cell biology. While cytotoxicity has already been ruled out in previous studies, we consider the non-fatal influence of fluorescent nanodiamonds on the formation of reactive oxygen species (an important stress indicator and potential target for intracellular sensing) for the first time...
January 26, 2018: Sensors
James A Coan, Lane Beckes, Marlen Z Gonzalez, Erin L Maresh, Casey L Brown, Karen Hasselmo
Strong social ties correspond with better health and well being, but the neural mechanisms linking social contact to health remain speculative. This study extends work on the social regulation of brain activity by supportive handholding in 110 participants (51 female) of diverse racial and socioeconomic origins. In addition to main effects of social regulation by handholding, we assessed the moderating effects of both perceived social support and relationship status (married, cohabiting, dating or platonic friends)...
October 1, 2017: Social Cognitive and Affective Neuroscience
Casey L Brown, Lane Beckes, Joseph P Allen, James A Coan
OBJECTIVE: Social support is associated with better health. This association may be partly mediated through the social regulation of adrenomedullary activity related to poor cardiovascular health and glucocorticoid activity known to inhibit immune functioning. These physiological cascades originate in the hypothalamic areas that are involved in the neural response to threat. The aim of the study investigated whether the down regulation, by social support, of hypothalamic responses to threat is associated with better subjective health...
July 2017: Psychosomatic Medicine
Longyi Chen, Wai Hei Tse, Yi Chen, Matthew W McDonald, James Melling, Jin Zhang
In this paper, a nanostructured biosensor is developed to detect glucose in tear by using fluorescence resonance energy transfer (FRET) quenching mechanism. The designed FRET pair, including the donor, CdSe/ZnS quantum dots (QDs), and the acceptor, dextran-binding malachite green (MG-dextran), was conjugated to concanavalin A (Con A), an enzyme with specific affinity to glucose. In the presence of glucose, the quenched emission of QDs through the FRET mechanism is restored by displacing the dextran from Con A...
May 15, 2017: Biosensors & Bioelectronics
Luis E Flores, Howard Berenbaum
Memories for emotional events tend to be stronger than for neutral events, and weakening negative memories can be helpful to promote well-being. The present study examined whether the social regulation of emotion (in the form of handholding) altered the strength of emotional long-term memory. A sample of 219 undergraduate students viewed sets of negative, neutral, and positive images. Each participant held a stress ball while viewing half of the images and held someone's hand while viewing the other half. Participants returned 1 week later to complete a recognition task...
April 2017: Emotion
Luis E Flores, Howard Berenbaum
The social regulation of emotion reduces negative affect and may also help remove negative contents from working memory. The present studies investigated whether the social regulation of emotion (in the form of handholding) altered the ability to update negative contents from working memory and whether a person's level of desired emotional closeness moderated this effect. In each of 2 studies, an unselected sample of undergraduate students completed an emotional working memory task that measured the ability to remove irrelevant information from working memory and a self-report questionnaire measuring their level of desired emotional closeness...
June 2017: Emotion
Alka Barua, Venkatraman Chandra-Mouli
Following the International Conference on Population and Development Adolescent Reproductive and Sexual Health (ARSH) was recognized as a top development priority in India's National Population Policy 2000. In 2006 a separate ARSH strategy was articulated within the National Rural Health Mission. In Jharkhand, one of the poorest and least developed states in India, in 2008 the state government launched a Tarunya Project in collaboration with EngenderHealth. The project provided cascading ARSH training to government staff at secondary care facilities and strengthened outreach activities to enhance community engagement...
June 16, 2016: International Journal of Adolescent Medicine and Health
George Kontochristopoulos, Anargyros Kouris, Eftychia Platsidaki, Vasiliki Markantoni, Maria Gerodimou, Christina Antoniou
BACKGROUND: Dark circles (DC), seen in the periorbital area, are defined as bilateral, round, homogeneous pigmented macules whose aetiology is thought to be multifactorial. Available treatments include bleaching creams, topical retinoic acid, chemical peels, lasers, autologous fat transplantation, injectable fillers and surgery (blepharoplasty). OBJECTIVE: To evaluate the efficacy and safety of a combination of microneedling and 10% trichloroacetic acid (TCA) peels in the treatment of DC...
October 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Ruopeng Sun, John B Shea
The present study investigated the attention allocation during reactive stepping using a continuous finger-tapping task. Ten healthy young subjects were recruited to participate in this study. Subjects were required to perform a rapid voluntary step with either left or right leg after hearing an auditory tone while tapping their right index finger on a handhold numeric keypad. Step initiation conditions included simple and choice reaction forward stepping with three variants of continuous tapping task that were: (1) single task--no concurrent finger-tapping task; (2) dual task easy--one-button tapping task; (3) dual task hard--four-button tapping task...
April 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Joseph J Capuno, Aleli D Kraft, Stella Quimbo, Carlos R Tan, Adam Wagstaff
A cluster randomized experiment was undertaken testing two sets of interventions encouraging enrollment in the Individually Paying Program (IPP), the voluntary component of the Philippines' social health insurance program. In early 2011, 1037 unenrolled IPP-eligible families in 179 randomly selected intervention municipalities were given an information kit and offered a 50% premium subsidy valid until the end of 2011; 383 IPP-eligible families in 64 control municipalities were not. In February 2012, the 787 families in the intervention sites who were still IPP-eligible but had not enrolled had their vouchers extended, were resent the enrollment kits and received SMS reminders...
June 2016: Health Economics
Yvonne Göpel, Muna Ayesha Khan, Boris Görke
In E. coli, small RNA GlmZ activates the glmS mRNA by base-pairing in an Hfq dependent manner. When not required, GlmZ is bound by adaptor protein RapZ and recruited to RNase E, which cleaves GlmZ in its base-pairing sequence. Small RNA GlmY counteracts cleavage of GlmZ by sequestration of RapZ. Although both sRNAs are highly homologous, only GlmZ specifically binds Hfq and undergoes cleavage by RNase E. We used domain swapping to identify the responsible modules. Two elements, the 3' terminal oligo(U) stretch and the base-pairing region enable GlmZ to interact with Hfq...
January 29, 2016: Nucleic Acids Research
Bong-Hee Kim, Hee-Young Kang, Eun-Young Choi
AIMS AND OBJECTIVES: This study evaluated the effects of handholding and spoken information provided on the anxiety of patients undergoing percutaneous vertebroplasty under local anaesthesia. BACKGROUND: A surgical intervention usually entails physical discomfort and psychological burden. Furthermore, patients under local anaesthesia are conscious during the surgical intervention, which leads to more anxiety, as patients are aware of their surroundings in the operating theatre...
December 2015: Journal of Clinical Nursing
Andreas Straube, J Ellrich, O Eren, B Blum, R Ruscheweyh
BACKGROUND: Aim of the study was assessment of efficacy and safety of transcutaneous stimulation of the auricular branch of the vagal nerve (t-VNS) in the treatment of chronic migraine. METHODS: A monocentric, randomized, controlled, double-blind study was conducted. After one month of baseline, chronic migraine patients were randomized to receive 25 Hz or 1 Hz stimulation of the sensory vagal area at the left ear by a handhold battery driven stimulator for 4 h/day during 3 months...
2015: Journal of Headache and Pain
N Janardhana, D Muralidhar, D M Naidu, Guru Raghevendra
BACKGROUND: Persons with disabilities comprise at least 4 to 8 percent of the Indian population. Children with disabilities in India are subject to multiple deprivations and limited opportunities in several dimensions of their lives. Their families and caregivers also go through lot of stress and challenges in having a person with disability at home which ultimately leads to grave discriminatory practices towards these children. MATERIALS AND METHODS: The article attempts to analyze and describe the common discriminatory grounds that children with disabilities commonly face from their immediate families and from the larger community through analyzing the filed visit reports of the Basic Needs India Staff providing on job training (handholding support) for the community based rehabilitation workers...
January 2015: Journal of Natural Science, Biology, and Medicine
Benjamin R McDonald, Karl A Scheidt
Natural products continue to provide a wealth of opportunities in the areas of chemical and therapeutic development. These structures are effective measuring sticks for the current state of chemical synthesis as a field and constantly inspire new approaches and strategies. Tetrahydropryans and tetrahydropyran-4-ones are found in numerous bioactive marine natural products and medicinal compounds. Our interest in exploring the therapeutic potential of natural products containing these motifs provided the impetus to explore new methods to access highly functionalized, chiral pyran molecules in the most direct and rapid fashion possible...
April 21, 2015: Accounts of Chemical Research
J A Kuivenhoven, A K Groen
There is unequivocal evidence that high-density lipoprotein (HDL) cholesterol levels in plasma are inversely associated with the risk of cardiovascular disease (CVD). Studies of families with inherited HDL disorders and genetic association studies in general (and patient) population samples have identified a large number of factors that control HDL cholesterol levels. However, they have not resolved why HDL cholesterol and CVD are inversely related. A growing body of evidence from nongenetic studies shows that HDL in patients at increased risk of CVD has lost its protective properties and that increasing the cholesterol content of HDL does not result in the desired effects...
2015: Handbook of Experimental Pharmacology
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