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https://www.readbyqxmd.com/read/27310001/the-tarunya-project-s-efforts-to-improve-the-quality-of-adolescent-reproductive-and-sexual-health-services-in-jharkhand-state-india-a-post-hoc-evaluation
#1
Alka Barua, Venkatraman Chandra-Mouli
Following the International Conference on Population and Development Adolescent Reproductive and Sexual Health (ARSH) was recognized as a top development priority in India's National Population Policy 2000. In 2006 a separate ARSH strategy was articulated within the National Rural Health Mission. In Jharkhand, one of the poorest and least developed states in India, in 2008 the state government launched a Tarunya Project in collaboration with EngenderHealth. The project provided cascading ARSH training to government staff at secondary care facilities and strengthened outreach activities to enhance community engagement...
June 16, 2016: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/26967571/combination-of-microneedling-and-10-trichloroacetic-acid-peels-in-the-management-of-infraorbital-dark-circles
#2
George Kontochristopoulos, Anargyros Kouris, Eftychia Platsidaki, Vasiliki Markantoni, Maria Gerodimou, Christina Antoniou
BACKGROUND: Dark circles (DC), seen in the periorbital area, are defined as bilateral, round, homogeneous pigmented macules whose aetiology is thought to be multifactorial. Available treatments include bleaching creams, topical retinoic acid, chemical peels, lasers, autologous fat transplantation, injectable fillers and surgery (blepharoplasty). OBJECTIVE: To evaluate the efficacy and safety of a combination of microneedling and 10% trichloroacetic acid (TCA) peels in the treatment of DC...
October 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/26708519/probing-attention-prioritization-during-dual-task-step-initiation-a-novel-method
#3
Ruopeng Sun, John B Shea
The present study investigated the attention allocation during reactive stepping using a continuous finger-tapping task. Ten healthy young subjects were recruited to participate in this study. Subjects were required to perform a rapid voluntary step with either left or right leg after hearing an auditory tone while tapping their right index finger on a handhold numeric keypad. Step initiation conditions included simple and choice reaction forward stepping with three variants of continuous tapping task that were: (1) single task--no concurrent finger-tapping task; (2) dual task easy--one-button tapping task; (3) dual task hard--four-button tapping task...
April 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/26620394/effects-of-price-information-and-transactions-cost-interventions-to-raise-voluntary-enrollment-in-a-social-health-insurance-scheme-a-randomized-experiment-in-the-philippines
#4
Joseph J Capuno, Aleli D Kraft, Stella Quimbo, Carlos R Tan, Adam Wagstaff
A cluster randomized experiment was undertaken testing two sets of interventions encouraging enrollment in the Individually Paying Program (IPP), the voluntary component of the Philippines' social health insurance program. In early 2011, 1037 unenrolled IPP-eligible families in 179 randomly selected intervention municipalities were given an information kit and offered a 50% premium subsidy valid until the end of 2011; 383 IPP-eligible families in 64 control municipalities were not. In February 2012, the 787 families in the intervention sites who were still IPP-eligible but had not enrolled had their vouchers extended, were resent the enrollment kits and received SMS reminders...
June 2016: Health Economics
https://www.readbyqxmd.com/read/26531825/domain-swapping-between-homologous-bacterial-small-rnas-dissects-processing-and-hfq-binding-determinants-and-uncovers-an-aptamer-for-conditional-rnase-e-cleavage
#5
Yvonne Göpel, Muna Ayesha Khan, Boris Görke
In E. coli, small RNA GlmZ activates the glmS mRNA by base-pairing in an Hfq dependent manner. When not required, GlmZ is bound by adaptor protein RapZ and recruited to RNase E, which cleaves GlmZ in its base-pairing sequence. Small RNA GlmY counteracts cleavage of GlmZ by sequestration of RapZ. Although both sRNAs are highly homologous, only GlmZ specifically binds Hfq and undergoes cleavage by RNase E. We used domain swapping to identify the responsible modules. Two elements, the 3' terminal oligo(U) stretch and the base-pairing region enable GlmZ to interact with Hfq...
January 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/26333111/effects-of-handholding-and-providing-information-on-anxiety-in-patients-undergoing-percutaneous-vertebroplasty
#6
Bong-Hee Kim, Hee-Young Kang, Eun-Young Choi
AIMS AND OBJECTIVES: This study evaluated the effects of handholding and spoken information provided on the anxiety of patients undergoing percutaneous vertebroplasty under local anaesthesia. BACKGROUND: A surgical intervention usually entails physical discomfort and psychological burden. Furthermore, patients under local anaesthesia are conscious during the surgical intervention, which leads to more anxiety, as patients are aware of their surroundings in the operating theatre...
December 2015: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/26156114/treatment-of-chronic-migraine-with-transcutaneous-stimulation-of-the-auricular-branch-of-the-vagal-nerve-auricular-t-vns-a-randomized-monocentric-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Andreas Straube, J Ellrich, O Eren, B Blum, R Ruscheweyh
BACKGROUND: Aim of the study was assessment of efficacy and safety of transcutaneous stimulation of the auricular branch of the vagal nerve (t-VNS) in the treatment of chronic migraine. METHODS: A monocentric, randomized, controlled, double-blind study was conducted. After one month of baseline, chronic migraine patients were randomized to receive 25 Hz or 1 Hz stimulation of the sensory vagal area at the left ear by a handhold battery driven stimulator for 4 h/day during 3 months...
2015: Journal of Headache and Pain
https://www.readbyqxmd.com/read/25810627/discrimination-against-differently-abled-children-among-rural-communities-in-india-need-for-action
#8
N Janardhana, D Muralidhar, D M Naidu, Guru Raghevendra
BACKGROUND: Persons with disabilities comprise at least 4 to 8 percent of the Indian population. Children with disabilities in India are subject to multiple deprivations and limited opportunities in several dimensions of their lives. Their families and caregivers also go through lot of stress and challenges in having a person with disability at home which ultimately leads to grave discriminatory practices towards these children. MATERIALS AND METHODS: The article attempts to analyze and describe the common discriminatory grounds that children with disabilities commonly face from their immediate families and from the larger community through analyzing the filed visit reports of the Basic Needs India Staff providing on job training (handholding support) for the community based rehabilitation workers...
January 2015: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/25742935/pyranone-natural-products-as-inspirations-for-catalytic-reaction-discovery-and-development
#9
Benjamin R McDonald, Karl A Scheidt
Natural products continue to provide a wealth of opportunities in the areas of chemical and therapeutic development. These structures are effective measuring sticks for the current state of chemical synthesis as a field and constantly inspire new approaches and strategies. Tetrahydropryans and tetrahydropyran-4-ones are found in numerous bioactive marine natural products and medicinal compounds. Our interest in exploring the therapeutic potential of natural products containing these motifs provided the impetus to explore new methods to access highly functionalized, chiral pyran molecules in the most direct and rapid fashion possible...
April 21, 2015: Accounts of Chemical Research
https://www.readbyqxmd.com/read/25522992/beyond-the-genetics-of-hdl-why-is-hdl-cholesterol-inversely-related-to-cardiovascular-disease
#10
REVIEW
J A Kuivenhoven, A K Groen
There is unequivocal evidence that high-density lipoprotein (HDL) cholesterol levels in plasma are inversely associated with the risk of cardiovascular disease (CVD). Studies of families with inherited HDL disorders and genetic association studies in general (and patient) population samples have identified a large number of factors that control HDL cholesterol levels. However, they have not resolved why HDL cholesterol and CVD are inversely related. A growing body of evidence from nongenetic studies shows that HDL in patients at increased risk of CVD has lost its protective properties and that increasing the cholesterol content of HDL does not result in the desired effects...
2015: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/25302694/covalent-inhibition-of-new-delhi-metallo-%C3%AE-lactamase-1-ndm-1-by-cefaclor
#11
Pei W Thomas, Michael Cammarata, Jennifer S Brodbelt, Walter Fast
Covalent irreversible inhibitors can successfully treat antibiotic-resistant infections by targeting serine β-lactamases. However, this strategy is useless for New Delhi metallo-β-lactamase (NDM), which uses a non-covalent catalytic mechanism and lacks an active-site serine. Here, NDM-1 was irreversibly inactivated by three β-lactam substrates: cephalothin, moxalactam, and cefaclor, albeit at supratherapeutic doses (e.g., cefaclor KI =2.3 ± 0.1 mM; k(inact) =0.024 ± 0.001 min(-1)). Inactivation by cephalothin and moxalactam was mediated through Cys208...
November 24, 2014: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/25240958/electrical-signaling-of-enzyme-linked-immunosorbent-assays-with-an-ion-sensitive-field-effect-transistor
#12
Hyun-June Jang, Junhyoung Ahn, Min-Gon Kim, Yong-Beom Shin, Minhong Jeun, Won-Ju Cho, Kwan Hyi Lee
Optical laboratory-based immunoassays, such as enzyme-linked immunosorbent assay (ELISA) give a high sensitivity and specificity of various fatal diseases. However, these assays are no longer efficient in on-spot diagnostics of wide-spreading and contagious infections. At this point in time, portable and handhold devices play a pivotal role in infectious diseases with quick diagnostics at or near the site of the disease propagation. In this paper, we demonstrated a novel electrical immunoassay of ELISA that was not based on optical signaling but on electrical signaling...
February 15, 2015: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/24963738/-association-between-trunk-muscle-activation-and-wall-inclination-during-various-static-climbing-positions-implications-for-therapeutic-climbing
#13
C Grzybowski, L Donath, H Wagner
BACKGROUND: Sport climbing has been increasingly applied as therapy for patients with orthopaedic problems. Results from previous intervention studies have already revealed positive effects, especially for people with back problems, although there is a lack of baseline knowledge regarding the general effects of climbing. The aim of this present study is to investigate the muscle activation of the trunk while performing various static climbing positions at different inclination angles...
June 2014: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/24278126/soothing-the-threatened-brain-leveraging-contact-comfort-with-emotionally-focused-therapy
#14
Susan M Johnson, Melissa Burgess Moser, Lane Beckes, Andra Smith, Tracy Dalgleish, Rebecca Halchuk, Karen Hasselmo, Paul S Greenman, Zul Merali, James A Coan
Social relationships are tightly linked to health and well-being. Recent work suggests that social relationships can even serve vital emotion regulation functions by minimizing threat-related neural activity. But relationship distress remains a significant public health problem in North America and elsewhere. A promising approach to helping couples both resolve relationship distress and nurture effective interpersonal functioning is Emotionally Focused Therapy for couples (EFT), a manualized, empirically supported therapy that is strongly focused on repairing adult attachment bonds...
2013: PloS One
https://www.readbyqxmd.com/read/24223942/do-aging-and-dual-tasking-impair-the-capacity-to-store-and-retrieve-visuospatial-information-needed-to-guide-perturbation-evoked-reach-to-grasp-reactions
#15
Kenneth C Cheng, Jay Pratt, Brian E Maki
A recent study involving young adults showed that rapid perturbation-evoked reach-to-grasp balance-recovery reactions can be guided successfully with visuospatial-information (VSI) retained in memory despite: 1) a reduction in endpoint accuracy due to recall-delay (time between visual occlusion and perturbation-onset, PO) and 2) slowing of the reaction when performing a concurrent cognitive task during the recall-delay interval. The present study aimed to determine whether this capacity is compromised by effects of aging...
2013: PloS One
https://www.readbyqxmd.com/read/24147591/the-influence-of-political-jurisdiction-age-and-sex-on-handholding-in-public-by-same-sex-couples
#16
Alison Che, Isaac Siemens, Monika Fejtek, Richard J Wassersug
Three hundred-forty lesbians and 62 gay males, largely from North America and in partnered relationships, completed online surveys that explored what handholding means to same-sex couples. The data suggest that lesbians in the United States are more likely now than ¼ century ago to hold hands in public spaces. Younger lesbians are more likely to hold hands in public than older lesbians, and Canadian lesbians hold hands more often in public than American lesbians. In response to the question, "What does handholding mean to you?," 26% of the female respondents from North America overtly referred to public handholding as either a political act or a risky behavior...
2013: Journal of Homosexuality
https://www.readbyqxmd.com/read/24147590/who-takes-the-lead-hand-correlates-of-handholding-position-in-lesbian-couples
#17
Alison Che, Isaac Siemens, Monika Fejtek, Richard J Wassersug
When couples hold hands, one partner must take the lead hand and the other the following hand position. As potential correlates or predictors of handholding positions within lesbian couples, this article explored differences in height, age, income, who initiated the relationship, who usually initiates sexual intimacy, previous history of partnership with a male, and who has the most "say" in decision-making. Data revealed only 2 significant variables: The taller partner was more likely to have the lead hand, and a woman who had previously been partnered with a male was more likely to take the trailing hand position...
2013: Journal of Homosexuality
https://www.readbyqxmd.com/read/23829029/maximum-hand-rung-coupling-forces-in-children-the-effects-of-handhold-diameter
#18
RANDOMIZED CONTROLLED TRIAL
Peter F Ehrlich, Justin G Young, Sheryl Ulin, Charles Woolley, Thomas J Armstrong, Andrzej Galecki, Shu Chen, James A Ashton-Miller
OBJECTIVE: To quantify the effect of handhold size (diameter) on the maximum breakaway strength between a hand and handhold for children. BACKGROUND: Falls from playground equipment are a major cause of childhood injury and death. It is unclear if recommendations for handholds on playground equipment are too broad. METHODS: Breakaway strength was defined as the maximum quasistatic force that can be exerted on a grasped object before the object is forcibly pulled from the grasp...
June 2013: Human Factors
https://www.readbyqxmd.com/read/23639347/childhood-maternal-support-and-social-capital-moderate-the-regulatory-impact-of-social-relationships-in-adulthood
#19
James A Coan, Lane Beckes, Joseph P Allen
For this functional magnetic resonance imaging (fMRI) study, we assessed the impact of early social experiences on the social regulation of neural threat responding in a sample of 22 individuals that have been followed for over a decade. At 13 years old, a multidimensional measure of neighborhood quality was derived from parental reports. Three measures of neighborhood quality were used to estimate social capital-the level of trust, reciprocity, cooperation, and shared resources within a community. At 16 years old, an observational measure of maternal emotional support behavior was derived from a mother/child social interaction task...
June 2013: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/23635599/effects-of-spatial-memory-decay-and-dual-task-interference-on-perturbation-evoked-reach-to-grasp-reactions-in-the-absence-of-online-visual-feedback
#20
Kenneth C Cheng, Jay Pratt, Brian E Maki
Recent findings suggest that rapid perturbation-evoked reach-to-grasp balance-recovery reactions can be (and often are) guided by visuospatial information stored in working memory. To further our understanding, the present study examined the influence of memory-decay and concurrent cognitive-task performance on the speed, accuracy and effectiveness of these reactions by using liquid-crystal goggles to initiate occlusion of vision at various "recall-delay" times prior to perturbation-onset, in ten healthy young-adults...
April 2013: Human Movement Science
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