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https://www.readbyqxmd.com/read/28231575/individual-biomarkers-using-molecular-personalized-medicine-approaches
#1
Hans P Zenner
Molecular personalized medicine tries to generate individual predictive biomarkers to assist doctors in their decision making. These are thought to improve the efficacy and lower the toxicity of a treatment. The molecular basis of the desired high-precision prediction is modern "omex" technologies providing high-throughput bioanalytical methods. These include genomics and epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, imaging, and functional analyses. In most cases, producing big data also requires a complex biomathematical analysis...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28231481/the-influence-of-personality-traits-and-emotional-and-behavioral-problems-on-repetitive-nonsuicidal-self-injury-in-a-school-sample
#2
Janine Lüdtke, Benedict Weizenegger, Rachel Rauber, Brigitte Contin, Tina In-Albon, Marc Schmid
BACKGROUND: Nonsuicidal self-injury (NSSI) is highly prevalent among adolescents and associated with various mental health problems and suicidality. Previous studies have found that certain personality traits are related to NSSI behavior, however only few studies examined personality traits in adolescents with NSSI. Our study aimed to assess the relationship between personality traits and emotional and behavioral problems in predicting repetitive NSSI among adolescents from a school sample...
February 14, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28231252/toward-a-comprehensive-taxonomy-of-human-motives
#3
Jennifer R Talevich, Stephen J Read, David A Walsh, Ravi Iyer, Gurveen Chopra
A major success in personality has been the development of a consensual structure of traits. However, much less progress has been made on the structure of an equally important aspect of human psychology: motives. We present an empirically and theoretically structured hierarchical taxonomy of 161 motives gleaned from a literature review from McDougall to the present and based on the cluster analysis of similarity judgments among these 161 motives, a broader sampling of motives than previous work. At the broadest level were: Meaning, Communion, and Agency...
2017: PloS One
https://www.readbyqxmd.com/read/28230459/estimated-cost-effectiveness-cost-benefit-and-risk-reduction-associated-with-an-endocrinologist-pharmacist-diabetes-intense-medical-management-tune-up-clinic
#4
Jan D Hirsch, Mark Bounthavong, Anisa Arjmand, David R Ha, Christine L Cadiz, Andrew Zimmerman, Heather Ourth, Anthony P Morreale, Steven V Edelman, Candis M Morello
BACKGROUND: In 2012 U.S. diabetes costs were estimated to be $245 billion, with $176 billion related to direct diabetes treatment and associated complications. Although a few studies have reported positive glycemic and economic benefits for diabetes patients treated under primary care physician (PCP)-pharmacist collaborative practice models, no studies have evaluated the cost-effectiveness of an endocrinologist-pharmacist collaborative practice model treating complex diabetes patients versus usual PCP care for similar patients...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28230441/exploring-salutogenesis-as-a-concept-of-health-and-wellbeing-in-nurses-who-thrive-professionally
#5
Eleanor Stock
AIM: To determine whether salutogenesis, a concept of health and wellbeing, can be identified in nurses who self-describe as thriving professionally. BACKGROUND: Nurse burnout can potentially impact clinical performance, patient safety, and increase the turnover of nurses, which all contribute to additional healthcare costs. The ability to not only avoid burnout, but to thrive in stressful environments is an important factor worth exploring. The salutogenic concept is related to this...
February 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28228864/innovative-payer-engagement-strategies-will-the-convergence-lead-to-better-value-creation-in-personalized-medicine
#6
REVIEW
Ildar Akhmetov, Rostyslav V Bubnov
BACKGROUND: As reimbursement authorities are gaining greater power to influence the prescription behavior of physicians, it remains critical for life science companies focusing on personalized medicine to develop "tailor-made" payer engagement strategies to secure reimbursement and assure timely patient access to their innovative products. Depending on the types of such engagement, pharmaceutical and diagnostic companies may benefit by obtaining access to medical and pharmacy claims data, getting invaluable upfront inputs on evidence requirements and clinical trial design, and strengthening trust by payers, therefore avoiding uncertainties with regards to pricing, reimbursement, and research and development reinvestment...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/28228740/why-do-people-act-like-the-proverbial-ostrich-investigating-the-reasons-that-people-provide-for-not-monitoring-their-goal-progress
#7
Betty P I Chang, Thomas L Webb, Yael Benn
Two studies examined peoples' reasons for not monitoring their progress toward their personal goals-a phenomenon that has been termed "the ostrich problem" (Webb et al., 2013). Study 1 used factor analysis to organize the reasons that people gave for not monitoring their goal progress, resulting in 10 factors. The most strongly endorsed reasons were: (a) that information on goal progress would demand a change in beliefs, or (b) undesired action; (c) that progress was poor, and (d) that thinking about and/or working on the goal was associated with negative emotions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28228424/widespread-sucralose-exposure-in-a-randomized-clinical-trial-in-healthy-young-adults
#8
Allison C Sylvetsky, Peter J Walter, H Martin Garraffo, Kim Robien, Kristina I Rother
Background: Low-calorie sweeteners (LCSs) are found in many foods and beverages, but consumers may not realize their presence, and their role in appetite, weight, and health is controversial. Although consumption limits based on toxicologic safety are well established, the threshold required to exert clinically relevant metabolic effects is unknown.Objectives: This study aimed to determine whether individuals who do not report consumption of LCSs can be correctly characterized as "unexposed" and to investigate whether instructions to avoid LCSs are effective in minimizing exposure...
February 22, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28228053/hiv-related-pneumococcal-disease-prevention-in-adults
#9
Charles Feldman, Ronald Anderson, Theresa Rossouw
HIV-infected persons are particularly susceptible to the development of severe pneumococcal disease, even in the setting of combination antiretroviral therapy (cART), due to slow, incomplete recovery of anti-pneumococcal host defenses. This risk is increased by avoidable aspects of lifestyle, particularly smoking, which intensify immunosuppression. Clearly, more effective preventive measures are needed to counter this threat. Areas covered: This is a detailed review of the published literature focusing on currently available strategies for prevention of pneumococcal infection in HIV-infected patients, including cotrimoxazole prophylaxis, cART, pneumococcal vaccination, and smoking cessation strategies...
March 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28227226/learning-approaches-to-improve-prediction-of-drug-sensitivity-in-breast-cancer-patients
#10
Turki Turki, Zhi Wei, Turki Turki, Zhi Wei, Turki Turki, Zhi Wei
Predicting drug response to cancer disease is an important problem in modern clinical oncology that attracted increasing recent attention from various domains such as computational biology, machine learning, and data mining. Cancer patients respond differently to each cancer therapy owing to disease diversity, genetic factors, and environmental causes. Thus, oncologists aim to identify the effective therapies for cancer patients and avoid adverse drug reactions in patients. By predicting the drug response to cancer, oncologists gain full understanding of the effective treatments on each patient, which leads to better personalized treatment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226318/existential-orientation-on-the-phenomenology-of-values-attitudes-and-worldviews-in-schizophrenia-ancillary-article-to-eawe-domain-6
#11
Elizabeth Pienkos, Louis Sass
Since the appearance of schizophrenia as a distinct diagnosis, various researchers and clinicians, particularly those in the phenomenological and existential tradition, have noted the unique contribution of attitudinal and characterological factors to the illness. There has been a notable lack of attention paid to these features in most recent research on the disorder; still, understanding the values, attitudes, and worldviews - what might be termed the "existential orientation" - of persons with schizophrenia may be essential for comprehending the illness and developing effective approaches to treatment...
February 23, 2017: Psychopathology
https://www.readbyqxmd.com/read/28223206/accumulation-of-heavy-metals-in-people-on-a-gluten-free-diet
#12
Stephanie L Raehsler, Rok Seon Choung, Eric V Marietta, Joseph A Murray
BACKGROUND & AIMS: Specific foods such as fish and rice have high concentrations of metals such as arsenic, mercury, lead, cadmium, and cobalt. Many gluten-free diets (GFDs) include these foods, so we evaluated whether a GFD was associated with increased metal bioaccumulation. METHODS: We performed a population-based cross-sectional study using data collected from the National Health and Nutrition Examination Survey (NHANES), from 2009 through 2012, collecting information on the diagnosis of celiac disease and adherence to a GFD...
February 18, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28222331/the-moro-reaction-more-than-a-reflex-a-ritualized-behavior-of-nonverbal-communication
#13
Pierre V Rousseau, Florence Matton, Renaud Lecuyer, Willy Lahaye
OBJECTIVE: To propose a phylogenetic significance to the Moro reflex which remains unexplained since its publication in 1918 because both hands are free at the end of the gesture. METHOD: Among the 75 videos of healthy term newborns we have filmed in a research project on antenatal education to parenthood, we describe a sequence that clearly showed the successive movements of the Moro reflex and we report the occurrence of this reflex in the videos that were recorded from Time 0 of birth defined as the moment that lies between the birth of the thorax and the pelvis of the infant...
February 18, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28221842/consumer-response-to-gastrointestinal-illness-perceived-to-originate-from-food-service-facilities
#14
Erin S Garnett, Stephanie R Gretsch, Clair Null, Christine L Moe
Consumer responses to food product recalls have been documented, but there is little information on how consumers respond to illnesses or outbreaks associated with food service facilities. This study uses an on-line survey of 885 adults conducted in 2012 to determine how respondents changed their dining behavior following personal experiences with and secondhand reports of gastrointestinal illness believed to be associated with food service facilities. In response to personally experiencing gastrointestinal illness that they attributed to a food service facility, 90% of survey participants reported that they avoided the implicated facility for a time following the incident; almost one-half decided to never return to the facility they believed had made them ill...
October 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221814/an-amperometric-glucose-sensor-integrated-into-an-insulin-delivery-cannula-in-vitro-and-in-vivo-evaluation
#15
W Kenneth Ward, Gabriel Heinrich, Matthew Breen, Sheila Benware, Nicole Vollum, Kristin Morris, Chad Knutsen, Joseph D Kowalski, Scott Campbell, Jerry Biehler, Mark S Vreeke, Scott M Vanderwerf, Jessica R Castle, Robert S Cargill
BACKGROUND: Labeling prohibits delivery of insulin at the site of subcutaneous continuous glucose monitoring (CGM). Integration of the sensing and insulin delivery functions into a single device would likely increase the usage of CGM in persons with type 1 diabetes. METHODS: To understand the nature of such interference, we measured glucose at the site of bolus insulin delivery in swine using a flexible electrode strip that was laminated to the outer wall of an insulin delivery cannula...
February 21, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28221160/-urinary-lithiasis-the-patient-also-plays
#16
Juan Antonio Galán Llopis, Aleixandre Vergés Prósper, Helena Pérez-Seoane Ballester, Eva Escudero Fontano, Leonardo Tortolero Blanco
Renal lithiasis is known for its high incidence and prevalence, but mainly for its morbidity and recurrence. Despite a good indication and appropriate surgical treatment, the essential problem, the origin of the formation of the stones, generally persists and it is not uncommon that patients suffer multiple treatments and discomfort secondary to ancillary measures normally used to prevent complications. It is widely known, for consistency, that a prophylactic treatment with general or, in a smaller group of patients, specific measures are appropriate to diminish recurrences...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28221159/what-should-we-do-with-residual-fragments
#17
Kemal Sarica, Emrah Yuruk
OBJECTIVE: To address various issues concerning the fate of residual fragments (and the patients carrying them), their detection, and current and future techniques to avoid them. METHODS: Narrative overview of the all relevant articles retrieved from Pubmed research together with the experiences of personal practice was conducted. RESULTS: Clinically insignificant residual fragments (CIRFs) are defined as asymptomatic, non-obstructing residual fragments smaller than 4 mm (1...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28219453/a-consult-is-just-a-page-away-a-prospective-observational-study-on-the-impact-of-jinxing-on-call-karma-in-neurosurgery
#18
Holger Joswig, Lauren Zarnett, David A Steven, Martin N Stienen
OBJECTIVE: Our aim was to assess the impact of jinxing on "call karma" in neurosurgery. METHODS: We conducted a prospective observational study on 15 residents on call for the neurosurgery service, recording the total number of admissions, consults, deaths encountered, surgeries performed, hours of sleep and subjective call rating on a numeric rating scale (NRS) of 0-10 in terms of general awfulness. RESULTS: Some 204 on-call nightshifts were analyzed, of which 61 (29...
February 21, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28218333/effects-of-exercise-therapy-on-polymyositis-complicated-by-post-myocarditis-cardiomyopathy-a-case-report
#19
Hidetoshi Yanagi, Naohisa Shindo
BACKGROUND: A 42-year-old woman with chronic polymyositis complicated by post-myocarditis cardiomyopathy underwent supervised and unsupervised exercise therapy with staged increases in intensity. METHODS: Supervised exercise therapy, which included adopted standards for patients with heart failure, was performed for 6 months. After one month, unsupervised exercise therapy was commenced, in the form of 15 min walking, the duration of which was increased to 30 min after 2 months...
February 16, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28217589/relationship-between-attachment-styles-and-happiness-in-medical-students
#20
Marzyeh Moghadam, Farzin Rezaei, Ebrahim Ghaderi, Negar Rostamian
BACKGROUND: Attachment theory is one of the most important achievements of contemporary psychology. Role of medical students in the community health is important, so we need to know about the situation of happiness and attachment style in these students. OBJECTIVES: This study was aimed to assess the relationship between medical students' attachment styles and demographic characteristics. MATERIALS AND METHODS: This cross-sectional study was conducted on randomly selected students of Medical Sciences in Kurdistan University, in 2012...
July 2016: Journal of Family Medicine and Primary Care
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