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Biomatrix

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https://www.readbyqxmd.com/read/29536609/5-year-clinical-follow-up-of-the-cobra-complex-coronary-bifurcation-lesions-randomized-comparison-of-a-strategy-using-a-dedicated-self-expanding-biolimus-a9-eluting-stent-vs-a-culotte-strategy-using-everolimus-eluting-stents-study
#1
J Bennett, T Adriaenssens, K McCutcheon, J Dens, W Desmet, P Sinnaeve, M Vrolix, C Dubois
OBJECTIVES: We evaluated healing responses with optical coherence tomography, and long-term clinical outcomes after treatment with a dedicated stent versus a conventional culotte technique. BACKGROUND: Dedicated bifurcation stents have been proposed as an alternative treatment for coronary bifurcation lesions. The long-term performance of dedicated stents versus conventional dual-stent techniques for the treatment of complex coronary bifurcation lesions is unknown...
March 14, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29518974/one-step-preparation-of-phenyl-boron-modified-magnetic-mesoporous-silica-for-selective-enrichment-of-cis-diol-containing-substances
#2
Hua Fu, Jing Hu, Min Zhang, Yuerong Wang, Hongyang Zhang, Ping Hu
For enrichment and separation of cis -diol-containing compounds from biomatrix, a new type of magnetic nanoparticles named MS-48-PBSC, whichwas facilely prepared in a one-step heterogeneous reaction. The morphology results demonstrated that the MS-48-PBSC was a spherical nanomaterial containing a core of silica-coated magnetic particle with a diameter of about 200 nm, and a cover layer of mesoporous silica with a thickness of approximate 50 nm. The characterization results showed that MS-48-PBSC presented a pore size of 4...
March 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29427885/a-nonenzymatic-dna-nanomachine-for-biomolecular-detection-by-target-recycling-of-hairpin-dna-cascade-amplification
#3
Jiao Zheng, Ningxing Li, Chunrong Li, Xinxin Wang, Yucheng Liu, Guobin Mao, Xinghu Ji, Zhike He
Synthetic enzyme-free DNA nanomachine performs quasi-mechanical movements in response to external intervention, suggesting the promise of constructing sensitive and specific biosensors. Herein, a smart DNA nanomachine biosensor for biomolecule (such as nucleic acid, thrombin and adenosine) detection is developed by target-assisted enzyme-free hairpin DNA cascade amplifier. The whole DNA nanomachine system is constructed on gold nanoparticle which decorated with hundreds of locked hairpin substrate strands serving as DNA tracks, and the DNA nanomachine could be activated by target molecule toehold-mediated exchange on gold nanoparticle surface, resulted in the fluorescence recovery of fluorophore...
June 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29355413/treatment-of-carious-lesions-using-self-assembling-peptides
#4
M Alkilzy, R M Santamaria, J Schmoeckel, C H Splieth
Modern approaches in caries treatment involve lesion management without tissue removal. Regenerative medicine focuses on replacing damaged tissues with biologically similar tissues. This article discusses the scientific evidence and clinical results for self-assembling peptides in modern caries management. The biomimetic remineralization promoted by self-assembling peptide P11-4 has been proven in vitro as an effective therapy for initial caries. P11-4 was rationally designed to promote formation of hydroxyapatite on its surface...
February 2018: Advances in Dental Research
https://www.readbyqxmd.com/read/29321021/silver-pig-skin-nanocomposites-and-mesenchymal-stem-cells-suitable-antibiofilm-cellular-dressings-for-wound-healing
#5
Mario Alberto Pérez-Díaz, Phaedra Silva-Bermudez, Binisa Jiménez-López, Valentín Martínez-López, Yaaziel Melgarejo-Ramírez, Ana Brena-Molina, Clemente Ibarra, Isabel Baeza, M Esther Martínez-Pardo, M Lourdes Reyes-Frías, Erik Márquez-Gutiérrez, Cristina Velasquillo, Gabriel Martínez-Castañon, Fidel Martinez-Gutierrez, Roberto Sánchez-Sánchez
BACKGROUND: Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-resistant and multidrug-resistant bacteria...
January 10, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29226914/longitudinal-deformation-bench-testing-using-a-coronary-artery-model-a-new-standard
#6
COMMENT
Tawfiq R Choudhury, Salwan Al-Saigh, Steve Burley, Lin Li, Nizar Shakhshir, Nazanin Mirhosseini, Tao Wang, Samer Arnous, Muhammad A Khan, Mamas A Mamas, Douglas G W Fraser
Objectives: To compare susceptibility of five different stent platforms with longitudinal stent deformation (LSD) using a clinically relevant bench testing model simulating both short and long malapposed lengths. Background: Recent data suggest that design modifications to the Promus Element stent which led to the Promus Premier stent has reduced susceptibility to LSD. However, susceptibility to LSD at long malapposed lengths has not been tested. Furthermore, the mechanisms behind susceptibility to LSD are as yet unclear...
2017: Open Heart
https://www.readbyqxmd.com/read/29173725/hyaluronan-and-hyaluronan-fragments
#7
REVIEW
Mary K Cowman
The glycosaminoglycan hyaluronan (HA) is a key component of the microenvironment surrounding cells. In healthy tissues, HA molecules have extremely high molecular mass and consequently large hydrodynamic volumes. Tethered to the cell surface by clustered receptor proteins, HA molecules crowd each other, as well as other macromolecular species. This leads to severe nonideality in physical properties of the biomatrix, because steric exclusion leads to an increase in effective concentration of the macromolecules...
2017: Advances in Carbohydrate Chemistry and Biochemistry
https://www.readbyqxmd.com/read/29075651/modeling-physiologic-microenvironments-in-three-dimensional-microtumors-maintains-brain-tumor-initiating-cells
#8
Ashley N Gilbert, Kiera Walker, Anh Nhat Tran, Nathaniel H Boyd, G Yancey Gillespie, Raj K Singh, Anita B Hjelmeland
Development of effective novel anti-tumor treatments will require improved in vitro models that incorporate physiologic microenvironments and maintain intratumoral heterogeneity, including tumor initiating cells. Brain tumor initiating cells (BTIC) are a target for cancer therapy, because BTICs are highly tumorigenic and contribute to tumor angiogenesis, invasion, and therapeutic resistance. Current leading studies rely on BTIC isolation from patient-derived xenografts followed by propagation as neurospheres...
2017: Journal of Cancer Stem Cell Research
https://www.readbyqxmd.com/read/28922982/porcine-mesothelium-wrapped-diced-cartilage-grafts-for-nasal-reconstruction
#9
Athanasios Bramos, David P Perrault, Alexander N Fedenko, Gene H Kim, Sofia Bougioukli, Jay R Lieberman, Jay W Calvert, Alex K Wong
BACKGROUND: Fascia-wrapped diced cartilage grafts have become a useful tool in modern rhinoplasty surgery. Unfortunately, fascial harvest is associated with donor site morbidity; therefore, a nonautologous alternative to fascia would be ideal. Decellularized porcine mesothelium (PM), Meso BioMatrix™, is an acellular scaffold that could potentially fill this need. To determine if PM could serve as an acceptable alternative, we histologically compared diced cartilage grafts wrapped in fascia versus PM...
April 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28797113/clinical-outcomes-of-biodegradable-polymer-biolimus-eluting-biomatrix-stents-versus-durable-polymer-everolimus-eluting-xience-stents
#10
MULTICENTER STUDY
Da Hyon Lee, Taek Kyu Park, Young Bin Song, Woo Jung Chun, Rak Kyeong Choi, Jin-Ok Jeong, Eul Soon Im, Sang Wook Kim, Joo Myung Lee, Jeong Hoon Yang, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon
There are limited data about clinical outcomes of biodegradable polymer biolimus-eluting BioMatrix stents (BP-BES) and durable polymer everolimus-eluting Xience stents (DP-EES) in real world practice. We sought to compare the clinical outcomes of BP-BES and DP-EES in real world cohorts of patients undergoing percutaneous coronary intervention. A prospective multicenter registry enrolled 999 patients treated with BP-BES and 1,000 patients treated with DP-EES. The primary outcome was target lesion failure, defined as a composite of cardiac death, target vessel-related myocardial infarction, or target lesion revascularization...
2017: PloS One
https://www.readbyqxmd.com/read/28692308/lc-ms-determination-of-triazolam-and-its-hydroxy-metabolites-in-mouse-dried-blood-spots-application-to-transgenic-mouse-pharmacokinetic-studies
#11
Prashant Kole, Abhijith Rao, Vishwanath Kurawattimath, Sandhya Mandlekar
AIM: The objective of this study was to develop a LC-MS/MS method for the simultaneous determination of triazolam (TRZ) and its two hydroxy metabolites in transgenic mouse dried blood spots (DBS) using BALB/c mouse blood as a surrogate biomatrix. METHODOLOGY/RESULTS: The DBS method involved spotting volume of 10 μl using Ahlstrom 226 sample collection cards. A 'whole spot' analysis (6-mm punch) involved extraction of analytes using water and acetonitrile containing an internal standard...
July 2017: Bioanalysis
https://www.readbyqxmd.com/read/28665236/formation-of-adipose-stromal-vascular-fraction-cell-laden-spheroids-using-a-three-dimensional-bioprinter-and-superhydrophobic-surfaces
#12
Brian C Gettler, Joseph S Zakhari, Piyani S Gandhi, Stuart K Williams
The therapeutic infusion of adipose-derived stromal vascular fraction (SVF) cells for the treatment of multiple diseases, has progressed to numerous human clinical trials; however, the often poor retention of the cells following implantation remains a common drawback of direct cell injection. One solution to cellular retention at the injection site has been the use of biogels to encapsulate cells within a microenvironment before and upon implantation. The current study utilized three-dimensional bioprinting technology to evaluate the ability to form SVF cell-laden spheroids with collagen I as a gel-forming biomatrix...
September 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28647315/safety-and-efficacy-of-new-biodegradable-polymer-based-sirolimus-eluting-stents-in-a-preclinical-model
#13
Armando Pérez de Prado, Claudia Pérez Martínez, Carlos Cuellas Ramón, Marta Regueiro Purriños, María López Benito, José Manuel Gonzalo Orden, José Antonio Rodríguez Altónaga, Rodrigo Estévez Loureiro, Tomás Benito González, David Viñuela Baragaño, María Molina Crisol, Marc Amorós Aguilar, Isabel Pérez Serranos, Arnau Vidal Parreu, Ana Benavides Montegordo, Luis Duocastella Codina, Felipe Fernández Vázquez
INTRODUCTION AND OBJECTIVES: New drug-eluting stents (DES) designed to overcome the limitations of existing devices should initially be tested in preclinical studies. Our objective was to analyze the safety and efficacy of new biodegradable polymer-based DES compared with bare-metal stents (BMS) and commercially available DES in a model of normal porcine coronary arteries. METHODS: We randomly implanted 101 stents (BMS and biodegradable polymer-based sirolimus-eluting stents: 3 test stent iterations [BD1, BD2, and BD3], Orsiro, Biomime and Biomatrix) in the coronary arteries of 34 domestic pigs...
December 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28613136/biosorption-of-basic-blue-7-by-fungal-cells-immobilized-on-the-green-type-biomatrix-of-phragmites-australis-spongy-tissue
#14
Tamer Akar, Cansu Uzun, Sema Çelik, Sibel Tunali Akar
Biosorption is an effective alternative method for the control of water pollution caused by different pollutants such as synthetic dyes and metals. A new and efficient biomass system was developed from the passively immobilized fungal cells. The spongy tissue of Phragmites australis was considered as the carrier for the immobilization of Neurospora sitophila cells employed for the biosorption of Basic Blue 7. This plant tissue was used for the first time as a carrier for fungal cells. The biosorption was examined through batch- and continuous-mode operations...
January 28, 2018: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28581716/transfer-of-biomatrix-wood-cell-interactions-to-hemicellulose-based-materials-to-control-water-interaction
#15
REVIEW
Anas Ibn Yaich, Ulrica Edlund, Ann-Christine Albertsson
The family of hemicelluloses stands out as a very promising natural resource that can be utilized as a biobased materials feedstock. An in-depth understanding of the hemicellulose inherent structural and property features as well as the structure-property relationships induced by the specific supramolecular hierarchical organization of lignocellulosic biopolymers will be a key enabling technology in the emerging biorefinery sector. This Review aims to give a perspective on these issues and demonstrate how the transfer of molecular wood cell interactions into hemicellulose-based materials may offer new design principles for material formulations...
June 28, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28564546/polyurethane-microgel-based-microtissue-interface-guided-assembly-and-spreading
#16
Michael J Hill, Debanjan Sarkar
Colloidal gels are three-dimensional networks of microgel particles and can be utilized to design microtissues where the differential adhesive interactions between the particles and cells, guided by their surface energetics, are engineered to spatially assemble the cellular and colloidal components into three-dimensional microtissues. In this work we utilized a colloidal interaction approach to design cell-polyurethane (PU) microgel bimodal microtissues using endothelial cells (ECs) as a normal cell model and a nonmalignant breast cancer cell line (MCF-7) as a cancer cell model...
June 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28544186/safety-and-efficacy-outcomes-of-3rd-generation-des-in-an-all-comer-population-of-patients-undergoing-pci-12-month-and-24-month-results-of-the-e-biomatrix-french-registry
#17
Eric Maupas, Janusz Lipiecki, Raphy Levy, Benjamin Faurie, Bernard Karsenty, Marc Eric Moulichon, François Brunelle, Luc Maillard, Fabien de Poli, Thierry Lefèvre
OBJECTIVES: The French Ebiomatrix registry aimed to confirm the results of the Leaders trial in an all-comer population in France. BACKGROUND: The Leaders trial showed the Biolimus-eluting-sent (BES) to be equivalent to the Cypher stent in terms of safety and efficacy at 1 year and superior regarding stent thrombosis after 1 year. METHODS: BES recipients were enrolled in 42 French centers with up to 24-month clinical follow up. RESULTS: 2365 patients were included...
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28544146/real-life-clinical-outcomes-with-everolimus-eluting-platinum-chromium-stent-with-an-abluminal-biodegradable-polymer-in-patients-from-the-swedish-coronary-angiography-and-angioplasty-registry-scaar
#18
Giovanna Sarno, Bo Lagerqvist, Göran Olivecrona, Christoph Varenhorst, Mikael Danielewicz, Kristina Hambraeus, Daniel Lindholm, Truls Råmunddal, Nils Witt, Stefan James
BACKGROUND: No previous studies have evaluated the performance of the Synergy stent in a large real-life population. OBJECTIVES: To describe the initial real-life experience with a novel everolimus eluting platinum chromium stent with abluminal biodegradable polymer (SYNERGY) in unselected patients from a nationwide registry. METHODS: All implanted Synergy stents were compared with other new generation drug eluting stents (n-DES) with >1,000 implantations in Sweden between March 2013 and October 2015...
May 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28466123/the-role-of-quantitative-estrogen-receptor-status-in-predicting-tumor-response-at-surgery-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy
#19
REVIEW
Jacques Raphael, Sonal Gandhi, Nim Li, Fang-I Lu, Maureen Trudeau
PURPOSE: Estrogen receptor (ER) negative (-) breast cancer (BC) patients have better tumor response rates than ER-positive (+) patients after neoadjuvant chemotherapy (NCT). We conducted a retrospective review using the institutional database "Biomatrix" to assess the value of quantitative ER status in predicting tumor response at surgery and to identify potential predictors of survival outcomes. METHODS: Univariate followed by multivariable regression analyses were conducted to assess the association between quantitative ER and tumor response assessed as tumor size reduction and pathologic complete response (pCR)...
May 2, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28323397/in-vivo-response-to-decellularized-mesothelium-scaffolds
#20
Michael J Cronce, Renea A Faulknor, Irina Pomerantseva, Xiang-Hong Liu, Scott M Goldman, Emmanuel C Ekwueme, Olive Mwizerwa, Craig M Neville, Cathryn A Sundback
Biological surgical scaffolds are used in plastic and reconstructive surgery to support structural reinforcement and regeneration of soft tissue defects. Macrophage and fibroblast cell populations heavily regulate scaffold integration into host tissue following implantation. In the present study, the biological host response to a commercially available surgical scaffold (Meso BioMatrix Surgical Mesh (MBM)) was investigated for up to 9 weeks after subcutaneous implantation; this scaffold promoted superior cell migration and infiltration previously in in vitro studies relative to other commercially available scaffolds...
February 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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