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Eric Maupas, Janusz Lipiecki, Raphy Levy, Benjamin Faurie, Bernard Karsenty, Marc Eric Moulichon, François Brunelle, Luc Maillard, Fabien de Poli, Thierry Lefèvre
OBJECTIVES: The French Ebiomatrix registry aimed to confirm the results of the Leaders trial in an all-comer population in France. BACKGROUND: The Leaders trial showed the Biolimus-eluting-sent (BES) to be equivalent to the Cypher stent in terms of safety and efficacy at 1 year and superior regarding stent thrombosis after 1 year. METHODS: BES recipients were enrolled in 42 French centers with up to 24-month clinical follow up. RESULTS: 2365 patients were included...
May 22, 2017: Catheterization and Cardiovascular Interventions
Giovanna Sarno, Bo Lagerqvist, Göran Olivecrona, Christoph Varenhorst, Mikael Danielewicz, Kristina Hambraeus, Daniel Lindholm, Truls Råmunddal, Nils Witt, Stefan James
BACKGROUND: No previous studies have evaluated the performance of the Synergy stent in a large real-life population. OBJECTIVES: To describe the initial real-life experience with a novel everolimus eluting platinum chromium stent with abluminal biodegradable polymer (SYNERGY) in unselected patients from a nationwide registry. METHODS: All implanted Synergy stents were compared with other new generation drug eluting stents (n-DES) with >1,000 implantations in Sweden between March 2013 and October 2015...
May 22, 2017: Catheterization and Cardiovascular Interventions
Jacques Raphael, Sonal Gandhi, Nim Li, Fang-I Lu, Maureen Trudeau
PURPOSE: Estrogen receptor (ER) negative (-) breast cancer (BC) patients have better tumor response rates than ER-positive (+) patients after neoadjuvant chemotherapy (NCT). We conducted a retrospective review using the institutional database "Biomatrix" to assess the value of quantitative ER status in predicting tumor response at surgery and to identify potential predictors of survival outcomes. METHODS: Univariate followed by multivariable regression analyses were conducted to assess the association between quantitative ER and tumor response assessed as tumor size reduction and pathologic complete response (pCR)...
May 2, 2017: Breast Cancer Research and Treatment
Michael J Cronce, Renea A Faulknor, Irina Pomerantseva, Xiang-Hong Liu, Scott M Goldman, Emmanuel C Ekwueme, Olive Mwizerwa, Craig M Neville, Cathryn A Sundback
Biological surgical scaffolds are used in plastic and reconstructive surgery to support structural reinforcement and regeneration of soft tissue defects. Macrophage and fibroblast cell populations heavily regulate scaffold integration into host tissue following implantation. In the present study, the biological host response to a commercially available surgical scaffold (Meso BioMatrix Surgical Mesh (MBM)) was investigated for up to 9 weeks after subcutaneous implantation; this scaffold promoted superior cell migration and infiltration previously in in vitro studies relative to other commercially available scaffolds...
March 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
N R Efimochkina, I B Bykova, Yu M Markova, Yu V Korotkevich, V V Stetsenko, L P Minaeva, S A Sheveleva
We analyzed the formation of biofilms by 7 strains of Campylobacter genus bacteria and 18 strains of Enterobacteriaceae genus bacteria that were isolated from plant and animal raw materials, from finished products, and swabs from the equipment of the food industry. Biofilm formation on glass plates, slides and coverslips, microtubes made of polymeric materials and Petri dishes, and polystyrene plates of different profiles were analyzed. When studying the process of films formation, different effects on bacterial populations were simulated, including variation of growth factor composition of culture media, technique of creating of anaerobiosis, and biocide treatment (active chlorine solutions in a concentration of 100 mg/dm(3))...
February 2017: Bulletin of Experimental Biology and Medicine
Jacques Raphael, Thivaher Paramsothy, Nim Li, Justin Lee, Sonal Gandhi
PURPOSE: Progression during neoadjuvant chemotherapy (NAT) for early and locally advanced breast cancer is generally uncommon. However, these patients tend to do poorly, and salvage therapy (ST) use is variable and often not well defined. We aimed to establish the characteristics and outcomes of breast cancer (BC) patients progressing on NAT, report the patterns of institutional ST usage, and identify predictors of ST failure. METHODS: A retrospective review was conducted using the "Biomatrix" institutional database...
February 27, 2017: Breast Cancer Research and Treatment
Mohammad Alidoosti, Vahideh Sharifnia, Seyed Ebrahim Kassaian, Alimohammad Hajizeinali, Hamidreza Poorhosseini, Mojtaba Salarifar, Younes Nozari, Elham Hakki Kazazi
Background: The biolimus-eluting stent (BES), with a biodegradable polymer, has not been previously compared with the everolimus-eluting stent (EES), as a second-generation drug-eluting stent (DES).We sought to compare the 1-year outcome between the PROMUS(™) stent (EES type) and the BioMatrix(™) stent (BES type). Methods: From March 2008 to September 2011, all patients treated with the PROMUS™ stent or the BioMatrix™ stent for coronary artery stenosis at Tehran Heart Center were enrolled. The primary end points were 1-year adverse events, comprising death, myocardial infarction, target vessel revascularization, and target lesion revascularization...
April 13, 2016: Journal of Tehran Heart Center
Zheng-Yu Yan, Qing-Qing Du, Jing Qian, Dong-Yu Wan, Sheng-Mei Wu
In the paper, a green and efficient biosynthetical technique was reported for preparing cadmium sulfide (CdS) quantum dots, in which Escherichia coli (E. coli) was chosen as a biomatrix. Fluorescence emission spectra and fluorescent microscopic photographs revealed that as-produced CdS quantum dots had an optimum fluorescence emission peak located at 470nm and emitted a blue-green fluorescence under ultraviolet excitation. After extracted from bacterial cells and located the nanocrystals' foci in vivo, the CdS quantum dots showed a uniform size distribution by transmission electron microscope...
January 2017: Enzyme and Microbial Technology
J Ribamar Costa, Daniel Chamié, Alexandre A C Abizaid, Expedito Ribeiro, George C Meireles, Maurício Prudente, Carlos A Campos, Juliana P Castro, Ricardo Costa, Pedro A Lemos
We sought to compare, by means of IVUS and OCT imaging, the performance of a novel sirolimus-eluting drug-eluting stent (DES) with biodegradable polymer (Inspiron™) to the Biomatrix™ DES. From the DESTINY trial, a total of 70 randomized patients (2:1) were enrolled in the IVUS substudy (Inspiron™, n = 46; Biomatrix™: n = 20) while 25 patients were evaluated with OCT (Inspiron™, n = 19; Biomatrix™: n = 06) at 9-month follow-up. The main endpoints were % of neointimal tissue obstruction (IVUS) and neointimal stut coverage (OCT) at 9 months...
October 6, 2016: International Journal of Cardiovascular Imaging
Yan-Fei Wang, Huo-Xi Jin, Yang-Guang Wang, Li-Ye Yang, Xiao-Kun OuYang, Wei-Jian Wu
A new method for the isolation and enrichment of ofloxacin enantiomers from fish samples was developed using magnetic molecularly imprinted polymers (MMIPs). These polymers can be easily collected and rapidly separated using an external magnetic field, and also exhibit a high specific recognition for ofloxacin enantiomers. The preparation of amino-functionalized MMIPs was carried out via suspension polymerization and a ring-opening reaction using rac-ofloxacin as a template, ethylenediamine as an active group, glycidyl methacrylate and methyl methacrylate as functional monomers, divinylbenzene as a cross-linker, and Fe₃O₄ nanoparticles as magnetic cores...
July 14, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Kishore Kumar Kadimpati
Polyvinyl alcohol-sodium alginate (PVA-SA) matrix was fabricated and red algae Jania rubens was embedded for removal of lead from aqueous solutions. The Pb(II) uptake rate was rapid primarily at 1 h and equilibrium was achieved within 2 h. The optimum pH was 5, the data were well fitted by Langmuir and Freundlich models, and RL values are in the range of 0.1-0.38. The sorption capacity (qe) of PVA-calcium alginate (CA)-J. rubens matrix increased from 10.77 to 37.195 mg g(-1) with increasing Pb(II) concentration from 24...
February 2017: International Journal of Phytoremediation
Jaryl Ng, Nicolas Foin, Hui Ying Ang, Jiang Ming Fam, Sayan Sen, Sukhjinder Nijjer, Ricardo Petraco, Carlo Di Mario, Justin Davies, Philip Wong
BACKGROUND: Previously, we examined the difference in stent designs across different sizes for six widely used Drug Eluting Stents (DESs). Although stent post-dilatation to larger diameter is commonly done, typically in the setting of long tapering segment or left-main PCI, there is an increasing recognition that information with regard to the different stent model designs has a critical impact on overexpansion results. This study aims to provide an update on stent model designs for contemporary DES platforms as well as test overexpansion results under with oversized post-dilatation...
October 15, 2016: International Journal of Cardiology
Vivek Verma, Young Kim, Min-Cheol Lee, Jae-Tae Lee, Sunghoon Cho, In-Kyu Park, Jung Joon Min, Je Jung Lee, Shee Eun Lee, Joon Haeng Rhee
Dendritic cell (DC) based anti-cancer immunotherapy is well tolerated in patients with advanced cancers. However, the clinical responses seen after adoptive DC therapy have been suboptimal. Several factors including scarce DC numbers in tumors and immunosuppressive tumor microenvironments contribute to the inefficacy of DCs as cellular vaccines. Hence DC based vaccines can benefit from novel methods of cell delivery that would prevent the direct exposure of immune cells to suppressive tumor microenvironments...
June 28, 2016: Oncotarget
Wenbo Zhang, Yanhong Huo, Xinling Wang, Yingmin Jia, Li Su, Caixia Wang, Ying Li, Yonghong Yang, Yuanyuan Liu
The differentiation rate of adipose-derived mesenchymal stem cells (Ad-MSCs) into endothelial cells is always lower under normal condition, which limits further clinical application of Ad-MSCs for angiogenesis regenerative medicine and needs to be enhanced. In the present study, the tissue-specific-derived decellularized ovine arteries matrix (DCS) was used as scaffold to investigate the pro-endothelial differentiation ability of decellularized ovine arteries matrix as well as the underlying mechanisms. The prepared decellularized ovine arteries matrix by the combination of enzymatic and chemical decellularization approaches preserved macroscopic 3D architecture, native composition and ultrastructure of natural ovine arteries...
November 2016: Heart and Vessels
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Brett Cowan
The hemodynamic influence of vessel shape such as bifurcation angle is not fully understood with clinical and quantitative observations being equivocal. The aim of this study is to use computational modeling to study the hemodynamic effect of shape characteristics, in particular bifurcation angle (BA), for non-stented and stented coronary arteries. Nine bifurcations with angles of 40°, 60° and 80°, representative of ±1 SD of 101 asymptomatic computed tomography angiogram cases (average age 54±8 years; 57 females), were generated for (1) a non-stented idealized, (2) stented idealized, and (3) non-stented patient-specific geometry...
June 14, 2016: Journal of Biomechanics
Abbasali Rafighdust, Ali Eshraghi
The invention of the drug-eluting stent (DES) has brought about revolutionary changes in the field of interventional cardiology. In the DES era, in-stent restenosis has declined but new issues such as stent thrombosis have emerged. One of the emerging paradigms in the DES era is stent fracture. There are reports about stent fracture leading to in-stent restenosis or stent thrombosis. Most of these reports concern the Sirolimus-eluting stent. The present case is a representation of a Biolimus-eluting stent fracture...
October 27, 2015: Journal of Tehran Heart Center
Xiaolong Yang, Yanan Tang, Sean D Mason, Junbo Chen, Feng Li
Herein, we report a DNA nanomachine, built from a DNA-functionalized gold nanoparticle (DNA-AuNP), which moves a DNA walker along a three-dimensional (3-D) DNA-AuNP track and executes the task of releasing payloads. The movement of the DNA walker is powered by a nicking endonuclease that cleaves specific DNA substrates on the track. During the movement, each DNA walker cleaves multiple substrates, resulting in the rapid release of payloads (predesigned DNA sequences and their conjugates). The 3-D DNA nanomachine is highly efficient due to the high local effective concentrations of all DNA components that have been co-conjugated on the same AuNP...
February 23, 2016: ACS Nano
Martina Moritz, Sabine Pfeifer, Elizabeth R Balmayor, Rainer Mittermayr, Susanne Wolbank, Heinz Redl, Martijn van Griensven
Skeletal ischaemia-reperfusion (I-R) injury may influence patient outcome after severe vascular trauma or clamping of major vessels. The aim of this study was to observe whether locally applied vascular endothelial growth factor (VEGF) in fibrin could induce the expression of VEGF-receptor-2 (VEGFR-2) and improve the outcome after I-R injury. Transgenic mice expressing VEGFR-2 promoter-controlled luciferase were used for the assessment of VEGFR-2 expression. Ischaemia was induced for 2 h by a tension-controlled tourniquet to the hind limb, followed by 24 h of reperfusion...
January 17, 2016: Journal of Tissue Engineering and Regenerative Medicine
Xiao Luo, Katherine M Kulig, Eric B Finkelstein, Margaret F Nicholson, Xiang-Hong Liu, Scott M Goldman, Joseph P Vacanti, Brian E Grottkau, Irina Pomerantseva, Cathryn A Sundback, Craig M Neville
Decellularized extracellular matrix (ECM) biomaterials are increasingly used in regenerative medicine for abdominal tissue repair. Emerging ECM biomaterials with greater compliance target surgical procedures like breast and craniofacial reconstruction to enhance aesthetic outcome. Clinical studies report improved outcomes with newly designed ECM scaffolds, but their comparative biological characteristics have received less attention. In this study, we investigated scaffolds derived from dermis (AlloDerm Regenerative Tissue Matrix), small intestinal submucosa (Surgisis 4-layer Tissue Graft and OASIS Wound Matrix), and mesothelium (Meso BioMatrix Surgical Mesh and Veritas Collagen Matrix) and evaluated biological properties that modulate cellular responses and recruitment...
April 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Fumiyuki Otsuka, Qi Cheng, Kazuyuki Yahagi, Eduardo Acampado, Alexander Sheehy, Saami K Yazdani, Kenichi Sakakura, Kristina Euller, Laura E L Perkins, Frank D Kolodgie, Renu Virmani, Michael Joner
OBJECTIVES: This study sought to evaluate whether the permanent fluoropolymer-coated Xience Xpedition everolimus-eluting stent (Xience-EES) exhibits lower acute thrombogenicity compared with contemporary drug-eluting stents (DES) with biodegradable polymer coatings in an acute swine shunt model. BACKGROUND: Previous pre-clinical and clinical experience suggests that several factors may influence the predisposition for acute thrombus formation of polymer-coated DES, including stent design and the polymer coating technology...
August 17, 2015: JACC. Cardiovascular Interventions
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