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J Ribamar Costa, Daniel Chamié, Alexandre A C Abizaid, Expedito Ribeiro, George C Meireles, Maurício Prudente, Carlos A Campos, Juliana P Castro, Ricardo Costa, Pedro A Lemos
We sought to compare, by means of IVUS and OCT imaging, the performance of a novel sirolimus-eluting drug-eluting stent (DES) with biodegradable polymer (Inspiron™) to the Biomatrix™ DES. From the DESTINY trial, a total of 70 randomized patients (2:1) were enrolled in the IVUS substudy (Inspiron™, n = 46; Biomatrix™: n = 20) while 25 patients were evaluated with OCT (Inspiron™, n = 19; Biomatrix™: n = 06) at 9-month follow-up. The main endpoints were % of neointimal tissue obstruction (IVUS) and neointimal stut coverage (OCT) at 9 months...
October 6, 2016: International Journal of Cardiovascular Imaging
Yan-Fei Wang, Huo-Xi Jin, Yang-Guang Wang, Li-Ye Yang, Xiao-Kun OuYang, Wei-Jian Wu
A new method for the isolation and enrichment of ofloxacin enantiomers from fish samples was developed using magnetic molecularly imprinted polymers (MMIPs). These polymers can be easily collected and rapidly separated using an external magnetic field, and also exhibit a high specific recognition for ofloxacin enantiomers. The preparation of amino-functionalized MMIPs was carried out via suspension polymerization and a ring-opening reaction using rac-ofloxacin as a template, ethylenediamine as an active group, glycidyl methacrylate and methyl methacrylate as functional monomers, divinylbenzene as a cross-linker, and Fe₃O₄ nanoparticles as magnetic cores...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Kishore Kumar Kadimpati
Polyvinyl alcohol-Sodium alginate (PVA-SA) matrix was fabricated and red algae Jania rubens was embedded for removal of lead from aqueous solutions. The Pb (II) uptake rate was rapid primarily at 1 h and equilibrium was achieved within 2 h. The optimum pH was 5, the data was well fitted by langmuir and freundlich models and RL values are in range of 0.1-0.38. The sorption capacity (qe) of PVA-CA-J. rubens matrix increased from 10.77 to 37.195 mg g(-1) with increasing Pb (II) concentration from 24.86 to 98...
July 14, 2016: International Journal of Phytoremediation
Jaryl Ng, Nicolas Foin, Hui Ying Ang, Jiang Ming Fam, Sayan Sen, Sukhjinder Nijjer, Ricardo Petraco, Carlo Di Mario, Justin Davies, Philip Wong
BACKGROUND: Previously, we examined the difference in stent designs across different sizes for six widely used Drug Eluting Stents (DESs). Although stent post-dilatation to larger diameter is commonly done, typically in the setting of long tapering segment or left-main PCI, there is an increasing recognition that information with regard to the different stent model designs has a critical impact on overexpansion results. This study aims to provide an update on stent model designs for contemporary DES platforms as well as test overexpansion results under with oversized post-dilatation...
October 15, 2016: International Journal of Cardiology
Vivek Verma, Young Kim, Min-Cheol Lee, Jae-Tae Lee, Sunghoon Cho, In-Kyu Park, Jung Joon Min, Je Jung Lee, Shee Eun Lee, Joon Haeng Rhee
Dendritic cell (DC) based anti-cancer immunotherapy is well tolerated in patients with advanced cancers. However, the clinical responses seen after adoptive DC therapy have been suboptimal. Several factors including scarce DC numbers in tumors and immunosuppressive tumor microenvironments contribute to the inefficacy of DCs as cellular vaccines. Hence DC based vaccines can benefit from novel methods of cell delivery that would prevent the direct exposure of immune cells to suppressive tumor microenvironments...
May 21, 2016: Oncotarget
Wenbo Zhang, Yanhong Huo, Xinling Wang, Yingmin Jia, Li Su, Caixia Wang, Ying Li, Yonghong Yang, Yuanyuan Liu
The differentiation rate of adipose-derived mesenchymal stem cells (Ad-MSCs) into endothelial cells is always lower under normal condition, which limits further clinical application of Ad-MSCs for angiogenesis regenerative medicine and needs to be enhanced. In the present study, the tissue-specific-derived decellularized ovine arteries matrix (DCS) was used as scaffold to investigate the pro-endothelial differentiation ability of decellularized ovine arteries matrix as well as the underlying mechanisms. The prepared decellularized ovine arteries matrix by the combination of enzymatic and chemical decellularization approaches preserved macroscopic 3D architecture, native composition and ultrastructure of natural ovine arteries...
April 29, 2016: Heart and Vessels
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Brett Cowan
The hemodynamic influence of vessel shape such as bifurcation angle is not fully understood with clinical and quantitative observations being equivocal. The aim of this study is to use computational modeling to study the hemodynamic effect of shape characteristics, in particular bifurcation angle (BA), for non-stented and stented coronary arteries. Nine bifurcations with angles of 40°, 60° and 80°, representative of ±1 SD of 101 asymptomatic computed tomography angiogram cases (average age 54±8 years; 57 females), were generated for (1) a non-stented idealized, (2) stented idealized, and (3) non-stented patient-specific geometry...
June 14, 2016: Journal of Biomechanics
Abbasali Rafighdust, Ali Eshraghi
The invention of the drug-eluting stent (DES) has brought about revolutionary changes in the field of interventional cardiology. In the DES era, in-stent restenosis has declined but new issues such as stent thrombosis have emerged. One of the emerging paradigms in the DES era is stent fracture. There are reports about stent fracture leading to in-stent restenosis or stent thrombosis. Most of these reports concern the Sirolimus-eluting stent. The present case is a representation of a Biolimus-eluting stent fracture...
October 27, 2015: Journal of Tehran Heart Center
Xiaolong Yang, Yanan Tang, Sean D Mason, Junbo Chen, Feng Li
Herein, we report a DNA nanomachine, built from a DNA-functionalized gold nanoparticle (DNA-AuNP), which moves a DNA walker along a three-dimensional (3-D) DNA-AuNP track and executes the task of releasing payloads. The movement of the DNA walker is powered by a nicking endonuclease that cleaves specific DNA substrates on the track. During the movement, each DNA walker cleaves multiple substrates, resulting in the rapid release of payloads (predesigned DNA sequences and their conjugates). The 3-D DNA nanomachine is highly efficient due to the high local effective concentrations of all DNA components that have been co-conjugated on the same AuNP...
February 23, 2016: ACS Nano
Martina Moritz, Sabine Pfeifer, Elizabeth R Balmayor, Rainer Mittermayr, Susanne Wolbank, Heinz Redl, Martijn van Griensven
Skeletal ischaemia-reperfusion (I-R) injury may influence patient outcome after severe vascular trauma or clamping of major vessels. The aim of this study was to observe whether locally applied vascular endothelial growth factor (VEGF) in fibrin could induce the expression of VEGF-receptor-2 (VEGFR-2) and improve the outcome after I-R injury. Transgenic mice expressing VEGFR-2 promoter-controlled luciferase were used for the assessment of VEGFR-2 expression. Ischaemia was induced for 2 h by a tension-controlled tourniquet to the hind limb, followed by 24 h of reperfusion...
January 17, 2016: Journal of Tissue Engineering and Regenerative Medicine
Xiao Luo, Katherine M Kulig, Eric B Finkelstein, Margaret F Nicholson, Xiang-Hong Liu, Scott M Goldman, Joseph P Vacanti, Brian E Grottkau, Irina Pomerantseva, Cathryn A Sundback, Craig M Neville
Decellularized extracellular matrix (ECM) biomaterials are increasingly used in regenerative medicine for abdominal tissue repair. Emerging ECM biomaterials with greater compliance target surgical procedures like breast and craniofacial reconstruction to enhance aesthetic outcome. Clinical studies report improved outcomes with newly designed ECM scaffolds, but their comparative biological characteristics have received less attention. In this study, we investigated scaffolds derived from dermis (AlloDerm Regenerative Tissue Matrix), small intestinal submucosa (Surgisis 4-layer Tissue Graft and OASIS Wound Matrix), and mesothelium (Meso BioMatrix Surgical Mesh and Veritas Collagen Matrix) and evaluated biological properties that modulate cellular responses and recruitment...
December 10, 2015: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Fumiyuki Otsuka, Qi Cheng, Kazuyuki Yahagi, Eduardo Acampado, Alexander Sheehy, Saami K Yazdani, Kenichi Sakakura, Kristina Euller, Laura E L Perkins, Frank D Kolodgie, Renu Virmani, Michael Joner
OBJECTIVES: This study sought to evaluate whether the permanent fluoropolymer-coated Xience Xpedition everolimus-eluting stent (Xience-EES) exhibits lower acute thrombogenicity compared with contemporary drug-eluting stents (DES) with biodegradable polymer coatings in an acute swine shunt model. BACKGROUND: Previous pre-clinical and clinical experience suggests that several factors may influence the predisposition for acute thrombus formation of polymer-coated DES, including stent design and the polymer coating technology...
August 17, 2015: JACC. Cardiovascular Interventions
A A Kamalovl, V I Kirpatovckij, D A Ohobotov, D M Kamalov, V K Karpovl
The paper presents leading problems faced by surgeons performing reconstructive plastic replacement of the bladder, types of biomatrix used in urology, their application and the perspectives for their further use.
March 2015: Urologii︠a︡
Yu Ling Huang, Chih-Kuan Tung, Anqi Zheng, Beum Jun Kim, Mingming Wu
Malignant tumors are often associated with an elevated fluid pressure due to the abnormal growth of vascular vessels, and thus an increased interstitial flow out of the tumors. Recent in vitro works revealed that interstitial flows critically regulated tumor cell migration within a three dimensional biomatrix, and breast cancer cell migration behavior depended sensitively on the cell seeding density, chemokine availability and flow rates. In this paper, we focus on the role of interstitial flows in modulating the heterogeneity of cancer cell motility phenotype within a three dimensional biomatrix...
November 2015: Integrative Biology: Quantitative Biosciences From Nano to Macro
Kannan Badri Narayanan, Hyun Ho Park, Sung Soo Han
Sustainable and greener synthesis of intracellular gold nanoparticles using mushroom Flammulina velutipes is reported. Incubation of a mushroom in chloroaurate solution resulted in the synthesis and immobilization of stable gold nanoparticles inside the mushroom mycelia. Transmission electron microscopic (TEM) analysis revealed the presence of gold nanoparticles (⩽20nm) inside the mycelia, primarily on the inner surface of the cell membrane. Inductively coupled plasma-optical emission spectrometry (ICP-OES) revealed that the accumulated gold concentration ranged from 64...
December 2015: Chemosphere
Lorenz Räber, Roland Klingenberg, Dik Heg, Henning Kelbæk, Marco Roffi, David Tüller, Andreas Baumbach, Thomas Zanchin, David Carballo, Miodrag Ostojic, Giulio G Stefanini, Nicolas Rodondi, Clemens von Birgelen, Aris Moschovitis, Thomas Engstrøm, Baris Gencer, Reto Auer, Bernhard Meier, Francois Mach, Thomas F Lüscher, Peter Jüni, Christian M Matter, Stephan Windecker
OBJECTIVES: The aim of this study was to assess the safety of the concurrent administration of a clopidogrel and prasugrel loading dose in patients undergoing primary percutaneous coronary intervention. BACKGROUND: Prasugrel is one of the preferred P2Y12 platelet receptor antagonists for ST-segment elevation myocardial infarction patients. The use of prasugrel was evaluated clinically in clopidogrel-naive patients. METHODS: Between September 2009 and October 2012, a total of 2,023 STEMI patients were enrolled in the COMFORTABLE (Comparison of Biomatrix Versus Gazelle in ST-Elevation Myocardial Infarction [STEMI]) and the SPUM-ACS (Inflammation and Acute Coronary Syndromes) studies...
July 2015: JACC. Cardiovascular Interventions
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Brett Cowan
Stent induced hemodynamic changes in the coronary arteries are associated with higher risk of adverse clinical outcome. The purpose of this study was to evaluate the impact of stent design on wall shear stress (WSS), time average WSS, and WSS gradient (WSSG), in idealized stent geometries using computational fluid dynamics. Strut spacing, thickness, luminal protrusion, and malapposition were systematically investigated and a comparison made between two commercially available stents (Omega and Biomatrix). Narrower strut spacing led to larger areas of adverse low WSS and high WSSG but these effects were mitigated when strut size was reduced, particularly for WSSG...
February 2016: Annals of Biomedical Engineering
Barry O'Brien, Haroon Zafar, Ahmad Ibrahim, Junaid Zafar, Faisal Sharif
This paper reviews the current state of the art for coronary stent materials and surface coatings, with an emphasis on new technologies that followed on from first-generation bare metal and drug-eluting stents. These developments have been driven mainly by the need to improve long term outcomes, including late stent thrombosis. Biodegradable drug-eluting coatings aim to address the long term effects of residual durable polymer after drug elution; the SYNERGY, BioMatrix, and Nobori stents are all promising devices in this category, with minimal polymer through the use of abluminal coatings...
February 2016: Annals of Biomedical Engineering
Sorina Dinescu, Bianca Galateanu, Eugen Radu, Anca Hermenean, Adriana Lungu, Izabela Cristina Stancu, Dana Jianu, Tudorita Tumbar, Marieta Costache
Cartilage has limited regeneration potential. Thus, there is an imperative need to develop new strategies for cartilage tissue engineering (CTE) amenable for clinical use. Recent CTE approaches rely on optimal cell-scaffold interactions, which require a great deal of optimization. In this study we attempt to build a novel gelatin- (G-) alginate- (A-) polyacrylamide (PAA) 3D interpenetrating network (IPN) with superior performance in promoting chondrogenesis from human adipose-derived stem cells (hADSCs). We show that our G-A-PAA scaffold is capable of supporting hADSCs proliferation and survival, with no apparent cytotoxic effect...
2015: Stem Cells International
Celso K Takimura, Micheli Z Galon, Paulo S Gutierrez, Prakash Sojitra, Ashwin Vyas, Manish Doshi, Pedro A Lemos
BACKGROUND: Permanent polymers in first generation drug-eluting stent (DES) have been imputed to be a possible cause of persistent inflammation, remodeling, malapposition and late stent thrombosis. We aim to describe the in vivo experimental result of a new polymer-free DES eluting sirolimus from stent-plus-balloon (Focus np stent, Envision Scientific) compared with a bare-metal stent (BMS) (Amazonia CroCo, Minvasys) and with a biolimus A9 eluting stent (Biomatrix, Biosensors). METHODS: In 10 juvenile pigs, 23 coronary stents were implanted in the coronary arteries (8 Amazonia CroCo, 8 Focus np, and 7 Biomatrix)...
April 2015: Cardiovascular Diagnosis and Therapy
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