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https://www.readbyqxmd.com/read/28328352/identification-isolation-and-phylogenetic-analysis-of-clostridium-perfringens-type-a-and-type-c-from-wild-boar-sus-scrofa-in-the-people-s-republic-of-china
#1
Meng Li, Xu Zhang, Lingwei Zhu, Haifeng Wang, Na Zhao, Jing Luo, Chengmin Wang, Yutian Wang, Yanhua Liu, Wei Zhou, Bikai Zhang, Huancheng Guo, Hongxuan He
Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that can induces gas gangrene or enteritis in poultry and humans and many other mammalian species. Here, we report an outbreak of C. perfringens type A and type C coinfection in wild boars ( Sus scrofa ). In February 2016, 10 dead wild boars, including two fresh carcasses, were found in Zhaosu County, Xinjiang Province, People's Republic of China. The two fresh carcasses were included in this study. Two strains of C. perfringens were isolated, identified, genotyped, and phylogenetically analyzed...
March 22, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28328183/seroprevalence-of-bartonella-species-coxiella-burnetii-and-toxoplasma-gondii-among-patients-with-hematological-malignancies-a-pilot-study-in-romania
#2
C J Messinger, E S Gurzau, E B Breitschwerdt, C I Tomuleasa, S J Trufan, M M Flonta, R G Maggi, I B Neagoe, P M Rabinowitz
Patients receiving immunosuppressive cancer treatments in settings where there is a high degree of human-animal interaction may be at increased risk for opportunistic zoonotic infections or reactivation of latent infections. We sought to determine the seroprevalence of selected zoonotic pathogens among patients diagnosed with haematologic malignancies and undergoing chemotherapeutic treatments in Romania, where much of the general population lives and/or works in contact with livestock. A convenience sample of 51 patients with haematologic cancer undergoing chemotherapy at a referral clinic in Cluj-Napoca, Romania, was surveyed regarding animal exposures...
March 22, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28327690/kyasanur-forest-disease-kfd-rare-disease-of-zoonotic-origin
#3
M Muraleedharan
Kyasanur forest disease (KFD) is a rare tick borne zoonotic disease that causes acute febrile hemorrhagic illness in humans and monkeys especially in southern part of India. The disease is caused by highly pathogenic KFD virus (KFDV) which belongs to member of the genus Flavivirus and family Flaviviridae. The disease is transmitted to monkeys and humans by infective tick Haemaphysalisspinigera. Seasonal outbreaks are expected to occur during the months of January to June. The aim of this paper is to briefly summarize the epidemiology, mode of transmission of KFD virus, clinical findings, diagnosis, treatment, control and prevention of the disease...
September 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28326655/systemic-insecticides-used-in-dogs-potential-candidates-for-phlebotomine-vector-control
#4
Sonia Ares Gomez, Albert Picado
Zoonotic Visceral Leishmaniasis (ZVL) is a public health problem endemic in some countries. Current control measures, in particular culling infected dogs, have not reduced ZVL incidence in humans. We evaluated the use of five systemic insecticides (spinosad, fluralaner, afoxolaner, sarolaner and moxidectin) currently used in dogs for other purposes (e.g. tick, flea control) in controlling ZVL transmission. The anti-phlebotomine capacity of these compounds confirmed in experimental studies makes their use in ZVL control programs very promising...
March 22, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28326294/the-eukaryote-like-serine-threonine-kinase-stk-regulates-the-growth-and-metabolism-of-zoonotic-streptococcus-suis
#5
Chunyan Zhang, Wen Sun, Meifang Tan, Mengmeng Dong, Wanquan Liu, Ting Gao, Lu Li, Zhuofei Xu, Rui Zhou
Like eukaryotes, bacteria express one or more serine/threonine kinases (STKs) that initiate diverse signaling networks. The STK from Streptococcus suis is encoded by a single-copy stk gene, which is crucial in stress response and virulence. To further understand the regulatory mechanism of STK in S. suis, a stk deletion strain (Δstk) and its complementary strain (CΔstk) were constructed to systematically decode STK characteristics by applying whole transcriptome RNA sequencing (RNA-Seq) and phosphoproteomic analysis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28325922/variability-in-h9n2-haemagglutinin-receptor-binding-preference-and-the-ph-of-fusion
#6
Thomas P Peacock, Donald J Benton, Jean-Remy Sadeyen, Pengxiang Chang, Joshua E Sealy, Juliet E Bryant, Stephen R Martin, Holly Shelton, John W McCauley, Wendy S Barclay, Munir Iqbal
H9N2 avian influenza viruses are primarily a disease of poultry; however, they occasionally infect humans and are considered a potential pandemic threat. Little work has been performed to assess the intrinsic biochemical properties related to zoonotic potential of H9N2 viruses. The objective of this study, therefore, was to investigate H9N2 haemagglutinins (HAs) using two well-known correlates for human adaption: receptor-binding avidity and pH of fusion. Receptor binding was characterized using bio-layer interferometry to measure virus binding to human and avian-like receptor analogues and the pH of fusion was assayed by syncytium formation in virus-infected cells at different pHs...
March 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28325494/modelling-h5n1-in-bangladesh-across-spatial-scales-model-complexity-and-zoonotic-transmission-risk
#7
Edward M Hill, Thomas House, Madhur S Dhingra, Wantanee Kalpravidh, Subhash Morzaria, Muzaffar G Osmani, Mat Yamage, Xiangming Xiao, Marius Gilbert, Michael J Tildesley
Highly pathogenic avian influenza H5N1 remains a persistent public health threat, capable of causing infection in humans with a high mortality rate while simultaneously negatively impacting the livestock industry. A central question is to determine regions that are likely sources of newly emerging influenza strains with pandemic causing potential. A suitable candidate is Bangladesh, being one of the most densely populated countries in the world and having an intensifying farming system. It is therefore vital to establish the key factors, specific to Bangladesh, that enable both continued transmission within poultry and spillover across the human-animal interface...
February 21, 2017: Epidemics
https://www.readbyqxmd.com/read/28325159/-a-preschooler-with-a-skin-lesion-on-the-face
#8
C van der Bas-Wolvers, R W A Janssens, R S Rijlaarsdam
A 4-year-old girl presented to the paediatric department with a red squamous spot around her right eye. Based on the clinical presentation and anamnesis, we suspected a zoonotic dermatomycosis obtained via her guinea pigs. PCR of the skin flakes revealed dermatophytes.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28322708/detection-and-molecular-characterization-of-zoonotic-poxviruses-circulating-in-the-amazon-region-of-colombia-2014
#9
Jose A Usme-Ciro, Andrea Paredes, Diana M Walteros, Erica Natalia Tolosa-Pérez, Katherine Laiton-Donato, Maria Del Carmen Pinzón, Brett W Petersen, Nadia F Gallardo-Romero, Yu Li, Kimberly Wilkins, Whitni Davidson, Jinxin Gao, Nishi Patel, Yoshinori Nakazawa, Mary G Reynolds, P S Satheshkumar, Ginny L Emerson, Andrés Páez-Martínez
During 2014, cutaneous lesions were reported in dairy cattle and farmworkers in the Amazon Region of western Colombia. Samples from 6 patients were analyzed by serologic and PCR testing, and results demonstrated the presence of vaccinia virus and pseudocowpox virus. These findings highlight the need for increased poxvirus surveillance in Colombia.
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28322705/three-divergent-subpopulations-of-the-malaria-parasite-plasmodium-knowlesi
#10
Paul C S Divis, Lee C Lin, Jeffrine J Rovie-Ryan, Khamisah A Kadir, Fread Anderios, Shamilah Hisam, Reuben S K Sharma, Balbir Singh, David J Conway
Multilocus microsatellite genotyping of Plasmodium knowlesi isolates previously indicated 2 divergent parasite subpopulations in humans on the island of Borneo, each associated with a different macaque reservoir host species. Geographic divergence was also apparent, and independent sequence data have indicated particularly deep divergence between parasites from mainland Southeast Asia and Borneo. To resolve the overall population structure, multilocus microsatellite genotyping was conducted on a new sample of 182 P...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28320976/a-study-on-the-efficacy-of-the-recombinant-yersinia-adhesin-a-vaccine-against-yersiniosis-in-the-early-phase
#11
Kosuke Tsugo, Shin/Ichi Nakamura, Hiroko Yamanaka, Yumi Une
Yersinia pseudotuberculosis (Y. ptb) is a zoonotic pathogenic bacterial species of the family Enterobacteriaceae and causes yersiniosis, an acute intestinal infection in humans and animals. Y. ptb is often implicated in lethal epidemics in zoo animals and reductions in the breeding population, but a valid prevention method has not been established. Therefore, this study aimed to develop a vaccine for yersiniosis control. The immunogenicity of one of the adhesion factors involved in pathogenic mechanisms of Y...
March 20, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28319184/streptococcus-suis-sortase-a-is-ca2-independent-and-is-inhibited-by-acteoside-isoquercitrin-and-baicalin
#12
Fuguang Chen, Fang Xie, Baoling Yang, Chengcheng Wang, Siguo Liu, Yueling Zhang
Sortase A (SrtA) has long been recognized as an ideal drug target for therapeutic agents against Gram-positive pathogens. However, the SrtA of Streptococcus suis (Ss-SrtA), an important zoonotic agent, has not been studied. In this study, the enzymatic properties of Ss-SrtA were investigated, and inhibition of Ss-SrtA by natural products was evaluated. Ss-SrtA was expressed and purified. The purified recombinant Ss-SrtA had maximal activity at pH 6.0-7.5, 45°C, and showed a Km of 6.7 μM for the hydrolysis of substrate abz-LPATG-dnp...
2017: PloS One
https://www.readbyqxmd.com/read/28318383/detection-of-brucellosis-in-sika-deer-cervus-nippon-through-loop-mediated-isothermal-amplification-lamp
#13
Qianhong Liu, Jie Wei, Qingsong Sun, Ben Wang, Yuting Wang, Ying Hu, Wenrong Wu
Brucellosis (Brucella bovis) in sika deer ( Cervus nippon ) can cause enormous losses to stag breeding, especially in areas in which stag breeding has become an important industry. It also poses a threat to humans because it is a zoonotic disease. Use of the loop-mediated isothermal amplification (LAMP) assay has been poorly described in the diagnosis of brucellosis in deer. We developed a LAMP assay targeting the omp25 gene sequence to detect brucellosis (Brucella bovis) in sika deer. The reaction can be completed in 60 min at 63 C and, with a detection limit of 17 pg, it was more sensitive than conventional PCR, with its detection limit of 1...
March 20, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28318148/barriers-to-innovation-in-human-rabies-prophylaxis-and-treatment-a-causal-analysis-of-insights-from-key-opinion-leaders-and-literature
#14
L H M van de Burgwal, A M G Neevel, C A C M Pittens, A D M E Osterhaus, C E Rupprecht, E Claassen
Rabies is an essentially 100% fatal, zoonotic disease, caused by Lyssaviruses. Currently, the disease is vaccine-preventable with pre- and post-exposure prophylaxis (PrEP and PEP). Still, rabies virus is estimated to cause up to 60,000 human deaths annually, of which the vast majority occurs in rural Asia and Africa, due to the inaccessibility of prophylaxis and non-existence of treatment. Despite these unmet clinical needs, rabies control mainly focuses on the sylvatic reservoir and drug innovation receives relatively little attention compared to other neglected tropical diseases (NTDs)...
March 20, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28317494/pathogenic-potential-and-genotypic-diversity-of-campylobacter-jejuni-a-neglected-food-borne-pathogen-in-brazil
#15
Miliane Rodrigues Frazão, Marta Inês Cazentini Medeiros, Sheila da Silva Duque, Juliana Pfrimer Falcão
Purpose and methodology.Campylobacter jejuni is a major zoonotic pathogen that causes food-borne gastroenteritis worldwide. However, there are only a few studies available that have molecularly characterized C. jejuni strains isolated in Brazil. The aim of this study was to genotype 111 C. jejuni strains isolated from sick humans (43), monkey faeces (19), chicken faeces (14), chicken meat (33) and sewage (2) between 1996 and 2016 in Brazil using flaA-SVR (short variable region) sequencing and PFGE. Furthermore, the presence of 16 virulence genes was analysed by PCR...
March 20, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28316425/molecular-characterization-of-leishmania-parasites-isolated-from-sandflies-species-of-a-zoonotic-cutaneous-leishmaniasis-in-musiyan-south-west-iran
#16
Farzaneh Kavarizadeh, Shahram Khademvatan, Babak Vazirianzadeh, Mohammad Hossein Feizhaddad, Mehdi Zarean
Cutaneous leishmaniasis (CL) is vector borne parasitic disease, considered as public health problem especially in border of Iran and Iraq, Dehloran County (Musian district). The aim of this study was molecular identification of Leishmania parasites in sandfly as vectors of Leishmaniasis. Totally 280 female sandflies were trapped by sticky traps from 7 rural areas of Musiyan in September-November 2012. All sandflies were identified using morphological characters of the head and abdominal terminalia. DNA was extracted from female sandflies and Leishmania was identified using PCR and sequencing...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28315796/ultrasound-assisted-neuronavigation-guided-removal-of-a-live-worm-in-cerebral-sparganosis
#17
Sunday Nkwerem, Tetsuya Goto, Toshihiro Ogiwara, Yasunaga Yamamoto, Kazuhiro Hongo, Samuel Ohaegbulam
BACKGROUND: Cerebral sparganosis is a rare zoonotic infestation which often mimics glioma and metastatic tumors. CASE DESCRIPTION: A case of 71-year-old man who presented with disturbing dysarthria. Initial neuroimages were suggestive of glioma. The histology was, however, suggestive of inflammatory lesion. Follow-up neuroimages and serology were suggestive of sparganosis. He subsequently had craniotomy with ultrasound-guided aspiration of a live worm. Saline soaked surgicel was used to provide an acoustic window...
March 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28315671/spatial-distribution-of-soil-contaminated-with-toxoplasma-gondii-oocysts-in-relation-to-the-distribution-and-use-of-domestic-cat-defecation-sites-on-dairy-farms
#18
J A Simon, S Kurdzielewicz, E Jeanniot, E Dupuis, F Marnef, D Aubert, I Villena, M-L Poulle
Little information is available on the relationship between the spatial distribution of zoonotic parasites in soil and the pattern of hosts' faeces deposition at a local scale. In this study, the spatial distribution of soil contaminated by the parasite Toxoplasma gondii was investigated in relation to the distribution and use of the defecation sites of its definitive host, the domestic cat (Felis catus). The study was conducted on six dairy farms with a high number of cats (seven to 30 cats). During regular visits to the farms over a 10month period, the cat population and cat defecation sites (latrines and sites of scattered faeces) on each farm were systematically surveyed...
March 16, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28314902/potential-factors-enabling-human-body-colonization-by-animal-streptococcus-dysgalactiae-subsp-equisimilis-strains
#19
Marcin Ciszewski, Eligia M Szewczyk
Streptococcus dysgalactiae subsp. equisimilis (SDSE) is a pyogenic, Lancefield C or G streptococcal pathogen. Until recently, it has been considered as an exclusive animal pathogen. Nowadays, it is responsible for both animal infections in wild animals, pets, and livestock and human infections often clinically similar to the ones caused by group A streptococcus (Streptococcus pyogenes). The risk of zoonotic infection is the most significant in people having regular contact with animals, such as veterinarians, cattlemen, and farmers...
March 18, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28302884/zoonotic-diseases-sharing-insights-from-interdisciplinary-research
#20
Mary R Ryan, Sarah Cleaveland
Researchers and others involved with the Zoonoses and Emerging Livestock Systems (ZELS) initiative gathered in Tanzania earlier this year to discuss progress with projects being carried out as part of the five- year programme. Mary Ryan and Sarah Cleaveland report.
March 18, 2017: Veterinary Record
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