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Cardiac remolding

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https://www.readbyqxmd.com/read/27236666/mesenchymal-stem-cells-in-cardiology
#1
Ian A White, Cristina Sanina, Wayne Balkan, Joshua M Hare
Cardiovascular disease (CVD) accounts for more deaths globally than any other single disease. There are on average 1.5 million episodes of myocardial infarction (heart attack) each year in the United States alone with roughly one-third resulting in death. There is therefore a major need for developing new and effective strategies to promote cardiac repair. Intramyocardial transplantation of mesenchymal stem cells (MSCs) has emerged as a leading contender in the pursuit of clinical intervention and therapy. MSCs are potent mediators of cardiac repair and are therefore an attractive tool in the development of preclinical and clinical trials...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27210827/the-effects-of-different-angiotensin-ii-type-1-receptor-blockers-on-the-regulation-of-the-ace-angii-at1-and-ace2-ang-1-7-mas-axes-in-pressure-overload-induced-cardiac-remodeling-in-male-mice
#2
Xingxu Wang, Yong Ye, Hui Gong, Jian Wu, Jie Yuan, Shijun Wang, Peipei Yin, Zhiwen Ding, Le Kang, Qiu Jiang, Weijing Zhang, Yang Li, Junbo Ge, Yunzeng Zou
Angiotensin II (AngII) type 1 receptor blockers (ARBs) have been effectively used in hypertension and cardiac remodeling. However, the differences among them are still unclear. We designed this study to examine and compare the effects of several ARBs widely used in clinics, including Olmesartan, Candesartan, Telmisartan, Losartan, Valsartan and Irbesartan, on the ACE-AngII-AT1 axis and the ACE2-Ang(1-7)-Mas axis during the development of cardiac remodeling after pressure overload. Although all of the six ARBs, attenuated the development of cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC) for 2 or 4weeks in the wild-type mice evaluated by echocardiography and hemodynamic measurements, the degree of attenuation by Olmesartan, Candesartan and Losartan tended to be larger than that of the other three drugs tested...
August 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/25065860/coronary-vasospasm-during-ct-angiography
#3
Takehiro Nakahara, Takuji Toyama, Yoshito Tsushima, Masahiko Kurabayashi
A 71-year-old man, a heavy smoker, was admitted for evaluation of "chest oppression" after every dinner. Cardiac CT with a beta-blocker showed coronary stenosis in the left circumflex. Although adenosine triphosphate-stress perfusion single-photon emission CT revealed no ischemia, Holter electrocardiography belatedly indicated an ST elevation associated with his symptoms while smoking. He was diagnosed to have vasospastic angina. Cardiac CT without a beta-blocker showed thin diffuse plaque and negative remolding without any significant stenosis at the same site...
July 2014: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/24337854/left-ventricle-geometry-remolding-after-heart-transplantation-a-two-dimensional-ultrasound-study
#4
Xiao-juan Qin, He Li, Jun You, Qing Lv, Jing Zhang, Han-jing Gao, Ming-xing Xie
The function of the transplanted heart will be affected by acute allograft rejection, chronic rejection, high blood pressure and so on, which may induce the reconstruction of the left ventricle and the increase of left ventricular mass (LVM), and eventually lead to left ventricular hypertrophy that will significantly affect the prognosis of heart transplantation (HT). The purpose of this study was to dynamically monitor the changes of left ventricular geometric patterns after HT using two-dimensional echocardiography and to understand the remodeling process and its possible influencing factors...
December 2013: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/22443049/-effect-of-selenium-on-the-protection-of-myocardial-cells-from-injuries-induced-by-overloaded-reactive-oxygen-species-and-on-the-expression-of-actin-in-myocardial-cells
#5
Jing Tang, Wuhong Tan, Yanhe Zhu, Lixin Wang, Lianbang Zhai
OBJECTIVE: To investigate the effect of selenium on the protection of myocardial cells from injuries induced by H2O2 and on the expression of alpha-actin and beta-actin in myocardial cells. METHOD: Myocardial cells of suckling mice in the culture were divided into six groups: Controls group (without H2O2 or Se), H2O2 group, Se 0.05 micromol/ L group, Se 0.5 micromol/L group, Se 1.0 micromol/L group and Se 5.0 micromol/L group. The ultrastructure of myocardial cells was observed by transmission electron microscope (TEM), and the LDH and MDA contents in the culture media were determined by colorimetry...
January 2012: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/19471099/transcriptional-control-of-pacemaker-channel-genes-hcn2-and-hcn4-by-sp1-and-implications-in-re-expression-of-these-genes-in-hypertrophied-myocytes
#6
Huixian Lin, Jiening Xiao, Xiaobin Luo, Guorong Chen, Zhiguo Wang
Cardiac hypertrophy is characterized by electrical remolding with increased risk of arrhythmogenesis. Enhanced abnormal automaticity of ventricular cells may contribute to hypertrophic arrhythmias. The pacemaker current I(f), carried by the hyperpolarization-activated channels encoded mainly by the HCN2 and HCN4 genes in the heart, plays an important role in rhythmogenesis. Their expressions reportedly increase in hypertrophic and failing hearts, contributing to arrhythmogenesis under these conditions. However, how their expressions are controlled remained unclear...
2009: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/18544375/impact-of-left-atrial-volume-reduction-concomitant-with-atrial-fibrillation-surgery-on-left-atrial-geometry-and-mechanical-function
#7
COMPARATIVE STUDY
Akira Marui, Yoshiaki Saji, Takeshi Nishina, Eiji Tadamura, Shotaro Kanao, Takeshi Shimamoto, Nozomu Sasahashi, Tadashi Ikeda, Masashi Komeda
OBJECTIVE: Left atrial geometry and mechanical functions exert a profound effect on left ventricular filling and overall cardiovascular performance. We sought to investigate the perioperative factors that influence left atrial geometry and mechanical functions after the Maze procedure in patients with refractory atrial fibrillation and left atrial enlargement. METHODS: Seventy-four patients with atrial fibrillation and left atrial enlargement (diameter > or = 60 mm) underwent the Maze procedure in association with mitral valve surgery...
June 2008: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/18458081/down-regulation-of-mir-1-mir-133-contributes-to-re-expression-of-pacemaker-channel-genes-hcn2-and-hcn4-in-hypertrophic-heart
#8
Xiaobin Luo, Huixian Lin, Zhengwei Pan, Jiening Xiao, Yong Zhang, Yanjie Lu, Baofeng Yang, Zhiguo Wang
Cardiac hypertrophy is characterized by electrical remolding with increased risk of arrhythmogenesis. Enhanced abnormal automaticity of ventricular cells contributes critically to hypertrophic arrhythmias. The pacemaker current I(f), carried by the hyperpolarization-activated channels encoded mainly by the HCN2 and HCN4 genes in the heart, plays an important role in determining cardiac automaticity. Their expressions reportedly increase in hypertrophic and failing hearts, contributing to arrhythmogenesis under these conditions...
July 18, 2008: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/18364144/transplantation-of-magnetically-labeled-mesenchymal-stem-cells-improves-cardiac-function-in-a-swine-myocardial-infarction-model
#9
Chun-mei Qi, Gen-shan Ma, Nai-feng Liu, Cheng-xing Shen, Zhong Chen, Xiao-jun Liu, Yao-peng Hu, Xiao-li Zhang, Gao-jun Teng, Sheng-hong Ju, Ming Ma, Yao-liang Tang
BACKGROUND: Mesenchymal stem cells (MSCs) transplantation provides a new approach for myocardial repair. However, many important fundamental questions about MSCs transplantation remain unanswered. There is an urgent need to identify MSCs from the beating heart and analyze the efficacy of this new approach. This study aimed to localize the magnetically labeled MSCs (MR-MSCs) and monitor the restorative effects of MR-MSCs with magnetic resonance (MR) imaging. METHODS: Acute myocardial infarction (AMI) was created in swine by a balloon occlusion of the left anterior descending coronary artery...
March 20, 2008: Chinese Medical Journal
https://www.readbyqxmd.com/read/14607530/oxidative-damage-to-mitochondrial-dna-in-atrial-muscle-of-patients-with-atrial-fibrillation
#10
Po Han Lin, Shih Huang Lee, Chia Ping Su, Yau Huei Wei
Atrial fibrillation (AF) is the most common cause of arrhythmia and is an aging-related disease encountered in clinical practice. The electrophysiological remolding with Ca(2+) overloading and cellular structure changes were found in cardiomyocytes of AF patients. In previous studies, increased oxidative stress and oxidative damage was found in cardiomyocytes during the ischemia/reperfusion injury. Besides, mitochondrial DNA (mtDNA) deletion and mtDNA proliferation occur frequently in affected tissues of patients with certain degenerative diseases and during aging of the human...
November 15, 2003: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/12536639/-effects-of-lorsartan-fosinopril-on-myocardial-fibrosis-angiotensin-ii-and-cardiac-remolding-in-hypertensive-rats
#11
B X He, G L Yu, X Q Liang
OBJECTIVE: To investigate effects of lorsartan, fosinopril on myocardial fibrosis, angiotensin II and cardiac remolding in the spontaneously hypertensive rats (SHR). METHODS: 16-week-old SHRs were divided randomly into 3 groups: SHR-L (treated with lorsartan), SHR-F (treated with fosinopril) and SHR-C (untreated), each group consisting of 10 rats. After 8 weeks' and 16 weeks' therapeutic period, collagen volume fraction (CVF), perivascular circumferential area (PVCA), plasma and myocardium angiotensin II concentrations were examined by pathological examination with computed processing and radioimmunoassay respectively...
April 28, 2001: Hunan Yi Ke da Xue Xue Bao, Hunan Yike Daxue Xuebao, Bulletin of Hunan Medical University
https://www.readbyqxmd.com/read/12536482/-contrast-of-losartan-fosinopril-and-amlodipine-on-cardiomyocyte-apoptosis-and-left-ventricular-remolding-in-hypertensive-rats
#12
COMPARATIVE STUDY
G L Yu, X Q Liang, J Q Zheng
OBJECTIVE: To investigate effects of losartan, fosinopril and amlodipine on cardiomyocyte apoptosis, cardiac remolding in the spontaneously hypertensive rats (SHR). METHODS: SHRs were treated with lorsartan (SHR-L), fosinopril (SHR-F), amlodipine (SHR-A), and untreated (SHR-C) respectively for 8 and 16 weeks. Cardiomyocyte apoptotic index (APOI), left ventricular mass, left ventricular mass index (LVM, LVMI), and plasma and myocardium angiotensin II(PAng II, MAng II) concentrations were examined...
October 28, 2001: Hunan Yi Ke da Xue Xue Bao, Hunan Yike Daxue Xuebao, Bulletin of Hunan Medical University
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