Yanbing Li, Jie Zhou, Ou Zhang, Xuejiao Wu, Xiaonan Guan, Yajun Xue, Siyuan Li, Xianjing Zhuang, Boda Zhou, Guobin Miao, Lin Zhang
OBJECTIVE: Recently, the function of microRNAs (miRNAs) has been clarified in human diseases, we aimed to identify the role of miR-185 in myocardial infarction (MI). METHODS: Bone marrow mesenchymal stem cells (BMSCs) were cultured, from which the exosomes were extracted. MI mice models were established by coronary artery ligation and injected with transfected BMSCs. The echocardiographic and ventricle indicators, and hemodynamics of mice were measured. Moreover, the ultrastructure and apoptosis of cardiomyocytes were determined, and expression of miR-185, suppressor of cytokine signaling 2 (SOCS2), collagens, and apoptotic proteins in myocardial tissues were evaluated...
January 13, 2020: International Immunopharmacology