keyword
https://read.qxmd.com/read/37900003/defining-biventricular-abnormalities-by-cardiac-magnetic-resonance-in-pre-dialysis-patients-with-chronic-kidney-disease
#1
JOURNAL ARTICLE
Li Qi, Beibei Zhi, Jun Zhang, Lingyan Zhang, Song Luo, Longjiang Zhang
INTRODUCTION: The aim of the study was to investigate biventricular structural and functional abnormalities in pre-dialysis patients across stages of chronic kidney disease (CKD) by cardiac magnetic resonance (CMR). METHODS: Fifty-one CKD patients with CMR exams were retrospectively analyzed. Patients were divided into three groups according to estimated glomerular filtration rate (eGFR): CKD 1 group (patients with normal eGFR≥90 mL/min/1.73 m2 , n = 20), CKD 2-3 group (patients with eGFR< 90 to ≥30 mL/min/1...
August 2023: Kidney Diseases
https://read.qxmd.com/read/37852321/integrative-proteomic-analysis-reveals-the-cytoskeleton-regulation-and-mitophagy-difference-between-ischemic-cardiomyopathy-and-dilated-cardiomyopathy
#2
JOURNAL ARTICLE
Muyin Liu, Linhui Zhai, Zhaohua Yang, Su Li, Tianxian Liu, Ao Chen, Lulu Wang, Youran Li, Ruidong Li, Chenguang Li, Minjia Tan, Zhangwei Chen, Juying Qian
Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are the two primary etiologies of end-stage heart failure. However, there remains a dearth of comprehensive understanding the global perspective and the dynamics of the proteome and phosphoproteome in ICM and DCM, which hinders the profound comprehension of pivotal biological characteristics as well as differences in signal transduction activation mechanisms between these two major types of heart failure. We conducted high-throughput quantification proteomics and phosphoproteomics analysis of clinical heart tissues with ICM or DCM, which provided us the system-wide molecular insights into pathogenesis of clinical heart failure in both ICM and DCM...
October 16, 2023: Molecular & Cellular Proteomics: MCP
https://read.qxmd.com/read/37608837/elucidating-the-primary-mechanisms-of-high-intensity-interval-training-for-improved-cardiac-fitness-in-obesity
#3
REVIEW
Bing Bo, Aijing Guo, Severa Jafeth Kaila, Zhe Hao, Huiqing Zhang, Jianshe Wei, Yuan Yao
Obesity is a global and rising multifactorial pandemic associated with the emergence of several comorbidities that are risk factors for malignant cardiac remodeling and disease. High-intensity interval training (HIIT) has gained considerable attention due to its favorable outcomes of cardiometabolic health in individuals with overweight or obese. The primary aim of this review is to discuss the fundamental processes through which HIIT improves cardiac impairment in individuals with obesity to develop viable treatments for obesity management...
2023: Frontiers in Physiology
https://read.qxmd.com/read/36786193/dectin-1-acts-as-a-non-classical-receptor-of-ang-ii-to-induce-cardiac-remodeling
#4
JOURNAL ARTICLE
Shiju Ye, He Huang, Xue Han, Wu Luo, Lili Wu, Yang Ye, Yingchao Gong, Xia Zhao, Weijian Huang, Yi Wang, Xiaohong Long, Guosheng Fu, Guang Liang
BACKGROUND: Cardiac remodeling in heart failure involves macrophage-mediated immune responses. Recent studies have shown that a PRR (pattern recognition receptor) called dectin-1, expressed on macrophages, mediates proinflammatory responses. Whether dectin-1 plays a role in pathological cardiac remodeling is unknown. Here, we identified a potential role of dectin-1 in this disease. METHODS: To model aberrant cardiac remodeling, we utilized mouse models of chronic Ang II (angiotensin II) infusion...
March 17, 2023: Circulation Research
https://read.qxmd.com/read/36312292/hemodynamics-of-transcatheter-tricuspid-valve-replacement-with-lux-valve
#5
JOURNAL ARTICLE
Wang Wei, Li Ning, Ning Xiaoping, Xu Zhiyun, Li Bailing, Cai Chengliang, Yang Fan, Zhou Guangwei, Bai Yifan, Han Lin, Qiao Fan, Lu Fanglin
Objective: Transcatheter tricuspid valve intervention (TTVI) has emerged as an alternative treatment option for high-risk and inoperable patients with symptomatic tricuspid regurgitation (TR). However, scarce data in hemodynamic profiles were available on TTVI. In this paper, we attempt to report the hemodynamic profiles of LuX-Valve. Methods: 30 patients from July 2020 to July 2021 were enrolled in this study. The patient was diagnosed with severe symptomatic TR...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/35928895/association-of-metabolic-dysfunction-associated-fatty-liver-disease-with-left-ventricular-diastolic-function-and-cardiac-morphology
#6
JOURNAL ARTICLE
Dandan Peng, Zhenqiu Yu, Mingwei Wang, Junping Shi, Lei Sun, Yuanyuan Zhang, Wenbin Zhao, Chen Chen, Jiake Tang, Chunyi Wang, Jie Ni, Wen Wen, Jingjie Jiang
Background and Aim: Non-alcoholic fatty liver disease (NAFLD) is closely related to cardiovascular diseases (CVD). A newly proposed definition is metabolic dysfunction-associated fatty liver disease (MAFLD), which was changed from NAFLD. The clinical effect of this change on abnormalities of cardiac structure and function is yet unknown. We aimed to examine whether MAFLD is associated with left ventricular (LV) diastolic dysfunction (LVDD) and cardiac remolding and further identify the impact of different subgroups and severity of MAFLD...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/35770948/astragaloside-iv-attenuate-mi-induced-myocardial-fibrosis-and-cardiac-remodeling-by-inhibiting-ros-caspase-1-gsdmd-signaling-pathway
#7
JOURNAL ARTICLE
Xiaoqing Zhang, Huiyan Qu, Tao Yang, Qian Liu, Hua Zhou
Astragalus membranaceus is a traditional Chinese medicine and has been widely used in treating cardiovascular diseases (CVDs), such as asthma, edema, and chest tightness. Astragaloside IV (AS-IV), one of the major active components extracted from Astragalus membranaceus , has a series of pharmacological effects, including inhibiting inflammation, regulating energy metabolism, reducing oxidative stress and apoptosis. However, the effect of AS-IV on myocardial infarction (MI) and the underlying molecular mechanism remains unclear...
June 30, 2022: Cell Cycle
https://read.qxmd.com/read/34814233/exosomes-derived-from-mir-129-5p-modified-bone-marrow-mesenchymal-stem-cells-represses-ventricular-remolding-of-mice-with-myocardial-infarction
#8
JOURNAL ARTICLE
Shuo Wang, Jingjie Dong, Liu Li, Rubing Wu, Lei Xu, Yanchun Ren, Xitian Hu
BACKGROUND: Myocardial infraction (MI) is a severe disease with great mortality. Mesenchymal stem cells (MSCs)-derived exosomes display protection against MI. MicroRNA-129-5p was reported to exert anti-inflammation activity by targeting high mobility group box 1 (HMGB1). In the present study, the effects of MSCs-derived exosomes overexpressing miR-129-5p on MI were evaluated. METHODS: Bone marrow mesenchymal stem cells (BMSCs) were transfected with miR-129-5p for exosomes isolation...
November 23, 2021: Journal of Tissue Engineering and Regenerative Medicine
https://read.qxmd.com/read/33480219/muscone-alleviates-myocardial-ischemia-reperfusion-injury-via-inhibition-of-oxidative-stress-and-enhancement-of-sirt3
#9
JOURNAL ARTICLE
C J Wei, F Hua, Y H Chen, Z W Zhang, Z Y Shen
This study aimed at probing into the function of muscone in ameliorating myocardial ischemiareperfusion (I/R) injury and exploring the underlying mechanism. To analyze the function of muscone, H9c2 cardiomyocytes were treated with hypoxia/reoxygenation (H/R) and Sprague-Dawley (SD) rats were treated with left anterior descending (LAD) of the coronary artery ligation for 30 min and reperfusion for 2 h to induce myocardial I/R injury. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were used to detect the expression of SIRT3...
January 2021: Journal of Biological Regulators and Homeostatic Agents
https://read.qxmd.com/read/32451098/utility-of-cardiac-mri-in-atrial-fibrillation-management
#10
REVIEW
Mohammadali Habibi, Jonathan Chrispin, David D Spragg, Stefan L Zimmerman, Harikrishna Tandri, Saman Nazarian, Henry Halperin, Natalia Trayanova, Hugh Calkins
Advances in cardiac magnetic resonance (CMR) techniques and image acquisition have made it an excellent tool in the assessment of atrial myopathy. Remolding of the left atrium is the mainstay of atrial fibrillation (AF) development and its progression. CMR can detect phasic atrial volumes, atrial function, and atrial fibrosis using cine, and contrast-enhanced or non-contrast-enhanced images. These abilities make CMR a versatile and extraordinary tool in management of patients with AF including for risk stratification, ablation prognostication and planning, and assessment of stroke risk...
June 2020: Cardiac Electrophysiology Clinics
https://read.qxmd.com/read/31945609/bone-marrow-mesenchymal-stem-cells-derived-exosomal-microrna-185-represses-ventricular-remolding-of-mice-with-myocardial-infarction-by-inhibiting-socs2
#11
JOURNAL ARTICLE
Yanbing Li, Jie Zhou, Ou Zhang, Xuejiao Wu, Xiaonan Guan, Yajun Xue, Siyuan Li, Xianjing Zhuang, Boda Zhou, Guobin Miao, Lin Zhang
OBJECTIVE: Recently, the function of microRNAs (miRNAs) has been clarified in human diseases, we aimed to identify the role of miR-185 in myocardial infarction (MI). METHODS: Bone marrow mesenchymal stem cells (BMSCs) were cultured, from which the exosomes were extracted. MI mice models were established by coronary artery ligation and injected with transfected BMSCs. The echocardiographic and ventricle indicators, and hemodynamics of mice were measured. Moreover, the ultrastructure and apoptosis of cardiomyocytes were determined, and expression of miR-185, suppressor of cytokine signaling 2 (SOCS2), collagens, and apoptotic proteins in myocardial tissues were evaluated...
January 13, 2020: International Immunopharmacology
https://read.qxmd.com/read/31612078/mir-154-5p-functions-as-an-important-regulator-of-angiotensin-ii-mediated-heart-remodeling
#12
JOURNAL ARTICLE
Que Wang, Xiaoxue Yu, Lin Dou, Xiuqing Huang, Kaiyi Zhu, Jun Guo, Mingjing Yan, Siming Wang, Yong Man, Weiqing Tang, Tao Shen, Jian Li
Chronic hypertension, valvular heart disease, and heart infarction cause cardiac remodeling and potentially lead to a series of pathological and structural changes in the left ventricular myocardium and a progressive decrease in heart function. Angiotensin II (AngII) plays a key role in the onset and development of cardiac remodeling. Many microRNAs (miRNAs), including miR-154-5p, may be involved in the development of cardiac remolding, but the underlying molecular mechanisms remain unclear. We aimed to characterize the function of miR-154-5p and reveal its mechanisms in cardiac remodeling induced by AngII...
2019: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/31415848/tongsaimai-reverses-the-hypertension-and-left-ventricular-remolding-caused-by-abdominal-aortic-constriction-in-rats
#13
JOURNAL ARTICLE
Qinghai Meng, Yao Guo, Dini Zhang, Qichun Zhang, Yu Li, Huimin Bian
Treating ventricular remodeling continues to be a clinical challenge. Studies have shown that hypertension is one of the most common causes of ventricular remodeling, and is a major cause of cardiovascular risk in adults. Here, we report that Tongsaimai (TSM), a Chinese traditional medicine, could inhibit arterial pressure and left ventricular pressure to improve hemodynamic abnormalities in rats impaired by abdominal aortic constriction (AAC). Administration of TSM significantly reduced the heart mass index and the left ventricular mass index significantly in AAC rats...
January 10, 2020: Journal of Ethnopharmacology
https://read.qxmd.com/read/31264342/forkhead-box-o3-protects-the-heart-against-paraquat-induced-aging-associated-phenotypes-by-upregulating-the-expression-of-antioxidant-enzymes
#14
JOURNAL ARTICLE
Zao-Shang Chang, Jing-Bo Xia, Hai-Yan Wu, Wen-Tao Peng, Fu-Qing Jiang, Jing Li, Chi-Qian Liang, Hui Zhao, Kyu-Sang Park, Guo-Hua Song, Soo-Ki Kim, Ruijin Huang, Li Zheng, Dong-Qing Cai, Xu-Feng Qi
Paraquat (PQ) promotes cell senescence in brain tissue, which contributes to Parkinson's disease. Furthermore, PQ induces heart failure and oxidative damage, but it remains unknown whether and how PQ induces cardiac aging. Here, we demonstrate that PQ induces phenotypes associated with senescence of cardiomyocyte cell lines and results in cardiac aging-associated phenotypes including cardiac remodeling and dysfunction in vivo. Moreover, PQ inhibits the activation of Forkhead box O3 (FoxO3), an important longevity factor, both in vitro and in vivo...
July 1, 2019: Aging Cell
https://read.qxmd.com/read/30899391/phasic-change-and-apoptosis-regulation-of-jak2-stat3-pathway-in-a-type-2-diabetic-rat-model
#15
JOURNAL ARTICLE
Haiyang Gao, Dewei Wu, Erli Zhang, Tuo Liang, Xianmin Meng, Lanying Chen, Yongjian Wu
JAK2/STAT3 is a cardio-protective, pro-inflammation pathway, the function of which in cardiomyopathy caused by diabetic (DCM) is currently unknown. Here we explore the role of the JAK2/STAT3 pathway in DCM employing different time courses and a type 2 DM (T2DM) rat model. We examined the interactions of metformin and sitagliptin treatment with the JAK2/STAT3 pathway and cardiac remodeling. A T2DM rat model was induced by high fat diet/streptozotocin (HFD/STZ) and treated with metformin, sitagliptin (10 mg/d or 20 mg/d) or a placebo...
2019: American Journal of Translational Research
https://read.qxmd.com/read/30710682/exogenous-testosterone-alleviates-cardiac-fibrosis-and-apoptosis-via-gas6-axl-pathway-in-the-senescent-mice
#16
JOURNAL ARTICLE
Fang-Fang Chen, Fang-Qiang Song, Yan-Qing Chen, Zhi-Hao Wang, Yi-Hui Li, Ming-Hao Liu, Ya Li, Ming Song, Wei Zhang, Jing Zhao, Ming Zhong
BACKGROUND: Androgen has been implicated in aging-related cardiac remodeling, but its precise role in aging heart remains controversial. We aimed to investigate the role of testosterone in the development of aging-related cardiac remodeling and the mechanisms involved. METHODS: Wild type and Axl knockout mice (Axl-/- ) were randomized into three groups: the young group (n = 30, 3 months old), the aging group (n = 30, 18 months old), the testosterone undecanoate treatment group (TU, n = 30, 18 months old)...
May 2019: Experimental Gerontology
https://read.qxmd.com/read/30609312/cardiac-fibrotic-remodeling-on-a-chip-with-dynamic-mechanical-stimulation
#17
JOURNAL ARTICLE
Ming Kong, Junmin Lee, Iman K Yazdi, Amir K Miri, Yi-Dong Lin, Jungmok Seo, Yu Shrike Zhang, Ali Khademhosseini, Su Ryon Shin
Cardiac tissue is characterized by being dynamic and contractile, imparting the important role of biomechanical cues in the regulation of normal physiological activity or pathological remodeling. However, the dynamic mechanical tension ability also varies due to extracellular matrix remodeling in fibrosis, accompanied with the phenotypic transition from cardiac fibroblasts (CFs) to myofibroblasts. It is hypothesized that the dynamic mechanical tension ability regulates cardiac phenotypic transition within fibrosis in a strain-mediated manner...
February 2019: Advanced Healthcare Materials
https://read.qxmd.com/read/30478251/p27-protects-cardiomyocytes-from-sepsis-via-activation-of-autophagy-and-inhibition-of-apoptosis
#18
JOURNAL ARTICLE
Xianyuan Zhao, Hong Qi, Jiamin Zhou, Shuqi Xu, Yuan Gao
BACKGROUND It has been reported that p27Kip1 plays an important role not only in the inhibition of cyclin-dependent kinases but also in the regulation of autophagy under various metabolically related stress conditions, including glucose deprivation and endoplasmic reticulum stress. However, its effect on lipopolysaccharide (LPS)-induced cardiomyocyte stress in vitro remains unclear. Here, we measured the increased expression of LC3-II and visualized autophagosomes in vitro by immunofluorescent assays after treatment with a p27 fusion protein...
November 27, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30369154/-underlying-mechanism-and-preventive-measures-of-distal-stent-graft-induced-new-entry-after-thoracic-endovascular-aortic-repair-for-stanford-type-b-aortic-dissection
#19
JOURNAL ARTICLE
F Liu, Y Y Ge, W Guo
Distal stent graft-induced new entry (dSINE) is the complication with high incidence following thoracic endovascular aortic repair (TEVAR) for Stanford type B aortic dissection. This review the underlying mechanism and preventive measures regarding dSINE. General mechanism include: the fragile state of dissected aortic wall and intimal flap is pathophysiologic foundation of dSINE; the continued resistive force to the deformation of stent-graft is mechanical cause of intimal injury; the intimal flap movement within a cardiac cycle result in local damage accumulation in distal site of stent-graft...
October 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://read.qxmd.com/read/30291912/11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibitor-attenuates-high-fat-diet-induced-cardiomyopathy
#20
JOURNAL ARTICLE
Min Huang, Juan Liu, Yunlu Sheng, Yifan Lv, Jing Yu, Hanmei Qi, Wenjuan Di, Shan Lv, Suming Zhou, Guoxian Ding
BACKGROUND: High-fat diet (HFD) induces cardiac hypertrophy; however, the underlying cellular and molecular mechanisms are yet unclear. In the present study, we investigated the roles of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an amplifier of local glucocorticoid activity, in the pathogenesis of cardiac dysfunction. METHODS: Male Wistar rats were fed normal chow diet (NC) or HFD and examined the cardiac remolding and functional alteration by echocardiography and histology...
December 2018: Journal of Molecular and Cellular Cardiology
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