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https://www.readbyqxmd.com/read/29161695/a-randomized-controlled-trial-of-comparing-ultrasound-guided-transversus-abdominis-plane-block-with-local-anesthetic-infiltration-in-peritoneal-dialysis-catheter-implantation
#1
Qi Li, Xiaohong Tang, Tian Tao, Wenjuan Zhang, Wei Qin, Jie Zhang, Zi Li
BACKGROUND: The ultrasound-guided transversus abdominis plane (TAP) block has been demonstrated as a useful analgesia technique in lower-abdomen surgeries. We hypothesized that it could be the principal anesthesia technique for end-stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD) catheter (PDC) implantation using the open dissection method. METHODS: This was a single-center, prospective, randomized, and double-blinded study. All eligible patients were randomized into 2 groups: the TAP block group (n = 20) and the local anesthetic infiltration (LAI) group (n = 20)...
November 22, 2017: Blood Purification
https://www.readbyqxmd.com/read/29161665/switchable-electrochemiluminescence-aptasensor-coupled-with-resonance-energy-transfer-for-selective-attomolar-detection-of-hg-2-via-cdte-cds-dendrimer-probe-and-au-nanoparticle-quencher
#2
Bahareh Babamiri, Abdollah Salimi, Rahman Hallaj
In the present study, an ultrasensitive electrochemiluminescence (ECL) aptasensing assay for selective detection of Hg(2+) was designed. In this electrochemiluminescence resonance energy transfer (ECL-RET) approach, Fe3O4@SiO2/dendrimers/QDs exhibited amplified ECL emissions (switch "on" state) and with the hybridization between T-rich ssDNA(S1) immobilized on the Fe3O4@SiO2/dendrimers/QDs and AuNPs modified with complementary aptamer (AuNPs-S2), the ECL of QDs nanocomposites was efficiently quenched (switch "off" state)...
November 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29161256/hiv-pre-exposure-prophylaxis-and-early-antiretroviral-treatment-among-female-sex-workers-in-south-africa-results-from-a-prospective-observational-demonstration-project
#3
Robyn Eakle, Gabriela B Gomez, Niven Naicker, Rutendo Bothma, Judie Mbogua, Maria A Cabrera Escobar, Elaine Saayman, Michelle Moorhouse, W D Francois Venter, Helen Rees
BACKGROUND: Operational research is required to design delivery of pre-exposure prophylaxis (PrEP) and early antiretroviral treatment (ART). This paper presents the primary analysis of programmatic data, as well as demographic, behavioural, and clinical data, from the TAPS Demonstration Project, which offered both interventions to female sex workers (FSWs) at 2 urban clinic sites in South Africa. METHODS AND FINDINGS: The TAPS study was conducted between 30 March 2015 and 30 June 2017, with the enrolment period ending on 31 July 2016...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29161113/disseminability-of-computerized-cognitive-training-performance-across-coaches
#4
Ashley S Fournier-Goodnight, Jason M Ashford, Kellie N Clark, Karen Martin-Elbahesh, Kristina K Hardy, Thomas E Merchant, Sima Jeha, Robert J Ogg, Hui Zhang, Lei Wang, Heather M Conklin
Cogmed is a computerized cognitive intervention utilizing coaches who receive standardized instruction in analyzing training indices and tailoring feedback to remotely monitor participant's performance. The goal of this study was to examine adherence, satisfaction, and efficacy of Cogmed across coaches. Survivors of pediatric brain tumors and acute lymphoblastic leukemia (N = 68) were randomized to intervention (Cogmed) or waitlist control. The intervention group was matched with one of two coaches. Cognitive assessments were completed before and after intervention, and participants and caregivers in the intervention group completed satisfaction surveys...
November 21, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29160627/native-and-microwave-modified-terminalia-mantaly-gums-as-sustained-release-and-bioadhesive-excipients-in-naproxen-matrix-tablet-formulations
#5
Michael Ayodele Odeniyi, Babatunde Mukhtar Oyedokun, Oluyemisi Adebowale Bamiro
BACKGROUND: Hydrophilic polymers provide a means of sustaining drug delivery. Native gums may be limited in function, but modification may improve their activity. OBJECTIVES: The aim of the study was to evaluate native and modified forms of Terminalia mantaly gum for their sustained-release and bioadhesive properties. MATERIAL AND METHODS: The native gum (NTM) was modified by microwave irradiation for 20 seconds (MTM20) and 60 seconds (MTM60) and characterized using microscopy, Fourier transform infrared spectroscopy (FTIR) and packing properties...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29160394/effect-of-milk-renewal-on-cell-viability-in-vitro-at-different-time-frames
#6
Beatriz Dulcineia Mendes de Souza, Ana Maria Hecke Alves, Dayane Machado Ribeiro, Luciane Geanini Pena Dos Santos, Claudia Maria de Oliveira Simões, Wilson Tadeu Felippe, Mara Cristina Santos Felippe
The purpose of this study was to evaluate if the renewal of milk as a storage medium, every 12, 24 and 48 h, is able to increase its ability to maintain human periodontal ligament fibroblasts (PDLF) viability over time. PDLF were soaked in Minimum Essential Medium at 37 °C (MEM-37) (positive control), tap water (Water) (negative control) and in skimmed milk (44 wells) at 5 °C and 20 °C. The skimmed milk was renewed every 12 h (Milk-12), 24 h (Milk-24) and 48 h (Milk-48) in 11 wells of each plate, and the milk in the remaining 11 wells of each plate was maintained in situ (not renewed milk) (NRM)...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29159799/memory-for-retinotopic-locations-is-more-accurate-than-memory-for-spatiotopic-locations-even-for-visually-guided-reaching
#7
Anna Shafer-Skelton, Julie D Golomb
To interact successfully with objects, we must maintain stable representations of their locations in the world. However, their images on the retina may be displaced several times per second by large, rapid eye movements. A number of studies have demonstrated that visual processing is heavily influenced by gaze-centered (retinotopic) information, including a recent finding that memory for an object's location is more accurate and precise in gaze-centered (retinotopic) than world-centered (spatiotopic) coordinates (Golomb & Kanwisher, 2012b)...
November 20, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29157971/health-risk-assessment-of-haloacetonitriles-in-drinking-water-based-on-internal-dose
#8
Ying Zhang, Xuemei Han, Zhiguang Niu
To estimate the health risk of haloacetonitriles in different kinds of drinking water, the concentrations of haloacetonitriles in tap water, boiled water and direct drinking water were detected. The physiologically based pharmacokinetic (PBPK) model was used to calculate internal dose in the human body for haloacetonitriles through ingestion, and the probability distributions of the non-carcinogenic risk of haloacetonitriles for human via drinking water were assessed. This study found that the mean concentrations of dichloroacetonitrile (DCAN) in tap water, boiled water and direct drinking water were 0...
November 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29156561/adsorptive-stripping-voltammetric-determination-of-amaranth-and-tartrazine-in-drinks-and-gelatins-using-a-screen-printed-carbon-electrode
#9
Yeny Perdomo, Verónica Arancibia, Olimpo García-Beltrán, Edgar Nagles
A fast, sensitive, and selective method for the simultaneous determination of one pair of synthetic colorants commonly found mixed in food products, Amaranth (AM) and Tartrazine (TZ), based on their adsorption and oxidation on a screen-printed electrode (SPE) is presented. The variation of peak current with pH, supporting electrolyte, adsorption time, and adsorption potential were optimized using square wave adsorptive voltammetry. The optimal conditions were found to be: pH 3.2 (PBS), Eads 0.00 V, and tads 30 s...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29155844/hypoxia-and-hypoxia-inducible-factor-hif-downregulate-antigen-presenting-mhc-class-i-molecules-limiting-tumor-cell-recognition-by-t-cells
#10
Shalini Sethumadhavan, Murillo Silva, Phaethon Philbrook, Thao Nguyen, Stephen M Hatfield, Akio Ohta, Michail V Sitkovsky
Human cancers are known to downregulate Major Histocompatibility Complex (MHC) class I expression thereby escaping recognition and rejection by anti-tumor T cells. Here we report that oxygen tension in the tumor microenvironment (TME) serves as an extrinsic cue that regulates antigen presentation by MHC class I molecules. In support of this view, hypoxia is shown to negatively regulate MHC expression in a HIF-dependent manner as evidenced by (i) lower MHC expression in the hypoxic TME in vivo and in hypoxic 3-dimensional (3D) but not 2-dimensional (2D) tumor cell cultures in vitro; (ii) decreased MHC in human renal cell carcinomas with constitutive expression of HIF due to genetic loss of von Hippel-Lindau (VHL) function as compared with isogenically paired cells with restored VHL function, and iii) increased MHC in tumor cells with siRNA-mediated knockdown of HIF...
2017: PloS One
https://www.readbyqxmd.com/read/29155374/testing-the-waters-from-moringa-seeds-to-fruit-peels-researchers-are-seeking-out-new-ways-to-clean-up-the-world-s-drinking-water
#11
Wudan Yan
Water on Earth-in our oceans, rivers, lakes, and wetlands-might seem plentiful, but water that is clean and safe enough to drink actually isn't so abundant. Nearly one in ten people still lacks access to safe water worldwide, according to the World Health Organization. In some of the world's most remote and impoverished communities, people live with no taps, showers, flushing toilets, or nearby springs, making it difficult to keep water supplies safe from bacteria, chemicals, and particulates. Moreover, access to clean drinking water isn't just a problem in the developing world; groundwater in developed countries is typically used far more quickly than it is being replenished...
November 2017: IEEE Pulse
https://www.readbyqxmd.com/read/29154770/density-and-shape-factor-terms-in-stokes-equation-for-aerodynamic-behavior-of-aerosols
#12
Anthony J Hickey, David A Edwards
Pharmaceutical aerosols are used to treat many pulmonary diseases. The use of low density powders has proven useful to support efficient drug delivery. Measurements must account for the low density, spherical particle features contributing to aerodynamic behavior. Ideally, the aerodynamic particle size distribution (APSD) is measured experimentally. Without formal measurement of APSD, calculations may be performed using surrogate measures such as bulk or tapped density and dynamic shape factor in Stokes' equation...
November 14, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29154205/identification-and-temporal-decrease-of-137-cs-and-134-cs-in-groundwater-in-minami-soma-city-following-the-accident-at-the-fukushima-dai-ichi-nuclear-power-plant
#13
Kiyoshi Shizuma, Yoko Fujikawa, Momo Kurihara, Yushi Sakurai
The Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident on March 11, 2011, caused severe radioactive contamination in Fukushima Prefecture. In order to clarify the safety of drinking water, we have conducted radiocesium monitoring of public tap water and groundwater in Minami-Soma City, which is 10-40 km north of the nuclear power plant. The source of tap water for Minami-Soma City is groundwater, which is treated by rapid filtration before distribution in two of the three treatment plants. The tap water was collected from six stations during 2012-2016 and groundwater was collected from 11 stations with wells between 5 and 100 m deep during 2014-2016...
November 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29153515/daily-and-seasonal-trends-of-electricity-and-water-use-on-pasture-based-automatic-milking-dairy-farms
#14
J Shortall, B O'Brien, R D Sleator, J Upton
The objective of this study was to identify the major electricity and water-consuming components of a pasture-based automatic milking (AM) system and to establish the daily and seasonal consumption trends. Electricity and water meters were installed on 7 seasonal calving pasture-based AM farms across Ireland. Electricity-consuming processes and equipment that were metered for consumption included milk cooling components, air compressors, AM unit(s), auxiliary water heaters, water pumps, lights, sockets, automatic manure scrapers, and so on...
November 15, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29152696/degradation-of-the-earthy-and-musty-odorant-2-4-6-tricholoroanisole-by-persulfate-activated-with-iron-of-different-valences
#15
Kejia Zhang, Xinyan Zhou, Tuqiao Zhang, Lang Yu, Zheming Qian, Wenchao Liao, Cong Li
2,4,6-Trichloroanisole (TCA) is an odorous compound that is often detected in tap water and is difficult to be removed via water treatment. In this study, the transformation efficiency of TCA in the presence of persulfate (PS) activated by iron (Fe(2+), Fe(0), and Fe(3+)) was investigated for the first time. The effects of the activator dosage, oxidant dosage, pH, dosing method, chelating agents, humic acid, and temperature were evaluated. The degradation rate of TCA increased with increasing PS dosages (0...
November 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29152590/introversion-the-prevalent-trait-of-adolescents-with-idiopathic-scoliosis-an-observational-study
#16
Elisabetta D'Agata, Judith Sánchez-Raya, Juan Bagó
Background: A large number of studies about adolescents with idiopathic scoliosis focus on health-related quality of life (HRQOL). However, only a few articles aim at evaluating the personality of these patients. Therefore, the purpose of the present research is to assess the personality traits of adolescents with idiopathic scoliosis and their relationship with HRQOL.Our hypothesis is that adolescents with idiopathic scoliosis present the principal personality trait of introversion, defined as self-reliance and inhibition in social relationships...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/29150776/hyperpyrexia-as-the-presenting-symptom-of-intracranial-hypotension
#17
Omar Hussein, Michel Torbey
INTRODUCTION: Hyperpyrexia is a severely elevated core body temperature secondary to an elevated hypothalamic set thermo-regulatory threshold. Hyperthermia is an elevated core body temperature beyond the normal hypothalamic set thermo-regulatory threshold. Intracranial hypotension can present with a wide variety of symptoms ranging from orthostatic headache up to coma. We report a rare case of hyperpyrexia associated with intracranial hypotension. METHODS: A case report of a 55-year-old female patient with a history of angiogram-negative subarachnoid hemorrhage status post-ventriculoperitoneal (VP) shunt placement six years prior to admission who suddenly developed encephalopathy and high fever...
November 17, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29149699/tetrahymena-cilia-cap-is-built-in-a-multi-step-process-a-study-by-atomic-force-microscopy
#18
Cecília Seixas, João Gonçalves, Luís Viseu Melo, Helena Soares
Cilia are complex and dynamic organelles that have motility and sensory functions. Defects in cilia biogenesis and function are at the origin of human ciliopathies. In motile cilia, a basal body organizes the axoneme composed of nine microtubule doublets surrounding a central pair of singlet microtubules. The distal ends of axonemal microtubules are attached to the membrane by microtubule-capping structures. Little is known about the early steps of cilium assembly. Although cilia grow and resorb from their distal tips, it remains poorly understood where and when the components of the caps are first assembled...
October 20, 2017: Protist
https://www.readbyqxmd.com/read/29149686/preliminary-application-of-structure-from-motion-and-gis-to-document-decomposition-and-taphonomic-processes
#19
Connor D Carlton, Samantha Mitchell, Patrick Lewis
Over the past decade, Structure from Motion (SfM) has increasingly been used as a means of digital preservation and for documenting archaeological excavations, architecture, and cultural material. However, few studies have tapped the potential of using SfM to document and analyze taphonomic processes affecting burials for forensic sciences purposes. This project utilizes SfM models to elucidate specific post-depositional events that affected a series of three human cadavers deposited at the South East Texas Applied Forensic Science Facility (STAFS)...
November 2, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29149143/efficacy-of-magnesium-sulfate-added-to-local-anesthetic-in-a-transversus-abdominis-plane-block-for-analgesia-following-total-abdominal-hysterectomy-a-randomized-trial
#20
Kelany A Abd-Elsalam, Khaled M Fares, Montaser A Mohamed, Mohamed F Mohamed, Ahmad M Abd El-Rahman, Moaaz M Tohamy
BACKGROUND: Major abdominal surgeries are associated with severe pain, which can affect respiratory and cardiac functions if insufficiently treated; this increases postoperative morbidity. OBJECTIVE: We aim at evaluating the efficacy of magnesium sulfate as an adjuvant to local anesthetic in an ultrasound-guided transversus abdominis plane (TAP) block for postoperative analgesia in total abdominal hysterectomy. STUDY DESIGN: A prospective, randomized, double-blinded clinical trial...
November 2017: Pain Physician
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