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https://www.readbyqxmd.com/read/28441018/correction-to-the-silicon-version-of-phosphine-chalcogenides-synthesis-and-bonding-analysis-of-stabilized-heavy-silaaldehydes
#1
Dennis Lutters, Anastasia Merk, Marc Schmidtmann, Thomas Müller
No abstract text is available yet for this article.
April 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28437389/normothermic-perfusion-in-the-assessment-and-preservation-of-declined-livers-before-transplantation-hyperoxia-and-vasoplegia-important-lessons-from-the-first-12-cases
#2
Christopher J E Watson, Vasilis Kosmoliaptsis, Lucy V Randle, Alexander E Gimson, Rebecca Brais, John R Klinck, Mazin Hamed, Anastasia Tsyben, Andrew J Butler
BACKGROUND: A program of normothermic ex situ liver perfusion (NESLiP) was developed to facilitate better assessment and use of marginal livers, while minimizing cold ischemia. METHODS: Declined marginal livers and those offered for research were evaluated. Normothermic ex situ liver perfusion was performed using an erythrocyte-based perfusate. Viability was assessed with reference to biochemical changes in the perfusate. RESULTS: Twelve livers (9 donation after circulatory death [DCD] and 3 from brain-dead donors), median Donor Risk Index 2...
May 2017: Transplantation
https://www.readbyqxmd.com/read/28434860/direct-brain-stimulation-modulates-encoding-states-and-memory-performance-in-humans
#3
Youssef Ezzyat, James E Kragel, John F Burke, Deborah F Levy, Anastasia Lyalenko, Paul Wanda, Logan O'Sullivan, Katherine B Hurley, Stanislav Busygin, Isaac Pedisich, Michael R Sperling, Gregory A Worrell, Michal T Kucewicz, Kathryn A Davis, Timothy H Lucas, Cory S Inman, Bradley C Lega, Barbara C Jobst, Sameer A Sheth, Kareem Zaghloul, Michael J Jutras, Joel M Stein, Sandhitsu R Das, Richard Gorniak, Daniel S Rizzuto, Michael J Kahana
People often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting, then decoded neural activity in later sessions in which we applied stimulation during learning...
April 13, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28434101/predicting-dream-recall-eeg-activation-during-nrem-sleep-or-shared-mechanisms-with-wakefulness
#4
Serena Scarpelli, Aurora D'Atri, Anastasia Mangiaruga, Cristina Marzano, Maurizio Gorgoni, Cinzia Schiappa, Michele Ferrara, Luigi De Gennaro
The common knowledge of a uniqueness of REM sleep as a privileged scenario of dreaming still persists, although consolidated empirical evidence shows that the assumption that dreaming is just an epiphenomenon of REM sleep is no longer tenable. However, the brain mechanisms underlying dream generation and its encoding in memory during NREM sleep are still mostly unknown. In fact, only few studies have investigated on the mechanisms of dream phenomenology related to NREM sleep. For this reason, our study is specifically aimed to elucidate the electrophysiological (EEG) correlates of dream recall (DR) upon NREM sleep awakenings...
April 22, 2017: Brain Topography
https://www.readbyqxmd.com/read/28433500/psychometric-characteristics-of-the-matrics-consensus-cognitive-battery-in-a-large-pooled-cohort-of-stable-schizophrenia-patients
#5
Anastasia Georgiades, Vicki G Davis, Alexandra S Atkins, Anzalee Khan, Trina W Walker, Antony Loebel, George Haig, Dana C Hilt, Eduardo Dunayevich, Daniel Umbricht, Michael Sand, Richard S E Keefe
The MATRICS Consensus Cognitive Battery (MCCB) was developed to assess cognitive treatment effects in schizophrenia clinical trials, and is considered the FDA gold standard outcome measure for that purpose. The aim of the present study was to establish pre-treatment psychometric characteristics of the MCCB in a large pooled sample. The dataset included 2616 stable schizophrenia patients enrolled in 15 different clinical trials between 2007 and 2016 within the United States (94%) and Canada (6%). The MCCB was administered twice prior to the initiation of treatment in 1908 patients...
April 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28429185/high-content-assessment-of-cardiac-function-using-heart-on-a-chip-devices-as-drug-screening-model
#6
Genevieve Conant, Benjamin Fook Lun Lai, Rick Xing Ze Lu, Anastasia Korolj, Erika Yan Wang, Milica Radisic
Drug discovery and development continues to be a challenge to the pharmaceutical industry despite great advances in cell and molecular biology that allow for the design of better targeted therapeutics. Many potential drug compounds fail during the clinical trial due to inefficacy and toxicity that were not predicted during preclinical stages. The fundamental problem lies with the use of traditional drug screening models that still largely rely on the use of cell lines or animal cell monolayers, which leads to lack of predictive power of human tissue and organ response to the drug candidates...
April 20, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28428352/thrombin-mediated-degradation-of-human-cardiac-troponin-t
#7
Ivan A Katrukha, Alexander E Kogan, Alexandra V Vylegzhanina, Marina V Serebryakova, Ekaterina V Koshkina, Anastasia V Bereznikova, Alexey G Katrukha
BACKGROUND: Cardiac troponin T (cTnT) is an acknowledged biomarker of acute myocardial infarction (AMI) that is known to be prone to proteolytic degradation in serum. Such degradation is usually explained by the action of μ -calpain, although there could be other candidates for that role. In the current study, we explored the hypothesis that thrombin-mediated cTnT cleavage occurs as a result of the serum sample preparation. METHODS: cTnT degradation was studied by using immunoblotting and mass spectrometry (MS) analysis...
April 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28428263/different-requirements-of-functional-telomeres-in-neural-stem-cells-and-terminally-differentiated-neurons
#8
Anastasia Lobanova, Robert She, Simon Pieraut, Charlie Clapp, Anton Maximov, Eros Lazzerini Denchi
Telomeres have been studied extensively in peripheral tissues, but their relevance in the nervous system remains poorly understood. Here, we examine the roles of telomeres at distinct stages of murine brain development by using lineage-specific genetic ablation of TRF2, an essential component of the shelterin complex that protects chromosome ends from the DNA damage response machinery. We found that functional telomeres are required for embryonic and adult neurogenesis, but their uncapping has surprisingly no detectable consequences on terminally differentiated neurons...
April 20, 2017: Genes & Development
https://www.readbyqxmd.com/read/28423722/the-importance-of-the-genomic-landscape-in-waldenstr%C3%A3-m-s-macroglobulinemia-for-targeted-therapeutical-interventions
#9
REVIEW
Antonio Sacco, Adriano Fenotti, Loredana Affò, Stefano Bazzana, Domenico Russo, Marco Presta, Michele Malagola, Antonella Anastasia, Marina Motta, Christopher J Patterson, Giuseppe Rossi, Luisa Imberti, Steven P Treon, Irene M Ghobrial, Aldo M Roccaro
The Literature has recently reported on the importance of genomics in the field of hematologic malignancies, including B-cell lymphoproliferative disorders such as Waldenström's Macrolgobulinemia (WM). Particularly, whole exome sequencing has led to the identification of the MYD88L265P and CXCR4C1013G somatic variants in WM, occurring in about 90% and 30% of the patients, respectively. Subsequently, functional studies have demonstrated their functional role in supporting WM pathogenesis and disease progression, both in vitro and in vivo, thus providing the pre-clinical evidences for extremely attractive targets for novel therapeutic interventions in WM...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423051/biochemical-and-molecular-characterization-of-the-isocitrate-dehydrogenase-with-dual-coenzyme-specificity-from-the-obligate-methylotroph-methylobacillus-flagellatus
#10
Anastasia Y Romkina, Michael Y Kiriukhin
The isocitrate dehydrogenase (MfIDH) with unique double coenzyme specificity from Methylobacillus flagellatus was purified and characterized, and its gene was cloned and overexpressed in E. coli as a fused protein. This enzyme is homodimeric,-with a subunit molecular mass of 45 kDa and a specific activity of 182 U mg -1 with NAD+ and 63 U mg -1 with NADP+. The MfIDH activity was dependent on divalent cations and Mn2+ enhanced the activity the most effectively. MfIDH exhibited a cofactor-dependent pH-activity profile...
2017: PloS One
https://www.readbyqxmd.com/read/28419374/patient-radiation-doses-in-therapeutic-endoscopic-retrograde-cholangiopancreatography-in-patras-and-the-key-role-of-the-operator
#11
Anastasia C Hadjiconstanti, Gerasimos A T Messaris, Konstantinos C Thomopoulos, George S Panayiotakis
The patient radiation doses, in conjunction with the operator experience, in therapeutic endoscopic retrograde cholangiopancreatography (ERCP) procedures, performed in our hospital, were obtained. Ninety-six patients participated in the study and were divided into 3 groups, based on the operator experience. The dosemetric indices, fluoroscopy time (FT), cumulative dose (Ka,r) and air kerma-area product (PKA), were collected. For the total and weight banding group the third quartile values of the distribution of FT, Ka,r and PKA were 2...
April 17, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28418006/radiomics-based-prognosis-analysis-for-non-small-cell-lung-cancer
#12
Yucheng Zhang, Anastasia Oikonomou, Alexander Wong, Masoom A Haider, Farzad Khalvati
Radiomics characterizes tumor phenotypes by extracting large numbers of quantitative features from radiological images. Radiomic features have been shown to provide prognostic value in predicting clinical outcomes in several studies. However, several challenges including feature redundancy, unbalanced data, and small sample sizes have led to relatively low predictive accuracy. In this study, we explore different strategies for overcoming these challenges and improving predictive performance of radiomics-based prognosis for non-small cell lung cancer (NSCLC)...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417595/influence-of-demographic-characteristics-on-attenuated-positive-psychotic-symptoms-in-a-young-help-seeking-at-risk-population
#13
Anastasia Theodoridou, Michael P Hengartner, Karsten Heekeren, Diane Dvorsky, Frauke Schultze-Lutter, Miriam Gerstenberg, Susanne Walitza, Wulf Rössler
AIM: Presentation of attenuated positive psychotic symptoms (APS) was reported to be modestly influenced by age, sex and education in a psychosis-risk sample. We re-examined the influence of demographic variables on APS in an independent psychosis-risk sample. METHOD: In a clinical high-risk-sample (N = 188; 13-35 years; 60.1% men), bivariate correlations were examined with Spearman correlations. All other associations were computed with generalized linear models...
April 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28416981/relationship-between-right-and-left-ventricular-function-in-candidates-for-implantable-cardioverter-defibrillator-with-low-left-ventricular-ejection-fraction
#14
Laura Jimenez-Juan, Gauri R Karur, Kim A Connelly, Djeven Deva, Raymond T Yan, Rachel M Wald, Sheldon Singh, General Leung, Anastasia Oikonomou, Paul Dorian, Paul Angaran, Andrew T Yan
BACKGROUND: Indications for the primary prevention of sudden death using an implantable cardioverter defibrillator (ICD) are based predominantly on left ventricular ejection fraction (LVEF). However, right ventricular ejection fraction (RVEF) is also a known prognostic factor in a variety of structural heart diseases that predispose to sudden cardiac death. We sought to investigate the relationship between right and left ventricular parameters (function and volume) measured by cardiovascular magnetic resonance (CMR) among a broad spectrum of patients considered for an ICD...
April 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28416461/detection-of-penetration-of-the-dorsal-cortex-by-epiphyseal-screwsof-distal-radius-volar-plates-anatomical-study-comparing-ultrasoundandfluoroscopy
#15
Vernet Paul, Durry Anastasia, Nicolau Xavier, D'Ambrosio Adrien, Collinet Arnaud, Salazar Botero Santiago, Liverneaux Philippe, Hidalgo Diaz Juan José
Osteosynthesis of the distal radius by a volar plate can be complicated by lesions of extensor tendons by screws penetrating the dorsal cortex. The fluoroscopic skyline view enables to confirm the length of the screws. To avoid its risk of irradiation, some authors have recommended to use ultrasound instead. The goal of this study was to demonstrate that the detection rate of screws penetrating the dorsal cortex was at least as good using ultrasound compared to fluoroscopic skyline. A volar plate in which one screw penetrated the dorsal cortex was implanted in 10 cadaveric wrists...
April 14, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28414329/alternatively-activated-macrophages-do-not-synthesize-catecholamines-or-contribute-to-adipose-tissue-adaptive-thermogenesis
#16
Katrin Fischer, Henry H Ruiz, Kevin Jhun, Brian Finan, Douglas J Oberlin, Verena van der Heide, Anastasia V Kalinovich, Natasa Petrovic, Yochai Wolf, Christoffer Clemmensen, Andrew C Shin, Senad Divanovic, Frank Brombacher, Elke Glasmacher, Susanne Keipert, Martin Jastroch, Joachim Nagler, Karl-Werner Schramm, Dasa Medrikova, Gustav Collden, Stephen C Woods, Stephan Herzig, Dirk Homann, Steffen Jung, Jan Nedergaard, Barbara Cannon, Matthias H Tschöp, Timo D Müller, Christoph Buettner
Adaptive thermogenesis is the process of heat generation in response to cold stimulation. It is under the control of the sympathetic nervous system, whose chief effector is the catecholamine norepinephrine (NE). NE enhances thermogenesis through β3-adrenergic receptors to activate brown adipose tissue and by 'browning' white adipose tissue. Recent studies have reported that alternative activation of macrophages in response to interleukin (IL)-4 stimulation induces the expression of tyrosine hydroxylase (TH), a key enzyme in the catecholamine synthesis pathway, and that this activation provides an alternative source of locally produced catecholamines during the thermogenic process...
April 17, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28411779/prescribing-propranolol-for-infantile-hemangioma-assessment-of-dosing-errors
#17
Anastasia O Kurta, Daisy Dai, Eric S Armbrecht, Elaine C Siegfried
No abstract text is available yet for this article.
May 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28410997/international-incidence-of-childhood-cancer-2001-10-a-population-based-registry-study
#18
Eva Steliarova-Foucher, Murielle Colombet, Lynn A G Ries, Florencia Moreno, Anastasia Dolya, Freddie Bray, Peter Hesseling, Hee Young Shin, Charles A Stiller
BACKGROUND: Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. METHODS: This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001-10...
April 11, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28408375/uric-acid-is-associated-with-inflammatory-biomarkers-and-induces-inflammation-via-activating-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-hepg2-cells
#19
Rosangela Spiga, Maria Adelaide Marini, Elettra Mancuso, Concetta Di Fatta, Anastasia Fuoco, Francesco Perticone, Francesco Andreozzi, Gaia Chiara Mannino, Giorgio Sesti
OBJECTIVE: Serum uric acid (UA) has been associated with increased risk of cardiovascular and metabolic diseases. However, the causal mechanisms linking elevated UA levels to cardio-metabolic diseases are still unsettled. One potential explanation for how UA might contribute to cardio-metabolic disease might be its ability to induce systemic inflammation. APPROACH AND RESULTS: Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults...
April 13, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28407967/molecular-characterization-of-an-unauthorized-genetically-modified-bacillus-subtilis-production-strain-identified-in-a-vitamin-b2-feed-additive
#20
Valentina Paracchini, Mauro Petrillo, Ralf Reiting, Alexandre Angers-Loustau, Daniela Wahler, Andrea Stolz, Birgit Schönig, Anastasia Matthies, Joachim Bendiek, Dominik M Meinel, Sven Pecoraro, Ulrich Busch, Alex Patak, Joachim Kreysa, Lutz Grohmann
Many food and feed additives result from fermentation of genetically modified (GM) microorganisms. For vitamin B2 (riboflavin), GM Bacillus subtilis production strains have been developed and are often used. The presence of neither the GM strain nor its recombinant DNA is allowed for fermentation products placed on the EU market as food or feed additive. A vitamin B2 product (80% feed grade) imported from China was analysed. Viable B. subtilis cells were identified and DNAs of two bacterial isolates (LHL and LGL) were subjected to three whole genome sequencing (WGS) runs with different devices (MiSeq, 454 or HiSeq system)...
September 1, 2017: Food Chemistry
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