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https://www.readbyqxmd.com/read/29026733/safety-of-a-new-synbiotic-starter-formula
#1
Yvan Vandenplas, Antonis Analitis, Chara Tziouvara, Athina Kountzoglou, Anastasia Drakou, Manos Tsouvalas, Antigoni Mavroudi, Ioannis Xinias
PURPOSE: Breastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding. METHODS: The safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, with lactose and a whey/casein 60/40 protein ratio was tested in 280 infants during 3 months. RESULTS: The median age of the infants at inclusion was 0...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29022758/pharmacokinetic-profiling-of-conjugated-therapeutic-oligonucleotides-a-high-throughput-method-based-upon-serial-blood-microsampling-coupled-to-peptide-nucleic-acid-hybridization-assay
#2
Bruno M D C Godinho, James W Gilbert, Reka A Haraszti, Andrew H Coles, Annabelle Biscans, Loic Roux, Mehran Nikan, Dimas Echeverria, Matthew Hassler, Anastasia Khvorova
Therapeutic oligonucleotides, such as small interfering RNAs (siRNAs), hold great promise for the treatment of incurable genetically defined disorders by targeting cognate toxic gene products for degradation. To achieve meaningful tissue distribution and efficacy in vivo, siRNAs must be conjugated or formulated. Clear understanding of the pharmacokinetic (PK)/pharmacodynamic behavior of these compounds is necessary to optimize and characterize the performance of therapeutic oligonucleotides in vivo. In this study, we describe a simple and reproducible methodology for the evaluation of in vivo blood/plasma PK profiles and tissue distribution of oligonucleotides...
October 12, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29021339/phosphorylation-regulates-connexin43-zo-1-binding-and-release-an-important-step-in-gap-junction-turnover
#3
Anastasia F Thévenin, Rachel A Margraf, Charles G Fisher, Rachael M Kells-Andrews, Matthias M Falk
To investigate whether connexin phosphorylation regulates ZO-1's known role in gap junction (GJ) function, we generated and analyzed a series of phosphomimetic and phosphorylation-dead mutants by exchanging known conserved regulatory serine (S) residues 255, 279/282, 365, 368, and 373 located in the C-terminal domain of connexin43 (Cx43) into glutamic acid (E) or alanine (A) residues. All connexin mutants were translated into stable, full-length proteins and assembled into GJs when expressed in HeLa or MDCK cells...
October 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29019957/application-of-multilayer-perceptron-with-automatic-relevance-determination-on-weed-mapping-using-uav-multispectral-imagery
#4
Afroditi A Tamouridou, Thomas K Alexandridis, Xanthoula E Pantazi, Anastasia L Lagopodi, Javid Kashefi, Dimitris Kasampalis, Georgios Kontouris, Dimitrios Moshou
Remote sensing techniques are routinely used in plant species discrimination and of weed mapping. In the presented work, successful Silybum marianum detection and mapping using multilayer neural networks is demonstrated. A multispectral camera (green-red-near infrared) attached on a fixed wing unmanned aerial vehicle (UAV) was utilized for the acquisition of high-resolution images (0.1 m resolution). The Multilayer Perceptron with Automatic Relevance Determination (MLP-ARD) was used to identify the S. marianum among other vegetation, mostly Avena sterilis L...
October 11, 2017: Sensors
https://www.readbyqxmd.com/read/29019643/skeletal-diversity-in-combinatorial-fashion-a-new-format-for-the-castagnoli-cushman-reaction
#5
Anastasia Lepikhina, Dmitry Dar'in, Olga Bakulina, Evgeny Chupakhin, Mikhail Krasavin
A new format for the Castagnoli-Cushman reaction of structurally diverse dicarboxylic acids, amines and aldehydes in the presence of acetic anhydride as dehydrating agent is described. The reaction is distinctly amenable to parallel format: the combinatorial array of 180 reactions delivered 157 products of >85% purity without chromatographic purification (of this number, 143 compounds had >94% purity). The new method offers a convenient preparation of the skeletally and peripherally diverse, lead- and druglike - and -lactam carboxylic acids with high diastereoselectivity in combinatorial fashion...
October 11, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/29017817/classification-of-%C3%AE-hairpin-repeat-proteins
#6
Daniel B Roche, Phuong Do Viet, Anastasia Bakulina, Layla Hirsh, Silvio C E Tosatto, Andrey V Kajava
In recent years, a number of new protein structures that possess tandem repeats have emerged. Many of these proteins are comprised of tandem arrays of β-hairpins. Today, the amount and variety of the data on these β-hairpin repeat (BHR) structures have reached a level that requires detailed analysis and further classification. In this paper, we classified the BHR proteins, compared structures, sequences of repeat motifs, functions and distribution across the major taxonomic kingdoms of life and within organisms...
October 7, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28993784/the-intergenic-interplay-between-aldose-1-epimerase-like-protein-and-pectin-methylesterase-in-abiotic-and-biotic-stress-control
#7
Ekaterina V Sheshukova, Tatiana V Komarova, Denis V Pozdyshev, Natalia M Ershova, Anastasia V Shindyapina, Vadim N Tashlitsky, Eugene V Sheval, Yuri L Dorokhov
The mechanical damage that often precedes the penetration of a leaf by a pathogen promotes the activation of pectin methylesterase (PME); the activation of PME leads to the emission of methanol, resulting in a "priming" effect on intact leaves, which is accompanied by an increased sensitivity to Tobacco mosaic virus (TMV) and resistance to bacteria. In this study, we revealed that mRNA levels of the methanol-inducible gene encoding Nicotiana benthamiana aldose 1-epimerase-like protein (NbAELP) in the leaves of intact plants are very low compared with roots...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28992521/morphology-and-phylogeny-of-the-testate-amoebae-euglypha-bryophila-brown-1911-and-euglypha-cristata-leidy-1874-rhizaria-euglyphida
#8
Andrey N Tsyganov, Anastasia V Shatilovich, Anton S Esaulov, Viktor A Chernyshov, Natalia G Mazei, Elena A Malysheva, Yuri A Mazei
The genus Euglypha contains the largest number of filose testate amoeba taxa which were mainly described based on the morphological characteristics of shells. Despite the increasing amount of molecular data, the phylogenetic relationships within the genus Euglypha remain unresolved. In this work we provide new data on SSU rRNA gene sequences, light and electron microscopy for the two euglyphid species Euglypha bryophilaBrown, 1911 and Euglypha cristataLeidy, 1874. Both species are characterised by the presence of a turf of spines on the aboral pole of the shells but differ in shell cross sections (elliptical and circular, respectively)...
September 18, 2017: European Journal of Protistology
https://www.readbyqxmd.com/read/28992182/association-of-dna-repair-gene-polymorphisms-with-genotoxic-stress-in-underground-coal-miners
#9
Maxim Yu Sinitsky, Varvara I Minina, Maxim A Asanov, Arseniy E Yuzhalin, Anastasia V Ponasenko, Vladimir G Druzhinin
In underground coal mining, numerous harmful substances and ionising radiation pose a major threat to the occupational safety and health of workers. Because cell DNA repair machinery eliminates genotoxic stress conferred by these agents, we examined whether single nucleotide polymorphisms in hOGG1 (rs1052133), XRCC1 (rs25487), ADPRT (rs1136410), XRCC4 (rs6869366) and LIG4 (rs1805388) genes modulate the genotoxic damage assessed by the cytokinesis-block micronucleus assay in lymphocytes from 143 underground coal miners and 127 healthy non-exposed males...
August 8, 2017: Mutagenesis
https://www.readbyqxmd.com/read/28990854/impact-of-membrane-partitioning-on-the-spatial-structure-of-an-s-type-cobra-cytotoxin
#10
Peter V Dubovskii, Maxim A Dubinnyi, Pavel E Volynsky, Yulia E Pustovalova, Anastasia G Konshina, Yuri N Utkin, Alexander S Arseniev, Roman G Efremov
Cobra cytotoxins (CTs) belong to the three-fingered protein family. They are classified into S- and P-types, the latter exhibiting higher membrane-perturbing capacity. In this work we investigated the interaction of CTs with phospholipid bilayers, using coarse-grained (CG) and full-atom (FA) molecular dynamics (MD). The object of this work is a CT of an S-type, cytotoxin I (CT1) from N.oxiana venom. Its spatial structure in aqueous solution and in the micelles of dodecylphosphocholine (DPC) were determined by (1)H-NMR spectroscopy...
October 9, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28990748/cal-mediconnect-enrollment-why-are-dual-eligible-consumers-in-los-angeles-county-opting-out
#11
Kate McBride, Ana Reynoso, Tiffany Alunan, Brenda Gutierrez, Adrien Bacong, Marge Moon, Anastasia Bacigalupo, A E Benjamin, Steven P. Wallace, Kathryn G Kietzman
Los Angeles County has the state’s lowest rate of consumer enrollment in Cal MediConnect, a program that is responsible for the delivery and coordination of medical, behavioral health, and long-term services and support benefits for individuals who are dually eligible for Medicare and Medi-Cal. This policy brief examines the factors that influence consumer decisions and may contribute to low enrollment rates. Influential factors include consumer knowledge of health care options, perception of choice, and disruption of existing care...
September 2017: Policy Brief
https://www.readbyqxmd.com/read/28990520/collagenolytic-enzymes-and-their-applications-in-biomedicine
#12
Anatoly Borisovich Shekhter, Anastasia V Balakireva, Natalia V Kuznetsova, Marina N Vukolova, Petr F Litvitsky, Andrey A Zamyatnin
Nowadays, enzymatic therapy is a very promising line of treatment for many different diseases. There is a group of disorders and conditions, caused by fibrotic and scar processes and associated with the excessive accumulation of collagen that needs to be catabolized to normalize the connective tissue content. The human body normally synthesizes special extracellular enzymes, matrix metalloproteases (MMPs) by itself. These enzymes can cleave components of extracellular matrix (ECM) and different types of collagen and thus maintain the balance of the connective tissue components...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28989789/bi-logistic-model-for-disease-dynamics-caused-by-mycobacterium-tuberculosis-in-russia
#13
Anastasia I Lavrova, Eugene B Postnikov, Olga A Manicheva, Boris I Vishnevsky
In this work, we explore epidemiological dynamics by the example of tuberculosis in Russian Federation. It has been shown that the epidemiological dynamics correlates linearly with the virulence of Mycobacterium tuberculosis during the period 1987-2012. To construct an appropriate model, we have analysed (using LogLet decomposition method) epidemiological World Health Organization (WHO) data (period 1980-2014) and obtained, as result of their integration, a curve approximated by a bi-logistic function. This fact allows a subdivision of the whole population into parts, each of them satisfies the Verhulst-like models with different constant virulences introduced into each subsystem separately...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28989072/pentoxifylline-treatment-enhances-antihypertensive-activity-of-captopril-through-hemorheological-improvement-in-spontaneously-hypertensive-rats-during-development-of-arterial-hypertension
#14
Mark B Plotnikov, Alexander Y Shamanaev, Oleg I Aliev, Anastasia V Sidekhmenova, Anna M Anishchenko, Alexander M Arkhipov
The rheological properties of blood play a significant role in the onset and progression of arterial hypertension. The aim of our work was to evaluate the effect of the angiotensin-converting enzyme inhibitor captopril (20 mg/kg/d), pentoxifylline (PTX; 100 mg/kg/d), and the combination of captopril + PTX (20 + 100 mg/kg/d) on the hemodynamic and hemorheological parameters in spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. In the group of animals that received captopril, the mean arterial pressure (MAP) was significantly lower by 30% due to a decrease in cardiac output of 23% and in total peripheral resistance (TPR) of 26% compared with the control group, whereas blood viscosity did not change significantly...
September 27, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28988342/spectrum-of-outcomes-following-traumatic-brain-injury-relationship-between-functional-impairment-and-health-related-quality-of-life
#15
Anastasia Tsyben, Mathew Guilfoyle, Ivan Timofeev, Fahim Anwar, Judith Allanson, Joanne Outtrim, David Menon, Peter Hutchinson, Adel Helmy
BACKGROUND: The outcome following traumatic brain injury (TBI) is heterogeneous and poorly defined and physical disability scales like the extended Glasgow Outcome Score (GOSE) while providing valuation information in terms of broad categorisation of outcome are unlikely to capture the full spectrum of deficits. Quality of life questionnaires such as SF-36 are emerging as potential tools to help characterise factors important to patients' recovery. This study assessed the association between physical disability and subjective health rating...
October 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28988149/neural-dysfunction-during-temporal-discounting-in-paediatric-attention-deficit-hyperactivity-disorder-and-obsessive-compulsive-disorder
#16
Luke J Norman, Christina O Carlisi, Anastasia Christakou, Kaylita Chantiluke, Clodagh Murphy, Andrew Simmons, Vincent Giampietro, Michael Brammer, David Mataix-Cols, Katya Rubia
Both Attention-Deficit/Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) are associated with choice impulsivity, i.e. the tendency to prefer smaller immediate rewards over larger delayed rewards. However, the extent to which this impulsivity is mediated by shared or distinct underlying neural mechanisms is unclear. Twenty-six boys with ADHD, 20 boys with OCD and 20 matched controls (aged 12-18) completed an fMRI version of an individually adjusted temporal discounting (TD) task which requires choosing between a variable amount of money now or £100 in one week, one month or one year...
November 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28988127/comparative-genome-analysis-of-novel-podoviruses-lytic-for-hypermucoviscous-klebsiella-pneumoniae-of-k1-k2-and-k57-capsular-types
#17
Ekaterina V Solovieva, Vera P Myakinina, Angelina A Kislichkina, Valentina M Krasilnikova, Vladimir V Verevkin, Vladimir V Mochalov, Anastasia I Lev, Nadezhda K Fursova, Nikolay V Volozhantsev
Hypermucoviscous (HV) strains of capsular types K1, K2 and K57 are the most virulent representatives of the Klebsiella pneumoniae species. Eight novel bacteriophages lytic for HV K. pneumoniae were isolated and characterized. Three bacteriophages, KpV41, KpV475, and KpV71 were found to have a lytic activity against mainly K. pneumoniae of capsular type K1. Two phages, KpV74, and KpV763 were lytic for K2 capsular type K. pneumoniae, and the phage KpV767 was specific to K57-type K. pneumoniae only. Two more phages, KpV766, and KpV48 had no capsular specificity...
October 5, 2017: Virus Research
https://www.readbyqxmd.com/read/28983652/what-the-radiologist-needs-to-know-about-gastrointestinal-endoscopic-surgical-procedures
#18
REVIEW
Chandana Lall, Anastasia A Cruz, Vlad Bura, Adam A Rudd, Thangavijayan Bosemani, Kenneth J Chang
Natural orifice transluminal endoscopic surgery (NOTES) is a novel surgical approach, currently performed for an array of conditions. Endoscopic procedures offer significant benefits, including lower cost, no surgical incisions, and shorter hospital stays. These advantages align with the current trends in health care, namely a push for "cost-effective care." There are a multitude of health issues which are now being addressed by the endoscopic surgical approach, including peroral endoscopic myotomy (POEM), which is a relatively new technique used in the treatment of achalasia...
October 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28983129/galaxy-formation-with-becdm-i-turbulence-and-relaxation-of-idealized-haloes
#19
Philip Mocz, Mark Vogelsberger, Victor H Robles, Jesús Zavala, Michael Boylan-Kolchin, Anastasia Fialkov, Lars Hernquist
We present a theoretical analysis of some unexplored aspects of relaxed Bose-Einstein condensate dark matter (BECDM) haloes. This type of ultralight bosonic scalar field dark matter is a viable alternative to the standard cold dark matter (CDM) paradigm, as it makes the same large-scale predictions as CDM and potentially overcomes CDM's small-scale problems via a galaxy-scale de Broglie wavelength. We simulate BECDM halo formation through mergers, evolved under the Schrödinger-Poisson equations. The formed haloes consist of a soliton core supported against gravitational collapse by the quantum pressure tensor and an asymptotic r(-3) NFW-like profile...
November 2017: Monthly Notices of the Royal Astronomical Society
https://www.readbyqxmd.com/read/28982892/uveal-melanoma-gnaq-and-gna11-mutations-in-a-greek-population
#20
Filippos Psinakis, Anastasia Katseli, Chryssanthy Koutsandrea, Konstantina Frangia, Lina Florentin, Despina Apostolopoulou, Konstantina Dimakopoulou, Dimitrios Papakonstantinou, Eleni Georgopoulou, Dimitrios Brouzas
BACKGROUND/AIM: Uveal melanoma is the most common primary adult intraocular malignancy. It is known to have a strong metastatic potential, fatal for the vast majority of patients. In recent years, meticulous cytogenetic and molecular profiling has led to precise prognostication, that unfortunately is not matched by advancements in adjuvant therapies. G Protein subunits alpha Q (GNAQ) and alpha 11 (GNA11) are two of the major driver genes that contribute to the development of uveal melanoma...
October 2017: Anticancer Research
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