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https://www.readbyqxmd.com/read/29905927/multicenter-randomized-double-blind-phase-2-trial-of-folfiri-with-regorafenib-or-placebo-as-second-line-therapy-for-metastatic-colorectal-cancer
#1
Hanna K Sanoff, Richard M Goldberg, Anastasia Ivanova, Seamus O'Reilly, Samer S Kasbari, Richard D Kim, Ray McDermott, Dominic T Moore, William Zamboni, William Grogan, Allen Lee Cohn, Tanios S Bekaii-Saab, Gregory Leonard, Theresa Ryan, Olugbenga O Olowokure, Nishan H Fernando, John McCaffrey, Bassel F El-Rayes, Anne M Horgan, Gary Bradley Sherrill, George Hosni Yacoub, Bert H O'Neil
BACKGROUND: Regorafenib, a multikinase inhibitor that inhibits angiogenesis, growth, and proliferation, prolongs survival as monotherapy in patients with refractory colorectal cancer. This international, double-blind, placebo-controlled, multicenter trial assessed the efficacy of regorafenib with folinic acid, fluorouracil, and irinotecan (FOLFIRI) as a second-line treatment for metastatic colorectal cancer. METHODS: Patients with metastatic colorectal cancer who progressed on first-line oxaliplatin and fluoropyrimidine enrolled at 45 sites in the United States and Ireland...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29904363/production-and-comprehension-of-prosodic-markers-in-sign-language-imperatives
#2
Diane Brentari, Joshua Falk, Anastasia Giannakidou, Annika Herrmann, Elisabeth Volk, Markus Steinbach
In signed and spoken language sentences, imperative mood and the corresponding speech acts such as for instance, command, permission or advice, can be distinguished by morphosyntactic structures, but also solely by prosodic cues, which are the focus of this paper. These cues can express paralinguistic mental states or grammatical meaning, and we show that in American Sign Language (ASL), they also exhibit the function, scope, and alignment of prosodic, linguistic elements of sign languages. The production and comprehension of prosodic facial expressions and temporal patterns therefore can shed light on how cues are grammaticalized in sign languages...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29902185/body-mass-index-and-waist-circumference-in-early-adulthood-are-associated-with-thoracolumbar-spine-shape-at-age-60-64-the-medical-research-council-national-survey-of-health-and-development
#3
Anastasia V Pavlova, Stella G Muthuri, Rachel Cooper, Fiona R Saunders, Jennifer S Gregory, Rebecca J Barr, Kathryn R Martin, Judith E Adams, Diana Kuh, Rebecca J Hardy, Richard M Aspden
This study investigated associations between measures of adiposity from age 36 and spine shape at 60-64 years. Thoracolumbar spine shape was characterised using statistical shape modelling on lateral dual-energy x-ray absorptiometry images of the spine from 1529 participants of the MRC National Survey of Health and Development, acquired at age 60-64. Associations of spine shape modes with: 1) contemporaneous measures of total and central adiposity (body mass index (BMI), waist circumference (WC)) and body composition (android:gynoid fat mass ratio and lean and fat mass indices, calculated as whole body (excluding the head) lean or fat mass (kg) divided by height2 (m)2); 2) changes in total and central adiposity between age 36 and 60-64 and 3) age at onset of overweight, were tested using linear regression models...
2018: PloS One
https://www.readbyqxmd.com/read/29899712/impaired-voluntary-control-in-ptsd-probing-self-regulation-of-the-acc-with-real-time-fmri
#4
Jana Zweerings, Eliza M Pflieger, Krystyna A Mathiak, Mikhail Zvyagintsev, Anastasia Kacela, Guido Flatten, Klaus Mathiak
Background: Post-traumatic stress disorder (PTSD) is characterized by deficits in the self-regulation of cognitions and emotions. Neural networks of emotion regulation may exhibit reduced control mediated by the anterior cingulate cortex (ACC), contributing to aberrant limbic responses in PTSD. Methods: Real-time fMRI neurofeedback (rt-fMRI NF) assessed self-regulation of the ACC in nine patients with PTSD after single trauma exposure and nine matched healthy controls. All participants were instructed to train ACC upregulation on three training days...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29898368/novel-cluster-and-monomer-based-galnac-structures-induce-effective-uptake-of-sirnas-in-vitro-and-in-vivo
#5
Vivek Kumar Sharma, Maire F Osborn, Matthew Hassler, Dimas Echeverria, Socheata Ly, Egor Ulashchik, Yury Martynenko-Makaev, Vadim V Shmanai, Timofei S Zatsepin, Anastasia Khvorova, Jonathan Watts
GalNAc conjugation is emerging as a dominant strategy for delivery of therapeutic oligonucleotides to hepatocytes. The structure and valency of the GalNAc ligand contributes to the potency of the conjugates. Here we present a panel of multivalent GalNAc variants using two different synthetic strategies. Specifically, we present a novel conjugate based on a support-bound trivalent GalNAc cluster, and three others using a GalNAc phosphoramidite monomer that was readily assembled into tri- or tetravalent designs during solid phase oligonucleotide synthesis...
June 13, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29897039/potential-adjustment-methodology-for-missing-data-and-reporting-delay-in-the-hiv-surveillance-system-european-union-european-economic-area-2015
#6
Magdalena Rosinska, Nikos Pantazis, Janusz Janiec, Anastasia Pharris, Andrew J Amato-Gauci, Chantal Quinten, Ecdc Hiv/Aids Surveillance Network
Accurate case-based surveillance data remain the key data source for estimating HIV burden and monitoring prevention efforts in Europe. We carried out a literature review and exploratory analysis of surveillance data regarding two crucial issues affecting European surveillance for HIV: missing data and reporting delay. Initial screening showed substantial variability of these data issues, both in time and across countries. In terms of missing data, the CD4+ cell count is the most problematic variable because of the high proportion of missing values...
June 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29894756/developmental-dynamics-of-prepiriform-cortex-in-prenatal-human-ontogenesis
#7
Anastasia S Kharlamova, Olga S Godovalova, Olga I Junemann, Sergei V Saveliev
No abstract text is available yet for this article.
June 9, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29891607/the-prevalence-of-a-cefazolin-inoculum-effect-associated-with-blaz-gene-types-among-methicillin-susceptible-staphylococcus-aureus-isolates-from-four-major-medical-centers-in-chicago
#8
Sheila K Wang, Annette Gilchrist, Anastasia Loukitcheva, Balbina J Plotkin, Ira M Sigar, Alan E Gross, John N O'Donnell, Natasha Pettit, Amy Buros, Tristan O'Driscoll, Nathaniel J Rhodes, Cindy Bethel, John Segreti, Angella Charnot-Katsikas, Kamaljit Singh, Marc H Scheetz
Cefazolin efficacy with high inoculum methicillin-susceptible Staphylococcus aureus (MSSA) infections remains in question due to therapeutic failure inferred from an inoculum effect. This study investigated the local prevalence of a cefazolin inoculum effect (CInE) and its association with staphylococcal blaZ gene types among MSSA isolates in the Chicago area. Four medical centers in Chicago, Illinois contributed MSSA isolates. Cefazolin MICs (C-MIC) were determined at 24 hours by broth microdilution method using standard inocula (SI, 5 x 105 CFU/mL) and high inocula (HI, 5 x 107 CFU/mL)...
June 11, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29891359/molecular-characterization-of-pyrethroid-resistance-in-the-olive-fruit-fly-bactrocera-oleae
#9
Nena Pavlidi, Anastasia Kampouraki, Vasilis Tseliou, Nicky Wybouw, Wannes Dermauw, Emmanouil Roditakis, Ralf Nauen, Thomas Van Leeuwen, John Vontas
Α reduction of pyrethroid efficacy has been recently recorded in Bactrocera oleae, the most destructive insect of olives. The resistance levels of field populations collected from Crete-Greece scaled up to 22-folds, compared to reference laboratory strains. Sequence analysis of the IIS4-IIS6 region of para sodium channel gene in a large number of resistant flies indicated that resistance may not be associated with target site mutations, in line with previous studies in other Tephritidae species. We analyzed the transcriptomic differences between two resistant populations versus an almost susceptible field population and two laboratory strains...
June 2018: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29890349/healing-after-resection-of-colonic-endometriosis-and-growth-factor-enriched-agents-an-experimental-rat-model
#10
Anastasia Prodromidou, Kitty Pavlakis, Vasileios Pergialiotis, Maximos Frountzas, Nikolaos Machairas, Ioannis D Kostakis, Laskarina M Korou, Konstantinos Stergios, Dimitrios Dimitroulis, George Vaos, Despoina N Perrea
STUDY OBJECTIVE: To examine the potential beneficial effect of platelet rich plasma (PRP) and fibrin sealant (TISSEEL; Baxter Healthcare Corporation, Deerfield, IL) on bowel wound healing after shaving of an experimentally induced endometriotic lesion. DESIGN: Single-blind, randomized study (Canadian Task Force classification I). SETTING: Certified animal research facility. ANIMALS: Thirty female Sprague-Dawley rats...
June 8, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29890206/pain-perception-during-levonorgestrel-releasing-intrauterine-device-insertion-in-nulliparous-women-a-systematic-review
#11
REVIEW
Christos Anthoulakis, Eirini Iordanidou, Anastasia Vatopolou
STUDY OBJECTIVE: Intrauterine devices (IUDs) still remain underused in adolescents. Pain during insertion may prevent adolescents to opt for a levonorgestrel (LNG) - releasing IUD. This study aimed to conduct a systematic review, following the PRISMA guidelines, and critically appraise published data with respect to the efficacy of various substances (analgesics or not) in preventing pain during LNG-IUD insertion in nulliparous women as a proxy for adolescents. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: A comprehensive computerized systematic literature search of all English language studies between 2006 and 2016 was performed in PubMed, EMBASE, Scopus, Evidence Based Medicine Reviews (Cochrane Database and Cochrane Central Register of Controlled Trials), and Google Scholar...
June 8, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29890134/car-mediated-repression-of-cdkn1a-p21-is-accompanied-by-the-akt-activation
#12
Andrei A Yarushkin, Mark E Mazin, Anastasia Y Yunusova, Kseniya V Korchagina, Yuliya A Pustylnyak, Elena A Prokopyeva, Vladimir O Pustylnyak
It was shown that CAR participates in the regulation of many cell processes. Thus, the activation of CAR causes a proliferating effect in the liver, which provides grounds to consider CAR as a therapeutic target when having a partial resection of this organ. Even though a lot of work has been done on the function of CAR in regulating hepatocyte proliferation, very little has been done on its complex mediating mechanism. This study, therefore, showed that the liver growth resulting from CAR activation leads to the decline in the level of PTEN protein and subsequent Akt activation in mouse liver...
June 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29888756/estrogen-related-receptors-mediate-the-adaptive-response-of-brown-adipose-tissue-to-adrenergic-stimulation
#13
Erin L Brown, Bethany C Hazen, Elodie Eury, Jean-Sébastien Wattez, Marin L Gantner, Verena Albert, Sarah Chau, Manuel Sanchez-Alavez, Bruno Conti, Anastasia Kralli
Adrenergic stimulation of brown adipose tissue (BAT) induces acute and long-term responses. The acute adrenergic response activates thermogenesis by uncoupling oxidative phosphorylation and enabling increased substrate oxidation. Long-term, adrenergic signaling remodels BAT, inducing adaptive transcriptional changes that expand thermogenic capacity. Here, we show that the estrogen-related receptors alpha and gamma (ERRα, ERRγ) are collectively critical effectors of adrenergically stimulated transcriptional reprogramming of BAT...
April 27, 2018: iScience
https://www.readbyqxmd.com/read/29888544/should-the-mitral-valve-be-repaired-for-moderate-ischemic-mitral-regurgitation-at-the-time-of-revascularization-surgery
#14
REVIEW
Mohammad Y Salmasi, Amer Harky, Mohammed F Chowdhury, Ali Abdelnour, Anastasia Benjafield, Farah Suker, Stephanie Hubbard, Hunaid A Vohra
BACKGROUND: Ischemic mitral regurgitation (IMR) is associated with increased mortality and recurrent congestive heart failure following coronary artery bypass graft (CABG) surgery. While mitral surgery should be undertaken for severe MR during CABG, the treatment of moderate IMR remains controversial. We conducted a meta-analysis to determine the outcomes of CABG alone and combine with mitral valve repair (MVr) in moderate IMR. METHODS: A literature search was conducted by Pubmed, Ovid, and Embase, which included 643 articles...
June 10, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29886481/growth-hormone-deficiency-in-the-transition-age
#15
Sandro Loche, Natascia Di Iorgi, Giuseppa Patti, Serena Noli, Marta Giaccardi, Irene Olivieri, Anastasia Ibba, Mohamad Maghnie
Growth hormone (GH) is essential not only for normal growth during childhood, but also for the acquisition of bone mass and muscle strength in both sexes. This process is completed after the achievement of adult height in the phase of transition from adolescence to adulthood. Adolescents with childhood onset GH deficiency (GHD) show reduction of bone mineral density, decrease in lean body mass, increase in fat mass, and deterioration of the lipid profile. For this reason, continuation of GH replacement therapy in the transition age is recommended in all patients with a confirmed diagnosis of GHD...
2018: Endocrine Development
https://www.readbyqxmd.com/read/29886169/structure-and-gene-cluster-of-the-k125-capsular-polysaccharide-from-acinetobacter-baumannii-mar13-1452
#16
Nikolay P Arbatsky, Mikhail M Shneider, Andrei S Dmitrenok, Anastasia V Popova, Dmitry A Shagin, Andrey A Shelenkov, Yulia V Mikhailova, Mikhail V Edelstein, Yuriy A Knirel
A capsular polysaccharide (CPS) was isolated from strain MAR13-1452 of an emerging pathogen Acinetobacter baumannii and assigned type K125. The following structure of the CPS was established by sugar analysis, Smith degradation, and 1D and 2D 1 H and 13 C NMR spectroscopy: Proteins encoded by the KL125 gene cluster in the genome of MAR13-1452, including three glycosyltransferases, were assigned roles in the biosynthesis of the K125 CPS.
June 7, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29885959/increased-right-atrial-appendage-apoptosis-is-associated-with-differential-regulation-of-candidate-micrornas-1-and-133a-in-patients-who-developed-atrial-fibrillation-after-cardiac-surgery
#17
James N Tsoporis, Anastasia Fazio, Ioannis K Rizos, Shehla Izhar, Gerald Proteau, Vasileos Salpeas, Angelos Rigopoulos, Eleftarios Sakadakis, Ioannis K Toumpoulis, Thomas G Parker
Atrial fibrillation (AF) following on-pump coronary artery bypass grafting (CABG) is a common condition associated with increased morbidity and mortality. We investigated the possibility that miRs may play a contributory role in postoperative AF and associated apoptosis. A total of 42 patients (31 males and 11 females, mean age 65.0 ± 1.3 years) with sinus rhythm and without a history of AF were prospectively enrolled. We examined the levels of the muscle-specific miRs 1 and 133A and markers of apoptosis including TUNEL staining, caspase-3 activation, Bcl2 and Bax mRNAs in right atrial appendage (RAA) biopsies and blood plasma taken before aortic cross-clamping and after reperfusion...
June 7, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29885623/drug-resistant-tuberculosis-challenges-and-opportunities-for-diagnosis-and-treatment
#18
REVIEW
Anastasia Koch, Helen Cox, Valerie Mizrahi
With an estimated incidence of 490000 cases in 2016, multidrug resistant tuberculosis (TB), against which key first-line anti-tuberculars are less efficacious, presents major challenges for global health. Poor treatment outcomes coupled with a yawning treatment gap between those in need of second-line therapy and those who receive it, underscore the urgent need for new approaches to tackle the scourge of drug-resistant TB. Against this background, significant progress has been made in understanding the complex biology of TB drug resistance and disease pathogenesis, and in establishing a pipeline for delivering new drugs and drug combinations...
June 6, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29885382/pain-and-modifiable-risk-factors-among-weight-loss-seeking-veterans-with-overweight
#19
Kathryn M Godfrey, Anastasia Bullock, Lindsey Dorflinger, Kathryn M Min, Christopher Ruser, Robin M Masheb
OBJECTIVE: Overweight/obesity and chronic pain frequently co-occur and demonstrate a bidirectional relationship. Modifiable risk factors, such as eating behaviors and mental health symptoms, may be important to understand this relationship and improve interventions in Veterans. DESIGN: Cross-sectional. SETTING: Veterans Health Administration Medical Center outpatient clinic. SUBJECTS: The sample of Veterans (N = 126) was mostly male (89...
June 6, 2018: Appetite
https://www.readbyqxmd.com/read/29884113/genome-wide-association-and-genomic-prediction-of-resistance-to-viral-nervous-necrosis-in-european-sea-bass-dicentrarchus-labrax-using-rad-sequencing
#20
Christos Palaiokostas, Sophie Cariou, Anastasia Bestin, Jean-Sebastien Bruant, Pierrick Haffray, Thierry Morin, Joëlle Cabon, François Allal, Marc Vandeputte, Ross D Houston
BACKGROUND: European sea bass (Dicentrarchus labrax) is one of the most important species for European aquaculture. Viral nervous necrosis (VNN), commonly caused by the redspotted grouper nervous necrosis virus (RGNNV), can result in high levels of morbidity and mortality, mainly during the larval and juvenile stages of cultured sea bass. In the absence of efficient therapeutic treatments, selective breeding for host resistance offers a promising strategy to control this disease. Our study aimed at investigating genetic resistance to VNN and genomic-based approaches to improve disease resistance by selective breeding...
June 8, 2018: Genetics, Selection, Evolution: GSE
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