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rota ablation

Rentaro Okazaki, Toru Doi, Kentaro Hayakawa, Kazuhito Morioka, Osamu Imamura, Kunio Takishima, Makoto Hamanoue, Yasuhiro Sawada, Motoshi Nagao, Sakae Tanaka, Toru Ogata
BACKGROUND: Brain inflammation is a crucial component of demyelinating diseases such as multiple sclerosis. Although the initiation of inflammatory processes by the production of cytokines and chemokines by immune cells is well characterized, the processes of inflammatory aggravation of demyelinating diseases remain obscure. Here, we examined the contribution of Erk2, one of the isoforms of the extracellular signal-regulated kinase, to demyelinating inflammation. METHODS: We used the cuprizone-induced demyelinating mouse model...
September 5, 2016: Journal of Neuroinflammation
Prasanth Ganesan, Elizabeth M Cherry, Arkady M Pertsov, Behnaz Ghoraani
Atrial fibrillation (AF) is the most common arrhythmia in USA with more than 2.3 million people affected annually. Catheter ablation procedure is a method for treatment of AF, which involves 3D electroanatomic mapping of the patient's left atrium (LA) by maneuvering a conventional multipolar diagnostic catheter (MPDC) along the LA endocardial surface after which pulmonary vein (PV) isolation is performed, thus eliminating the AF triggers originating from the PVs. However, it remains unclear how to effectively utilize the information provided by the MPDC to locate the AF-sustaining sites, known as sustained rotor-like activities (RotAs)...
2015: BioMed Research International
Habib Khan, Kareem Salhiyyah, Sunil Ohri
Trapping of interventional devices used to treat in-stent restenosis is rarely reported in the literature. Among those is a trapped rota ablation wire causing longitudinal stent deformation, sometime requiring another stent deployment onto the collapse stent. A Rota ablator getting stuck into the stent is very rare, and a lethal complication. We report a case of 79-year-old gentleman who underwent rota ablation for in-stent restenosis. During the procedure, the rota ablator got stuck into the stent resulting in haemodynamic compromise...
May 2015: Interactive Cardiovascular and Thoracic Surgery
Mustafa Bulut, Rezzan Deniz Acar, Bilal Boztosun
Atherectomy is a procedure that clears blockages in the coronary arteries in order to improve blood flow to the heart and relieve symptoms of coronary artery disease. The procedure may be performed instead of or in addition to other procedures and can improve both the immediate and long-term success of balloon angioplasty and stenting. Although it is no longer a common procedure, it does play an important role in interventional cardiology. When the challenging atherosclerotic coronary artery lesions cannot be crossed by a balloon or cannot be adequately dilated even with non-compliant balloon, such lesions may be better treated by rota-ablation, which is carried out by operators who are experienced in rotational atherectomy...
April 2014: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
B Ghoraani, R Dalvi, S Gizurarson, M Das, A Ha, A Suszko, S Krishnan, V S Chauhan
BACKGROUND: In humans, the existence of rotors or reentrant sources maintaining atrial fibrillation (AF) and the underlying electroanatomic substrate has not been well defined. OBJECTIVE: Our aim was to determine the prevalence of localized rotational activation (RotA) in the left atrium (LA) during human AF and whether complex fractionated atrial electrograms (CFAEs) or low-voltage areas colocalize with RotA sites. METHODS: We prospectively studied 32 patients (mean age 57 ± 8 years; 88% with persistent AF) undergoing AF catheter ablation...
December 2013: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Elisabetta Cariani, Massimo Pilli, Alessandro Zerbini, Cristina Rota, Andrea Olivani, Paola Zanelli, Adele Zanetti, Tommaso Trenti, Carlo Ferrari, Gabriele Missale
PURPOSE: We evaluated the impact of the killer immunoglobulin-like receptors (KIR) of natural killer (NK) cells and of their HLA ligands over the clinical outcome of hepatitis C virus (HCV)-related hepatocellular carcinoma after curative treatment by either surgical resection or radiofrequency thermal ablation (RTA). EXPERIMENTAL DESIGN: Sixty-one consecutive patients with HCV-related hepatocellular carcinoma underwent KIR genotyping and HLA typing. A phenotypic/functional characterization of NK cells was carried out in patients with different KIR/KIR-ligand genotype...
October 1, 2013: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Xiaomeng Zhang, Linda J Rennick, W Paul Duprex, Bert K Rima
There is a paradox between the remarkable genetic stability of measles virus (MV) in the field and the high mutation rates implied by the frequency of the appearance of monoclonal antibody escape mutants generated when the virus is pressured to revert in vitro (S. J. Schrag, P. A. Rota, and W. J. Bellini, J. Virol. 73:51-54, 1999). We established a highly sensitive assay to determine frequencies of various categories of mutations in large populations of wild-type and laboratory-adapted MVs using recombinant viruses containing an additional transcription unit (ATU) encoding enhanced green fluorescent protein (EGFP)...
March 2013: Journal of Virology
Ada Rota, Paola Pregel, Francesca T Cannizzo, Alessandra Sereno, Simonetta Appino
This report describes an unusual case of uterine stump pyometra in a cat whose main clinical sign at presentation was abdominal straining. At the time of ovariohysterectomy, the surgeon reported that the uterine body had a purulent content. Nearly a month after the surgery the cat showed abdominal straining. The enlarged uterine stump, filled with purulent fluid, had caused a compression of the rectum and secondary intestinal sub-occlusion. Surgical revision consisted of draining the purulent content of the remnant of the uterine body and ablating as much of it as possible; checking of the ovarian pedicles revealed the presence of a small fragment of whitish tissue on the right side, which was shown to contain, by means of histological observation and immunohistochemical staining, ovarian tissue...
June 2011: Journal of Feline Medicine and Surgery
A A Khattab, G Richardt
Rotational atherectomy has been regaining interest over the last couple of years after it almost has disappeared from most interventional catheterization laboratories for several years due to failure to prove its original concept of improving long term results of percutaneous coronary interventions (PCI) as was repeatedly shown in studies in the 1990s. Its revival coupled the introduction of drug-eluting stents (DES); these devices have led to treating much more complex lesions and high-risk patients by PCI...
February 2008: Minerva Cardioangiologica
Marcello Rota, Nicole LeCapitaine, Toru Hosoda, Alessandro Boni, Antonella De Angelis, Maria Elena Padin-Iruegas, Grazia Esposito, Serena Vitale, Konrad Urbanek, Claudia Casarsa, Marco Giorgio, Thomas F Lüscher, Pier Giuseppe Pelicci, Piero Anversa, Annarosa Leri, Jan Kajstura
Diabetes leads to a decompensated myopathy, but the etiology of the cardiac disease is poorly understood. Oxidative stress is enhanced with diabetes and oxygen toxicity may alter cardiac progenitor cell (CPC) function resulting in defects in CPC growth and myocyte formation, which may favor premature myocardial aging and heart failure. We report that in a model of insulin-dependent diabetes mellitus, the generation of reactive oxygen species (ROS) leads to telomeric shortening, expression of the senescent associated proteins p53 and p16INK4a, and apoptosis of CPCs, impairing the growth reserve of the heart...
July 7, 2006: Circulation Research
Makoto Mutoh, Tetsuya Ishikawa, Hiroshi Sakamoto, Hisayuki Okada, Tetsuji Tsurusaki, Masato Ohta, Michiaki Higashitani, Junichi Yamaguchi, Takahiro Sato, Kenji Enta, Yuji Fuda, Kamon Imai, Toshinobu Horie, Satoru Onoda, Takahiro Shibata, Seibu Mochizuki
In the present study, the usefulness and feasibility of a new measuring microcatheter, the Navicath (Type-MUTO) microcatheter, for facilitating the stenting procedure subsequent to ablation using a rotablator (rota-stenting) is described. A method for measuring the length of the targeted lesion (lesion length) angiographically with the Navicath when exchanging the guide wires is presented using 2 representative cases of rota-stenting. In addition, the validity of the selected stent according to the measurement of lesion length with the Navicath was evaluated by comparing the length of the selected stent with lesion length before PCI measured by quantitative coronary angiography...
January 2006: International Heart Journal
Yasuji Kitabatake, Takatoshi Hikida, Dai Watanabe, Ira Pastan, Shigetada Nakanishi
The striatum in the basal ganglia-thalamocortical circuitry is a key neural substrate that is implicated in motor balance and procedural learning. The projection neurons in the striatum are dynamically modulated by nigrostriatal dopaminergic input and intrastriatal cholinergic input. The role of intrastriatal acetylcholine (ACh) in learning behaviors, however, remains to be fully clarified. In this investigation, we examine the involvement of intrastriatal ACh in different categories of learning by selectively ablating the striatal cholinergic neurons with use of immunotoxin-mediated cell targeting...
June 24, 2003: Proceedings of the National Academy of Sciences of the United States of America
A Kini, J D Marmur, S Duvvuri, G Dangas, S Choudhary, S K Sharma
We present our single-center experience of rotational atherectomy (RA) in the first 1,000 consecutive patients divided arbitrarily into three different time periods corresponding to significant changes in technique or equipment for RA. Period I (August 1994 to April 1995; 172 cases) is characterized by early experience, longer ablation, and frequent use of intra-aortic balloon pump; period II (May 1995 to January 1996; 254 cases) is characterized by short ablation runs (20-30 sec) and use of rotaflush; period III (February 1996 to February 1997; 574 cases) is characterized by ReoPro use, neosynephrine boluses to avoid hypotension, and rota floppy wire and flexible shaft burrs...
March 1999: Catheterization and Cardiovascular Interventions
S Della Casa, S M Corsello, M A Satta, C A Rota, P Putignano, V Vangeli, C Colosimo, C Anile, A Barbarino
We report a case of a 52-year-old woman presenting with a recurrence of a large pituitary adenoma with suprasellar extension and an overt Cushing's clinical picture, five years after successful transsphenoidal treatment. After transfrontal ablation of the tumour, followed by external radiotherapy, she was asymptomatic for six years before she exhibited epileptic seizures. A left frontal intracranial neoplasm was diagnosed and removed, and at histological examination it was found to be constituted by a localization of the pituitary ACTH secreting neoplasia...
1997: Annales D'endocrinologie
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