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Endometrial intra epithelial neoplasia

Yeliz Atik, Bilge Cetinkaya Demir, Hakan Ozan, Sema Baykara, Alp Usubutun, Fatma Yılmaz Erturk
AIM: To investigate the expression of Wilms' tumor 1 (WT1) protein in endometrial adenocarcinoma (EC) and endometrial intra-epithelial neoplasia (EIN). METHODS: WT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative (n = 7), secretory (n = 9) and atrophic endometrium (n = 9) and benign endometrial polyps (n = 28) was used as the control group. Cellular and vascular WT1 staining was scored semiquantitatively...
July 2016: Journal of Obstetrics and Gynaecology Research
Assem A M Elbiaa, Ibrahim A Abdelazim, Mohamed M Farghali, M Hussain, A E Omu
AIM OF THE STUDY: Aim of the study was to estimate the incidence of unexpected premalignant gynecological lesions in women undergoing vaginal hysterectomy for utero-vaginal prolapse. MATERIAL AND METHODS: Eighty women with asymptomatic utero-vaginal prolapse were included in this prospective study for vaginal hysterectomy after preoperative preparation and after written informed consent. Women included in this study were screened preoperatively by high vaginal swab, Pap smear, endometrial biopsy and trans-vaginal ultrasound...
September 2015: Przeglad Menopauzalny, Menopause Review
Aime Munro, Vincent Williams, James Semmens, Yee Leung, Colin J R Stewart, Jim Codde, Katrina Spilsbury, Nerida Steel, Paul Cohen, Peter O'leary
BACKGROUND: In 2006, Australia adopted a revised cervical cytology terminology system, known as the Australian Modified Bethesda System (AMBS). One substantial change in the AMBS was the introduction of the diagnostic category of atypical endocervical cells (AEC) of undetermined significance. AIM: The aim of this study was to investigate the incidence of histologically confirmed high-grade cervical dysplasia (cervical intra-epithelial neoplasia (CIN) grades 2 and 3 and adenocarcinoma in situ (ACIS)), cervical carcinoma and endometrial carcinoma in women presenting with AEC on cervical cytology...
June 2015: Australian & New Zealand Journal of Obstetrics & Gynaecology
Aytekin Tokmak, Ali Irfan Guzel, Emre Ozgu, Murat Oz, Serap Akbay, Salim Erkaya, Tayfun Gungor
BACKGROUND: To evaluate the clinical significance of atypical squamous cells of undetermined significance (ASCUS) in PAP test in post-menopausal women and compare with reproductive age women. MATERIALS AND METHODS: A total of 367 patients who referred to our gynecologic oncology clinic were included to the study between September 2012 and August 2013. Data for 164 post-menopausal (group 1) and 203 pre-menopausal (group 2) women with ASCUS cytology were evaluated retrospectively...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Junxia Gu, Xiaoyun Li, Yuting Liang, Longwei Qiao, Deyuan Ran, Yaojuan Lu, Xingang Li, Wenxiang Wei, Qiping Zheng
URI, or RMP, is a RNA polymerase II subunit RPB5-associated protein known to play essential roles in ubiquitination and transcription. Recently, we and others have shown that URI/RMP is also important for progression of hepatocellular carcinoma, ovarian, and prostate cancers. To identify the mechanistic basis of URI/RMP during multiple cellular processes, we investigated URI/RMP expression in a tissue microarray (TMA) containing multiple normal human tissues. The results showed that URI/RMP is ubiquitously but differentially expressed in these human tissues which partially explains its multiple cellular functions...
2013: International Journal of Clinical and Experimental Pathology
Osanna Y K Wan, Rachel Y K Cheung, Symphorosa S C Chan, Tony K H Chung
AIMS: To evaluate the risk of missing a malignancy in surgical specimens following hysterectomy for uterine prolapse if routine pathological examination is not performed. Additionally, information on the risk of missing an hitherto unsuspected malignancy if uterine preservation is the preferred management option will be provided. MATERIALS AND METHODS: A retrospective study was performed on all cases of surgery performed for uterine prolapse in a tertiary referral institution from 2003 to 2011...
April 2013: Australian & New Zealand Journal of Obstetrics & Gynaecology
Maria Wołuń-Cholewa, Krzysztof Szymanowski, Mirosław Andrusiewicz, Wojciech Warchoł
OBJECTIVE: The aim of the present study was to examine whether the effects of endometriosis-targeted photodynamic therapy (PDT), dependent on 5-aminolevulinic acid (ALA), rely on the presence of P-glycoprotein (P-gp), which is regarded as constituting one of the causes of multidrug resistance phenomenon. BACKGROUND: The significance of the undertaken studies reflects the complete absence of reports related to the modulation of P-gp activity and efficacy of PDT in patients with endometriosis...
December 2010: Photomedicine and Laser Surgery
Christine Nyiraneza, Etienne Marbaix, Mireille Smets, Christine Galant, Christine Sempoux, Karin Dahan
Lynch syndrome is an autosomal dominant cancer-susceptibility disorder caused by mutations in DNA mismatch repair genes. Women with Lynch syndrome have an increased lifetime risk for endometrial and ovarian cancers. While there is evidence of efficacy for prophylactic surgery, no standard recommendations have been developed to support screening for premalignant endometrial and ovarian epithelial lesions in high-risk women. Here, we report a case of a healthy woman carrying a germline mutation in MLH1 gene with endometrial intra-epithelial neoplasia and ovarian endometriotic lesions exhibiting a loss of MLH1 protein expression...
September 2010: Familial Cancer
Mo'iad Alazzam, Aileen Patterson, Mahmood Shafi
OBJECTIVE: To evaluate the role of cervical cytology and colposcopy in the management of patients with cervical smear reported "? glandular neoplasia". STUDY DESIGN: A retrospective study of 116 patients referred to the colposcopy clinic with cytology samples showing "? glandular neoplasia". RESULTS: Histological results were available for 114 patients; of those, 103 had cervical biopsy, 52 had endometrial biopsy and 41 patients had both. 17 (15...
April 2010: Archives of Gynecology and Obstetrics
G Ferrandina, G F Zannoni, E Martinelli, V Vellone, M G Prisco, G Scambia
Endometrial carcinosarcoma is a rare, aggressive disease, accounting for approximately 3% of all uterine neoplasms. The emergence of sarcomatous elements is considered the evolution of subclones arising from high grade endometrial carcinomas. Here, we report two cases of primary endometrial carcinomas recurring as carcinosarcoma. Case 1. a 58-year-old postmenopausal woman diagnosed to have a poorly differentiated endometrial endometrioid adenocarcinoma (FIGO stage IB) developed an intra-abdominal recurrence of disease after 17 months from diagnosis...
2007: Pathology, Research and Practice
J-L Brun, E Descat, B Boubli, D Dallay
Endometrial hyperplasias can be divided into two categories based on the presence or absence of cytological atypia and further classified as simple or complex according to the extent of architectural abnormalities. They are usually diagnosed because of irregular bleeding in perimenopause. Hysteroscopy with a biopsy gives a more accurate diagnosis than transvaginal ultrasonography, sonohysterography, or blind curettage. Endometrial hyperplasias with no cytological atypia, regarded as a response to unopposed endogenous estrogenic stimulation, are normally treated with progestins...
October 2006: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
J M Kirwan, C S Herrington, P A Smith, L S Turnbull, J J O Herod
The aims of this study were to review the diagnostic pathway of women with smears reported as 'glandular neoplasia' and to outline the management, colposcopy findings, treatment and final histological diagnosis in these women. The design was a retrospective review. A total of 114 women were identified over a 5-year period from the cytology database at the Royal Liverpool University Hospital Cytology Department, whose hospital case notes were available for review. Methods included a review of the case notes for the demographic details, indication for smear, colposcopic findings, investigation and/or treatment procedures, histology, final diagnosis and current disease status...
August 2004: Cytopathology: Official Journal of the British Society for Clinical Cytology
B Piura, A Rabinovich, M Huleihel
The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, which are capable of degradation of the proteins composing the extracellular matrix and basement membrane. Their proteolytic activity depends on their binding to metal Zinc and is controlled by tissue inhibitors of MMP (TIMPs). Degradation of the extracellular matrix and basement membrane is an important component of the process of tumor invasiveness, progression, angiogenesis and metastatic spread. Since MMPs may serve as markers of tumor behavior and as predictors of survival and since synthetic inhibitors of MMP may have a place in the treatment of cancer, researching MMPs and their tissue inhibitors in malignant diseases has attracted growing attention...
November 2003: Harefuah
L Mascarenhas, A van Beek, H C Bennink, J Newton
The objectives of this study were to evaluate the endometrial histology and cervical cytology of users of two contraceptive implants releasing etonogestrel/3-keto-desogestrel (Implanon) and levonorgestrel (Norplant) in West Midlands (UK) users. A 2-year prospective randomized design was used to study 60 implant users. Endometrial histology and cervical cytology were compared before insertion and after 12 and 24 months. At the end of 12 months, the majority of samples were inactive/weakly proliferative in both groups...
November 1998: Human Reproduction
J P Lefranc, L Juncker, A de Gayffier, J J Gelberg, J Blondon
Epidemiology and natural history of cervical and endometrial carcinomas are not identical. So, the part of surgery in their prevention is different. For cervical carcinoma, mass screening and prevention allowed reduction of rates of incidence and mortality. Surgery concerns such intra-epithelial neoplasias. All the procedures, either destructive, either ablative, expose to failures as recurrence of intra-epithelial neoplasia and more as invasive carcinoma. For high grade epidermoid intra-epithelial neoplasia, conisation is the best of ablative procedures to set up an accurate pathologic diagnosis and consequently to determine adequate therapy: conservative by conisation, total hysterectomy or extended hysterectomy and lymphadenectomy...
October 1997: Bulletin de L'Académie Nationale de Médecine
D Pfeiffer, R Kimmig, J Herrmann, M Ruge, A Fisseler-Eckhoff, P Scheidel, A Jensen, H Schatz, A Pfeiffer
The role of the epidermal-growth-factor receptor (EGFR) in cervical cancer is controversial, due to technical difficulties in localizing or in quantifying EGFR by homogenate assays or immunohistochemistry. Our autoradiographic approach, in combination with morphometry, allowed cell-type-specific quantification of EGFR, leading to the following observations: (i) In normal cervical epithelium, EGFR levels per cell were high in non-dividing squamous cells of the upper layers of normal epithelium, where a mitogenic function of these EGFRs can be excluded...
February 20, 1998: International Journal of Cancer. Journal International du Cancer
C W Burger, H M Prinssen, P Kenemans
Since 1982 LHRH agonists have been used as a treatment modality in patients with disseminated breast cancer and gynecologic malignancies, based on the assumption of steroid dependence of these cancers. They have been successfully used in the treatment of premenopausal women with breast cancer; response rates reported are 31-63%. Less optimistic results have been reported in postmenopausal breast cancer patients as well as in the treatment of women suffering from ovarian cancer. Response rates for treatment of postmenopausal breast- and ovarian cancer patients appear to be up to 22% and 29%, respectively...
July 1996: European Journal of Obstetrics, Gynecology, and Reproductive Biology
C C Yu, N Wilkinson, M J Brito, C H Buckley, H Fox, D A Levison
Immunohistochemical staining was carried out on a spectrum of normal, hyperplastic and malignant endometrial curettings, for proliferating cell nuclear antigen--PCNA (using the monoclonal antibody PC10) and for abnormally stabilized p53 (using the polyclonal antibody CM-1). The mean proportion of glandular epithelial cells showing PCNA immunoreactivity was significantly lower in atypical hyperplasia/intra-endometrial adenocarcinoma than in invasive adenocarcinoma, but the degree of overlap between the cases was such that this was not considered to be of diagnostic value...
October 1993: Histopathology
C La Vecchia, A Decarli, M Fasoli, S Franceschi, A Gentile, E Negri, F Parazzini, G Tognoni
We analysed data from a case-control investigation conducted in Milan, Northern Italy, to evaluate the relation between the use of combination oral contraceptives and the risk of cancers of the breast, ovary, endometrium and cervix uteri. For the present analysis, 776 cases of histologically confirmed breast cancer, 406 of epithelial ovarian cancer and 170 of endometrial cancer aged under 60 were compared with a group of 1,282 subjects below age 60 admitted for a spectrum of acute conditions apparently unrelated to oral contraceptive use or to any of the known or potential risk factors for the diseases under study...
August 1986: British Journal of Cancer
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