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What to do now in Heart Failure with Preserved Ejection Fraction

Akshay S Desai, Pardeep S Jhund
Although patients with heart failure and preserved ejection fraction (HF-PEF) represent nearly half of the population with chronic heart failure, few evidence-based medical therapies are available. The neutral overall results of the TOPCAT trial of spironolactone in HF-PEF leave clinicians who treat heart failure with an ongoing clinical dilemma. In this review, we outline an approach to the clinical management of the patient with HF-PEF synthesizing data from available clinical trials and expert consensus.
April 13, 2016: European Heart Journal
Pierpaolo Pellicori, John G F Cleland
PURPOSE OF REVIEW: The number of patients developing heart failure is increasing dramatically, and will likely continue to do so for the next few decades. At least half of the patients with symptoms and signs of heart failure have a normal left ventricular ejection fraction on echocardiography [heart failure with preserved ejection fraction (HFPEF)]. This review updates the current management of patients with HFPEF and summarizes what is in development. RECENT FINDINGS: Many different pathophysiologies may result in HFPEF...
January 19, 2015: Current Opinion in Cardiology
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