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Young Chul Kim, Dae Hoon Kim, Sang Eok Lee, Chan Hyung Kim, Woong Choi, Sang Jin Lee, Hyo-Yung Yun
OBJECTIVE: Spontaneous oscillation of tone of blood vessel called vasomotion cause vessel to flow blood which is an oscillation of flow into an organ. Microcirculation is sensitive to hypoxic condition and metabolism but mechanism of vasomotion is still poorly understood. DESIGN AND METHOD: Purpose: We studied involvement of metabolism-mediated regulation by intracellular ATP level of vasomotion in human gastric artery. METHODS: Conventional contractile measuring system and Western blot were used...
September 2016: Journal of Hypertension
John V Tyberg, Lindsay M Burrowes, Robert S Sheldon
No abstract text is available yet for this article.
June 14, 2016: Canadian Journal of Cardiology
Thomas F Lüscher
No abstract text is available yet for this article.
September 14, 2016: European Heart Journal
Artemis Ailianou, Karthik Ramachandran, Mary Beth Kossuth, James Paul Oberhauser, Julia A Kornfield
Poly(l-lactide) (PLLA) is the structural material of the first clinically approved bioresorbable vascular scaffold (BVS), a promising alternative to permanent metal stents for treatment of coronary heart disease. BVSs are transient implants that support the occluded artery for 6 mo and are completely resorbed in 2 y. Clinical trials of BVSs report restoration of arterial vasomotion and elimination of serious complications such as late stent thrombosis. It is remarkable that a scaffold made from PLLA, known as a brittle polymer, does not fracture when crimped onto a balloon catheter or during deployment in the artery...
September 26, 2016: Proceedings of the National Academy of Sciences of the United States of America
Young Chul Kim, Dae Hoon Kim, Sang Eok Lee, Chan Hyung Kim, Woong Choi, Sang Jin Lee, Hyo-Yung Yun
OBJECTIVE: Spontaneous oscillation of tone of blood vessel called vasomotion cause vessel to flow blood which is an oscillation of flow into an organ. Microcirculation is sensitive to hypoxic condition and metabolism but mechanism of vasomotion is still poorly understood. DESIGN AND METHOD: HASH(0x359d4c8) PURPOSE: We studied involvement of metabolism-mediated regulation by intracellular ATP level of vasomotion in human gastric artery. METHODS: Conventional contractile measuring system and Western blot were used...
September 2016: Journal of Hypertension
Nabil El Bitar, Bernard Pollin, Elias Georges Karroum, Ivanne Pincedé, Daniel Le Bars
In thermal neutral condition, rats display cyclic variations of the vasomotion of the tail and paws, the most widely used target organs in current acute or chronic animal models of pain. Systemic morphine elicits their vasoconstriction followed by hyperthermia in a naloxone-reversible and dose-dependant fashion. The dose-response curves were steep with ED50 in the 0.5-1 mg/kg range. Given the pivotal functional role of Rostral Ventro-medial Medulla (RVM) in nociception and rostral Medullary Raphe (rMR) in thermoregulation, two largely overlapping brain regions, the RVM/rMR was blocked by muscimol: it suppressed the effects of morphine...
September 7, 2016: Journal of Neurophysiology
Na-Na Ping, Yan-Ni Mi, Dong-Zheng Liu, Sai Zhang, Jing-Guo Chen, Yong-Xiao Cao
Cyclosporine A (CsA) induces hypertension after transplantation. Hydrogen sulfide (H2S) was found to have hypotensive/vasoprotective effects in the cardiovascular system. The present study aims to investigate the role of H2S on CsA-induced vascular function disorder in rats. Rats were subcutaneously injected with CsA 25 mg/kg for 21 days. Blood pressure was measured by the tail-cuff method. Vasomotion was determined using a sensitive myograph. Western blotting and immunohistochemistry were used to quantify the protein expression of endothelin type A (ETA) receptor and essential MAPK pathway molecules...
August 27, 2016: Cardiovascular Toxicology
Mark M Smits, Lennart Tonneijck, Marcel H A Muskiet, Trynke Hoekstra, Mark H H Kramer, Michaela Diamant, Erik H Serné, Daniël H van Raalte
OBJECTIVE: To assess the effects of glucagon-like peptide (GLP)-1-based therapies (ie, GLP-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) on microvascular function in patients with type 2 diabetes mellitus. APPROACH AND RESULTS: We studied 57 patients with type 2 diabetes mellitus (mean±SD age: 62.8±6.9 years; body mass index: 31.8±4.1 kg/m(2); HbA1c [glycated hemoglobin] 7.3±0.6%) in an acute and 12-week randomized, placebo-controlled, double-blind trial conducted at the Diabetes Center of the VU University Medical Center...
October 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Vladimir Blazek, Nikolai Blanik, Claudia R Blazek, Michael Paul, Carina Pereira, Marcus Koeny, Boudewijn Venema, Steffen Leonhardt
Because of their obvious advantages, active and passive optoelectronic sensor concepts are being investigated by biomedical research groups worldwide, particularly their camera-based variants. Such methods work noninvasively and contactless, and they provide spatially resolved parameter detection. We present 2 techniques: the active photoplethysmography imaging (PPGI) method for detecting dermal blood perfusion dynamics and the passive infrared thermography imaging (IRTI) method for detecting skin temperature distribution...
August 17, 2016: Anesthesia and Analgesia
Eduardo Nava, Silvia Llorens
During the last quarter of the past century, the leading role the endocrine and nervous systems had on the regulation of vasomotion, shifted towards a more paracrine-based regulation. This begun with the recognition of endothelial cells as active players of vascular control, when the vessel's intimal layer was identified as the main source of prostacyclin and was followed by the discovery of an endothelium-derived smooth muscle cell relaxing factor (EDRF). The new position acquired by endothelial cells prompted the discovery of other endothelium-derived regulatory products: vasoconstrictors, generally known as EDCFs, endothelin, and other vasodilators with hyperpolarizing properties (EDHFs)...
August 12, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Alicia M Schiller, Peter Ricci Pellegrino, Irving H Zucker
Tubuloglomerular feedback and the myogenic response are widely appreciated as important regulators of renal blood flow, but the role of the sympathetic nervous system in physiological renal blood flow control remains controversial. Where classic studies using static measures of renal blood flow failed, dynamic approaches have succeeded in demonstrating sympathetic control of renal blood flow under normal physiological conditions. This review focuses on transfer function analysis of renal pressure-flow, which leverages the physical relationship between blood pressure and flow to assess the underlying vascular control mechanisms...
August 3, 2016: Autonomic Neuroscience: Basic & Clinical
Viola Vaccarino, J Douglas Bremner
Women have more of the stress-related behavioral profile that has been linked to cardiovascular disease than men. For example, women double the rates of stress-related mental disorders such as depression and posttraumatic stress disorder (PTSD) than men, and have higher rates of exposure to adversity early in life. This profile may signal a female vulnerability towards cardiometabolic conditions linked to stress, especially coronary heart disease (CHD). Exposure to stress early in life is associated with enduring neurobiological changes in women that may affect cardiovascular risk...
August 2, 2016: Neuroscience and Biobehavioral Reviews
Leonardo A Rivera-Rivera, Tilman Schubert, Patrick Turski, Kevin M Johnson, Sara E Berman, Howard A Rowley, Cynthia M Carlsson, Sterling C Johnson, Oliver Wieben
Cerebral blood flow, arterial pulsation, and vasomotion may be important indicators of cerebrovascular health in aging and diseases of aging such as Alzheimer's disease. Noninvasive markers that assess these characteristics may be helpful in the study of co-occurrence of these diseases and potential additive and interacting effects. In this study, 4D flow MRI was used to measure intra-cranial flow features with cardiac-gated phase contrast MRI in cranial arteries and veins. Mean blood flow and pulsatility index as well as the transit time of the peak flow from the middle cerebral artery to the superior sagittal sinus were measured in a total of 104 subjects comprising of four groups: (a) subjects with Alzheimer's disease, (b) age-matched controls, (c) subjects with mild cognitive impairment, and (d) a group of late middle-aged with parental history of sporadic Alzheimer's disease...
August 4, 2016: Journal of Cerebral Blood Flow and Metabolism
Helmut R Lieder, Theodor Baars, Philipp Kahlert, Petra Kleinbongard
Stent implantation into aortocoronary saphenous vein grafts (SVG) releases particulate debris and soluble vasoactive mediators, for example, serotonin. We now analyzed effects of the soluble mediators released into the coronary arterial blood during stent implantation on vasomotion of isolated rat epicardial coronary artery segments and on coronary flow and left ventricular developed pressure in isolated perfused rat hearts. Coronary blood was retrieved during percutaneous SVG intervention using a distal occlusion/aspiration protection device in nine symptomatic patients with stable angina pectoris and a flow-limiting SVG stenosis...
August 2016: Physiological Reports
Giuseppe Giacchi, Luis Ortega-Paz, Salvatore Brugaletta, Kohki Ishida, Manel Sabaté
Coronary bioresorbable vascular scaffolds are a new appealing therapeutic option in interventional cardiology. The most used and studied is currently the Absorb BVS™. Its backbone is made of poly-L-lactide and coated by a thin layer of poly-D,L-lactide, it releases everolimus and is fully degraded to H2O and CO2 in 2-3 years. Absorb BVS™ seems to offer several theoretical advantages over metallic stent, as it gives temporary mechanical support to vessel wall without permanently caging it. Therefore, long-term endothelial function and structure are not affected...
2016: Medical Devices: Evidence and Research
Luca Testa, Azeem Latib, Rocco A Montone, Antonio Colombo, Francesco Bedogni
Bioresorbable vascular scaffolds (BVS) represent a promising novel approach for the treatment of coronary artery disease. BVS promise to address some of the well-known limitations of current drug-eluting stents, while providing a transient scaffolding of the vessel to prevent acute vessel closure/recoil. Drug elution by BVS prevents neointimal proliferation in a similar fashion to drug-eluting stents, and complete bioresorption is associated with late vessel lumen enlargement, plaque regression, and restoration of vasomotion...
July 2016: Circulation. Cardiovascular Interventions
Ryuji Tsuburaya, Jun Takahashi, Akihiro Nakamura, Eiji Nozaki, Masafumi Sugi, Yoshito Yamamoto, Tetsuya Hiramoto, Satoru Horiguchi, Kanichi Inoue, Toshikazu Goto, Atsushi Kato, Tsuyoshi Shinozaki, Eiko Ishida, Satoshi Miyata, Satoshi Yasuda, Hiroaki Shimokawa
AIMS: It is widely known that drug-eluting stents (DES) induce coronary vasomotion abnormalities. We have previously demonstrated that chronic treatment with long-acting nifedipine suppresses coronary hyperconstricting responses induced by the first-generation DES (e.g. sirolimus- and pacritaxel-eluting stents) through inhibition of vascular inflammation in pigs. To examine whether this is also the case with the second-generation DES (everolimus-eluting stents, EES) in humans, the most widely used DES in the world, we conducted a prospective, randomized, multicentre trial, termed as the NOVEL Study...
September 14, 2016: European Heart Journal
Dilpreet Buxi, Jean-Michel Redoute, Mehmet Rasit Yuce
OBJECTIVE: We have developed and tested a new architecture for pulse transit time (PTT) estimation at the central arteries using electrical bioimpedance, electrocardiogram and continuous wave radar to estimate cuffless blood pressure. METHODS: A transmitter and receiver antenna is placed at the sternum to acquire the arterial pulsation at the aortic arch. A four-electrode arrangement across the shoulders acquires arterial pulse across the carotid and subclavian arteries from bioimpedance as well as a bipolar lead I electrocardiogram...
June 20, 2016: IEEE Transactions on Bio-medical Engineering
David Balaz, Andrea Komornikova, Peter Sabaka, Elena Leichenbergova, Kristina Leichenbergova, Matej Novy, Darina Kralikova, Ludovit Gaspar, Andrej Dukat
OBJECTIVES: To investigate vasomotion in diabetic patients who underwent sessions of hyperbaric oxygen (HBO2) therapy. MATERIALS AND METHODS: Seventy-one patients with diabetes Type 2 and lower-extremity neuropathy were enrolled in a prospective matched case-control study. A total of 39 patients underwent 15 sessions of HBO2 therapy consisting of 90 minutes of breathing 100% oxygen at 2.5 atmospheres; 32 were included in the control group without exposure to hyperbaric oxygen...
March 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Christine Baumgartner, Johanna Brandl, Götz Münch, Martin Ungerer
Animal models of atherosclerosis often present limitations of transferability, since important hallmarks of human disease are not completely reproduced in other species. Rabbits have been used in several approaches: 1) inbred strains: Watanabe hereditary hyperlipidemic animals which express a defect in the LDL receptor, 2) transgenic rabbits, which overexpress human lipoproteins, and first knock-out rabbits. 3) native New Zealand white rabbits (NZW) fed with cholesterol-rich diet for at least 8 weeks represent the quickest way to establish arteriosclerosis...
July 2016: Progress in Biophysics and Molecular Biology
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