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Vasomotion

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https://www.readbyqxmd.com/read/28339503/rat-retinal-vasomotion-assessed-by-laser-speckle-imaging
#1
Anastasiia Y Neganova, Dmitry D Postnov, Olga Sosnovtseva, Jens Christian B Jacobsen
Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns...
2017: PloS One
https://www.readbyqxmd.com/read/28286048/effect-of-age-on-cutaneous-vasomotor-responses-during-local-skin-heating
#2
Gary J Hodges, Matthew M Mallette, Garry A Tew, John M Saxton, James Moss, Alan D Ruddock, Markos Klonizakis
This study examined the effect of ageing on the low-frequency oscillations (vasomotion) of skin blood flow in response to local heating (LH). Skin blood flow was assessed by laser-Doppler flowmetry on the forearm at rest (33°C) and in response to LH of the skin to both 42°C and 44°C in 14 young (24±1years) and 14 older (64±1years) participants. Vasomotion was analyzed using a wavelet transform to investigate power of the frequency intervals associated with endothelial, neural, myogenic, respiratory, and cardiac activities of the laser-Doppler signal...
March 9, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28275942/bioresorbable-polymers-and-stent-devices
#3
REVIEW
Payam Dehghani
Percutaneous coronary interventions will never become obsolete, as evolution is inherent to interventional cardiology. Current drug-eluting platforms have appreciably improved their safety and efficacy profiles in different clinical settings compared to first-generation devices such that it is difficult to consider other alternatives. However, there is definite biological plausibility to consider devices with bioabsorbable polymers and/or scaffolds. It is also an undeniable fact that many patients, based on variety of belief systems, would prefer not to have a permanently implanted device...
February 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28256323/ivabradine-in-acute-coronary-syndromes-protection-beyond-heart-rate-lowering
#4
Giampaolo Niccoli, Josip Anđelo Borovac, Vincenzo Vetrugno, Paolo G Camici, Filippo Crea
Ivabradine is a heart rate reducing agent that exhibits anti-ischemic effects through the inhibition of funny electrical current in the sinus node resulting in heart rate reduction, thus enabling longer diastolic perfusion time, and reduced myocardial oxygen consumption without detrimental changes in arterial blood pressure, coronary vasomotion, and ventricular contractility. The current guideline-based clinical use of Ivabradine is reserved for patients with stable angina pectoris who cannot tolerate or whose symptoms are inadequately controlled with beta blockers...
February 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28122732/na-k-atpase-regulates-intercellular-communication-in-the-vascular-wall-via-csrc-kinase-dependent-connexin43-phosphorylation
#5
Lise Hangaard, Elena V Bouzinova, Christian Staehr, Vibeke S Dam, Sukhan Kim, Zijian Xie, Christian Aalkjaer, Vladimir V Matchkov
Communication between vascular smooth muscle cells (VSMCs) is dependent on gap junctions and is regulated by the Na,K-ATPase. The Na,K-ATPase is therefore important for synchronized VSMCs oscillatory activity, i.e. vasomotion. The signaling between the Na,K-ATPase and gap junctions is unknown. We tested here the hypothesis that that this signaling involves cSrc kinase. Intercellular communication was assessed by membrane capacitance measurements of electrically coupled VSMCs. Vasomotion in isometric myograph, input resistance and synchronized [Ca(2+)]i transients were used as readout for intercellular coupling in rat mesenteric small arteries in vitro...
January 25, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28076449/long-term-follow-up-of-patients-after-percutaneous-coronary-intervention-with-everolimus-eluting-bioresorbable-vascular-scaffold
#6
Rafael Alexandre Meneguz-Moreno, José de Ribamar Costa, Freddy Antônio Britto Moscoso, Rodolfo Staico, Luiz Fernando Leite Tanajura, Marinella Patrizia Centemero, Auréa Jacob Chaves, Andrea Claudia Leão de Sousa Abizaid, Amanda Guerra de Moraes Rego E Sousa, Alexandre Antonio Cunha Abizaid
Background: Bioresorbable vascular scaffolds (BVS) were developed to improve the long-term results of percutaneous coronary intervention, restoring vasomotion. Objectives: To report very late follow-up of everolimus-eluting Absorb BVS (Abbott Vascular, Santa Clara, USA) in our center. Methods: Observational retrospective study, in a single Brazilian center, from August 2011 to October 2013, including 49 patients submitted to Absorb BVS implantation...
January 9, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28012648/impact-of-vasomotion-type-on-prognosis-of-coronary-artery-spasm-induced-by-acetylcholine-provocation-test-of-left-coronary-artery
#7
Eun Mi Lee, Man Ho Choi, Hong Seog Seo, Hyun Ki Kim, Nam-Ho Kim, Cheol Ung Choi, Jin Won Kim, Hong Euy Lim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Dong Joo Oh
BACKGROUND AND AIMS: The impact of vasomotion types on long-term clinical outcomes in patients with coronary artery spasm (CAS) induced by the acetylcholine provocation test (ACH-test) remains unclear. METHODS: We evaluated 4644 consecutive patients with typical resting chest pain (CP), but no angiographically significant coronary artery lesion (<50% stenosis), who underwent an ACH-test. According to their vasomotor response, patients were categorized into four types: normal vasomotion (no CP, no ischemic electrocardiographic changes, and no vasoconstriction), microvascular spasm (CP with <75% vasoconstriction but with CP relief after nitroglycerin infusion), epicardial spasm (CP with ≥75% vasoconstriction), and ACH-test inconclusive (vasoconstriction and/or electrocardiographic changes, but no CP)...
February 2017: Atherosclerosis
https://www.readbyqxmd.com/read/27976498/insulin-treatment-restores-islet-microvascular-vasomotion-function-in-diabetic-mice
#8
Mingming Liu, Xiaoyan Zhang, Ailing Li, Xu Zhang, Bing Wang, Bingwei Li, Shuying Liu, Hongwei Li, Ruijuan Xiu
BACKGROUND: Microcirculation plays an important role in the pathogenesis of diabetes and its complications. We hypothesize that pancreatic-islet microvascular vasomotion as a parameter of functional status of pancreatic-islet microcirculation is abnormal in diabetic mice and insulin treatment might restore that dysfunction. METHODS: Mice were divided into non-diabetic control, untreated diabetic and diabetic treated with insulingroups (n = 6 in each group) randomly...
December 15, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27969766/tct-416-in-vivo-assessment-of-endothelial-dependent-vasomotion-in-a-coronary-segment-treated-by-the-second-generation-drug-eluting-absorbable-metal-scaffold-dreams-2g-insights-from-the-biosolve-ii-first-in-man-trial
#9
Michael Haude, Hubertus Degen, Hector Manel Garcia-Garcia, Ron Waksman, Myriam Stieler
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27912202/bioresorbable-stents-current-and-upcoming-bioresorbable-technologies
#10
REVIEW
Hui Ying Ang, Heerajnarain Bulluck, Philip Wong, Subbu S Venkatraman, Yingying Huang, Nicolas Foin
Bioresorbable scaffolds (BRS) represent a novel horizon in interventional cardiology for the treatment of coronary artery disease. The technology was introduced to overcome limitations of current metallic drug-eluting stents such as late in-stent restenosis and permanently caging the vessel. The concept of the BRS is to provide temporal support to the vessel during healing before being degraded and resorbed by the body, promoting restoration of the vessel vasomotion. Currently, there are several BRS that are under development or already commercially available...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27907892/the-parallel-tales-of-microvascular-angina-and-heart-failure-with-preserved-ejection-fraction-a-paradigm-shift
#11
Filippo Crea, C Noel Bairey Merz, John F Beltrame, Juan Carlos Kaski, Hisao Ogawa, Peter Ong, Udo Sechtem, Hiroaki Shimokawa, Paolo G Camici
No abstract text is available yet for this article.
October 23, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27858702/both-flow-mediated-dilation-and%C3%A2-constriction-are-associated-with%C3%A2-changes-in%C3%A2-blood-flow-and-shear-stress-%C3%A2-two%C3%A2-complementary-perspectives-on%C3%A2-endothelial-function
#12
EDITORIAL
Tommaso Gori, Urs von Henning, Selina Muxel, Sarina Schaefer, Federica Fasola, Marcus Vosseler, Boris Schnorbus, Harald Binder, John D Parker, Thomas Münzel
INTRODUCTION: Flow-mediated dilation (FMD) quantifies endothelium-dependent vasomotor responses to short-term increases in blood flow. Low-flow mediated vasoconstriction (L-FMC) has been more recently introduced as additional measure of endothelial function, and its relationship with changes in blood flow, cardiovascular risk factors and FMD ha∧s been less well characterized. MATERIALS AND METHODS: We evaluated radial artery FMD and L-FMC along with the changes in blood flow and shear rate/stress in 584 patients with known or suspected coronary artery disease (72...
2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27816391/the-coupling-between-peripheral-microcirculation-and-slow-breathing
#13
Zehava Ovadia-Blechman, Benjamin Gavish, Danit Levy-Aharoni, David Shashar, Vered Aharonson
Vasomotion (rhythmic changes in arteriolar diameter) is believed to enhance tissue perfusion at low oxygenation levels. We hypothesized that slow breathing and vasomotion may correlate temporally ("coupling"), especially at low oxygenation levels. We paced down spontaneous breathing to about 5 or 6breaths/min in 14 healthy subjects using device-guided breathing (DGB), and continuously monitored respiration, transcutaneous oxygen pressure ("oxygenation"), and skin capillary blood flow ("microflow") using a laser Doppler flowmeter...
January 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27806897/comparison-of-an-everolimus-eluting-bioresorbable-scaffold-with-an-everolimus-eluting-metallic-stent-for-the-treatment-of-coronary-artery-stenosis-absorb-ii-a-3-year-randomised-controlled-single-blind-multicentre-clinical-trial
#14
Patrick W Serruys, Bernard Chevalier, Yohei Sotomi, Angel Cequier, Didier Carrié, Jan J Piek, Ad J Van Boven, Marcello Dominici, Dariusz Dudek, Dougal McClean, Steffen Helqvist, Michael Haude, Sebastian Reith, Manuel de Sousa Almeida, Gianluca Campo, Andrés Iñiguez, Manel Sabaté, Stephan Windecker, Yoshinobu Onuma
BACKGROUND: No medium-term data are available on the random comparison between everolimus-eluting bioresorbable vascular scaffolds and everolimus-eluting metallic stents. The study aims to demonstrate two mechanistic properties of the bioresorbable scaffold: increase in luminal dimensions as a result of recovered vasomotion of the scaffolded vessel. METHODS: The ABSORB II trial is a prospective, randomised, active-controlled, single-blind, parallel two-group, multicentre clinical trial...
November 19, 2016: Lancet
https://www.readbyqxmd.com/read/27753906/os-02-06-physiological-regulation-of-vasomotion-by-intracellular-atp-mediated-system-in-human-artery
#15
Young Chul Kim, Dae Hoon Kim, Sang Eok Lee, Chan Hyung Kim, Woong Choi, Sang Jin Lee, Hyo-Yung Yun
OBJECTIVE: Spontaneous oscillation of tone of blood vessel called vasomotion cause vessel to flow blood which is an oscillation of flow into an organ. Microcirculation is sensitive to hypoxic condition and metabolism but mechanism of vasomotion is still poorly understood. DESIGN AND METHOD: Purpose: We studied involvement of metabolism-mediated regulation by intracellular ATP level of vasomotion in human gastric artery. METHODS: Conventional contractile measuring system and Western blot were used...
2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27687721/hemodynamic-evaluation-of-vasomotion-capacitance-vs-conductance
#16
John V Tyberg, Lindsay M Burrowes, Robert S Sheldon
No abstract text is available yet for this article.
June 14, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27678182/an-update-on-interventional-cardiology-management-of-cto-performance-of-absorbable-scaffolds-coronary-vasomotion-after-des-and-antithrombotics
#17
Thomas F Lüscher
No abstract text is available yet for this article.
September 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27671659/multiplicity-of-morphologies-in-poly-l-lactide-bioresorbable-vascular-scaffolds
#18
Artemis Ailianou, Karthik Ramachandran, Mary Beth Kossuth, James Paul Oberhauser, Julia A Kornfield
Poly(l-lactide) (PLLA) is the structural material of the first clinically approved bioresorbable vascular scaffold (BVS), a promising alternative to permanent metal stents for treatment of coronary heart disease. BVSs are transient implants that support the occluded artery for 6 mo and are completely resorbed in 2 y. Clinical trials of BVSs report restoration of arterial vasomotion and elimination of serious complications such as late stent thrombosis. It is remarkable that a scaffold made from PLLA, known as a brittle polymer, does not fracture when crimped onto a balloon catheter or during deployment in the artery...
October 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27643252/os-02-06-physiological-regulation-of-vasomotion-by-intracellular-atp-mediated-system-in-human-artery
#19
Young Chul Kim, Dae Hoon Kim, Sang Eok Lee, Chan Hyung Kim, Woong Choi, Sang Jin Lee, Hyo-Yung Yun
OBJECTIVE: Spontaneous oscillation of tone of blood vessel called vasomotion cause vessel to flow blood which is an oscillation of flow into an organ. Microcirculation is sensitive to hypoxic condition and metabolism but mechanism of vasomotion is still poorly understood. DESIGN AND METHOD: HASH(0x3150910) PURPOSE: We studied involvement of metabolism-mediated regulation by intracellular ATP level of vasomotion in human gastric artery. METHODS: Conventional contractile measuring system and Western blot were used...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27605533/entanglement-between-thermoregulation-and-nociception-in-the-rat-the-case-of-morphine
#20
Nabil El Bitar, Bernard Pollin, Elias Karroum, Ivanne Pincedé, Daniel Le Bars
In thermoneutral conditions, rats display cyclic variations of the vasomotion of the tail and paws, the most widely used target organs in current acute or chronic animal models of pain. Systemic morphine elicits their vasoconstriction followed by hyperthermia in a naloxone-reversible and dose-dependent fashion. The dose-response curves were steep with ED50 in the 0.5-1 mg/kg range. Given the pivotal functional role of the rostral ventromedial medulla (RVM) in nociception and the rostral medullary raphe (rMR) in thermoregulation, two largely overlapping brain regions, the RVM/rMR was blocked by muscimol: it suppressed the effects of morphine...
December 1, 2016: Journal of Neurophysiology
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