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https://www.readbyqxmd.com/read/28268068/understanding-mechanisms-to-improve-exercise-interventions-in-tendinopathy
#1
EDITORIAL
Peter Malliaras
No abstract text is available yet for this article.
December 23, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28263552/polyelectrolyte-layer-by-layer-assembly-on-organic-electrochemical-transistors
#2
Anna-Maria Pappa, Sahika Inal, Kirsty Roy, Yi Zhang, Charalampos Pitsalidis, Adel Hama, Jolien Pas, George G Malliaras, Roisin M Owens
Oppositely charged polyelectrolyte multilayers (PEMs) were built up in a layer-by-layer (LbL) assembly on top of the conducting polymer channel of an organic electrochemical transistor (OECT), aiming to combine the advantages of well-established PEMs with a high performance electronic transducer. The multilayered film is a model system to investigate the impact of biofunctionalization on the operation of OECTs comprising a poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS) film as the electrically active layer...
March 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28151759/patellar-tendinopathy-and-potential-risk-factors-an-international-database-of-cases-and-controls
#3
Sarah Morton, Sean Williams, Xavier Valle, David Diaz-Cueli, Peter Malliaras, Dylan Morrissey
OBJECTIVES: Numerous risk factors have been identified for patellar tendinopathy (PT), often in small population studies. The aim was to use an international online questionnaire to generate a large database and identify significant risk factors. DESIGN: Case-control study. SETTING: Private practice and sporting teams recruited from England, Spain, and Italy with the questionnaire available in all 3 languages (equivalence between online and self-administration shown previously)...
February 1, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28134450/lactate-detection-in-tumor-cell-cultures-using-organic-transistor-circuits
#4
Marcel Braendlein, Anna-Maria Pappa, Marc Ferro, Alexia Lopresti, Claire Acquaviva, Emilie Mamessier, George G Malliaras, Róisín M Owens
A biosensing platform based on an organic transistor circuit for metabolite detection in highly complex biological media is introduced. The sensor circuit provides inherent background subtraction allowing for highly specific, sensitive lactate detection in tumor cell cultures. The proposed sensing platform paves the way toward rapid, label-free, and cost-effective clinically relevant in vitro diagnostic tools.
April 2017: Advanced Materials
https://www.readbyqxmd.com/read/28121395/inkjet-printed-pedot-pss-electrodes-on-paper-for-electrocardiography
#5
Eloïse Bihar, Timothée Roberts, Mohamed Saadaoui, Thierry Hervé, Jozina B De Graaf, George G Malliaras
Inkjet-printed PEDOT:PSS electrodes are shown to record cutaneous electrophysiological signals such as electrocardiograms via a simple finger-to-electrode contact. The recordings are of high quality and show no deterioration over a 3 month period, paving the way for the development of the next generation of low-cost, convenient-to-use healthcare monitoring devices.
January 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28105401/voltage-amplifier-based-on-organic-electrochemical-transistor
#6
Marcel Braendlein, Thomas Lonjaret, Pierre Leleux, Jean-Michel Badier, George G Malliaras
Organic electrochemical transistors (OECTs) are receiving a great deal of attention as amplifying transducers for electrophysiology. A key limitation of this type of transistors, however, lies in the fact that their output is a current, while most electrophysiology equipment requires a voltage input. A simple circuit is built and modeled that uses a drain resistor to produce a voltage output. It is shown that operating the OECT in the saturation regime provides increased sensitivity while maintaining a linear signal transduction...
January 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28002923/tendinopathic-supraspinatus-tenocytes-may-have-a-neuroendocrine-like-function-secreting-cgrp-sp-and-vegf-a-pilot-immunohistochemistry-study
#7
R Sahemey, P Malliaras, J S Lewis, G J Michael, P Shortland, D Morrissey, N Maffulli
We wanted to observe and compare the appearance of neurovascular tissue from tendon ex vivo, in patients with and without painful rotator cuff tendinopathy. Supraspinatus tendons were biopsied from 5 participants with painful tendinopathy and normal tendon from a young male. Slides were stained with haematoxylin and eosin and toluidine blue for histological assessment. Immunohistochemical markers for general nerves (protein gene-product 9.5 and synaptophysin), sensory nerves (calcitonin gene-related peptide; substance-P) and vascularisation (vascular endothelial growth factor) were used...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27976677/erratum-n-type-organic-electrochemical-transistors-with-stability-in-water
#8
Alexander Giovannitti, Christian B Nielsen, Dan-Tiberiu Sbircea, Sahika Inal, Mary Donahue, Muhammad R Niazi, David A Hanifi, Aram Amassian, George G Malliaras, Jonathan Rivnay, Iain McCulloch
No abstract text is available yet for this article.
December 15, 2016: Nature Communications
https://www.readbyqxmd.com/read/27974769/the-rise-of-plastic-bioelectronics
#9
REVIEW
Takao Someya, Zhenan Bao, George G Malliaras
Plastic bioelectronics is a research field that takes advantage of the inherent properties of polymers and soft organic electronics for applications at the interface of biology and electronics. The resulting electronic materials and devices are soft, stretchable and mechanically conformable, which are important qualities for interacting with biological systems in both wearable and implantable devices. Work is currently aimed at improving these devices with a view to making the electronic-biological interface as seamless as possible...
December 14, 2016: Nature
https://www.readbyqxmd.com/read/27970213/tct-820-multivessel-intracoronary-infusion-of-allogeneic-cardiosphere-derived-cells-in-dilated-cardiomyopathy-long-term-outcomes-of-the-dilated-cardiomyopathy-intervention-with-allogeneic-myocardially-regenerative-cells-dynamic-trial
#10
Tarun Chakravarty, Raj Makkar, Timothy Henry, Michelle Kittleson, John Friedman, Daniel Berman, Joao Lima, Konstantinos Malliaras, Robert Siegel, Leandro Slipczuk, Jeff Rudy, Eduardo Marban, Janice Pogoda, Linda Marban, Deborah Ascheim
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27923685/a-combined-cellular-and-surgical-ventricular-reconstruction-therapeutic-approach-produces-attenuation-of-remodeling-in-infarcted-rats
#11
Michael J Bonios, Maria Anastasiou-Nana, Despina N Perrea, Konstantinos Malliaras
BACKGROUND: Left ventricular reconstruction (LVR) has been shown to provide transient benefits to the LV structure and function of infarcted hearts; however, long-term results have been disappointing as LVR-induced benefits are typically not sustained. We hypothesized that administration of cardiosphere-derived cells (CDCs), which promote myocardial repair and regeneration, may result in long-term preservation of the beneficial effects of LVR in ischemic cardiomyopathy. METHODS: Wistar Kyoto rats underwent myocardial infarction (MI) and two weeks later were randomized into 3 groups: in Group 1 (n=9), LVR was performed by plication of the infarcted apex and CDCs were injected in the infarct border zone (IBZ); group 2 animals (n=9) underwent LVR and received vehicle solution in the IBZ; and Group 3 animals (n=10) were injected with vehicle solution in the IBZ without undergoing LVR...
December 5, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27890630/arteriovenous-renal-replacement-therapy-in-end-stage-left-sided-heart-failure-patients-has-a-detrimental-effect-on-patients-with-impaired-right-ventricular-function
#12
Evangelos Repasos, Elisabeth Kaldara, Christos Pantsios, Chris Kapelios, Emmeleia Nana, Spiridon Vernadakis, Christina Melexopoulou, Konstantinos Malliaras, John Boletis, John N Nanas
OBJECTIVE: Chronic intermittent renal replacement therapy(RRT) is an alternate method of decongestion for patients presenting with diuretic-resistant, end-stage heart failure(HF) and cardiorenal syndrome. The optimal method of vascular access has not been confirmed. This study investigated the 6-month outcomes of patients with end-stage HF after the creation of arteriovenous communications (AVC) compared with other means of RRT. METHODS: We treated 40 patients with chronic, intermittent, ambulatory RRT, of whom 15 (37...
November 23, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27885829/autoclave-sterilization-of-pedot-pss-electrophysiology-devices
#13
Ilke Uguz, Mehran Ganji, Adel Hama, Atsunori Tanaka, Sahika Inal, Ahmed Youssef, Roisin M Owens, Pascale P Quilichini, Antoine Ghestem, Christophe Bernard, Shadi A Dayeh, George G Malliaras
Autoclaving, the most widely available sterilization method, is applied to poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) electrophysiology devices. The process does not harm morphology or electrical properties, while it effectively kills E. coli intentionally cultured on the devices. This finding paves the way to widespread introduction of PEDOT:PSS electrophysiology devices to the clinic.
December 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27845503/is-the-heavy-slow-resistance-program-effective-for-all-patients-with-tendinopathy-and-effective-for-all-its-sites
#14
Dimitrios Stasinopoulos, Peter Malliaras
No abstract text is available yet for this article.
November 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27790983/controlling-the-mode-of-operation-of-organic-transistors-through-side-chain-engineering
#15
Alexander Giovannitti, Dan-Tiberiu Sbircea, Sahika Inal, Christian B Nielsen, Enrico Bandiello, David A Hanifi, Michele Sessolo, George G Malliaras, Iain McCulloch, Jonathan Rivnay
Electrolyte-gated organic transistors offer low bias operation facilitated by direct contact of the transistor channel with an electrolyte. Their operation mode is generally defined by the dimensionality of charge transport, where a field-effect transistor allows for electrostatic charge accumulation at the electrolyte/semiconductor interface, whereas an organic electrochemical transistor (OECT) facilitates penetration of ions into the bulk of the channel, considered a slow process, leading to volumetric doping and electronic transport...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27717052/integration-of-organic-electrochemical-and-field-effect-transistors-for-ultraflexible-high-temporal-resolution-electrophysiology-arrays
#16
Wonryung Lee, Dongmin Kim, Jonathan Rivnay, Naoji Matsuhisa, Thomas Lonjaret, Tomoyuki Yokota, Hiromu Yawo, Masaki Sekino, George G Malliaras, Takao Someya
Integration of organic electrochemical transistors and organic field effect transistors has been successfully realized on a 600 nm thick parylene film toward an electrophysiology array. Single cell of integrated device and a 2 × 2 electrophysiology array have succeeded in detecting electromyogram with locally stimulating the motor nerve bundle of a transgenic rat by a laser pulse.
September 22, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27713414/n-type-organic-electrochemical-transistors-with-stability-in-water
#17
Alexander Giovannitti, Christian B Nielsen, Dan-Tiberiu Sbircea, Sahika Inal, Mary Donahue, Muhammad R Niazi, David A Hanifi, Aram Amassian, George G Malliaras, Jonathan Rivnay, Iain McCulloch
Organic electrochemical transistors (OECTs) are receiving significant attention due to their ability to efficiently transduce biological signals. A major limitation of this technology is that only p-type materials have been reported, which precludes the development of complementary circuits, and limits sensor technologies. Here, we report the first ever n-type OECT, with relatively balanced ambipolar charge transport characteristics based on a polymer that supports both hole and electron transport along its backbone when doped through an aqueous electrolyte and in the presence of oxygen...
October 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27652141/the-effect-of-long-term-amiodarone-administration-on-myocardial-fibrosis-and-evolution-of-left-ventricular-remodeling-in-a-porcine-model-of-ischemic-cardiomyopathy
#18
Anastasia Zagorianou, Meletios Marougkas, Stavros G Drakos, Nikolaos Diakos, Panagiotis Konstantopoulos, Despina N Perrea, Maria Anastasiou-Nana, Konstantinos Malliaras
Amiodarone is effective in suppressing arrhythmias in heart failure patients. We investigated the effect of long-term amiodarone administration on myocardial fibrosis and left ventricular (LV) remodeling in a porcine model of ischemic cardiomyopathy. Eighteen infarcted farm pigs were randomized to receive long-term amiodarone administration for 3 months (n = 9) or conventional follow-up (n = 9). Evolution of LV remodeling over 3 months post-myocardial infarction was examined at tissue level (myocyte size, myocardial fibrosis and vascular density assessed by whole-field digital histopathology), organ level (LV structure and function assessed by echocardiography), and systemic level (BNP and MMP-9 levels)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27643472/cardioprotective-effects-of-intracoronary-administration-of-4-chlorodiazepam-in-small-and-large-animal-models-of-ischemia-reperfusion
#19
Michalis Tsamatsoulis, Chris J Kapelios, Lambros Katsaros, Stella Vakrou, Vasilis Sousonis, Stefania Sventzouri, Nicholas Michelinakis, Despoina N Perrea, Maria Anastasiou-Nana, Konstantinos Malliaras
BACKGROUND: The Translocator Protein (TSPO) of the mitochondrial membrane has been recognized as a potential therapeutic target for mitigation of myocardial ischemia-reperfusion injury. Administration of 4-chlorodiazepam (4-CLD), a TSPO ligand, has been shown to confer acute cardioprotective effects in small animals; however, long-term studies and studies in clinically-relevant large animal models are lacking. In the present study we investigated a potential cardioprotective effect of intracoronary administration of 4-CLD in small and large animal models of ischemia-reperfusion...
December 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27506784/bioelectronic-neural-pixel-chemical-stimulation-and-electrical-sensing-at-the-same-site
#20
Amanda Jonsson, Sahika Inal, Llke Uguz, Adam J Williamson, Loïg Kergoat, Jonathan Rivnay, Dion Khodagholy, Magnus Berggren, Christophe Bernard, George G Malliaras, Daniel T Simon
Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale...
August 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
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