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https://www.readbyqxmd.com/read/29054749/men-with-unilateral-achilles-tendinopathy-have-impaired-balance-on-the-symptomatic-side
#1
M Scholes, S Stadler, D Connell, C Barton, R A Clarke, A L Bryant, P Malliaras
OBJECTIVES: To investigate single leg standing balance in males with mid-portion Achilles tendinopathy (AT). DESIGN: Cross sectional case study. METHODS: Centre of pressure (COP) path length was measured using a Wii Balance Board (WBB) in 21 male participants (20-60 years) with unilateral mid-portion AT during single-limb standing on each limb with eyes open and closed. Ultrasound imaging of both Achilles tendons was also performed by one blinded assessor, and the anteroposterior (AP) thickness and presence of pathology was determined...
October 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28993403/cognitive-and-contextual-factors-to-optimise-clinical-outcomes-in-tendinopathy
#2
EDITORIAL
Adrian James Mallows, James Robert Debenham, Peter Malliaras, Richmond Stace, Chris Littlewood
No abstract text is available yet for this article.
October 9, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28930452/electrowetting-on-immersed-conducting-hydrogel
#3
Caroline Duc, Alexis Vlandas, George G Malliaras, Vincent Senez
Conducting polymers demonstrate an interesting ability to change their wettability at ultralow voltage (<1 V). While the conducting hydrogel poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS) is increasingly used as an interface with biology partly thanks to its mechanical properties, little is known about the electrical control of its wettability. We rely on the captive bubble technique to study this hydrogel property under relevant conditions (fully immerged). We here report that the wettability variations of PEDOT:PSS are driven by an electrowetting phenomenon in contrast to other conducting polymers which are thought to undergo wettability changes due to oxido-reduction reactions...
October 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28923928/transparent-conformable-active-multielectrode-array-using-organic-electrochemical-transistors
#4
Wonryung Lee, Dongmin Kim, Naoji Matsuhisa, Masae Nagase, Masaki Sekino, George G Malliaras, Tomoyuki Yokota, Takao Someya
Mechanically flexible active multielectrode arrays (MEA) have been developed for local signal amplification and high spatial resolution. However, their opaqueness limited optical observation and light stimulation during use. Here, we show a transparent, ultraflexible, and active MEA, which consists of transparent organic electrochemical transistors (OECTs) and transparent Au grid wirings. The transparent OECT is made of Au grid electrodes and has shown comparable performance with OECTs with nontransparent electrodes/wirings...
October 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28888021/simultaneous-monitoring-of-single-cell-and-of-micro-organ-activity-by-pedot-pss-covered-multi-electrode-arrays
#5
Dimitrios A Koutsouras, Romain Perrier, Ariana Villarroel Marquez, Antoine Pirog, Eileen Pedraza, Eric Cloutet, Sylvie Renaud, Matthieu Raoux, George G Malliaras, Jochen Lang
Continuous and long-term monitoring of cellular and micro-organ activity is required for new insights into physiology and novel technologies such as Organs-on-Chip. Moreover, recent advances in stem cell technology and especially in the field of diabetes call for non-invasive approaches in quality testing of the large quantities of surrogate pancreatic islets to be generated. Electrical activity of such a micro-organ results in single cell action potentials (APs) of high frequency and in low frequency changes in local field potentials (slow potentials or SPs), reflecting coupled cell activity and overall organ physiology...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865991/highly-porous-scaffolds-of-pedot-pss-for-bone-tissue-engineering
#6
Anne Géraldine Guex, Jennifer L Puetzer, Astrid Armgarth, Elena Littmann, Eleni Stavrinidou, Emmanuel P Giannelis, George G Malliaras, Molly M Stevens
Conjugated polymers have been increasingly considered for the design of conductive materials in the field of regenerative medicine. However, optimal scaffold properties addressing the complexity of the desired tissue still need to be developed. The focus of this study lies in the development and evaluation of a conductive scaffold for bone tissue engineering. In this study PEDOT:PSS scaffolds were designed and evaluated in vitro using MC3T3-E1 osteogenic precursor cells, and the cells were assessed for distinct differentiation stages and the expression of an osteogenic phenotype...
October 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28717612/intratendinous-tears-of-the-achilles-tendon-a-new-pathology-analysis-of-a-large-4-year-cohort
#7
Otto Chan, Sarah Morton, Mel Pritchard, Tina Parkes, Peter Malliaras, Tom Crisp, Nat Padhiar, Nicola Maffulli, John King, Dylan Morrissey
BACKGROUND: Achillodynia is common and includes Achilles tendinopathy, partial Achilles tears and Achilles tendon ruptures. However, we believe an additional pathology should be considered for Achillodynia differentials - the intratendinous tear (ITT). METHODS: Examinations of 740 achillodynic patients in one specialist centre were reviewed. ITTs were defined as a clearly visualised echopoor area situated centrally and extending to, but not through the tendon periphery, with pain on palpation and no clinical findings consistent with Achilles rupture...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28642226/measuring-patient-reported-outcomes-pros-proms-in-people-with-achilles-tendinopathy-how-useful-is-the-visa-a
#8
EDITORIAL
Adrian Mallows, Chris Littlewood, Peter Malliaras
No abstract text is available yet for this article.
June 22, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28633477/loop-diuretics-for-chronic-heart-failure-a-foe-in-disguise-of-a-friend
#9
Chris J Kapelios, Konstantinos Malliaras, Elisabeth Kaldara, Stella Vakrou, John N Nanas
Loop diuretics are recommended for relieving symptoms and signs of congestion in patients with chronic heart failure and are administered to more than 80% of them. However, several of their effects have not systematically been studied. Numerous cohort and four interventional studies have addressed the effect of diuretics on renal function; apart from one prospective study, which showed that diuretics withdrawal is accompanied by increase in some markers of early-detected renal injury, all others converge to the conclusion that diuretics receipt, especially in high doses is associated with increased rates of renal dysfunction...
June 19, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28630894/next-generation-probes-particles-and-proteins-for-neural-interfacing
#10
REVIEW
Jonathan Rivnay, Huiliang Wang, Lief Fenno, Karl Deisseroth, George G Malliaras
Bidirectional interfacing with the nervous system enables neuroscience research, diagnosis, and therapy. This two-way communication allows us to monitor the state of the brain and its composite networks and cells as well as to influence them to treat disease or repair/restore sensory or motor function. To provide the most stable and effective interface, the tools of the trade must bridge the soft, ion-rich, and evolving nature of neural tissue with the largely rigid, static realm of microelectronics and medical instruments that allow for readout, analysis, and/or control...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28530451/effect-of-high-volume-injection-platelet-rich-plasma-and-sham-treatment-in-chronic-midportion-achilles-tendinopathy-a-randomized-double-blinded-prospective-study
#11
Anders Ploug Boesen, Rudi Hansen, Morten Ilum Boesen, Peter Malliaras, Henning Langberg
BACKGROUND: Injection therapies are often considered alongside exercise for chronic midportion Achilles tendinopathy (AT), although evidence of their efficacy is sparse. PURPOSE: To determine whether eccentric training in combination with high-volume injection (HVI) or platelet-rich plasma (PRP) injections improves outcomes in AT. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: A total of 60 men (age, 18-59 years) with chronic (>3 months) AT were included and followed for 6 months (n = 57)...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28513627/neuromorphic-device-architectures-with-global-connectivity-through-electrolyte-gating
#12
Paschalis Gkoupidenis, Dimitrios A Koutsouras, George G Malliaras
Information processing in the brain takes place in a network of neurons that are connected with each other by an immense number of synapses. At the same time, neurons are immersed in a common electrochemical environment, and global parameters such as concentrations of various hormones regulate the overall network function. This computational paradigm of global regulation, also known as homeoplasticity, has important implications in the overall behaviour of large neural ensembles and is barely addressed in neuromorphic device architectures...
May 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28503731/a-microfluidic-ion-pump-for-in-vivo-drug-delivery
#13
Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Anna-Maria Pappa, Mary J Donahue, Magali Ferro, Róisín M Owens, Dion Khodagholy, Sahika Inal, George G Malliaras
Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior...
May 15, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28485142/low-temperature-cross-linking-of-pedot-pss-films-using-divinylsulfone
#14
Daniele Mantione, Isabel Del Agua, Wandert Schaafsma, Mohammed ElMahmoudy, Ilke Uguz, Ana Sanchez-Sanchez, Haritz Sardon, Begoña Castro, George G Malliaras, David Mecerreyes
Recent interest in bioelectronics has prompted the exploration of properties of conducting polymer films at the interface with biological milieus. Poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS) from a commercially available source has been used as a model system for these studies. Different cross-linking schemes have been used to stabilize films of this material against delamination and redispersion, but the cost is a decrease in the electrical conductivity and/or additional heat treatment...
May 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28268068/understanding-mechanisms-to-improve-exercise-interventions-in-tendinopathy
#15
EDITORIAL
Peter Malliaras
No abstract text is available yet for this article.
September 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28263552/polyelectrolyte-layer-by-layer-assembly-on-organic-electrochemical-transistors
#16
Anna-Maria Pappa, Sahika Inal, Kirsty Roy, Yi Zhang, Charalampos Pitsalidis, Adel Hama, Jolien Pas, George G Malliaras, Roisin M Owens
Oppositely charged polyelectrolyte multilayers (PEMs) were built up in a layer-by-layer (LbL) assembly on top of the conducting polymer channel of an organic electrochemical transistor (OECT), aiming to combine the advantages of well-established PEMs with a high performance electronic transducer. The multilayered film is a model system to investigate the impact of biofunctionalization on the operation of OECTs comprising a poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS) film as the electrically active layer...
March 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28151759/patellar-tendinopathy-and-potential-risk-factors-an-international-database-of-cases-and-controls
#17
Sarah Morton, Sean Williams, Xavier Valle, David Diaz-Cueli, Peter Malliaras, Dylan Morrissey
OBJECTIVES: Numerous risk factors have been identified for patellar tendinopathy (PT), often in small population studies. The aim was to use an international online questionnaire to generate a large database and identify significant risk factors. DESIGN: Case-control study. SETTING: Private practice and sporting teams recruited from England, Spain, and Italy with the questionnaire available in all 3 languages (equivalence between online and self-administration shown previously)...
September 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28134450/lactate-detection-in-tumor-cell-cultures-using-organic-transistor-circuits
#18
Marcel Braendlein, Anna-Maria Pappa, Marc Ferro, Alexia Lopresti, Claire Acquaviva, Emilie Mamessier, George G Malliaras, Róisín M Owens
A biosensing platform based on an organic transistor circuit for metabolite detection in highly complex biological media is introduced. The sensor circuit provides inherent background subtraction allowing for highly specific, sensitive lactate detection in tumor cell cultures. The proposed sensing platform paves the way toward rapid, label-free, and cost-effective clinically relevant in vitro diagnostic tools.
April 2017: Advanced Materials
https://www.readbyqxmd.com/read/28121395/inkjet-printed-pedot-pss-electrodes-on-paper-for-electrocardiography
#19
Eloïse Bihar, Timothée Roberts, Mohamed Saadaoui, Thierry Hervé, Jozina B De Graaf, George G Malliaras
Inkjet-printed PEDOT:PSS electrodes are shown to record cutaneous electrophysiological signals such as electrocardiograms via a simple finger-to-electrode contact. The recordings are of high quality and show no deterioration over a 3 month period, paving the way for the development of the next generation of low-cost, convenient-to-use healthcare monitoring devices.
January 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28105401/voltage-amplifier-based-on-organic-electrochemical-transistor
#20
Marcel Braendlein, Thomas Lonjaret, Pierre Leleux, Jean-Michel Badier, George G Malliaras
Organic electrochemical transistors (OECTs) are receiving a great deal of attention as amplifying transducers for electrophysiology. A key limitation of this type of transistors, however, lies in the fact that their output is a current, while most electrophysiology equipment requires a voltage input. A simple circuit is built and modeled that uses a drain resistor to produce a voltage output. It is shown that operating the OECT in the saturation regime provides increased sensitivity while maintaining a linear signal transduction...
January 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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