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https://www.readbyqxmd.com/read/27923685/a-combined-cellular-and-surgical-ventricular-reconstruction-therapeutic-approach-produces-attenuation-of-remodeling-in-infarcted-rats
#1
Michael J Bonios, Maria Anastasiou-Nana, Despina N Perrea, Konstantinos Malliaras
BACKGROUND: Left ventricular reconstruction (LVR) has been shown to provide transient benefits in LV structure and function of infarcted hearts; however long-term results have been disappointing, as LVR-induced benefits are typically not sustained. We hypothesized that administration of cardiosphere-derived cells (CDCs), which promote myocardial repair and regeneration, may result in long-term preservation of the beneficial effects of LVR in ischemic cardiomyopathy. METHODS: Wistar Kyoto rats underwent myocardial infarction (MI) and two weeks later were randomized into 3 groups: in Group 1 (n=9) LVR was performed by plication of the infarcted apex and CDCs were injected in the infarct border zone (IBZ); group 2 animals (n=9) underwent LVR and received vehicle solution in the IBZ...
December 3, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27890630/arteriovenous-renal-replacement-therapy-in-end-stage-left-sided-heart-failure-patients-has-detrimental-effect-on-patients-with-impaired-right-ventricular-function
#2
Evangelos Repasos, Elisabeth Kaldara, Christos Pantsios, Chris Kapelios, Emmeleia Nana, Spiridon Vernadakis, Christina Melexopoulou, Konstantinos Malliaras, John Boletis, John N Nanas
INTRODUCTION: Chronic intermittent renal replacement therapy(RRT) is an alternate method of decongestion for patients presenting with diuretic-resistant, end-stage heart failure(HF) and cardiorenal syndrome. The optimal method of vascular access has not been confirmed. This study compared the 6-month outcomes of patients with end-stage HF after the creation of arteriovenous communications (AVC) versus other means of RRT. METHODS: We treated 40 patients with chronic, intermittent, ambulatory RRT, of whom 15 (37...
November 23, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27885829/autoclave-sterilization-of-pedot-pss-electrophysiology-devices
#3
Ilke Uguz, Mehran Ganji, Adel Hama, Atsunori Tanaka, Sahika Inal, Ahmed Youssef, Roisin M Owens, Pascale P Quilichini, Antoine Ghestem, Christophe Bernard, Shadi A Dayeh, George G Malliaras
Autoclaving, the most widely available sterilization method, is applied to poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) electrophysiology devices. The process does not harm morphology or electrical properties, while it effectively kills E. coli intentionally cultured on the devices. This finding paves the way to widespread introduction of PEDOT:PSS electrophysiology devices to the clinic.
November 25, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27845503/is-the-heavy-slow-resistance-program-effective-for-all-patients-with-tendinopathy-and-effective-for-all-its-sites
#4
Dimitrios Stasinopoulos, Peter Malliaras
No abstract text is available yet for this article.
November 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27790983/controlling-the-mode-of-operation-of-organic-transistors-through-side-chain-engineering
#5
Alexander Giovannitti, Dan-Tiberiu Sbircea, Sahika Inal, Christian B Nielsen, Enrico Bandiello, David A Hanifi, Michele Sessolo, George G Malliaras, Iain McCulloch, Jonathan Rivnay
Electrolyte-gated organic transistors offer low bias operation facilitated by direct contact of the transistor channel with an electrolyte. Their operation mode is generally defined by the dimensionality of charge transport, where a field-effect transistor allows for electrostatic charge accumulation at the electrolyte/semiconductor interface, whereas an organic electrochemical transistor (OECT) facilitates penetration of ions into the bulk of the channel, considered a slow process, leading to volumetric doping and electronic transport...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27717052/integration-of-organic-electrochemical-and-field-effect-transistors-for-ultraflexible-high-temporal-resolution-electrophysiology-arrays
#6
Wonryung Lee, Dongmin Kim, Jonathan Rivnay, Naoji Matsuhisa, Thomas Lonjaret, Tomoyuki Yokota, Hiromu Yawo, Masaki Sekino, George G Malliaras, Takao Someya
Integration of organic electrochemical transistors and organic field effect transistors has been successfully realized on a 600 nm thick parylene film toward an electrophysiology array. Single cell of integrated device and a 2 × 2 electrophysiology array have succeeded in detecting electromyogram with locally stimulating the motor nerve bundle of a transgenic rat by a laser pulse.
September 22, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27713414/n-type-organic-electrochemical-transistors-with-stability-in-water
#7
Alexander Giovannitti, Christian B Nielsen, Dan-Tiberiu Sbircea, Sahika Inal, Mary Donahue, Muhammad R Niazi, David A Hanifi, Aram Amassian, George G Malliaras, Jonathan Rivnay, Iain McCulloch
Organic electrochemical transistors (OECTs) are receiving significant attention due to their ability to efficiently transduce biological signals. A major limitation of this technology is that only p-type materials have been reported, which precludes the development of complementary circuits, and limits sensor technologies. Here, we report the first ever n-type OECT, with relatively balanced ambipolar charge transport characteristics based on a polymer that supports both hole and electron transport along its backbone when doped through an aqueous electrolyte and in the presence of oxygen...
October 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27652141/the-effect-of-long-term-amiodarone-administration-on-myocardial-fibrosis-and-evolution-of-left-ventricular-remodeling-in-a-porcine-model-of-ischemic-cardiomyopathy
#8
Anastasia Zagorianou, Meletios Marougkas, Stavros G Drakos, Nikolaos Diakos, Panagiotis Konstantopoulos, Despina N Perrea, Maria Anastasiou-Nana, Konstantinos Malliaras
Amiodarone is effective in suppressing arrhythmias in heart failure patients. We investigated the effect of long-term amiodarone administration on myocardial fibrosis and left ventricular (LV) remodeling in a porcine model of ischemic cardiomyopathy. Eighteen infarcted farm pigs were randomized to receive long-term amiodarone administration for 3 months (n = 9) or conventional follow-up (n = 9). Evolution of LV remodeling over 3 months post-myocardial infarction was examined at tissue level (myocyte size, myocardial fibrosis and vascular density assessed by whole-field digital histopathology), organ level (LV structure and function assessed by echocardiography), and systemic level (BNP and MMP-9 levels)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27643472/cardioprotective-effects-of-intracoronary-administration-of-4-chlorodiazepam-in-small-and-large-animal-models-of-ischemia-reperfusion
#9
Michalis Tsamatsoulis, Chris J Kapelios, Lambros Katsaros, Stella Vakrou, Vasilis Sousonis, Stefania Sventzouri, Nicholas Michelinakis, Despoina N Perrea, Maria Anastasiou-Nana, Konstantinos Malliaras
BACKGROUND: The Translocator Protein (TSPO) of the mitochondrial membrane has been recognized as a potential therapeutic target for mitigation of myocardial ischemia-reperfusion injury. Administration of 4-chlorodiazepam (4-CLD), a TSPO ligand, has been shown to confer acute cardioprotective effects in small animals; however, long-term studies and studies in clinically-relevant large animal models are lacking. In the present study we investigated a potential cardioprotective effect of intracoronary administration of 4-CLD in small and large animal models of ischemia-reperfusion...
September 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27506784/bioelectronic-neural-pixel-chemical-stimulation-and-electrical-sensing-at-the-same-site
#10
Amanda Jonsson, Sahika Inal, Llke Uguz, Adam J Williamson, Loïg Kergoat, Jonathan Rivnay, Dion Khodagholy, Magnus Berggren, Christophe Bernard, George G Malliaras, Daniel T Simon
Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale...
August 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27484198/innate-heart-regeneration-endogenous-cellular-sources-and-exogenous-therapeutic-amplification
#11
Konstantinos Malliaras, Styliani Vakrou, Chris J Kapelios, John N Nanas
INTRODUCTION: The -once viewed as heretical- concept of the adult mammalian heart as a dynamic organ capable of endogenous regeneration has recently gained traction. However, estimated rates of myocyte turnover vary wildly and the underlying mechanisms of cardiac plasticity remain controversial. It is still unclear whether the adult mammalian heart gives birth to new myocytes through proliferation of resident myocytes, through cardiomyogenic differentiation of endogenous progenitors or through both mechanisms...
November 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27457055/microsecond-response-in-organic-electrochemical-transistors-exceeding-the-ionic-speed-limit
#12
Jacob T Friedlein, Mary J Donahue, Sean E Shaheen, George G Malliaras, Robert R McLeod
Organic electrochemical transistors (OECTs) are transistors that can have extrinsic transconductances as high as 400 S m(-1) , but they typically have response times on the order of 1 ms or longer. These response speeds are limited by ion transport. It is shown that OECTs can exceed the ionic response speed by a factor of 30 when operated in a high-speed bias regime.
October 2016: Advanced Materials
https://www.readbyqxmd.com/read/27444189/molecular-design-of-semiconducting-polymers-for-high-performance-organic-electrochemical-transistors
#13
Christian B Nielsen, Alexander Giovannitti, Dan-Tiberiu Sbircea, Enrico Bandiello, Muhammad R Niazi, David A Hanifi, Michele Sessolo, Aram Amassian, George G Malliaras, Jonathan Rivnay, Iain McCulloch
The organic electrochemical transistor (OECT), capable of transducing small ionic fluxes into electronic signals in an aqueous environment, is an ideal device to utilize in bioelectronic applications. Currently, most OECTs are fabricated with commercially available conducting poly(3,4-ethylenedioxythiophene) (PEDOT)-based suspensions and are therefore operated in depletion mode. Here, we present a series of semiconducting polymers designed to elucidate important structure-property guidelines required for accumulation mode OECT operation...
August 17, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27385673/organic-transistor-arrays-integrated-with-finger-powered-microfluidics-for-multianalyte-saliva-testing
#14
Anna-Maria Pappa, Vincenzo F Curto, Marcel Braendlein, Xenofon Strakosas, Mary J Donahue, Michel Fiocchi, George G Malliaras, Roisin M Owens
A compact multianalyte biosensing platform is reported, composed of an organic electrochemical transistor (OECT) microarray integrated with a pumpless "finger-powered" microfluidic, for quantitative screening of glucose, lactate, and cholesterol levels. A biofunctionalization method is designed, which provides selectivity towards specific metabolites as well as minimization of any background interference. In addition, a simple method is developed to facilitate multi-analyte sensing and avoid electrical crosstalk between the different transistors by electrically isolating the individual devices...
September 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27302497/esophageal-dieulafoy-s-lesion-an-exceedingly-rare-cause-of-massive-upper-gi-bleeding
#15
George P Malliaras, Andrea Carollo, Gregg Bogen
Dieulafoy's lesion, a dilated aberrant submucosal vessel which erodes the overlying epithelium, is a relatively rare but potentially fatal cause of gastrointestinal (Gl) bleeding. The esophagus is a very rare location for the lesion. Here we present a case of massive upper GI bleeding, secondary to this remarkably rare occurrence, which was amendable to endoscopic intervention.
2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27291059/a-disposable-paper-breathalyzer-with-an-alcohol-sensing-organic-electrochemical-transistor
#16
Eloїse Bihar, Yingxin Deng, Takeo Miyake, Mohamed Saadaoui, George G Malliaras, Marco Rolandi
UNLABELLED: Breathalyzers estimate Blood Alcohol Content (BAC) from the concentration of ethanol in the breath. Breathalyzers are easy to use but are limited either by their high price and by environmental concerns, or by a short lifetime and the need for continuous recalibration. Here, we demonstrate a proof-of-concept disposable breathalyzer using an organic electrochemical transistor (OECT) modified with alcohol dehydrogenase (ADH) as the sensor. The OECT is made with the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) ( PEDOT: PSS), and is printed on paper...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27245574/orientation-selectivity-in-a-multi-gated-organic-electrochemical-transistor
#17
Paschalis Gkoupidenis, Dimitrios A Koutsouras, Thomas Lonjaret, Jessamyn A Fairfield, George G Malliaras
UNLABELLED: Neuromorphic devices offer promising computational paradigms that transcend the limitations of conventional technologies. A prominent example, inspired by the workings of the brain, is spatiotemporal information processing. Here we demonstrate orientation selectivity, a spatiotemporal processing function of the visual cortex, using a poly(3,4ethylenedioxythiophene):poly(styrene sulfonate) ( PEDOT: PSS) organic electrochemical transistor with multiple gates...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27196808/long-term-intra-aortic-balloon-pump-support-as-bridge-to-left-ventricular-assist-device-implantation
#18
Dimitrios Koudoumas, Konstantinos Malliaras, Stergios Theodoropoulos, Elisabeth Kaldara, Chris Kapelios, John Nanas
BACKGROUND: The intra-aortic balloon pump (IABP) can be used to bridge critically ill end-stage heart failure patients to left ventricular assist device (LVAD) implantation. However, the IABP's potential association with hemorrhagic complications raises concerns regarding its utilization in these patients. AIM: We investigated whether preoperative long-term IABP support increases hemorrhagic complications post-LVAD implantation. METHODS: Ten patients undergoing IABP support prior to LVAD implantation (IABP-LVAD group) were compared with 16 who did not require IABP support (LVAD group)...
July 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27194365/wettability-of-pedot-pss-films
#19
C Duc, A Vlandas, G G Malliaras, V Senez
UNLABELLED: Conducting polymers such as poly(3,4-ethylenedioxythiophene) polystyrene sulfonate ( PEDOT: PSS) are increasingly used to interface electronics with biology. Their wettability, however, remains poorly understood. We show that the frequently-used sessile drop technique yields results that are strongly dependent on the experimental conditions (measurement duration and relative humidity), due to the hydrogel-like behavior of PEDOT: PSS...
June 21, 2016: Soft Matter
https://www.readbyqxmd.com/read/27142535/movement-patterns-and-muscular-function-before-and-after-onset-of-sports-related-groin-pain-a-systematic-review-with-meta-analysis
#20
REVIEW
Paulina Kloskowska, Dylan Morrissey, Claire Small, Peter Malliaras, Christian Barton
BACKGROUND: Sports-related groin pain (SRGP) is a common entity in rotational sports such as football, rugby and hockey, accounting for 12-18 % of injuries each year, with high recurrence rates and often prolonged time away from sport. OBJECTIVE: This systematic review synthesises movement and muscle function findings to better understand deficits and guide rehabilitation. STUDY SELECTION: Prospective and retrospective cross-sectional studies investigating muscle strength, flexibility, cross-sectional area, electromyographic activation onset and magnitude in patients with SRGP were included...
December 2016: Sports Medicine
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