Read by QxMD icon Read


Wonryung Lee, Dongmin Kim, Jonathan Rivnay, Naoji Matsuhisa, Thomas Lonjaret, Tomoyuki Yokota, Hiromu Yawo, Masaki Sekino, George G Malliaras, Takao Someya
Integration of organic electrochemical transistors and organic field effect transistors has been successfully realized on a 600 nm thick parylene film toward an electrophysiology array. Single cell of integrated device and a 2 × 2 electrophysiology array have succeeded in detecting electromyogram with locally stimulating the motor nerve bundle of a transgenic rat by a laser pulse.
September 22, 2016: Advanced Materials
Alexander Giovannitti, Christian B Nielsen, Dan-Tiberiu Sbircea, Sahika Inal, Mary Donahue, Muhammad R Niazi, David A Hanifi, Aram Amassian, George G Malliaras, Jonathan Rivnay, Iain McCulloch
Organic electrochemical transistors (OECTs) are receiving significant attention due to their ability to efficiently transduce biological signals. A major limitation of this technology is that only p-type materials have been reported, which precludes the development of complementary circuits, and limits sensor technologies. Here, we report the first ever n-type OECT, with relatively balanced ambipolar charge transport characteristics based on a polymer that supports both hole and electron transport along its backbone when doped through an aqueous electrolyte and in the presence of oxygen...
October 7, 2016: Nature Communications
Anastasia Zagorianou, Meletios Marougkas, Stavros G Drakos, Nikolaos Diakos, Panagiotis Konstantopoulos, Despina N Perrea, Maria Anastasiou-Nana, Konstantinos Malliaras
Amiodarone is effective in suppressing arrhythmias in heart failure patients. We investigated the effect of long-term amiodarone administration on myocardial fibrosis and left ventricular (LV) remodeling in a porcine model of ischemic cardiomyopathy. Eighteen infarcted farm pigs were randomized to receive long-term amiodarone administration for 3 months (n = 9) or conventional follow-up (n = 9). Evolution of LV remodeling over 3 months post-myocardial infarction was examined at tissue level (myocyte size, myocardial fibrosis and vascular density assessed by whole-field digital histopathology), organ level (LV structure and function assessed by echocardiography), and systemic level (BNP and MMP-9 levels)...
2016: SpringerPlus
Michalis Tsamatsoulis, Chris J Kapelios, Lambros Katsaros, Stella Vakrou, Vasilis Sousonis, Stefania Sventzouri, Nicholas Michelinakis, Despoina N Perrea, Maria Anastasiou-Nana, Konstantinos Malliaras
BACKGROUND: The Translocator Protein (TSPO) of the mitochondrial membrane has been recognized as a potential therapeutic target for mitigation of myocardial ischemia-reperfusion injury. Administration of 4-chlorodiazepam (4-CLD), a TSPO ligand, has been shown to confer acute cardioprotective effects in small animals; however, long-term studies and studies in clinically-relevant large animal models are lacking. In the present study we investigated a potential cardioprotective effect of intracoronary administration of 4-CLD in small and large animal models of ischemia-reperfusion...
September 10, 2016: International Journal of Cardiology
Amanda Jonsson, Sahika Inal, Llke Uguz, Adam J Williamson, Loïg Kergoat, Jonathan Rivnay, Dion Khodagholy, Magnus Berggren, Christophe Bernard, George G Malliaras, Daniel T Simon
Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale...
August 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
Konstantinos Malliaras, Styliani Vakrou, Chris J Kapelios, John N Nanas
INTRODUCTION: The -once viewed as heretical- concept of the adult mammalian heart as a dynamic organ capable of endogenous regeneration has recently gained traction. However, estimated rates of myocyte turnover vary wildly and the underlying mechanisms of cardiac plasticity remain controversial. It is still unclear whether the adult mammalian heart gives birth to new myocytes through proliferation of resident myocytes, through cardiomyogenic differentiation of endogenous progenitors or through both mechanisms...
November 2016: Expert Opinion on Biological Therapy
Jacob T Friedlein, Mary J Donahue, Sean E Shaheen, George G Malliaras, Robert R McLeod
Organic electrochemical transistors (OECTs) are transistors that can have extrinsic transconductances as high as 400 S m(-1) , but they typically have response times on the order of 1 ms or longer. These response speeds are limited by ion transport. It is shown that OECTs can exceed the ionic response speed by a factor of 30 when operated in a high-speed bias regime.
October 2016: Advanced Materials
Christian B Nielsen, Alexander Giovannitti, Dan-Tiberiu Sbircea, Enrico Bandiello, Muhammad R Niazi, David A Hanifi, Michele Sessolo, Aram Amassian, George G Malliaras, Jonathan Rivnay, Iain McCulloch
The organic electrochemical transistor (OECT), capable of transducing small ionic fluxes into electronic signals in an aqueous environment, is an ideal device to utilize in bioelectronic applications. Currently, most OECTs are fabricated with commercially available conducting poly(3,4-ethylenedioxythiophene) (PEDOT)-based suspensions and are therefore operated in depletion mode. Here, we present a series of semiconducting polymers designed to elucidate important structure-property guidelines required for accumulation mode OECT operation...
August 17, 2016: Journal of the American Chemical Society
Anna-Maria Pappa, Vincenzo F Curto, Marcel Braendlein, Xenofon Strakosas, Mary J Donahue, Michel Fiocchi, George G Malliaras, Roisin M Owens
A compact multianalyte biosensing platform is reported, composed of an organic electrochemical transistor (OECT) microarray integrated with a pumpless "finger-powered" microfluidic, for quantitative screening of glucose, lactate, and cholesterol levels. A biofunctionalization method is designed, which provides selectivity towards specific metabolites as well as minimization of any background interference. In addition, a simple method is developed to facilitate multi-analyte sensing and avoid electrical crosstalk between the different transistors by electrically isolating the individual devices...
September 2016: Advanced Healthcare Materials
George P Malliaras, Andrea Carollo, Gregg Bogen
Dieulafoy's lesion, a dilated aberrant submucosal vessel which erodes the overlying epithelium, is a relatively rare but potentially fatal cause of gastrointestinal (Gl) bleeding. The esophagus is a very rare location for the lesion. Here we present a case of massive upper GI bleeding, secondary to this remarkably rare occurrence, which was amendable to endoscopic intervention.
2016: Journal of Surgical Case Reports
Eloїse Bihar, Yingxin Deng, Takeo Miyake, Mohamed Saadaoui, George G Malliaras, Marco Rolandi
UNLABELLED: Breathalyzers estimate Blood Alcohol Content (BAC) from the concentration of ethanol in the breath. Breathalyzers are easy to use but are limited either by their high price and by environmental concerns, or by a short lifetime and the need for continuous recalibration. Here, we demonstrate a proof-of-concept disposable breathalyzer using an organic electrochemical transistor (OECT) modified with alcohol dehydrogenase (ADH) as the sensor. The OECT is made with the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) ( PEDOT: PSS), and is printed on paper...
2016: Scientific Reports
Paschalis Gkoupidenis, Dimitrios A Koutsouras, Thomas Lonjaret, Jessamyn A Fairfield, George G Malliaras
UNLABELLED: Neuromorphic devices offer promising computational paradigms that transcend the limitations of conventional technologies. A prominent example, inspired by the workings of the brain, is spatiotemporal information processing. Here we demonstrate orientation selectivity, a spatiotemporal processing function of the visual cortex, using a poly(3,4ethylenedioxythiophene):poly(styrene sulfonate) ( PEDOT: PSS) organic electrochemical transistor with multiple gates...
2016: Scientific Reports
Dimitrios Koudoumas, Konstantinos Malliaras, Stergios Theodoropoulos, Elisabeth Kaldara, Chris Kapelios, John Nanas
BACKGROUND: The intra-aortic balloon pump (IABP) can be used to bridge critically ill end-stage heart failure patients to left ventricular assist device (LVAD) implantation. However, the IABP's potential association with hemorrhagic complications raises concerns regarding its utilization in these patients. AIM: We investigated whether preoperative long-term IABP support increases hemorrhagic complications post-LVAD implantation. METHODS: Ten patients undergoing IABP support prior to LVAD implantation (IABP-LVAD group) were compared with 16 who did not require IABP support (LVAD group)...
July 2016: Journal of Cardiac Surgery
C Duc, A Vlandas, G G Malliaras, V Senez
UNLABELLED: Conducting polymers such as poly(3,4-ethylenedioxythiophene) polystyrene sulfonate ( PEDOT: PSS) are increasingly used to interface electronics with biology. Their wettability, however, remains poorly understood. We show that the frequently-used sessile drop technique yields results that are strongly dependent on the experimental conditions (measurement duration and relative humidity), due to the hydrogel-like behavior of PEDOT: PSS...
June 21, 2016: Soft Matter
Paulina Kloskowska, Dylan Morrissey, Claire Small, Peter Malliaras, Christian Barton
BACKGROUND: Sports-related groin pain (SRGP) is a common entity in rotational sports such as football, rugby and hockey, accounting for 12-18 % of injuries each year, with high recurrence rates and often prolonged time away from sport. OBJECTIVE: This systematic review synthesises movement and muscle function findings to better understand deficits and guide rehabilitation. STUDY SELECTION: Prospective and retrospective cross-sectional studies investigating muscle strength, flexibility, cross-sectional area, electromyographic activation onset and magnitude in patients with SRGP were included...
May 3, 2016: Sports Medicine
Jonathan Rivnay, Sahika Inal, Brian A Collins, Michele Sessolo, Eleni Stavrinidou, Xenofon Strakosas, Christopher Tassone, Dean M Delongchamp, George G Malliaras
UNLABELLED: Poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate), PEDOT: PSS, has been utilized for over two decades as a stable, solution-processable hole conductor. While its hole transport properties have been the subject of intense investigation, recent work has turned to PEDOT: PSS as a mixed ionic/electronic conductor in applications including bioelectronics, energy storage and management, and soft robotics. Conducting polymers can efficiently transport both holes and ions when sufficiently hydrated, however, little is known about the role of morphology on mixed conduction...
2016: Nature Communications
Thomas S H Goom, Peter Malliaras, Michael P Reiman, Craig R Purdam
Synopsis Proximal hamstring tendinopathy (PHT) typically manifests as deep buttock pain at the hamstring common origin. Both athletic and nonathletic populations are affected by PHT. Pain and dysfunction are often long-standing and limit sporting and daily functions. There is limited evidence regarding diagnosis, assessment, and management; for example, there are no randomized controlled trials investigating rehabilitation of PHT. Some of the principles of management established in, for example, Achilles and patellar tendinopathy would appear to apply to PHT but are not as well documented...
June 2016: Journal of Orthopaedic and Sports Physical Therapy
Christos D Kontogiannis, Konstantinos Malliaras, Chris J Kapelios, Jay W Mason, John N Nanas
Cardiac recovery from cardiogenic shock (CS) and end-stage chronic heart failure (HF) remains an often insurmountable therapeutic challenge. The counterpulsation technique exerts numerous beneficial effects on systemic hemodynamics and left ventricular mechanoenergetics, rendering it attractive for promoting myocardial recovery in both acute and chronic HF. Although a recent clinical trial has questioned the clinical effectiveness of short-term hemodynamic support with intra-aortic balloon pump (IABP, the main representative of the counterpulsation technique) in CS complicating myocardial infarction, the issue remains open to further investigation...
March 24, 2016: World Journal of Transplantation
C J Barton, D R Bonanno, J Carr, B S Neal, P Malliaras, A Franklyn-Miller, H B Menz
IMPORTANCE: Running-related injuries are highly prevalent. OBJECTIVE: Synthesise published evidence with international expert opinion on the use of running retraining when treating lower limb injuries. DESIGN: Mixed methods. METHODS: A systematic review of clinical and biomechanical findings related to running retraining interventions were synthesised and combined with semistructured interviews with 16 international experts covering clinical reasoning related to the implementation of running retraining...
May 2016: British Journal of Sports Medicine
Hideaki Kanazawa, Eleni Tseliou, James F Dawkins, Geoffrey De Couto, Romain Gallet, Konstantinos Malliaras, Kristine Yee, Michelle Kreke, Ileana Valle, Rachel R Smith, Ryan C Middleton, Chak-Sum Ho, Rohan Dharmakumar, Debiao Li, Raj R Makkar, Keiichi Fukuda, Linda Marbán, Eduardo Marbán
BACKGROUND: Infusion of allogeneic cardiosphere-derived cells (allo-CDCs) postreperfusion elicits cardioprotective cellular postconditioning in pigs with acute myocardial infarction. However, the long-term effects of allo-CDCs have not been assessed. We performed a placebo-controlled pivotal study for long-term evaluation, as well as shorter-term mechanistic studies. METHODS AND RESULTS: Minipigs underwent 1.5-hour mid-left anterior descending balloon occlusion followed by reperfusion and were randomized to receive intracoronary allo-CDCs or vehicle 30 minutes postreperfusion...
February 2016: Journal of the American Heart Association
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"