Robert S Lee-Young, Nolan J Hoffman, Kate T Murphy, Darren C Henstridge, Dorit Samocha-Bonet, Andrew L Siebel, Peter Iliades, Borivoj Zivanovic, Yet H Hong, Timothy D Colgan, Michael J Kraakman, Clinton R Bruce, Paul Gregorevic, Glenn K McConell, Gordon S Lynch, Grant R Drummond, Bronwyn A Kingwell, Jerry R Greenfield, Mark A Febbraio
OBJECTIVE: The development of skeletal muscle insulin resistance is an early physiological defect, yet the intracellular mechanisms accounting for this metabolic defect remained unresolved. Here, we have examined the role of glucose-6-phosphate dehydrogenase (G6PDH) activity in the pathogenesis of insulin resistance in skeletal muscle. METHODS: Multiple mouse disease states exhibiting insulin resistance and glucose intolerance, as well as obese humans defined as insulin-sensitive, insulin-resistant, or pre-diabetic, were examined...
November 2016: Molecular Metabolism