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https://www.readbyqxmd.com/read/28521008/gemstone-orchestrated-prioritization-of-human-germline-mutations-in-the-cloud
#1
Siwei Chen, Juan F Beltrán, Clara Esteban-Jurado, Sebastià Franch-Expósito, Sergi Castellví-Bel, Steven Lipkin, Xiaomu Wei, Haiyuan Yu
Integrative analysis of whole-genome/exome-sequencing data has been challenging, especially for the non-programming research community, as it requires simultaneously managing a large number of computational tools. Even computational biologists find it unexpectedly difficult to reproduce results from others or optimize their strategies in an end-to-end workflow. We introduce Germline Mutation Scoring Tool fOr Next-generation sEquencing data (GeMSTONE), a cloud-based variant prioritization tool with high-level customization and a comprehensive collection of bioinformatics tools and data libraries (http://gemstone...
May 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28420889/evaluation-of-urinary-stone-composition-and-differentiation-between-urinary-stones-and-phleboliths-using-single-source-dual-energy-computed-tomography
#2
Nanako Ogawa, Shuhei Sato, Kentaro Ida, Katsuya Kato, Yuichi Ariyoshi, Koichiro Wada, Yasutomo Nasu, Susumu Kanazawa
The aim of this study was to investigate the utility of single-source dual-energy computed tomography (SS-DECT) composition analysis in characterizing different types of urinary stones and differentiating them from phleboliths. This study included 29 patients with urinary stones who were scheduled for surgery. All patients were scanned, first using single-energy computed tomography acquisition and then DECT acquisition on SS-DECT. Dual-energy data were archived to a Gemstone spectral imaging (GSI) viewer (GE Healthcare, Milwaukee, WI, USA)...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28411037/carotid-plaque-evaluation-using-gemstone-spectral-imaging-comparison-with-magnetic-resonance-angiography
#3
Yuki Shinohara, Makoto Sakamoto, Keita Kuya, Junichi Kishimoto, Eijiro Yamashita, Shinya Fujii, Masamichi Kurosaki, Toshihide Ogawa
BACKGROUND: The present study compared the applicability of computed tomography carotid plaque imaging using effective Z maps with gemstone spectral imaging (GSI) to that of magnetic resonance plaque imaging using 3-dimensional time-of-flight magnetic resonance angiography. METHODS: Stenosis was assessed in 18 carotid arteries of 14 patients, and the effective Z values of noncalcified carotid plaques were compared with the signal intensities of magnetic resonance angiography...
April 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28337891/screening-and-comparison-of-polychromatic-and-monochromatic-image-reconstruction-of-abdominal-arterial-energy-spectrum-ct
#4
X P Wang, B Wang, P Hou, R Li, J B Gao
We screened the suitable image reconstruction to observe the abdominal artery and compare the quality between the polychromatic and the monochromatic reconstruction images of the abdominal artery spectrum CT. Eighty patients underwent Gemstone CT energy spectrum imaging to obtain an abdominal artery polychromatic image (140 kVp) and a monochromatic image from 40 ~ 140 keV. The CT value of region of interest (ROI) was measured on the polychromatic image and the single energy image. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the abdominal aorta and hepatic artery were determined...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28321168/spectral-computed-tomography-in-advanced-gastric-cancer-can-iodine-concentration-non-invasively-assess-angiogenesis
#5
Xiao-Hua Chen, Ke Ren, Pan Liang, Ya-Ru Chai, Kui-Sheng Chen, Jian-Bo Gao
AIM: To investigate the correlation of iodine concentration (IC) generated by spectral computed tomography (CT) with micro-vessel density (MVD) and vascular endothelial growth factor (VEGF) expression in patients with advanced gastric carcinoma (GC). METHODS: Thirty-four advanced GC patients underwent abdominal enhanced CT in the gemstone spectral imaging mode. The IC of the primary lesion in the arterial phase (AP) and venous phase (VP) were measured, and were then normalized against that in the aorta to provide the normalized IC (nIC)...
March 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28267548/the-optimal-monochromatic-spectral-computed-tomographic-imaging-plus-adaptive-statistical-iterative-reconstruction-algorithm-can-improve-the-superior-mesenteric-vessel-image-quality
#6
Xiao-Ping Yin, Zi-Wei Zuo, Ying-Jin Xu, Jia-Ning Wang, Huai-Jun Liu, Guang-Lu Liang, Bu-Lang Gao
OBJECTIVE: To investigate the effect of the optimal monochromatic spectral computed tomography (CT) plus adaptive statistical iterative reconstruction on the improvement of the image quality of the superior mesenteric artery and vein. MATERIALS AND METHODS: The gemstone spectral CT angiographic data of 25 patients were reconstructed in the following three groups: 70KeV, the optimal monochromatic imaging, and the optimal monochromatic plus 40%iterative reconstruction mode...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28267528/non-small-cell-lung-cancer-spectral-computed-tomography-quantitative-parameters-for-preoperative-diagnosis-of-metastatic-lymph-nodes
#7
Fengfeng Yang, Jie Dong, Xiuting Wang, Xiaojiao Fu, Tong Zhang
OBJECTIVE: To investigate the application value of spectral computed tomography (CT)quantitative parameters for preoperative diagnosis of metastatic lymph nodes in patients with non-small cell lung cancer (NSLC). METHODS: 84 patients with suspected lung cancer who underwent chest dual-phase enhanced scan with gemstone spectral CT imaging (GSI) mode were selected. GSI quantitative parameters including normalized iodine concentrations (NIC), water concentration, slope of the spectral Hounsfield unit curve (λHU) were measured...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28242446/an-efficient-ionoluminescence-analysis-of-turquoise-gemstone-as-a-weakly-luminescent-mineral
#8
T Nikbakht, O Kakuee, M Lamehi-Rachti
The unique ionization pattern of MeV-energy ion beam is applied for efficient luminescence analysis of a collection of natural turquoise samples. The considerable penetration depth of tens of micrometer and enhancement of energy deposition with depth, suggests ionoluminescence as an appropriate technique for studying weakly luminescent minerals. Herein, the luminescence induced in deeper parts of turquoise samples is extracted through their relatively transparent adjacent host stones. The resulting intense spectra reveal the vibrational structure of the broad green luminescence band of turquoise which probably originates from O2(-) centers...
February 21, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28197873/ct-angiography-of-the-kidney-using-routine-ct-and-the-latest-gemstone-spectral-imaging-combination-of-different-noise-indexes-image-quality-and-radiation-dose
#9
COMPARATIVE STUDY
Yongxia Zhao, Yanmin Wu, Ziwei Zuo, Shujie Cheng
OBJECTIVE: The objective of our study was to compare the image quality and radiation dose of computed tomography angiography (CTA) of the kidney in patients with different body mass indexes using routine CT and the latest Gemstone Spectral Imaging (GSI) combination of different noise indexes (NI) with the adaptive statistical iterative reconstruction 2.0 algorithm (ASiR 2.0). METHODS: A total of 120 patients who had undergone a CTA of the kidney were divided into four groups (A, B, C and D), with 30 patients in each group...
May 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/27866516/-gsi-quantitative-parameters-preoperative-diagnosis-of-metastasis-lymph-nodes-in-lung-cancer
#10
Fengfeng Yang, Jie Dong, Xiaolong Yan, Xiuting Wang, Xiaojiao Fu, Tong Zhang
BACKGROUND: Mediastinal involvement in lung cancer is an important prognostic factor affecting survival, and accurate staging of the mediastinum lymph node correctly identifies patients who can benefit the most from surgery. The aim of this study is to investigate the value of dual-energy spectral computed tomography (DEsCT) imaging in differentiating metastatic from non-metastatic lymph nodes in lung cancer. METHODS: Forty-eight patients with non-small cell lung cancer (NSCLC) underwent arterial (AP) and portal venous (PP) phase contrast-enhanced DEsCT imaging followed by surgical treatment...
November 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27834975/ce-3-doped-garnet-phosphors-composition-modification-luminescence-properties-and-applications
#11
REVIEW
Zhiguo Xia, Andries Meijerink
Garnets have the general formula of A3B2C3O12 and form a wide range of inorganic compounds, occurring both naturally (gemstones) and synthetically. Their physical and chemical properties are closely related to the structure and composition. In particular, Ce(3+)-doped garnet phosphors have a long history and are widely applied, ranging from flying spot cameras, lasers and phosphors in fluorescent tubes to more recent applications in white light LEDs, as afterglow materials and scintillators for medical imaging...
January 3, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/27824666/a-comparison-of-the-image-quality-and-radiation-dose-with-routine-computed-tomography-and-the-latest-gemstone-spectral-imaging-combination-of-different-scanning-protocols-in-computed-tomography-angiography-of-the-kidney
#12
COMPARATIVE STUDY
Yong-Xia Zhao, Hong-Na Suo, Zi-Wei Zuo, Ying-Jin Xu, Jin Chang
OBJECTIVE: The objective of our study was to compare the image quality and radiation dose of computed tomography angiography (CTA) of the kidney in patients with different body mass indexes using routine CT and the latest gemstone spectral imaging (GSI) combination of different scanning protocols with the adaptive statistical iterative reconstruction 2.0 algorithm. METHODS: A total of 90 patients who had undergone a CTA of the kidney were divided into 3 groups (A, B, and C), with 30 patients in each group...
March 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27799426/the-ring-monstrance-from-the-loreto-treasury-in-prague-handheld-raman-spectrometer-for-identification-of-gemstones
#13
Jan Jehlička, Adam Culka, Markéta Baštová, Petr Bašta, Jaroslav Kuntoš
A miniature lightweight portable Raman spectrometer and a palm-sized device allow for fast and unambiguous detection of common gemstones mounted in complex jewels. Here, complex religious artefacts and the Ring Monstrance from the Loreto treasury (Prague, Czech Republic; eighteenth century) were investigated. These discriminations are based on the very good correspondence of the wavenumbers of the strongest Raman bands of the minerals. Very short laser illumination times and efficient collection of scattered light were sufficient to obtain strong diagnostic Raman signals...
December 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27760221/impaired-subset-progression-and-polyfunctionality-of-t-cells-in-mice-exposed-to-methamphetamine-during-chronic-lcmv-infection
#14
Uma Sriram, Beth L Hill, Jonathan M Cenna, Larisa Gofman, Nicole C Fernandes, Bijayesh Haldar, Raghava Potula
Methamphetamine (METH) is a widely used psychostimulant that severely impacts the host's innate and adaptive immune systems and has profound immunological implications. T cells play a critical role in orchestrating immune responses. We have shown recently how chronic exposure to METH affects T cell activation using a murine model of lymphocytic choriomeningitis virus (LCMV) infection. Using the TriCOM (trinary state combinations) feature of GemStone™ to study the polyfunctionality of T cells, we have analyzed how METH affected the cytokine production pattern over the course of chronic LCMV infection...
2016: PloS One
https://www.readbyqxmd.com/read/27703518/gemstone-spectral-imaging-for-measuring-adult-bone-mineral-density
#15
Wei-Guang Shao, Dian-Mei Liu
The present study aimed to detect the bone Ca(2+) content of L3 vertebrae in adults by gemstone spectral computed tomography. In total, 235 patients were selected and divided into age groups of 10 years each. The scanning data were used to detect the water-based and Ca(2+)-based substance levels on the L3 vertebral cancellous bone images. The results indicated that there were significant differences in vertebral Ca(2+)-water and water-Ca(2+) densities determined by gemstone spectral imaging (GSI) between males and females in subjects aged 50-59 years, 60-69 years, 70-79 years and ≥80 years (P<0...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27612002/the-value-of-spectral-imaging-to-reduce-artefacts-in-the-body-after-125-i-seed-implantation
#16
Jingang Liu, Wenjuan Wang, Xingsheng Zhao, Zhen Shen, Weiguang Shao, Xizhen Wang, Lixin Li, Bin Wang
INTRODUCTION: To explore the value of gemstone spectral imaging (GSI) and metal artefact reduction sequence (MARs) to reduce the artefacts of metal seeds. METHODS: Thirty-five patients with (125) I seed implantation in their abdomens underwent GSI CT. Six types of monochromatic images and the corresponding MARs images at 60-110 keV (interval of 10 keV) were reconstructed. The differences in the quality of the images of three imaging methods were subjectively assessed by three radiologists...
October 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27587042/approaches-to-reducing-photon-dose-calculation-errors-near-metal-implants
#17
Jessie Y Huang, David S Followill, Rebecca M Howell, Xinming Liu, Dragan Mirkovic, Francesco C Stingo, Stephen F Kry
PURPOSE: Dose calculation errors near metal implants are caused by limitations of the dose calculation algorithm in modeling tissue/metal interface effects as well as density assignment errors caused by imaging artifacts. The purpose of this study was to investigate two strategies for reducing dose calculation errors near metal implants: implementation of metal-based energy deposition kernels in the convolution/superposition (C/S) dose calculation method and use of metal artifact reduction methods for computed tomography (CT) imaging...
September 2016: Medical Physics
https://www.readbyqxmd.com/read/27529680/application-of-gemstone-spectral-computed-tomography-imaging-in-the-characterization-of-solitary-pulmonary-nodules-preliminary-result
#18
Ji-Zheng Lin, Liang Zhang, Chuan-Yu Zhang, Lei Yang, He-Nan Lou, Ze-Guo Wang
OBJECTIVE: This study aimed to observe the value of computed tomography (CT) spectral imaging parameters in the diagnosis of solitary pulmonary nodules, during the contrast-enhanced early phase and late phase. MATERIALS AND METHODS: This study was approved by the institutional review board and written informed consent was obtained from all patients. One hundred thirty-nine patients with solitary pulmonary nodules proved by pathology underwent double-phase enhanced CT scan using gemstone spectral imaging mode on a Discovery CT750 HD, and were divided into an active inflammatory group (43 cases), a malignant group (65 cases), and a tuberculosis group (31 cases)...
November 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27519786/evaluation-of-energy-spectrum-ct-for-the-measurement-of-thyroid-iodine-content
#19
Weiguang Shao, Jingang Liu, Dianmei Liu
BACKGROUND: This study aims to provide a reference for the diagnosis of iodine deficiency disorder by evaluating the normal thyroid iodine content by energy spectrum computed tomography (CT) and calculating the iodine content ratio of thyroid to sternocleidomastoid. METHODS: The thyroid glands of 226 patients were scanned by energy spectrum CT, and the images were analyzed using the GSI Viewer software. Based on the imaging findings, the iodine levels of the thyroid lobes as well as the bilateral sternocleidomastoids were evaluated, and their iodine content ratios were calculated...
2016: BMC Medical Imaging
https://www.readbyqxmd.com/read/27498560/differentiation-of-malignant-cervical-lymphadenopathy-by-dual-energy-ct-a-preliminary-analysis
#20
Liang Yang, Dehong Luo, Lin Li, Yanfeng Zhao, Meng Lin, Wei Guo, Chunwu Zhou
The accurate diagnosis of malignant cervical lymphadenopathy remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for differentiating malignant cervical lymphadenopathy caused by thyroid carcinoma (TC), salivary gland carcinoma (SC), squamous cell carcinoma (SCC) and lymphoma. We retrospectively analysed 92 patients with pathologically confirmed cervical lymphadenopathy due to TC, SC, SCC and lymphoma. All patients received a DECT scan before therapy...
August 8, 2016: Scientific Reports
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