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https://www.readbyqxmd.com/read/27879479/identify-signature-regulatory-network-for-glioblastoma-prognosis-by-integrative-mrna-and-mirna-co-expression-analysis
#1
Zhi-Tong Bing, Guang-Hui Yang, Jie Xiong, Ling Guo, Lei Yang
Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor in adults. Patients with this disease have a poor prognosis. The objective of this study is to identify survival-related individual genes (or miRNAs) and miRNA -mRNA pairs in GBM using a multi-step approach. First, the weighted gene co-expression network analysis and survival analysis are applied to identify survival-related modules from mRNA and miRNA expression profiles, respectively. Subsequently, the role of individual genes (or miRNAs) within these modules in GBM prognosis are highlighted using survival analysis...
December 2016: IET Systems Biology
https://www.readbyqxmd.com/read/27836413/development-of-a-new-field-test-procedure-for-cocaine
#2
Kenji Tsujikawa, Yuko T Iwata, Hiroki Segawa, Tadashi Yamamuro, Kenji Kuwayama, Tatsuyuki Kanamori, Hiroyuki Inoue
The Scott test, widely used as the field test for cocaine, is performed in three steps. If a sample contains cocaine, blue precipitates appear in step 1, the precipitates are dissolved and the solution turns pink in step 2, and the lower layer turns blue in step 3. However, some pyrrolidine-type cathinones produce cocaine-like results when tested, necessitating modification of the test procedure. Filtration of the second-step mixture weakened the blue color in step 3; however, the blue color did not completely disappear...
November 1, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27819873/hydrophilic-polymer-associated-ischemic-enterocolitis
#3
Jesus A Chavez, Wei Chen, Wendy L Frankel, Christina A Arnold
Hydrophilic polymer coating of medical devices serves to lubricate the device and prevent device-related complications. The coating can be mechanically disrupted and result in downstream injury via presumed thromboembolism. This process has been reported in the brain, heart, lung, and skin, and has been replicated through animal studies and in vitro histologic processing of the polymer coating. We report the first description of hydrophilic polymer-associated ischemic enterocolitis in a series of 7 specimens (small bowel=2, colon=4, aortic thrombus=1) from 3 patients...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27732689/activity-dependent-changes-in-gene-expression-in-schizophrenia-human-induced-pluripotent-stem-cell-neurons
#4
Panos Roussos, Boris Guennewig, Dominik C Kaczorowski, Guy Barry, Kristen J Brennand
Importance: Schizophrenia candidate genes participate in common molecular pathways that are regulated by activity-dependent changes in neurons. One important next step is to further our understanding on the role of activity-dependent changes of gene expression in the etiopathogenesis of schizophrenia. Objective: To examine whether neuronal activity-dependent changes of gene expression are dysregulated in schizophrenia. Design, Setting, and Participants: Neurons differentiated from human-induced pluripotent stem cells derived from 4 individuals with schizophrenia and 4 unaffected control individuals were depolarized using potassium chloride...
October 12, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27571956/weighted-gene-co-expression-network-analysis-of-colorectal-cancer-liver-metastasis-genome-sequencing-data-and-screening-of-anti-metastasis-drugs
#5
Bo Gao, Qin Shao, Hani Choudhry, Victoria Marcus, Kung Dong, Jiannis Ragoussis, Zu-Hua Gao
Approximately 9% of cancer-related deaths are caused by colorectal cancer (CRC). CRC patients are prone to liver metastasis, which is the most important cause for the high CRC mortality rate. Understanding the molecular mechanism of CRC liver metastasis could help us to find novel targets for the effective treatment of this deadly disease. Using weighted gene co-expression network analysis on the sequencing data of CRC with and with metastasis, we identified 5 colorectal cancer liver metastasis related modules which were labeled as brown, blue, grey, yellow and turquoise...
September 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27571920/the-biological-methane-forming-reaction-mechanism-confirmed-through-spectroscopic-characterization-of-a-key-intermediate
#6
Seigo Shima
Find your path: Methyl-coenzyme M reductase (MCR, turquoise) reversibly catalyzes the reduction of methyl-coenzyme M (methyl-S-CoM) with coenzyme B (CoB-SH) to form methane and the heterodisulfide. Recently, spectroscopic methods were used to detect trapped intermediates in a stopped-flow system, and CoM-S-Ni(II) was identified after half a turnover of the MCR reaction (F430 =nickel porphinoid). This finding supports a methyl-radical catalytic mechanism.
October 24, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27431786/smart-windows-application-of-carbazole-and-triazine-based-star-shaped-architecture
#7
Merve Guzel, Tugba Soganci, Rukiye Ayranci, Metin Ak
A novel triazine-based, star shape and electroactive monomer, 2,4,6-tris(2-(9H-carbazol-9-yl)ethoxy)-1,3,5-triazine (TCZ) which contains 2,4,6-trichloro-1,3,5-triazine as the core and 2-(9H-carbazol-9-yl)ethanol as the arms, was successfully synthesized. After electrochemical polymerization of the TCZ monomer, called PTCZ, the polymer shows superior optoelectronic and thermal properties due to its unique three-dimensional shape and highly-branched structure in comparison with linear analogues. Electrochromic studies exhibited that PTCZ has turquoise color in the oxidized state and is transparent in the neutral state...
August 3, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27423541/outgroups-and-positive-selection-the-nothobranchius-furzeri-case
#8
Arne Sahm, Matthias Platzer, Alessandro Cellerino
Applications of positive selection analysis increase with the number of species for which genome/transcriptome sequences become available. Using the recently sequenced turquoise killifish (Nothobranchius furzeri) genome as an example, we compare two different approaches based on different outgroup selection. The combination of these two methods allows the origin of positively selected sites in aging-related genes of the N. furzeri genome to be determined.
September 2016: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/27395240/a-new-dune-dwelling-lizard-of-the-genus-leiocephalus-iguania-leiocephalidae-from-the-dominican-republic
#9
Gunther Köhler, Marcos J Rodríguez Bobadilla, S Blair Hedges
We describe a new species of Leiocephalus from the coastal dunes of Bahía de las Calderas in the southwestern Dominican Republic. In external morphology, Leiocephalus sixtoi sp. nov. is most similar to L. schreibersii and L. inaguae. Leiocephalus sixtoi differs from L. inaguae in having a U-shaped bony parietal table (vs. V-shaped in L. inaguae), 3 or 4 enlarged postcloacal scales in males (vs. 2 in L. inaguae), most scales on snout posterior to internasal scales rugose to keeled scales (vs. smooth in L. inaguae), and a patternless throat in males, spots on the throat in females (vs...
2016: Zootaxa
https://www.readbyqxmd.com/read/27388556/laboratory-breeding-of-the-short-lived-annual-killifish-nothobranchius-furzeri
#10
Matej Polačik, Radim Blažek, Martin Reichard
Turquoise killifish, Nothobranchius furzeri, have an intrinsically short life span, with a median life span of <6 months and a maximum (90%) life span of 9 months. This short life span, which is unique among vertebrates, evolved naturally and has resulted in N. furzeri becoming a widely used laboratory model species in aging research and other disciplines. Here, we describe a protocol for the maintenance and breeding of the species under laboratory conditions. We provide details for egg incubation, hatching, everyday care of juvenile and adult fish, breeding and treatment of most common diseases...
August 2016: Nature Protocols
https://www.readbyqxmd.com/read/27331354/bilirubin-isomer-distribution-in-jaundiced-neonates-during-phototherapy-with-led-light-centered-at-497%C3%A2-nm-turquoise-vs-459%C3%A2-nm-blue
#11
Finn Ebbesen, Poul H Madsen, Pernille K Vandborg, Lasse H Jakobsen, Torleif Trydal, Hendrik J Vreman
BACKGROUND: Phototherapy using blue light is the treatment of choice worldwide for neonatal hyperbilirubinemia. However, treatment with turquoise light may be a desirable alternative. Therefore, the aim of this randomized, controlled study was to compare the bilirubin isomer distribution in serum of jaundiced neonates after 24 h of therapy with narrow-band (LED) light centered at 497 nm (turquoise) vs. 459 nm (blue), of essentially equal irradiance. MATERIALS: Eighty-three neonates (≥33 wk gestational age) with uncomplicated hyperbilirubinemia were included in the study...
October 2016: Pediatric Research
https://www.readbyqxmd.com/read/27052251/transcriptional-modules-related-to-hepatocellular-carcinoma-survival-coexpression-network-analysis
#12
Xinsen Xu, Yanyan Zhou, Runchen Miao, Wei Chen, Kai Qu, Qing Pang, Chang Liu
We performed weighted gene coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma (HCC). Raw microarray datasets (including 488 samples) were downloaded from the Gene Expression Omnibus (GEO) website. Data were normalized using the RMA algorithm. We utilized the WGCNA to identify the coexpressed genes (modules) after non-specific filtering. Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichment was applied to explore the possible mechanisms...
June 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27044031/fake-turquoises-investigated-by-raman-microscopy
#13
Nathália D'Elboux Bernardino, Celly M S Izumi, Dalva L A de Faria
Turquoise is frequently adulterated by unscrupulous dealers and, not rarely, simulants are commercialized as true stones. On the other hand, turquoise is a cryptocrystalline mineral and its use in adornments commonly demands some kind of treatment to facilitate its manipulation, such as impregnation using oil or fats, consolidation with resin and stabilization or reconstitution made with resins. In this work, Raman microscopy was employed in the investigation of turquoise adornments aiming to differentiate processed turquoise from fakes or simulants...
May 2016: Forensic Science International
https://www.readbyqxmd.com/read/26991796/stabilization-of-a-tetrahedral-mn-5-o4-chromophore-in-ternary-barium-oxides-as-a-strategy-toward-development-of-new-turquoise-green-colored-pigments
#14
Sourav Laha, Subramani Tamilarasan, Srinivasan Natarajan, Jagannatha Gopalakrishnan
An experimental investigation of the stabilization of the turquoise-colored chromophore Mn(5+)O4 in various oxide hosts, viz., A3(VO4)2 (A = Ba, Sr, Ca), YVO4, and Ba2MO4 (M = Ti, Si), has been carried out. The results reveal that substitution of Mn(5+)O4 occurs in Ba3(VO4)2 forming the entire solid solution series Ba3(V1-xMnxO4)2 (0 < x ≤ 1.0), while with the corresponding strontium derivative, only up to about 10% of Mn(5+)O4 substitution is possible. Ca3(VO4)2 and YVO4 do not stabilize Mn(5+)O4 at all...
April 4, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/26925824/anatomical-features-for-the-adequate-choice-of-experimental-animal-models-in-biomedicine-i-fishes
#15
REVIEW
Livia D'Angelo, Laura Lossi, Adalberto Merighi, Paolo de Girolamo
Fish constitute the oldest and most diverse class of vertebrates, and are widely used in basic research due to a number of advantages (e.g., rapid development ex-utero, large-scale genetic screening of human disease). They represent excellent experimental models for addressing studies on development, morphology, physiology and behavior function in other related species, as well as informative analysis of conservation and diversity. Although less complex, fish share many anatomical and physiological features with mammals, including humans, which make them an important complement to research in mammalian models...
May 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/26904815/-source-constraints-on-turquoise-of-the-erlitou-site-by-infrared-spectra
#16
Jia Ren, Xiao-hong Ye, Yan Wang, Shu-qiong Luo, Guang-hai Shi
Shiyan district in Hubei province is a famous locality of high-quality turquoise with brightcolor, finegrain in the world. Erlitou archacologicalsite, which is about 300km north to the Shiyan Turquoise mine, has been excavated a remarkable number of turquoise artifacts since 2002. Some researchers infer that there was "a road of turquoise" between the two sites in history. In order to check the inference, and identify local features of the turquoises found in Shiyan, and Eelitou site as well, spectra of three turquoise groups from Shiyan, Hubei and one group of Erlitou unearthed samples were obtained by means of IR...
October 2015: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
https://www.readbyqxmd.com/read/26892236/co-expression-networks-in-generation-of-induced-pluripotent-stem-cells
#17
Sharan Paul, Lance Pflieger, Warunee Dansithong, Karla P Figueroa, Fuying Gao, Giovanni Coppola, Stefan M Pulst
We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for a transient period of time, synchronizing the reprogramming process with the majority of transduced cells assuming induced pluripotent stem cell (iPSC)-like characteristics as early as three days post-transduction. These reprogrammed cells resembled human embryonic stem cells (ESCs) with regard to morphology, biomarker expression, and could be differentiated into cells of the germ layers in vitro and in vivo...
2016: Biology Open
https://www.readbyqxmd.com/read/26839399/the-short-lived-african-turquoise-killifish-an-emerging-experimental-model-for-ageing
#18
REVIEW
Yumi Kim, Hong Gil Nam, Dario Riccardo Valenzano
Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mechanistic and molecular insights into the common bases of biological ageing. In this Review, we briefly summarise the major applications of the most commonly used model organisms adopted in ageing research and highlight their relevance in understanding human ageing...
February 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/26781374/prospective-evaluation-of-the-chromogenic-medium-candiselect-4-for-differentiation-and-presumptive-identification-of-non-candida-albicans-candida-species
#19
Liang Zhao, G Sybren de Hoog, Akke Cornelissen, Qian Lyu, Lili Mou, Taohua Liu, Yu Cao, Mansoureh Vatanshenassan, Yingqian Kang
Rapid identification of pathogenic yeasts is a crucial step in timely and appropriate antifungal therapy. For diagnostics in the clinical laboratory, simplified alternatives to barcoding are needed. CandiSelect 4 (CS4) medium, a chromogenic medium for isolation of clinical yeasts, allows routine recognition of Candida albicans and presumptive identification of Candida tropicalis, Candida glabrata, and Candida krusei. We evaluated an extension of this method with 46 non-Candida albicans Candida (NCAC) and 7 Malassezia species...
February 2016: Fungal Biology
https://www.readbyqxmd.com/read/26743093/how-generalizable-are-the-results-from-trials-of-direct-antiviral-agents-to-people-coinfected-with-hiv-hcv-in-the-real-world
#20
Sahar Saeed, Erin C Strumpf, Sharon L Walmsley, Kathleen Rollet-Kurhajec, Neora Pick, Valerie Martel-Laferrière, Mark Hull, M John Gill, Joseph Cox, Curtis Cooper, Marina B Klein
BACKGROUND: Direct-acting antivirals (DAAs) against hepatitis C virus (HCV) have been described as revolutionary. However, it remains uncertain how effective these drugs will be for individuals coinfected with human immunodeficiency virus (HIV)-HCV. Bridging this gap between efficacy and effectiveness requires a focus on the generalizability of clinical trials. METHODS: Generalizability of DAA trials was assessed by applying the eligibility criteria from 5 efficacy trials: NCT01479868, PHOTON-1 (NCT01667731), TURQUOISE-I (NCT01939197), ION-4 (NCT02073656), and ALLY-2 (NCT02032888) that evaluated simeprevir; sofosbuvir; ombitasvir, paritaprevir/ritonavir/dasabuvir; sofosbuvir/ledipasvir; and daclatasvir/sofosbuvir, respectively, to the Canadian Coinfection Cohort, representing approximately 23% of the total coinfected population in care in Canada...
April 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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