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https://www.readbyqxmd.com/read/29656629/differences-in-cervical-sagittal-alignment-changes-in-patients-undergoing-laminoplasty-and-anterior-cervical-discectomy-and-fusion
#1
Su Hun Lee, Dong Wuk Son, Jun Seok Lee, Dong Ha Kim, Soon Ki Sung, Sang Weon Lee, Geun Sung Song
OBJECTIVE: Anterior cervical discectomy and fusion (ACDF) and laminoplasty (LP) are the most commonly performed procedures for degenerative cervical spondylosis. Cervical sagittal alignment (CSA) has recently been studied as an important predictor of clinical and radiological outcomes. The data from previous studies are insufficient for analysis using the recently designed CSA parameters, T1 slope (T1s), and T1s minus cervical angle (T1sCA). METHODS: We retrospectively collected data from patients who underwent ACDF and LP from January 2013 to May 2016...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656628/cerebral-thromboembolic-events-during-anterior-cervical-spine-surgery-retrospective-case-series-study-with-diffusion-weighted-magnetic-resonance-imaging-follow-up-in-the-immediate-postoperative-period
#2
Seok-Won Chung, Min-Soo Kang, Sang-Ho Lee, Shin-Young Lee, Yong-Hwan Shin, Chan-Hong Park
OBJECTIVE: We evaluated the efficacy of diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting perioperative cerebral thromboembolic events after anterior cervical discectomy and fusion (ACDF). METHODS: This retrospective case series included 51 consecutive patients that underwent ACDF. To assess baseline presence of plaque or stenosis, all patients were assessed for risk factors of cerebrovascular events and underwent carotid ultrasound preoperatively and cerebral DW-MRI was performed in all patients postoperatively, with areas of high signal intensity interpreted as a cerebral thromboembolic event...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656619/impact-of-resident-involvement-in-neurosurgery-an-american-college-of-surgeons-national-surgical-quality-improvement-program-database-analysis-of-33-977-patients
#3
Andreea Seicean, Prateek Kumar, Sinziana Seicean, Duncan Neuhauser, Warren R Selman, Nicholas C Bambakidis
OBJECTIVE: There is conflicting and limited literature on the effect of intraoperative resident involvement on surgical outcomes. Our study assessed effects of resident involvement on outcomes in patients undergoing neurosurgery. METHODS: We identified 33,977 adult neurosurgical cases from 374 hospitals in the 2006-2012 National Surgical Quality Improvement Program, a prospectively collected national database with established reproducibility and validity. Outcomes were compared according to resident involvement before and after 1:1 matching on procedure and perioperative risk factors...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656614/6-minute-walk-test-predicts-prolonged-hospitalization-in-patients-undergoing-transcatheter-mitral-valve-repair-by-mitraclip
#4
Mike Saji, Marc R Katz, Gorav Ailawadi, Timothy S Welch, Dale E Fowler, Jamie L W Kennedy, James D Bergin, Ivandito Kuntjoro, John M Dent, Michael Ragosta, D Scott Lim
BACKGROUND: The 6-minute walk test (6MWT) is a simple functional test that can predict exercise capacity and is widely employed to assess treatment outcomes. Although mortality with transcatheter mitral valve repair (TMVr) using the MitraClip (Abbott Vascular, Menlo Park, CA) is significantly less than for open mitral valve surgery in high-risk patients, identifying which patient will benefit the most from TMVr remains a concern. There are limited prognostic metrics guiding patient selection and, no studies have reported relationship between prolonged hospitalization and 6MWT...
April 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29656606/a-meta-analysis-on-the-surgical-management-of-paraganglioma-of-the-carotid-body-per-shamblin-class
#5
Thijs T G Jansen, Henri A M Marres, Johannes H A M Kaanders, Henricus P M Kunst
OBJECTIVE: The aim of the current study is to evaluate the risk associated with different types of surgery for carotid body paraganglioma of different Shamblin class. A meta-analysis was conducted to evaluate per tumour class, the local control, cranial nerve damage and complication rates of different techniques using internal carotid artery (ICA) and external carotid artery (ECA) ligation, clamping or bypassing, as well as the cranio-caudal versus caudo-cranial techniques. DESIGN: A meta-analysis is conducted after a systematic search in PubMed and the Cochrane library, in accordance with the PRISMA guidelines...
April 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29656601/culture-independent-analysis-of-hydrocarbonoclastic-bacterial-communities-in-environmental-samples-during-oil-bioremediation
#6
Narjes Dashti, Nedaa Ali, Samar Salamah, Majida Khanafer, Ghada Al-Shamy, Husain Al-Awadhi, Samir S Radwan
To analyze microbial communities in environmental samples, this study combined Denaturing Gradient Gel Electrophoresis of amplified 16S rRNA-genes in total genomic DNA extracts from those samples with gene sequencing. The environmental samples studied were oily seawater and soil samples, that had been bioaugmented with natural materials rich in hydrocarbonoclastic bacteria. This molecular approach revealed much more diverse bacterial taxa than the culture-dependent method we had used in an earlier study for the analysis of the same samples...
April 15, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29656595/pathways-of-association-from-stress-to-obesity-in-early-childhood
#7
REVIEW
Alison L Miller, Julie C Lumeng
OBJECTIVE: The objective of this study is to critically review the literature on early life stress in relation to obesity in humans, including the multiple biological and behavioral mechanisms through which early life stress exposure (birth to the age of 5 years) may associate with obesity risk during childhood. METHODS: A review of the literature was conducted to identify studies on associations between early childhood stress and risk for obesity and the mechanisms of association...
April 14, 2018: Obesity
https://www.readbyqxmd.com/read/29656588/the-use-of-funnel-plots-with-regression-as-a-tool-to-visually-compare-hiv-treatment-outcomes-between-centres-adjusting-for-patient-characteristics-and-size-a-uk-collaborative-hiv-cohort-study
#8
M Gompels, S Michael, S Jose, T Hill, R Trevelion, C A Sabin, M T May
OBJECTIVES: A measure used for assessing the effectiveness of HIV care and comparing clinical centres is the proportion of people starting antiretroviral therapy (ART) with viral suppression (VS) after 1 year. We propose a method that adjusts for patients' demographic characteristics, and visually compares this measure between different sites accounting for centre size. METHODS: We analysed viral load measurements for UK Collaborative HIV Cohort (UK CHIC) patients starting ART between 2006 and 2013...
April 14, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29656578/long-term-single-center-comparison-of-icd-lead-survival-evidence-for-premature-linox-lead-failure
#9
Matthew O'Connor, Darren Hooks, Matthew Webber, Bijia Shi, Stephanie Morrison, Scott Harding, Peter Larsen
INTRODUCTION: ICD lead failure is a potential source of significant morbidity and mortality. This study investigates the survival rates of Sprint Quattro, Endotak Reliance and Linox ICD leads. METHODS AND RESULTS: A retrospective cohort study of all patients with an ICD implanted between January 2007 and December 2012 from the Wellington Hospital region, New Zealand, a tertiary referral center. Lead and patient details were established by review of clinical notes and the PaceArt Optima database...
April 14, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29656561/advances-in-controlling-differentiation-of-adult-stem-cells-for-peripheral-nerve-regeneration
#10
REVIEW
Metin Uz, Suprem R Das, Shaowei Ding, Donald S Sakaguchi, Jonathan C Claussen, Surya K Mallapragada
Adult stems cells, possessing the ability to grow, migrate, proliferate, and transdifferentiate into various specific phenotypes, constitute a great asset for peripheral nerve regeneration. Adult stem cells' ability to undergo transdifferentiation is sensitive to various cell-to-cell interactions and external stimuli involving interactions with physical, mechanical, and chemical cues within their microenvironment. Various studies have employed different techniques for transdifferentiating adult stem cells from distinct sources into specific lineages (e...
April 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29656554/a-single-day-of-bed-rest-irrespective-of-energy-balance-does-not-affect-skeletal-muscle-gene-expression-or-insulin-sensitivity
#11
Marlou L Dirks, Francis B Stephens, Sarah R Jackman, Jesús Galera Gordo, David Machin, Richard M Pulsford, Luc Jc van Loon, Benjamin T Wall
NEW FINDINGS: What is the central question of this study? What are the initial metabolic and molecular events that underpin bed rest-induced skeletal muscle deconditioning, and what is the contribution of energy balance? What is the main finding and its importance? A single day of bed rest, irrespective of energy balance, did not lead to overt changes in skeletal muscle gene expression or insulin sensitivity. More than one day of physical inactivity is required to observe the insulin resistance and robust skeletal muscle transcriptional responses associated with bed rest and consequent alterations in energy balance...
April 15, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29656544/an-overview-on-the-identification-of-mait-cell-antigens
#12
Lars Kjer-Nielsen, Alexandra J Corbett, Zhenjun Chen, Ligong Liu, Jeffrey Y W Mak, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, James McCluskey, Sidonia B G Eckle
Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molecule, MHC-related protein-1 (MR1). Until 2012, the origin of the MAIT cell antigens (Ags) was unknown, although it was established that MAIT cells could be activated by a broad range of bacteria and yeasts, possibly suggesting a conserved Ag. Using a combination of protein chemistry, mass spectrometry, cellular biology, structural biology and chemistry, we discovered MAIT cell ligands derived from folic acid (vitamin B9) and from an intermediate in the microbial biosynthesis of riboflavin (vitamin B2)...
April 14, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29656530/mycobacterium-tuberculosis-after-solid-organ-transplantation-a-review-of-more-than-2000-cases
#13
Cybele Lara R Abad, Raymund R Razonable
BACKGROUND: Mycobacterium tuberculosis (TB) is a common pathogen worldwide, and it may cause significant infection after solid organ transplantation (SOT). We reviewed all reported TB cases to provide an update on its epidemiology, clinical presentation, management and outcome after SOT. METHODS: MEDLINE, EMBASE, and OVID were reviewed from January 1, 1998 to Dec 31, 2016 using key words tuberculosis and solid organ transplant or transplantation. RESULTS: There were 187 publications reporting 2082 cases of TB among kidney (n=1719), liver (n=253), heart (n=77), lung (n=25), and kidney-pancreas (n=8) recipients...
April 15, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29656524/the-prevalence-of-meibomian-gland-dysfunction-tear-film-and-ocular-surface-parameters-in-an-austrian-dry-eye-clinic-population
#14
Dieter Franz Rabensteiner, Haleh Aminfar, Ingrid Boldin, Gerold Schwantzer, Jutta Horwath-Winter
PURPOSE: The purpose of this study was to assess the prevalence of meibomian gland dysfunction (MGD) and its association with tear film and ocular surface parameters in an Austrian clinical population of dry eye patients. METHODS: The records of 1372 consecutive patients from a dry eye unit were analysed retrospectively. Symptoms and objective tear film and ocular surface parameters were evaluated. Patients were classified into pure MGD, pure aqueous tear deficiency (ATD), MGD combined with ATD, pure anterior blepharitis (AB), Sjogren's syndrome (SS) without MGD and SS together with MGD...
April 15, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29656518/genotype-specific-progression-of-hereditary-medullary-thyroid-cancer
#15
Andreas Machens, Kerstin Lorenz, Frank Weber, Henning Dralle
Although already 25 years into the genomic era, age-related progression of hereditary medullary thyroid cancer (MTC), the prevalence of which is estimated at 1 in 80,000 inhabitants, remains to be delineated for most unique RET (REarranged during Transfection) mutations. Included in this study were 567 RET carriers. The age-related progression of MTC across histopathological groups (normal thyroid/C-cell hyperplasia; node-negative MTC; node-positive MTC) was statistically significant for 13 unique RET mutations (p...
April 14, 2018: Human Mutation
https://www.readbyqxmd.com/read/29656514/microbial-diversity-and-biomarker-analysis-of-modern-freshwater-microbialites-from-laguna-bacalar-mexico
#16
D B Johnson, P A Beddows, T M Flynn, M R Osburn
Laguna Bacalar is a sulfate-rich freshwater lake on the Yucatan Peninsula that hosts large microbialites. High sulfate concentrations distinguish Laguna Bacalar from other freshwater microbialite sites such as Pavilion Lake and Alchichica, Mexico, as well as from other aqueous features on the Yucatan Peninsula. While cyanobacterial populations have been described here previously, this study offers a more complete characterization of the microbial populations and corresponding biogeochemical cycling using a three-pronged geobiological approach of microscopy, high-throughput DNA sequencing, and lipid biomarker analyses...
April 15, 2018: Geobiology
https://www.readbyqxmd.com/read/29656500/mitochondria-glycogen-and-lipid-droplets-in-skeletal-muscle-during-testosterone-treatment-and-strength-training-a-randomized-double-blinded-placebo-controlled-trial
#17
R C Jensen, L L Christensen, J Nielsen, H D Schrøder, T Kvorning, K Gejl, K Højlund, D Glintborg, M Andersen
Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels...
April 15, 2018: Andrology
https://www.readbyqxmd.com/read/29656474/assessment-of-motivation-levels-and-associated-factors-among-the-nursing-staff-of-tertiary-level-government-hospitals
#18
Rahul Pandey, Sonu Goel, Vipin Koushal
The present study assessed the motivation level of nurses working in 3 highly decorated tertiary-level government hospitals of India and also underpins the factors attributing to motivation levels. A sequential mixed-method design was used in this study wherein 400 nurses working in 5 units of nursing care in the hospitals were enrolled based upon proportionate random stratified sampling techniques. A self-administered questionnaire with Likert scale was developed based upon scale used by Mbindyo et al. The attributes of motivation were then categorized into external and internal attributes...
April 15, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29656472/in-vitro-and-in-vivo-characterization-of-an-interleukin-15-antagonist-peptide-by-metabolic-stability-99m-tc-labeling-and-biological-activity-assays
#19
Yunier Rodríguez-Álvarez, Ania Cabrales-Rico, Alejandro Perera-Pintado, Anais Prats-Capote, Hilda E Garay-Pérez, Osvaldo Reyes-Acosta, Erik Pérez-García, Araceli Chico-Capote, Alicia Santos-Savio
Interleukin (IL)-15 is an inflammatory cytokine that constitutes a validated therapeutic target in some immunopathologies, including rheumatoid arthritis (RA). Previously, we identified an IL-15 antagonist peptide named [K6T]P8, with potential therapeutic application in RA. In the current work, the metabolic stability of this peptide in synovial fluids from RA patients was studied. Moreover, [K6T]P8 peptide was labeled with 99m Tc to investigate its stability in human plasma and its biodistribution pattern in healthy rats...
April 15, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29656469/mortality-and-nursing-home-placement-of-dementia-patients-in-rural-and-urban-areas-a-cohort-study-from-the-swedish-dementia-registry
#20
Mandy Roheger, Eva Zupanic, Ingemar Kåreholt, Dorota Religa, Elke Kalbe, Maria Eriksdotter, Sara Garcia-Ptacek
BACKGROUND: Life in rural and urban areas differs in regard to social support and health care. Our aim was to examine the association between nursing home placement and survival of patients with dementia living in urban vs. rural areas. METHODS: We performed a longitudinal cohort study of patients with dementia at time of diagnosis (n = 58 154) and at first follow-up (n = 21 522) including patients registered from 2007 through 2014 in the Swedish Dementia Registry (SveDem)...
April 14, 2018: Scandinavian Journal of Caring Sciences
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