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https://www.readbyqxmd.com/read/29055289/trends-in-incidence-and-associated-risk-factors-of-suicide-mortality-among-breast-cancer-patients
#1
Apostolos Gaitanidis, Michail Alevizakos, Michail Pitiakoudis, Doreen Wiggins
OBJECTIVE: Breast cancer patients are associated with an increased risk for committing suicide. The purpose of this study is to study the trends in the incidence of suicide mortality and identify pertinent risk factors among patients with breast cancer. METHODS: A retrospective examination of the Surveillance Epidemiology and End Results (SEER) database between years 1973 and 2013 was performed. RESULTS: Overall, 474,128 patients were identified of which 773 had committed suicide...
October 21, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29055286/in-defense-of-progesterone-a-review-of-the-literature
#2
Allan Lieberman, Luke Curtis
Context • The medical literature on the use of progesterone in postmenopausal women is often confusing and contradictory. Some physicians implicate natural progesterone in an increase in the risk of breast cancer. The chemical structure of natural progesterone (P4) is quite different from chemically altered, synthetic chemicals called progestins, which results in different actions at the cell level. Objective • The research team intended to review the literature to examine the benefits and safety of natural progesterone and determine whether it can cause an increase or decrease in breast cancer risk...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055270/executive-functioning-concern-about-falling-and-quadriceps-strength-mediate-the-relationship-between-impaired-gait-adaptability-and-fall-risk-in-older-people
#3
Maria Joana D Caetano, Stephen R Lord, Matthew A Brodie, Daniel Schoene, Paulo H S Pelicioni, Daina L Sturnieks, Jasmine C Menant
BACKGROUND: Reduced ability to adapt gait, particularly under challenging conditions, may be an important reason why older adults have an increased risk of falling. This study aimed to identify cognitive, psychological and physical mediators of the relationship between impaired gait adaptability and fall risk in older adults. METHODS: Fifty healthy older adults (mean±SD: 74±7years) were categorised as high or low fall risk, based on past falls and their performance in the Physiological Profile Assessment...
October 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29055269/decision-making-measured-by-the-iowa-gambling-task-in-alcohol-use-disorder-and-gambling-disorder-a-systematic-review-and-meta-analysis
#4
REVIEW
Ildikó Kovács, Mara J Richman, Zoltán Janka, Aniko Maraz, Bálint Andó
BACKGROUND AND AIMS: Gambling disorder (GD) and alcohol use disorder (AD) have similar features, such as elevated impulsivity and decision-making deficits, which are directly linked to relapse and poor therapeutic outcomes. Our aim was to assess decision-making characteristics in GD and AD patients compared to healthy controls (HC) based on one of the most frequently used measures of decision-making: the Iowa Gambling Task (IGT). METHODS: In our systematic literature search of three databases, we identified 1198 empirical articles that mentioned decision-making deficits with the use of the IGT in patients diagnosed with either AD or GD...
October 12, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29055268/early-age-of-e-cigarette-use-onset-mediates-the-association-between-impulsivity-and-e-cigarette-use-frequency-in-youth
#5
Krysten W Bold, Meghan E Morean, Grace Kong, Patricia Simon, Deepa R Camenga, Dana A Cavallo, Suchitra Krishnan-Sarin
BACKGROUND: Identifying risk factors for youth e-cigarette use is critical, given high rates of e-cigarette use and unknown health effects of long-term use. The current study examined whether an early age of onset of e-cigarette use mediates the association between impulsivity and e-cigarette frequency. METHODS: Cross-sectional survey data of e-cigarette users (n=927) were collected from 8 high schools in southeastern Connecticut. The sample was 44.7% female (mean age 16...
October 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29055263/sub-cortical-brain-morphometry-and-its-relationship-with-cognition-in-rolandic-epilepsy
#6
Mahsa Shakeri, Alexandre N Datta, Domitille Malfait, Nadine Oser, Laurent Létourneau-Guillon, Philippe Major, Myriam Srour, Alan Tucholka, Samuel Kadoury, Sarah Lippé
PURPOSE: Rolandic epilepsy (RE), also called benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood epilepsy syndrome. RE is associated with cognitive difficulties, which can affect children's quality of life. The underlying causes of these cognitive impairments are unclear. The objective of this prospective study is to investigate sub-cortical morphological alterations in RE children with left, right, or bilateral hemispheric focus and its association with cognition...
October 7, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29055260/swimming-exercise-reverses-cums-induced-changes-in-depression-like-behaviors-and-hippocampal-plasticity-related-proteins
#7
Weina Liu, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi
BACKGROUND: Stress-induced failed resilience of brain plasticity can contribute to the onset and recurrence of depression. Chronic stress has been reported to open windows of epigenetic plasticity in hippocampus. However, how hippocampal plasticity underlies depression-like behaviors and how it adapts in response to stress has not been addressed. The present study aimed to investigate the signaling mechanisms of CUMS affecting hippocampal plasticity-related proteins expression and the regulation of swimming exercise in mice...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055258/cognitive-functioning-in-first-episode-bipolar-i-disorder-patients-with-and-without-history-of-psychosis
#8
Chakrabarty Trisha, Alamian Golnoush, Kozicky Jan-Marie, Ivan J Torres, Lakshmi N Yatham
BACKGROUND: Psychosis in bipolar I disorder (BDI) has been associated with increased cognitive dysfunction, which may relate to poorer functional outcomes. However, it is not known whether cognition differs between BDI patients with (BDP+) or without (BDP-) history of psychosis early in the disease course, or if it is impacted by the presence of mood congruent (MCP) versus incongruent (MIC) psychotic features. We compare cognition between these groups in BDI patients recently recovered from first episode of mania...
October 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055250/clinical-characteristics-of-patients-with-diagnostic-uncertainty-of-major-depressive-disorder
#9
Taichi Mogi, Hiroyuki Toda, Aihide Yoshino
BACKGROUND: Physicians do not always confidently diagnose psychiatric disorders. The present study was conducted to identify the clinical characteristics of patients in whom a definitive diagnosis of major depressive disorder (MDD) could not be established. METHODS: The participants were 199 consecutive outpatients with MDD, who were comprehensively diagnosed using the Mini International Neuropsychiatric Interview (MINI). The physician in charge of each patient quantified his/her sense of self-confidence in diagnosing the patient with MDD using the self-rating questionnaire in which the score ranged from 1 (not at all confident) to 5 (definitely MDD)...
October 16, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29055241/comparing-parent-and-child-reports-of-health-related-quality-of-life-and-their-relationship-with-leisure-participation-in-children-and-adolescents-with-cerebral-palsy
#10
Egmar Longo, Marta Badia, M Begoña Orgaz, María Gómez-Vela
The aim of this study was to examine the level of agreement between reports of health-related quality of life (HR-QoL) obtained from children and adolescents with cerebral palsy (CP) and their parents. We also examined the relationships between child and parent perception of the different domains of HR-QoL and participation dimensions. Sixty-nine children and adolescents with CP and their parents separately completed parallel forms of the KIDSCREEN questionnaire. The Spanish version of the Children's Assessment of Participation and Enjoyment (CAPE) was completed by the child/adolescent...
October 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29055240/automatic-processing-of-emotional-facial-expressions-as-a-function-of-social-anhedonia
#11
Vivien Günther, Juliane Zimmer, Anette Kersting, Karl-Titus Hoffmann, Donald Lobsien, Thomas Suslow
Anhedonia is an important feature of major depression and schizophrenia-spectrum disorders. Few neuroimaging studies have investigated neural alterations in high anhedonia, isolated from other psychopathological variables, by including only participants without clinical diagnoses. The present study examined healthy individuals scoring high (N = 18) vs. low (N = 19) in social anhedonia, who were carefully selected from a sample of N = 282 participants. To examine differences in automatic brain responses to social-affective stimuli between high vs...
October 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29055237/mechanisms-of-action-during-a-dissonance-based-intervention-through-14-month-follow-up-the-roles-of-body-shame-and-body-surveillance
#12
Lisa S Kilpela, Katherine E Schaumberg, Lindsey B Hopkins, Carolyn B Becker
Objectification theory posits that internalization of societal perspectives about the female body leads to increased body surveillance, which can result in body-related shame and subsequent eating disorder (ED) behaviors. Preliminary research indicates that these associations may be complex in nature. This study examined temporal relations among body surveillance, body shame, and eating disorder symptoms in the context of a dissonance-based body image intervention and through 14-month follow-up. College women (N=285) completed assessments at baseline, post-intervention, and at 8-week, 8-month, and 14-month follow-up...
October 18, 2017: Body Image
https://www.readbyqxmd.com/read/29055225/generation-and-characterization-of-a-human-ipsc-line-sani005-a-containing-the-gray-platelet-associated-heterozygous-mutation-p-q287-in-gfi1b
#13
Marten Hansen, Eszter Varga, Tatjana Wüst, Clemens Mellink, Anne-Marie van der Kevie-Kersemaekers, Anne E Marneth, Marieke von Lindern, Bert van der Reijden, Emile van den Akker
Peripheral blood mononuclear cells were isolated from an individual harboring a heterozygous c.859C→T p.Q287* mutation in GFI1B, causing an autosomal dominant bleeding disorder, platelet type, 17 (BDPLT17). PBMCs were differentiated to erythroblasts and reprogrammed by lentiviral delivery of a self-silencing hOKSM polycistronic vector. Pluripotency of iPSC line was confirmed by expression of associated markers and by in vitro spontaneous differentiation towards the 3 germ layers. Normal karyotype confirmed the genomic integrity of iPSCs and the presence of disease causing mutation was shown by Sanger sequencing...
October 12, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29055223/pituitary-apoplexy-a-single-center-retrospective-study-from-the-neurosurgical-perspective-and-review-of-the-literature
#14
Agnieszka Grzywotz, Bernadette Kleist, Lars C Möller, Volkmar H Hans, Sophia Göricke, Ulrich Sure, Oliver Müller, Ilonka Kreitschmann-Andermahr
OBJECTIVE: Thunderclap headache and visual disturbances are typical clinical features of pituitary apoplexy (PA). Because of the acute symptomatology, many patients are referred to a neurosurgical department without prior endocrinological assessment. It is the aim of the present study to analyze initial presenting symptoms, outcome and associated endocrine disturbances in a cohort of patients with pituitary apoplexy primarily seen by neurosurgeons. PATIENTS AND METHODS: Retrospective single-center study in a neurosurgical department...
October 10, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29055221/cage-with-anterior-plating-is-advantageous-over-the-stand-alone-cage-for-segmental-lordosis-in-the-treatment-of-two-level-cervical-degenerative-spondylopathy-a-retrospective-study
#15
Paolo Perrini, Federico Cagnazzo, Nicola Benedetto, Riccardo Morganti, Carlo Gambacciani
OBJECTIVES: To compare retrospectively the clinical and radiological outcomes in cervical spinal alignment after two consecutive levels PEEK cage-assisted ACDF when performed with or without plate fixation PATIENTS AND METHODS: Seventy-eight patients underwent two consecutive levels PEEK cage-assisted ACDF without plating (56 patients) or supplemented with plating (22 patients). The average clinical follow-up was 31.40±12.98months. The authors compared clinical parameters (Neck disability index and Robinson criteria), perioperative parameters (hospital stays, complications), and radiological parameters (global lordotic curvature, segmental lordosis, segmental height)...
October 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29055218/cyp2c9-and-vkorc1-in-therapeutic-dosing-and-safety-of-acenocoumarol-treatment-implication-for-clinical-practice-in-hungary
#16
Reka Varnai, Csilla Sipeky, Lajos Nagy, Sandor Balogh, Bela Melegh
The purpose of this work was to investigate the contribution of CYP2C9 and VKORC1 to acenocoumarol (AC) dose variability, bleeding events in Hungary. The study recruited 117 patients on long-term AC therapy (INR 2-3), and 510 healthy individuals to model the findings. Patients were genotyped for alleles proved to affect lower AC overdose CYP2C9*2, CYP2C9*3, VKORC1*2. Additionally, we tested VKORC1*3, VKORC1*4 to examine their effect in patients with higher AC requirements. Most impact on dose reduction is accountable for CYP2C9*2/*3 (59%) and for VKORC1*2/*2 (45...
October 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29055217/trends-in-and-factors-affecting-the-observed-levels-of-urinary-inorganic-and-total-blood-mercury-among-us-children-adolescents-adults-and-senior-citizens-over-2005-2012
#17
Ram B Jain
Data from National Health and Nutrition Examination Survey (NHANES) for 2005-2012 were used to (i) study adjusted and unadjusted trends in the levels of urinary inorganic mercury (UIHG) and total blood mercury (TBHG) and (ii) factors that affect the observed levels of UIHG and TBHG among children aged 1-5 (CHLD15) and 6-11 (CHLD611) years, adolescents aged 12-19 years (ADOL), adults aged 20-64 years (ADLT), and senior citizens aged >=65 years (SNR). Decrease in adjusted levels of UIHG for each 2-year NHANES cycle for CHLD611 was 0...
September 6, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29055185/effect-of-the-solvent-on-the-conformational-behavior-of-the-alanine-dipeptide-deduced-from-md-simulations
#18
Jaime Rubio-Martinez, M Santos Tomas, Juan J Perez
In general, peptides do not exhibit a well-defined conformational profile in solution. However, despite the experimental blurred picture associated with their structure, compelling spectroscopic evidence shows that peptides exhibit local order. The conformational profile of a peptide is the result of a balance between intramolecular interactions between different atoms of the molecule and intermolecular interactions between atoms of the molecule and the solvent. Accordingly, the conformational profile of a peptide will change upon the properties of the solvent it is soaked...
October 12, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29055183/democracy-and-health-evidence-from-within-country-heterogeneity-in-the-congo
#19
Peter van der Windt, Sotiris Vandoros
The literature documents a positive association between democracy and health, and studies supporting this claim have largely relied on cross-country panel analyses. In many developing countries, however, local traditional leaders at the micro-level play a key role in individuals' daily lives while the influence of the national government is largely negligible. In response, this study revisits the relationship between democracy and health using micro-level household data from 816 randomly selected villages in Eastern Congo...
October 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29055181/pfa-100-measured-aspirin-resistance-is-the-predominant-risk-factor-for-hospitalized-cardiovascular-events-in-aspirin-treated-patients-a-5-year-cohort-study
#20
H Y Chen, P Chou
WHAT IS KNOWN AND OBJECTIVE: Aspirin therapy is the clinical gold standard for the prevention of cardiovascular events. However, cardiovascular events still develop in some patients undergoing aspirin therapy. Many laboratory methods exist for measuring aspirin resistance. Using the platelet Function Analyzer (PFA)-100 system, we aimed to determine the effect of aspirin resistance on hospitalized cardiovascular events (hCVE) in a 5-year follow-up cohort. We also sought to determine the impact of aspirin resistance on the relationship between common cardiovascular risk factors and cardiovascular hospitalization...
October 21, 2017: Journal of Clinical Pharmacy and Therapeutics
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