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Association studies

S M Shugurov, A I Panin, S I Lopatin
RATIONALE: CeO2 -WO3 and CeO2 -MoO3 catalysts have shown excellent performance in the selective reduction of NOx by ammonia (NH3 -selective catalytic reduction) over a wide temperature range. Strong interaction between CeO2 and WO3 or MoO3 might be the dominant reason for the high activity of these mixed oxides. Studies of ceria-containing gaseous salts involve considerable experimental difficulties, since the transition of such salts to vapor requires high temperatures. To predict the possibility of the existence of gaseous associates formed by cerium and molybdenum (tungsten) oxides it is important to know their thermodynamic characteristics...
June 21, 2018: Rapid Communications in Mass Spectrometry: RCM
Peilin Zheng, Zhixia Li, Zhiguang Zhou
Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive familial and genome-wide association studies have revealed more than 50 risk loci in the genome. However, genetic susceptibility cannot explain the increased incidence of T1D worldwide, which is very likely attributed by the growing impact of environmental factors, especially gut microbiome. Recently, the role of gut microbiome in the pathogenesis of T1D have been uncovered by the increasing evidence from both human subjects and animal models, strongly indicating that gut microbiome might be a pivotal hub of T1D-triggering factors, especially environmental factors...
June 21, 2018: Diabetes/metabolism Research and Reviews
Afarin Rahimi-Movaghar, Jaleh Gholami, Laura Amato, Leila Hoseinie, Reza Yousefi-Nooraie, Masoumeh Amin-Esmaeili
BACKGROUND: Pharmacologic therapies for management of heroin withdrawal have been studied and reviewed widely. Opium dependence is generally associated with less severe dependence and milder withdrawal symptoms than heroin. The evidence on withdrawal management of heroin might therefore not be exactly applicable for opium. OBJECTIVES: To assess the effectiveness and safety of various pharmacologic therapies for the management of the acute phase of opium withdrawal...
June 21, 2018: Cochrane Database of Systematic Reviews
AndréOliveira Werneck, Danilo Rodrigues Pereira da Silva, Rômulo Araújo Fernandes, EnioRicardoVaz Ronque, Manuel J Coelho-E-Silva, Edilson Serpeloni Cyrino
Sports practice during childhood can influence health indicators in later ages through direct and indirect pathways. Thus, this study aimed to test direct and indirect pathways to the association between sports practice in childhood and metabolic risk in adolescence, adopting physical activity, adiposity, and cardiorespiratory fitness at adolescence as potential mediators. This cross-sectional study with retrospective information was conducted with 991 adolescents (579 girls, 412 boys) aged 10 to 16 y. Sports activity was self-reported in childhood (retrospective data) and physical activity evaluated in adolescence through questionnaires...
June 21, 2018: International Journal of Sports Medicine
Mehdi Menai, Hélène Charreire, Pilar Galan, Chantal Simon, Julie-Anne Nazare, Camille Perchoux, Christiane Weber, Christophe Enaux, Serge Hercberg, Léopold Fezeu, Jean-Michel Oppert
BACKGROUND: Research on the associations between walking and cycling with obesity-related phenotypes is growing but relies mostly on the use of BMI. The purpose of this study was to analyze associations of walking and cycling behaviors assessed separately with various obesity markers in French adults. METHODS: In 12,776 adult participants (71.3% women) of the on-going NutriNet Santé web-cohort, we assessed by self-report past-month walking and cycling (for commuting, errands and leisure), and obesity measures were taken during a visit at a clinical center (weight, height, waist circumference, and percent body fat by bioimpedance)...
June 22, 2018: Obesity Facts
Marco Zaffanello, Giorgio Piacentini, Luca Sacchetto, Angelo Pietrobelli, Emma Gasperi, Marco Barillari, Nicolò Cardobi, Luana Nosetti, Diego Ramaroli, Franco Antoniazzi
OBJECTIVE: Craniofacial disharmony in skeletal diseases is strongly associated with sleep-disordered breathing. Our aim was to study sleep respiratory patterns in young children with rare skeletal disorders. DESIGN: This retrospective study included children with achondroplasia, osteogenesis imperfecta and Ellis van Creveld Syndrome. Our subjects underwent an in-laboratory overnight respiratory polygraph between January 2012 and April 2016. All medical records were reviewed and brain Magnetic Resonance Imaging was conducted on patients with achondroplasia, nasopharynx, oropharynx and laryngopharynx spaces...
June 21, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Junyu Zhao, Chunmei Xu, Jinming Yao, Changzhen Yu, Lin Liao, Jianjun Dong
BACKGROUND/AIMS: Experimental studies have reported the antineoplastic effects of statins in thyroid carcinoma; however, observational studies suggested that statins might increase the risk of thyroid carcinoma. Therefore, this study evaluated the antineoplastic effects of statins in both in vitro studies and animal models, as well as the epidemiological evidence. METHODS: Databases-PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries- were searched...
June 19, 2018: Cellular Physiology and Biochemistry
Nolan Herssens, Evi Verbecque, Ann Hallemans, Luc Vereeck, Vincent Van Rompaey, Wim Saeys
BACKGROUND: Aging is often associated with changes in the musculoskeletal system, peripheral and central nervous system. These age-related changes often result in mobility problems influencing gait performance. Compensatory strategies are used as a way to adapt to these physiological changes. RESEARCH QUESTION: The aim of this review is to investigate the differences in spatiotemporal and gait variability measures throughout the healthy adult life. METHODS: This systematic review was conducted according to the PRISMA guidelines and registered in the PROSPERO database (no...
June 12, 2018: Gait & Posture
Kathryn L Humphreys, Lucy S King, Peter Choi, Ian H Gotlib
BACKGROUND: Parent-child interactions set the stage for child mental health and development. Given that maternal depressive symptoms are associated with poorer observed caregiving behaviors, examining potential cognitive mediators is important for identifying mechanisms underlying the intergenerational transmission of risk and possible targets for intervention. METHODS: We assessed depressive symptoms and levels of self-focus and psychological distancing from infant-centered verbal narratives obtained from 54 mothers, and examined caregiving behaviors in a structured interaction with their six-month-old infants...
June 8, 2018: Journal of Affective Disorders
Qinyi Bao, Lina Chen, Zhiyu Lu, Yongyan Ma, Lili Guo, Shuaishuai Zhang, Xiaoping Huang, Suling Xu, Liemin Ruan
BACKGROUND: Several studies were conducted to investigate the association between eczema and risk of depression. This was important because the care of patients with eczema might be inadequate if their psychological problems were not also recognized and treated. However, these studies had some inherent limitations such as small sample sizes or lack of controlling for potential confounders. Further, little was known about psychological co-morbidity of eczema from a global perspective. METHODS: We conducted a systematic literature search in PubMed (1966 through January 26th 2017), Cochrane Library (the Cochrane central register of controlled trials, up to January 26th 2017), Scopus (up to December 31st 2016) and Embase (1980 through January 26th 2017) supplemented by manual searches of bibliographies and conference proceedings...
May 15, 2018: Journal of Affective Disorders
Candice Y Lumibao, Stephen Formel, Vijaikrishnah Elango, John H Pardue, Michael Blum, Sunshine A Van Bael
The plant microbiome, composed of diverse interacting microorganisms, is thought to undergird host integrity and well-being. Though it is well understood that environmental perturbations like oil pollution can alter the diversity and composition of microbiomes, remarkably little is known about how disturbance alters plant-fungal associations. Using Next-Generation sequencing of the 18S rDNA internal transcribed spacer (ITS1) region, we examined outcomes of enduring oil exposure on aboveground leaf and belowground endophytic root and rhizosphere fungal communities of Spartina alterniflora, a highly valued ecosystem engineer in southeastern Louisiana marshes affected by the 2010 Deepwater Horizon accident...
June 18, 2018: Science of the Total Environment
Shiwei Chang, Xuqi Zhao, Siyu Li, Tuqiang Liao, Jimin Long, Zhiqiang Yu, Yi Cao
Recently we found that direct exposure of human umbilical vein endothelial cells (HUVECs) to multi-walled carbon nanotubes (MWCNTs) might induce toxicological responses through the modulation of ER stress gene expression, but whether this signal could be transferred from other cells to endothelial cells (ECs) is unknown. This study investigated the toxicity of pristine and carboxylated MWCNTs to HUVECs and alveolar-endothelial co-culture, the later of which could mimic the possible signaling communications between ECs and MWCNT exposed alveolar cells...
June 18, 2018: Ecotoxicology and Environmental Safety
Mingcui Ding, Yongli Yang, Xiaoran Duan, Sihua Wang, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Suxiang Liu, Lei Li, Junling Liu, Lixia Tang, Xinhua Niu, Yuhong Zhang, Guoyu Li, Wu Yao, Liuxin Cui, Wei Wang
Omethoate, an organophosphorous pesticide, can cause a variety of health effects, especially the decrease of cholinesterase activity. The aim of this study is to explore the association of genetic polymorphisms of telomere binding proteins with cholinesterase activity in omethoate-exposed population. Cholinesterase activities in whole blood, red blood cell and plasma were detected using acetylthiocholine and dithio-bis-(nitrobenzoic acid) method; Genetic Genotyping of POT1 rs1034794, POT1 rs10250202, TERF1 rs3863242 and TERT rs2736098 were performed with PCR-RFLP...
June 18, 2018: Ecotoxicology and Environmental Safety
Julia Higelin, Alberto Catanese, Lena Luisa Semelink-Sedlacek, Sertap Oeztuerk, Anne-Kathrin Lutz, Julia Bausinger, Gotthold Barbi, Günter Speit, Peter M Andersen, Albert C Ludolph, Maria Demestre, Tobias M Boeckers
Mutations in genes coding for proteins involved in DNA damage response (DDR) and repair, such as C9orf72 and FUS (Fused in Sarcoma), are associated with neurodegenerative diseases and lead to amyotrophic lateral sclerosis (ALS). Heterozygous loss-of-function mutations in NEK1 (NIMA-related kinase 1) have also been recently found to cause ALS. NEK1 codes for a multifunctional protein, crucially involved in mitotic checkpoint control and DDR. To resolve pathological alterations associated with NEK1 mutation, we compared hiPSC-derived motoneurons carrying a NEK1 mutation with mutant C9orf72 and wild type neurons at basal level and after DNA damage induction...
June 12, 2018: Stem Cell Research
M Canal-Rivero, J D López-Moríñigo, E Setién-Suero, M Ruiz-Veguilla, J L Ayuso-Mateos, R Ayesa-Arriola, B Crespo-Facorro
BACKGROUND: Suicide has been recognised as one of the major causes of premature death in psychosis. However, predicting suicidal behaviour (SB) is still challenging in the clinical setting and the association of neurocognition with SB in psychosis remains poorly understood. This study aimed to investigate the role of neurocognitive performance as predictor of SB. Also, we sought to explore differences in the evolution of clinical and neurocognitive functioning between participants with/without history of suicide attempts (SA) over follow-up period...
June 18, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Martine Fohlen, Delphine Taussig, Sarah Ferrand-Sorbets, Mathilde Chipaux, Nathalie Dorison, Olivier Delalande, Georg Dorfmüller
PURPOSE: Epilepsy surgery has been shown to be effective in treating focal epilepsy related to tuberous sclerosis complex (TSC). We analyzed the advantage of early surgical management in terms of seizure frequency and development. METHOD: We retrospectively studied the 15 patients younger than 6 years who underwent resective surgery between 2006 and 2016. Fourteen of them had invasive monitoring while the 15th was operated on under corticography. RESULTS: Epilepsy began before 5 months of age in all patients...
June 18, 2018: Seizure: the Journal of the British Epilepsy Association
Fabiola Hernández-Vázquez, Cosette Reyes-Guzmán, Milagros Méndez
Clinical studies have shown a positive correlation between novelty-seeking behavior and the susceptibility to consume drugs of abuse. Although several animal studies have demonstrated this correlation with psychostimulants or morphine, studies with alcohol have shown conflicting results. The aim of this work was to investigate alcohol-induced motor effects in Wistar rats with different responses to novelty. Animals were classified as Low- (LR) or High-Responders (HR) to novelty, depending on their horizontal activity in an automated open field...
February 17, 2018: Alcohol
Sarah Soyeon Oh, Woorim Kim, Kyu-Tae Han, Eun-Cheol Park, Sung-In Jang
OBJECTIVES: This study investigated the relationship between drinking behavior (alcohol consumption frequency, average alcohol intake per drinking session) and the prevalence of metabolic syndrome (MetS) and its components (central obesity, raised triglycerides, decreased HDL cholesterol, raised blood pressure, raised fasting plasma glucose) in Korean men and women above the age of 20. METHODS: Our study employed data from the Korea National Health and Nutritional Examination Survey (KNHANES) for the years 2007-2013...
February 1, 2018: Alcohol
Eleonora Iob, Clemens Kirschbaum, Andrew Steptoe
INTRODUCTION: While positive social support is associated with lower prevalence of disease and better treatment outcomes, negative social relationships can instead have unfavourable consequences for several physical and mental health conditions. However, the specific mechanisms by which this nexus might operate remain poorly understood. Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity owing to psychosocial stress has been proposed as a potential pathway underlying the link between social support and health...
June 12, 2018: Psychoneuroendocrinology
Preethi Premkumar, Juliana Onwumere, Lucy Betts, Fränze Kibowski, Elizabeth Kuipers
Schizotypal traits are a cluster of personality styles suggesting a potential liability for schizophrenia-spectrum disorders. Interpersonal schizotypal traits include cognitive disorganisation which consists of social anxiety, and introvertive anhedonia which consists of a lack of pleasure in social activities. Rejection sensitivity is evident all along this continuum. This study aimed to determine whether psychosocial quality of life (QOL), neuroticism and agreeableness mediates the relation between schizotypy and rejection sensitivity...
June 5, 2018: Psychiatry Research
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