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https://www.readbyqxmd.com/read/29157465/dietos-a-dietary-recommender-system-for-chronic-diseases-monitoring-and-management
#1
Giuseppe Agapito, Mariadelina Simeoni, Barbara Calabrese, Ilaria Caré, Theodora Lamprinoudi, Pietro H Guzzi, Arturo Pujia, Giorgio Fuiano, Mario Cannataro
BACKGROUND AND OBJECTIVE: Use of mobile and web-based applications for diet and weight management is currently increasing. However, the impact of known apps on clinical outcomes is not well-characterized so far. Moreover, availability of food recommender systems providing high quality nutritional advices to both healthy and diet-related chronic diseases users is very limited. In addition, the potentiality of nutraceutical properties of typical regional foods for improving app utility has not been exerted to this end...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29056159/should-we-recommend-renal-diet-related-apps-to-our-patients-an-evaluation-of-the-quality-and-health-literacy-demand-of-renal-diet-related-mobile-applications
#2
Kelly Lambert, Judy Mullan, Kylie Mansfield, Paris Owen
OBJECTIVE: Mobile phone applications (apps) are increasingly being used by patients with chronic kidney disease (CKD). We sought to describe the main purpose of commonly available renal diet apps and to quantify the accuracy of information, technical quality, and health literacy demand of renal diet apps. DESIGN: The design was content analysis. All eligible renal diet apps in the Australian Apple App Store, Google Play, Windows Phone, and Blackberry App World were evaluated...
November 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28751970/service-evaluation-of-the-implementation-of-a-digitally-enabled-care-pathway-for-the-recognition-and-management-of-acute-kidney-injury
#3
Alistair Connell, Hugh Montgomery, Stephen Morris, Claire Nightingale, Sarah Stanley, Mary Emerson, Gareth Jones, Omid Sadeghi-Alavijeh, Charles Merrick, Dominic King, Alan Karthikesalingam, Cian Hughes, Joseph Ledsam, Trevor Back, Geraint Rees, Rosalind Raine, Christopher Laing
Acute Kidney Injury (AKI), an abrupt deterioration in kidney function, is defined by changes in urine output or serum creatinine. AKI is common (affecting up to 20% of acute hospital admissions in the United Kingdom), associated with significant morbidity and mortality, and expensive (excess costs to the National Health Service in England alone may exceed £1 billion per year). NHS England has mandated the implementation of an automated algorithm to detect AKI based on changes in serum creatinine, and to alert clinicians...
2017: F1000Research
https://www.readbyqxmd.com/read/28698169/effectiveness-of-digital-medicines-to-improve-clinical-outcomes-in-patients-with-uncontrolled-hypertension-and-type-2-diabetes-prospective-open-label-cluster-randomized-pilot-clinical-trial
#4
Juan Frias, Naunihal Virdi, Praveen Raja, Yoona Kim, George Savage, Lars Osterberg
BACKGROUND: Hypertension and type 2 diabetes mellitus are major modifiable risk factors for cardiac, cerebrovascular, and kidney diseases. Reasons for poor disease control include nonadherence, lack of patient engagement, and therapeutic inertia. OBJECTIVE: The aim of this study was to assess the impact on clinic-measured blood pressure (BP) and glycated hemoglobin (HbA1c) using a digital medicine offering (DMO) that measures medication ingestion adherence, physical activity, and rest using digital medicines (medication taken with ingestible sensor), wearable sensor patches, and a mobile device app...
July 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28687348/design-and-approach-of-the-living-organ-video-educated-donors-loved-program-to-promote-living-kidney-donation-in-african-americans
#5
John C Sieverdes, Matthew Price, Kenneth J Ruggiero, Prabhakar K Baliga, Kenneth D Chavin, Brenda Brunner-Jackson, Sachin Patel, Frank A Treiber
PURPOSE: To describe the rationale, methodology, design, and interventional approach of a mobile health education program designed for African Americans with end stage renal disease (ESRD) to increase knowledge and self-efficacy to approach others about their need for a living donor kidney transplant (LDKT). METHODS: The Living Organ Video Educated Donors (LOVED) program is a theory-guided iterative designed, mixed methods study incorporating three phases: 1) a formative evaluation using focus groups to develop program content and approach; 2) a 2-month proof of concept trial (n=27) to primarily investigate acceptability, tolerability and investigate increases of LDKT knowledge and self-efficacy; and 3) a 6-month, 2-arm, 60-person feasibility randomized control trial (RCT) to primarily investigate increases in LDKT knowledge and self-efficacy, and secondarily, to increase the number of living donor inquiries, medical evaluations, and LDKTs...
October 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28676470/desirable-components-for-a-customized-home-based-digital-care-management-app-for-children-and-young-people-with-long-term-chronic-conditions-a-qualitative-exploration
#6
Ruth Nightingale, Andrew Hall, Carole Gelder, Simone Friedl, Eileen Brennan, Veronica Swallow
BACKGROUND: Mobile apps for mobile phones and tablet devices are widely used by children and young people aged 0-18 years with long-term health conditions, such as chronic kidney disease (CKD), and their healthy peers for social networking or gaming. They are also poised to become a major source of health guidance. However, app development processes that are coproduced, rigorously developed, and evaluated to provide tailored, condition-specific, practical advice on day-to-day care management are seldom systematic or sufficiently described to enable replication...
July 4, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28394535/-metaphylaxis-of-urolithiasis-new-look-modern-approach-implementation-in-a-mobile-application
#7
N K Gadzhiev, S S Brovkin, V E Grigorev, V V Dmitriev, V A Malkhasyan, D D Shkarupa, A V Pisarev, D A Mazurenko, V M Obidnyak, I N Orlov, S V Popov, N S Tagirov, S V Petrov
AIM: To analyze the sub-segment of mHealth devoted to assessing of the risk of recurrent stone formation and metaphylaxis of stone formation. To design a smartphone application (app.) in Russian language for urolithiasis patients. MATERIALS AND METHODS: Three working groups of urologists from three St. Petersburg clinics searched for downloadable medical applications relevant to the above requirements. After searching and analyzing existing medical applications, the most acceptable design and structure of our own application were identified...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28263408/cultural-competency-of-a-mobile-customized-patient-education-tool-for-improving-potential-kidney-transplant-recipients-knowledge-and-decision-making
#8
David A Axelrod, Crystal S Kynard-Amerson, David Wojciechowski, Marie Jacobs, Krista L Lentine, Mark Schnitzler, John D Peipert, Amy D Waterman
Patients considering renal transplantation face an increasingly complex array of choices as a result of the revised kidney transplant allocation system. Decision aids have been shown to improve patient decision-making through the provision of detailed, relevant, individualized clinical data. A mobile iOS-based application (app) including animated patient education and individualized risk-adjusted outcomes following kidney transplants with varying donor characteristics and DSA waiting times was piloted in two large US transplant programs with a diverse group of renal transplant candidates (N = 81)...
May 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/27463536/effect-of-a-mobile-web-app-on-kidney-transplant-candidates-knowledge-about-increased-risk-donor-kidneys-a-randomized-controlled-trial
#9
Elisa J Gordon, Min-Woong Sohn, Chih-Hung Chang, Gwen McNatt, Karina Vera, Nicole Beauvais, Emily Warren, Roslyn B Mannon, Michael G Ison
BACKGROUND: Kidney transplant candidates (KTCs) must provide informed consent to accept kidneys from increased risk donors (IRD), but poorly understand them. We conducted a multisite, randomized controlled trial to evaluate the efficacy of a mobile Web application, Inform Me, for increasing knowledge about IRDs. METHODS: Kidney transplant candidates undergoing transplant evaluation at 2 transplant centers were randomized to use Inform Me after routine transplant education (intervention) or routine transplant education alone (control)...
June 2017: Transplantation
https://www.readbyqxmd.com/read/27450140/kidney-transplant-recipients-attitudes-about-using-mobile-health-technology-for-managing-and-monitoring-medication-therapy
#10
Robert B Browning, John W McGillicuddy, Frank A Treiber, David J Taber
OBJECTIVES: To assess smartphone ownership, use of mobile health (mHealth) applications, and willingness to use this technology to facilitate medication management after kidney transplantation. METHODS: A survey was developed with the use of previously validated questions and administered to stable adult kidney recipients from May to July 2015. Descriptive and comparative statistics were used to assess willingness to utilize mHealth technology as it related to sociodemographics, medication adherence, and medication side effects...
July 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27227150/why-do-patients-forget-to-take-immunosuppression-medications-and-miss-appointments-can-a-mobile-phone-app-help
#11
Ajay Israni, Carl Dean, Brian Kasel, Lisa Berndt, Winston Wildebush, C Jason Wang
BACKGROUND: Kidney transplant recipients must adhere to their immunosuppressive medication regimen. However, non-adherence remains a major problem. OBJECTIVE: The aim of this paper is to determine how kidney transplant recipients remember to take their medications, and assess their perception and beliefs about adherence to immunosuppressive medications and barriers to medication adherence. In addition, we aim to assess perception and beliefs about willingness to use a hypothetical, mobile phone app to improve adherence...
January 2016: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/26900599/a-randomized-controlled-trial-of-a-mobile-medical-app-for-kidney-transplant-recipients-effect-on-use-of-sun-protection
#12
June K Robinson, John J Friedewald, Amishi Desai, Elisa J Gordon
BACKGROUND: Perception of skin cancer risk, belief that sun protection prevents skin cancer, and having sun protection choices enhance sun protection behaviors by kidney transplant recipients, who are at greater risk of developing skin cancer than the general population. METHODS: A randomized controlled trial used stratified recruitment of non-Hispanic White, non-Hispanic Black, and Hispanic/Latino kidney transplant recipients, who received a transplant 2-24 months prior to the study...
January 2016: Transplantation Direct
https://www.readbyqxmd.com/read/25959301/dietary-mobile-apps-and-their-effect-on-nutritional-indicators-in-chronic-renal-disease-a-systematic-review
#13
Janice Lai, Judi Porter
Dietary apps for mobile technology are becoming increasingly available and can assist in recording food and fluid intake for nutrition assessment or monitoring. Patients with chronic renal disease, particularly those on dialysis, are required to make significant dietary changes. This study systematically reviews the current literature to assess whether dietary mobile apps improve dietary intake and clinical outcomes in the renal population, specifically those with Chronic Kidney Disease levels 3-5, including dialysis...
May 10, 2015: Nephrology
https://www.readbyqxmd.com/read/25539976/the-transnephro-study-examining-a-new-transition-model-for-post-kidney-transplant-adolescents-and-an-analysis-of-the-present-health-care-study-protocol-for-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Martin Kreuzer, Jenny Prüfe, Dirk Bethe, Charlotte Vogel, Anika Großhennig, Armin Koch, Martina Oldhafer, Marie-Luise Dierks, Urs-Vito Albrecht, Silvia Müther, Reinhard Brunkhorst, Lars Pape
BACKGROUND: The transition from pediatric to nephrology care is not yet a standardized procedure. The result is an increased risk of deteriorating transplant function, with the potential for premature transplant failure. METHODS/DESIGN: In phase I of this study, we shall evaluate the current patient transition situation in all existing German pediatric and nephrology departments (n = 17), including an evaluation of the views of physicians, nurses, and psychosocial support staff regarding transition...
2014: Trials
https://www.readbyqxmd.com/read/24943534/mockup-design-of-personal-health-diary-app-for-patients-with-chronic-kidney-disease
#15
Hsiu-Wen Lin, Yu-Jen Wang, Ling-Fang Jing, Polun Chang
Health self-management is important in the care of patients with chronic kidney disease. It is possible to improve the efficiency of patient self-management through the use of mobile technology and related software. This study is divided into three stages: 1. analysis of need: through observation, interview and content analysis of the chronic kidney disease health management manual; 2. design of system prototype: establish interface and system function; 3. prototype evaluation: evaluate whether the prototype designed by this study meets user needs...
2014: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/21591562/mhealth
#16
Howard Larkin
More than 17,000 mHealth apps now are available for smart phones and other devices, and they do everything from monitoring urine flow for patients with enlarged prostates to reminding people prone to kidney stones to drink more water. And that's just on the consumer side. Countless apps are avail-able for use by clinicians and hospitals. Mobile apps are changing health care in dramatic ways.
April 2011: Hospitals & Health Networks
https://www.readbyqxmd.com/read/10693945/increased-generation-of-alternatively-cleaved-beta-amyloid-peptides-in-cells-expressing-mutants-of-the-amyloid-precursor-protein-defective-in-endocytosis
#17
R Cescato, E Dumermuth, M Spiess, P A Paganetti
The subcellular location of the secretases processing the beta-amyloid precursor protein (APP) is not established yet. We analyzed the generation of the beta-amyloid peptide (Abeta) in human embryonic kidney 293 cell lines stably expressing wild-type and noninternalizing mutants of human APP. APP lacking the entire cytoplasmic domain or with both tyrosine residues of the motif GYENPTY mutated to alanine showed at least fivefold reduced endocytosis. In these cell lines, the production of Abeta1-40 was substantially reduced, but accompanied by the appearance of two prominent alternative Abeta peptides differing at the amino-termini...
March 2000: Journal of Neurochemistry
https://www.readbyqxmd.com/read/8132561/the-release-of-alzheimer-s-disease-beta-amyloid-peptide-is-reduced-by-phorbol-treatment
#18
J S Jacobsen, M A Spruyt, A M Brown, S R Sahasrabudhe, A J Blume, M P Vitek, H A Muenkel, J Sonnenberg-Reines
Amyloid precursor protein (APP) is cleaved predominantly within the beta amyloid peptide (BAP) domain to release a non-amyloidogenic amino-terminal PN2 fragment. Treatment of cells with phorbol dibutyrate, an agent which activates protein kinase C, has been shown to increase the release of an amino-terminal fragment. A panel of mutant APP reporter constructs was expressed in which each of the potential phosphorylation sites located within the cytoplasmic domain of APP was replaced with alanine residues. Phorbol response patterns were unchanged for each of these mutants, suggesting that induced cleavage occurs independently of APP substrate phosphorylation...
March 18, 1994: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/7706247/extracellular-matrix-influences-the-biogenesis-of-amyloid-precursor-protein-in-microglial-cells
#19
U Mönning, R Sandbrink, A Weidemann, R B Banati, C L Masters, K Beyreuther
During axotomy studies, we discovered that the beta A4-amyloid precursor protein (APP) participates in immune responses of the central nervous system. Since microglia constitute the main immune effector cell population of this response, we used the murine microglial cell line BV-2 to analyze immune response-related APP expression. We show that interaction of microglia with the extracellular environment, particularly components of the extracellular matrix, affects APP secretion as well as intracellular APP biogenesis and catabolism...
March 31, 1995: Journal of Biological Chemistry
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