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Mobile apps kidney

Elisa J Gordon, Min-Woong Sohn, Chih-Hung Chang, Gwen McNatt, Karina Vera, Nicole Beauvais, Emily Warren, Roslyn B Mannon, Michael G Ison
BACKGROUND: Kidney transplant candidates (KTCs) must provide informed consent to accept kidneys from increased risk donors (IRD), but poorly understand them. We conducted a multisite, randomized controlled trial to evaluate the efficacy of a mobile Web application, Inform Me, for increasing knowledge about IRDs. METHODS: Kidney transplant candidates undergoing transplant evaluation at 2 transplant centers were randomized to use Inform Me after routine transplant education (intervention) or routine transplant education alone (control)...
July 12, 2016: Transplantation
Robert B Browning, John W McGillicuddy, Frank A Treiber, David J Taber
OBJECTIVES: To assess smartphone ownership, use of mobile health (mHealth) applications, and willingness to use this technology to facilitate medication management after kidney transplantation. METHODS: A survey was developed with the use of previously validated questions and administered to stable adult kidney recipients from May to July 2015. Descriptive and comparative statistics were used to assess willingness to utilize mHealth technology as it related to sociodemographics, medication adherence, and medication side effects...
July 2016: Journal of the American Pharmacists Association: JAPhA
Ajay Israni, Carl Dean, Brian Kasel, Lisa Berndt, Winston Wildebush, C Jason Wang
BACKGROUND: Kidney transplant recipients must adhere to their immunosuppressive medication regimen. However, non-adherence remains a major problem. OBJECTIVE: The aim of this paper is to determine how kidney transplant recipients remember to take their medications, and assess their perception and beliefs about adherence to immunosuppressive medications and barriers to medication adherence. In addition, we aim to assess perception and beliefs about willingness to use a hypothetical, mobile phone app to improve adherence...
January 2016: JMIR Public Health and Surveillance
June K Robinson, John J Friedewald, Amishi Desai, Elisa J Gordon
BACKGROUND: Perception of skin cancer risk, belief that sun protection prevents skin cancer, and having sun protection choices enhance sun protection behaviors by kidney transplant recipients, who are at greater risk of developing skin cancer than the general population. METHODS: A randomized controlled trial used stratified recruitment of non-Hispanic White, non-Hispanic Black, and Hispanic/Latino kidney transplant recipients, who received a transplant 2-24 months prior to the study...
January 2016: Transplantation Direct
Janice Lai, Judi Porter
Dietary apps for mobile technology are becoming increasingly available and can assist in recording food and fluid intake for nutrition assessment or monitoring. Patients with chronic renal disease, particularly those on dialysis, are required to make significant dietary changes. This study systematically reviews the current literature to assess whether dietary mobile apps improve dietary intake and clinical outcomes in the renal population, specifically those with Chronic Kidney Disease levels 3-5, including dialysis...
May 10, 2015: Nephrology
Martin Kreuzer, Jenny Prüfe, Dirk Bethe, Charlotte Vogel, Anika Großhennig, Armin Koch, Martina Oldhafer, Marie-Luise Dierks, Urs-Vito Albrecht, Silvia Müther, Reinhard Brunkhorst, Lars Pape
BACKGROUND: The transition from pediatric to nephrology care is not yet a standardized procedure. The result is an increased risk of deteriorating transplant function, with the potential for premature transplant failure. METHODS/DESIGN: In phase I of this study, we shall evaluate the current patient transition situation in all existing German pediatric and nephrology departments (n = 17), including an evaluation of the views of physicians, nurses, and psychosocial support staff regarding transition...
2014: Trials
Hsiu-Wen Lin, Yu-Jen Wang, Ling-Fang Jing, Polun Chang
Health self-management is important in the care of patients with chronic kidney disease. It is possible to improve the efficiency of patient self-management through the use of mobile technology and related software. This study is divided into three stages: 1. analysis of need: through observation, interview and content analysis of the chronic kidney disease health management manual; 2. design of system prototype: establish interface and system function; 3. prototype evaluation: evaluate whether the prototype designed by this study meets user needs...
2014: Studies in Health Technology and Informatics
Howard Larkin
More than 17,000 mHealth apps now are available for smart phones and other devices, and they do everything from monitoring urine flow for patients with enlarged prostates to reminding people prone to kidney stones to drink more water. And that's just on the consumer side. Countless apps are avail-able for use by clinicians and hospitals. Mobile apps are changing health care in dramatic ways.
April 2011: Hospitals & Health Networks
R Cescato, E Dumermuth, M Spiess, P A Paganetti
The subcellular location of the secretases processing the beta-amyloid precursor protein (APP) is not established yet. We analyzed the generation of the beta-amyloid peptide (Abeta) in human embryonic kidney 293 cell lines stably expressing wild-type and noninternalizing mutants of human APP. APP lacking the entire cytoplasmic domain or with both tyrosine residues of the motif GYENPTY mutated to alanine showed at least fivefold reduced endocytosis. In these cell lines, the production of Abeta1-40 was substantially reduced, but accompanied by the appearance of two prominent alternative Abeta peptides differing at the amino-termini...
March 2000: Journal of Neurochemistry
J S Jacobsen, M A Spruyt, A M Brown, S R Sahasrabudhe, A J Blume, M P Vitek, H A Muenkel, J Sonnenberg-Reines
Amyloid precursor protein (APP) is cleaved predominantly within the beta amyloid peptide (BAP) domain to release a non-amyloidogenic amino-terminal PN2 fragment. Treatment of cells with phorbol dibutyrate, an agent which activates protein kinase C, has been shown to increase the release of an amino-terminal fragment. A panel of mutant APP reporter constructs was expressed in which each of the potential phosphorylation sites located within the cytoplasmic domain of APP was replaced with alanine residues. Phorbol response patterns were unchanged for each of these mutants, suggesting that induced cleavage occurs independently of APP substrate phosphorylation...
March 18, 1994: Journal of Biological Chemistry
U Mönning, R Sandbrink, A Weidemann, R B Banati, C L Masters, K Beyreuther
During axotomy studies, we discovered that the beta A4-amyloid precursor protein (APP) participates in immune responses of the central nervous system. Since microglia constitute the main immune effector cell population of this response, we used the murine microglial cell line BV-2 to analyze immune response-related APP expression. We show that interaction of microglia with the extracellular environment, particularly components of the extracellular matrix, affects APP secretion as well as intracellular APP biogenesis and catabolism...
March 31, 1995: Journal of Biological Chemistry
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