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https://www.readbyqxmd.com/read/25811927/antitumor-effects-of-vitamin-d-analogs-on-hamster-and-mouse-melanoma-cell-lines-in-relation-to-melanin-pigmentation
#1
Tomasz Wasiewicz, Paulina Szyszka, Miroslawa Cichorek, Zorica Janjetovic, Robert C Tuckey, Andrzej T Slominski, Michal A Zmijewski
Deregulated melanogenesis is involved in melanomagenesis and melanoma progression and resistance to therapy. Vitamin D analogs have anti-melanoma activity. While the hypercalcaemic effect of the active form of Vitamin D (1,25(OH)2D3) limits its therapeutic use, novel Vitamin D analogs with a modified side chain demonstrate low calcaemic activity. We therefore examined the effect of secosteroidal analogs, both classic (1,25(OH)2D3 and 25(OH)D3), and novel relatively non-calcemic ones (20(OH)D3, calcipotriol, 21(OH)pD, pD and 20(OH)pL), on proliferation, colony formation in monolayer and soft-agar, and mRNA and protein expression by melanoma cells...
March 24, 2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/25695262/expression-of-the-platelet-activating-factor-receptor-enhances-benzyl-isothiocyanate-induced-apoptosis-in-murine-and-human-melanoma-cells
#2
Ravi Prakash Sahu
Melanoma cells often express platelet-activating factor receptor (PAF-R), which has been demonstrated to increase metastatic behavior. However, the effect of PAF-R on the responsiveness of melanoma to naturally occurring cytotoxic agents remains to be elucidated. The present study aimed to determine the relative cytotoxicity and mechanism of benzyl isothiocyanate (BITC), a component of cruciferous vegetables, in melanoma cells expressing PAF-R. To evaluate the importance of PAF-R signaling in melanoma cell growth, PAF-R-negative murine B16F10 cells were transduced with a retrovirus containing the cDNA for PAF-R to generate cells stably expressing PAF-R (B16-PAF-R) or an empty vector (MSCV) to generate PAF-R-deficient B16-MSCV control cells...
July 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25354695/restoring-physiological-levels-of-ascorbate-slows-tumor-growth-and-moderates-hif-1-pathway-activity-in-gulo-mice
#3
Elizabeth J Campbell, Margreet C M Vissers, Stephanie Bozonet, Arron Dyer, Bridget A Robinson, Gabi U Dachs
Hypoxia-inducible factor-1 (HIF-1) governs cellular adaption to the hypoxic microenvironment and is associated with a proliferative, metastatic, and treatment-resistant tumor phenotype. HIF-1 levels and transcriptional activity are regulated by proline and asparagine hydroxylases, which require ascorbate as cofactor. Ascorbate supplementation reduced HIF-1 activation in vitro, but only limited data are available in relevant animal models. There is no information of the effect of physiological levels of ascorbate on HIF activity and tumor growth, which was measured in this study...
February 2015: Cancer Medicine
https://www.readbyqxmd.com/read/24680613/anti-melanogenic-effects-of-%C3%AE-tocotrienol-are-associated-with-tyrosinase-related-proteins-and-mapk-signaling-pathway-in-b16-melanoma-cells
#4
Lean-Teik Ng, Liang-Tzung Lin, Chiu-Lan Chen, Hsiu-Wen Chen, Shu-Jing Wu, Chun-Ching Lin
Tocotrienols are known to possess potent antioxidant, anticancer, and cholesterol lowering activities. Being able to rapidly penetrate the skin, these vitamin E isoforms have been explored for potential treatment against melanoma. This study aimed to elucidate the mechanism involved in the anti-melanogenic effects of δ-tocotrienol (δT3) in B16 melanoma cells. Results showed that at 20 μM of δT3 significantly inhibited melanin formation and ROS generation. Treatment with δT3 also effectively suppressed the expression of melanogenesis-related proteins, including MC1R, MITF, TYRP-1, and TYRP-2...
June 15, 2014: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/24168697/antibacterial-and-anti-inflammatory-effects-of-syzygium-jambos-l-alston-and-isolated-compounds-on-acne-vulgaris
#5
Richa Sharma, Navneet Kishore, Ahmed Hussein, Namrita Lall
BACKGROUND: Acne vulgaris is a chronic skin disorder leading to inflammation as a result of the production of reactive oxygen species due to the active involvement of Propionibacterium acnes (P. acnes) in the infection site of the skin. The current study was designed to assess the potential of the leaf extract of Syzygium jambos L. (Alston) and its compounds for antibacterial and anti-inflammatory activity against the pathogenic P. acnes. METHODS: The broth dilution method was used to assess the antibacterial activity...
2013: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/23578836/in-vitro-melanogenesis-inhibitory-effects-of-n-feruloyldopamine
#6
S Leoty-Okombi, S Bonnet, D Rival, V Degrave, X Lin, B Vogelgesang, V André-Frei
Tyrosinase is the rate-limiting enzyme in the melanogenesis process. It remains the most efficient way to downregulate melanin production and improve unsightly pigmentary disorders. The aim of our investigations was to find a structurally characterized molecule with better efficacy than existing molecules without cell toxicity. We focused our investigations on compounds that could act as substrate-mimicking inhibitors of tyrosinase and identified N-feruloyldopamine as the best candidate. In vitro, N-feruloyldopamine inhibited human tyrosinase with higher efficacy than the reference inhibitor arbutin without cell toxicity at least up to 100 μM as measured in cultured normal human epidermal melanocytes (NHEMs)...
March 2013: Journal of Cosmetic Science
https://www.readbyqxmd.com/read/22669199/kineococcus-endophytica-sp-nov-a-novel-endophytic-actinomycete-isolated-from-a-coastal-halophyte-in-jiangsu-china
#7
Guang-Kai Bian, Zhao-Zhong Feng, Sheng Qin, Ke Xing, Zhe Wang, Cheng-Liang Cao, Chang-Hong Liu, Chuan-Chao Dai, Ji-Hong Jiang
A novel Gram-positive, motile, non-spore-forming coccus-shaped bacterial strain, designated KLBMP 1274(T), was isolated from a halophytic plant (Limonium sinense) collected from the coastal region of Nantong, Jiangsu Province, in east China. Phylogenetic analyses based on the 16S rRNA gene sequence showed that strain KLBMP 1274(T) belongs to the genus Kineococcus and is closely related to Kineococcus rhizosphaerae RP-B16(T) (98.72 %), Kineococcus aurantiacus IFO 15268(T) (98.71 %), Kineococcus radiotolerans SRS30216(T) (98...
November 2012: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/22391496/effects-of-employing-a-%C3%A2-%C3%A2-b-carrier-and-manipulating-intratumour-hypoxia-on-local-tumour-response-and-lung-metastatic-potential-in-boron-neutron-capture-therapy
#8
S Masunaga, Y Sakurai, H Tanaka, M Suzuki, Y Liu, N Kondo, A Maruhashi, Y Kinashi, K Ono
OBJECTIVES: To evaluate the effects of employing a (10)B-carrier and manipulating intratumour hypoxia on local tumour response and lung metastatic potential in boron neutron capture therapy (BNCT) by measuring the response of intratumour quiescent (Q) cells. METHODS: B16-BL6 melanoma tumour-bearing C57BL/6 mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. The tumours received reactor thermal neutron beam irradiation following the administration of a (10)B-carrier [L-para-boronophenylalanine-(10)B (BPA) or sodium mercaptoundecahydrododecaborate-(10)B (BSH)] in combination with an acute hypoxia-releasing agent (nicotinamide) or mild temperature hyperthermia (MTH)...
March 2012: British Journal of Radiology
https://www.readbyqxmd.com/read/22352891/effects-of-thymol-on-b16-f10-melanoma-cells
#9
Hiroki Satooka, Isao Kubo
Aromatic monoterpene, thymol, shows several beneficial activities, such as an antioxidative effect. However, the mechanism of its toxicity remains to be fully defined. In preliminary studies, thymol was characterized as a melanin formation inhibitor in an enzymatic system; however, thymol showed moderate cytotoxicity but not an antimelanogenic effect on B16-F10 melanoma cells. Thymol exhibited cytotoxicity, with an IC(50) value of 400 μM (60.09 μg/mL). This moderate toxic effect was suppressed with the addition of vitamin C and vitamin D, and 20 and 40% of cell viability was increased, respectively...
March 14, 2012: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/21540247/mevalonate-depletion-mediates-the-suppressive-impact-of-geranylgeraniol-on-murine-b16-melanoma-cells
#10
Rajasekhar Katuru, Nicolle V Fernandes, Manal Elfakhani, Dibyendu Dutta, Nathaniel Mills, DiAnna L Hynds, Clay King, Huanbiao Mo
The diterpene geranylgeraniol (all trans-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-ol) suppresses the growth of human liver, lung, ovary, pancreas, colon, stomach and blood tumors with undefined mechanisms. We evaluated the growth-suppressive activity of geranylgeraniol in murine B16 melanoma cells. Geranylgeraniol induced dose-dependent suppression of B16 cell growth (IC(50) = 55 ± 13 µmol/L) following a 48-h incubation in 96-well plates. Cell cycle arrest at the G1 phase, manifested by a geranylgeraniol-induced increase in the G1/S ratio and decreased expression of cyclin D1 and cyclin-dependent kinase 4, apoptosis detected by Guava Nexin™ assay and fluorescence microscopy following acridine orange and ethidium bromide dual staining, and cell differentiation shown by increased alkaline phosphatase activity, contributed to the growth suppression...
May 1, 2011: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/21539872/novel-tocotrienol-entrapping-vesicles-can-eradicate-solid-tumors-after-intravenous-administration
#11
Ju Yen Fu, Wei Zhang, David R Blatchford, Laurence Tetley, Gail McConnell, Christine Dufès
The therapeutic potential of tocotrienol, a vitamin E extract with anti-cancer properties, is hampered by its failure to specifically reach tumors after intravenous administration. In this work, we demonstrated that novel transferrin-bearing, tocopheryl-based multilamellar vesicles entrapping tocotrienol significantly improved tocotrienol uptake by cancer cells overexpressing transferrin receptors. This led to a dramatically improved therapeutic efficacy in vitro, ranging from 17-fold to 72-fold improvement depending on the cell lines, compared to the free drug...
August 25, 2011: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/21187473/d-%C3%AE-tocotrienol-mediated-cell-cycle-arrest-and-apoptosis-in-human-melanoma-cells
#12
Nicolle V Fernandes, Praveen K Guntipalli, Huanbiao Mo
BACKGROUND: The rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation or dolichylation of growth-related proteins. d-δ-tocotrienol, a post-transcriptional down-regulator of HMG CoA reductase, suppresses the proliferation of murine B16 melanoma cells. Dietary d-δ-tocotrienol suppresses the growth of implanted B16 melanomas without toxicity to host mice. MATERIALS AND METHODS: The proliferation of human A2058 and A375 melanoma cells following a 72 h incubation in 96-well plates was measured by CellTiter 96® Aqueous One Solution...
December 2010: Anticancer Research
https://www.readbyqxmd.com/read/20548792/vitamin-a-enhances-antitumor-effect-of-a-green-tea-polyphenol-on-melanoma-by-upregulating-the-polyphenol-sensing-molecule-67-kda-laminin-receptor
#13
Ju Hye Lee, Mutsumi Kishikawa, Motofumi Kumazoe, Koji Yamada, Hirofumi Tachibana
BACKGROUND: Green tea consumption has been shown to have cancer preventive qualities. Among the constituents of green tea, (-)-Epigallocatechin-3-O-gallate (EGCG) is the most effective at inhibiting carcinogenesis. However, the concentrations of EGCG that are required to elicit the anticancer effects in a variety of cancer cell types are much higher than the peak plasma concentration that occurs after drinking an equivalent of 2-3 cups of green tea. To obtain the anticancer effects of EGCG when consumed at a reasonable concentration in daily life, we investigated the combination effect of EGCG and food ingredient that may enhance the anticancer activity of EGCG on subcutaneous tumor growth in C57BL/6N mice challenged with B16 melanoma cells...
2010: PloS One
https://www.readbyqxmd.com/read/20430091/screening-of-chinese-herbal-medicines-for-antityrosinase-activity-in-a-cell-free-system-and-b16-cells
#14
Yan Ye, Gui-Xin Chou, Dan-Dan Mu, Hui Wang, Jian-Hong Chu, Alexander Kai-Man Leung, Wang-fun Fong, Zhi-Ling Yu
AIM OF THE STUDY: Tyrosinase inhibitors are becoming increasingly important in controlling skin hyperpigmentation. We aimed to screen 50 extracts from traditional Chinese medicines (TCM) for tyrosinase activity-inhibiting agents. MATERIALS AND METHODS: The 50 herbal extracts were prepared from 32 herbs and 18 TCM formulas, which are used as folk skin whiteners in China and have not been investigated for their skin-whitening mechanisms. Each herb and formula was extracted with 30% ethanol and water, respectively, and followed by column chromatography for isolating bioactive substances such as saponins, flavonoids and alkaloids for the antityrosinase activity study...
June 16, 2010: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/19568943/comparison-of-the-inhibitory-effects-of-vitamin-e-analogues-on-melanogenesis-in-mouse-b16-melanoma-cells
#15
Yuto Kamei, Yuri Otsuka, Kouichi Abe
The effect of eight vitamin E analogues (d-alpha-, dl-alpha-, d-beta-, d-gamma-, and d-delta-tocopherols, d-alpha- and dl-alpha-tocopheryl acetates) and 2,2,5,7,8-pentamethyl-6-hydroxychroman (PMC) on melanogenesis were compared in mouse B16 melanoma cells. D-beta-tocopherol at 250 mug ml(-1) inhibited not only 28% of melanin synthesis in B16 cells, but also 34% of the tyrosinase activity, a very important cascade enzyme involved in the synthesis of melanin in melanoma cells. D-gamma-tocopherol also strongly inhibited up to 39% of melanin synthesis and 45% of the tyrosinase enzyme activity at the same concentration...
April 2009: Cytotechnology
https://www.readbyqxmd.com/read/19082730/arsenic-induced-apoptosis-in-malignant-melanoma-cells-is-enhanced-by-menadione-through-ros-generation-p38-signaling-and-p53-activation
#16
Rajdeep Chowdhury, Suchandra Chowdhury, Paromita Roychoudhury, Chitra Mandal, Keya Chaudhuri
INTRODUCTION: Resistance to apoptosis is a prominent feature of melanoma. Pharmacological concentration of arsenic in combination with a widely known oxidant, menadione was explored in this study to synergistically sensitize malignant melanoma cells to apoptosis. The molecular mechanism of apoptosis and the signaling-pathways involved were thoroughly investigated. MATERIALS METHODS AND RESULTS: Menadione synergized NaAsO(2) to significantly increase ROS generation and facilitate the major apoptotic signaling events: alteration of mitochondrial membrane potential, cytochrome c release and anti-apoptotic protein Bcl-2 down-regulation and subsequent activation of caspase-9 and caspase-3 followed by poly-ADP-ribose polymerase-1 cleavage...
January 2009: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/18838813/depigmenting-mechanisms-of-all-trans-retinoic-acid-and-retinol-on-b16-melanoma-cells
#17
Kazuomi Sato, Masayuki Morita, Chihiro Ichikawa, Hideki Takahashi, Masaru Toriyama
We assessed the effects of ATRA and retinol on melanogenesis in murine B16 melanoma cells. In the present study, ATRA and retinol inhibited melanin synthesis in melanoma cells stimulated by alpha-melanocyte stimulating hormone (alpha-MSH) or 3-isobutyl-1-methylxanthine (IBMX). To elucidate the target points of ATRA and retinol on melanogenesis, we performed western blotting for melanogenic proteins, such as tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. ATRA inhibited the expression of tyrosinase and TRP-1, and retinol inhibited the expression of tyrosinase, in a dose-dependent manner...
October 2008: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/18499366/effect-of-antioxidant-supplementation-in-semen-extenders-on-semen-quality-and-reactive-oxygen-species-of-chilled-canine-spermatozoa
#18
A J Michael, C Alexopoulos, E A Pontiki, D J Hadjipavlou-Litina, P Saratsis, H N Ververidis, C M Boscos
The objective of this study was to evaluate quality of chilled dog semen processed with extenders containing various antioxidants. Single ejaculates from five dogs were always pooled and evaluated for concentration, sperm motility, progressive motility (RSF-movement), viability, acrosomal integrity and by the hypo-osmotic swelling (HOS)-test. Also, superoxide (O(2)(-)) production, hydroxyl radicals (OH) and total reactive oxygen species (tROS) were determined. Pooled semen was divided in seven aliquots (for control and test conditions), which were diluted to a final concentration of 67x10(6)spermatozoa/ml with TRIS-glucose-egg yolk extender with or without the following supplements: control (without antioxidants), vitamin C (0...
May 2009: Animal Reproduction Science
https://www.readbyqxmd.com/read/18294668/promotion-or-suppression-of-experimental-metastasis-of-b16-melanoma-cells-after-oral-administration-of-lapachol
#19
Masayo Maeda, Manabu Murakami, Tsutomu Takegami, Takahide Ota
Lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone] is a vitamin K antagonist with antitumor activity. The effect of lapachol on the experimental metastasis of murine B16BL6 melanoma cells was examined. A single oral administration of a high toxic dose of lapachol (80-100 mg/kg) 6 h before iv injection of tumor cells drastically promoted metastasis. This promotion of metastasis was also observed in T-cell-deficient mice and NK-suppressed mice. In vitro treatment of B16BL6 cells with lapachol promoted metastasis only slightly, indicating that lapachol promotes metastasis primarily by affecting host factors other than T cells and NK cells...
June 1, 2008: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/17760959/sodium-ascorbate-induces-apoptosis-in-neuroblastoma-cell-lines-by-interfering-with-iron-uptake
#20
Roberta Carosio, Guendalina Zuccari, Isabella Orienti, Salvatore Mangraviti, Paolo G Montaldo
BACKGROUND: Neuroblastoma (NB) is an extra-cranial solid tumour of childhood. In spite of the good clinical response to first-line therapy, complete eradication of NB cells is rarely achieved. Thus, new therapeutic strategies are needed to eradicate surviving NB cells and prevent relapse. Sodium ascorbate has been recently reported to induce apoptosis of B16 melanoma cells through down-regulation of the transferrin receptor, CD71. Since NB and melanoma share the same embryologic neuroectodermal origin, we used different human NB cell lines to assess whether the same findings occurred...
2007: Molecular Cancer
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