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osteomyelitis and multiorgan failure

Damaris Pena, Yaneidy Santana, Jose Perez Lara, Efrain Gonzalez, Misbahuddin Khaja
Introduction: Pasteurella multocida is a gram-negative coccobacillus pathogenic to animals. It can cause infection in humans by a bite, scratch, or lick from a cat or dog. P. multocida can cause a variety of infections in humans, including cellulitis, osteomyelitis, endocarditis, peritonitis, and septic shock. Case Presentation: A 56-year-old male presented to our hospital with a 2-day history of fever, abdominal pain, nausea, and vomiting. He denied exposure to cats, dogs or other pets...
2018: Case Reports in Infectious Diseases
Muhammad Qaisar Shah, Muhammad Shoib Zardad, Alamzeb Khan, Sajjad Ahmed, Abdus Saboor Awan, Taj Mohammad
BACKGROUND: Surgical site infection in orthopaedic implants is a major problem, causing long hospital stay, cost to the patient and is a burden on health care facilities. It increases rate of nonunion, osteomyelitis, implant failure, sepsis, multiorgan dysfunction and even death. Surgical site infection is defined as pain, erythema, swelling and discharge from wound site. Surgical site infection in orthopaedic implants is more challenging to the treating orthopaedic surgeon as the causative organism is protected by a biofilm over the implant's surface...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
Matthew Street, Haemish Crawford
BACKGROUND: Osteomyelitis is a common problem among the pediatric population. The humerus is the most commonly affected bone in the upper limb; however, there are relatively few series in the literature. This article retrospectively reviews a large number of cases of pediatric humeral osteomyelitis. We aim to further define the disease and its clinical course to aid in improved treatment. METHODS: A 10-year retrospective review was performed of clinical records of pediatric humeral osteomyelitis at the 2 children's orthopaedic departments in the Auckland region...
September 2015: Journal of Pediatric Orthopedics
Vikram Krishnasamy, Matthew Joseph
Tuberculous pyomyositis is a rare clinical entity with serious consequences if a diagnosis is not established early. A 53-year-old female with a past medical history of sarcoidosis and pulmonary fibrosis presented from an outside hospital with persistent fevers and a rash. She had been hospitalized multiple times at an outside hospital without any improvement in her symptoms. On examination, she was noted to have a large area of left upper lower extremity (LUE) tenderness with superimposed erythema. Laboratory data revealed a white blood cell count of 22,300...
2013: Case Reports in Medicine
Martin J Morrison, Martin J Herman
Pediatric musculoskeletal infections can cause devastating complications (including death) in this era of methicillin-resistant Staphylococcus aureus and other virulent bacterial strains. The complexity and severity of these infections require timely diagnosis and treatment. A thorough emergency department evaluation, diagnostic workup, and early surgical intervention can influence outcomes. Septic arthritis of the hip is best treated with open drainage and antibiotic therapy to avoid osteonecrosis of the hip and joint damage...
2013: Instructional Course Lectures
Jerzy Sulko
This paper presents a case report of a 15-year-old boy admitted to the hospital for persistent right knee pain and limping. The clinical appearance of his condition was the basis on which diagnosis of chronic recurrent multifocal osteomyelitis was made. Continuous deterioration in the clinical status also led to a suspicion of the presence of other pathological processes. A bone biopsy was performed and the results of histopathology showed diffused large cell B lymphoma. Chemotherapy was initiated; nevertheless, the patient's general state worsened gradually and subsequent pancytopenia resulted in septicemia and multiorgan failure that led to the patient's death...
March 2013: Journal of Pediatric Orthopedics. Part B
E Nectoux, A Mezel, S Raux, D Fron, M Maillet, B Herbaux
BACKGROUND: Purpura fulminans is a rare and extremely severe infection, mostly due to Neisseria meningitidis frequently causing early orthopedic lesions. Few studies have reported on the initial surgical management of acute purpura fulminans. The aim of this study is to look at the predictive factors in orthopedic outcome in light of the initial surgical management in children surviving initial resuscitation. METHODS: Nineteen patients referred to our institution between 1987 and 2005 were taken care of at the very beginning of the purpura fulminans...
October 2010: Journal of Children's Orthopaedics
Zeynep Eyileten, Ahmet Ruchan Akar, Sadik Eryilmaz, Mustafa Sirlak, Levent Yazicioglu, Serkan Durdu, Adnan Uysalel, Umit Ozyurda
PURPOSE: To assess the results of bilateral pectoralis major muscle flaps (BPMMF) and vacuum-assisted closure (VAC) at different stages of postcardiac surgery mediastinitis. METHODS: Of 65 patients with a deep sternal wound infection (DSWI) after cardiac surgery, 33 with a stable sternum were treated with VAC (59.3 +/- 11.7 years of age) and 32 with an unstable sternum or osteomyelitis (63.3 +/- 9.8 years of age) were treated with early BPMMF and continuous irrigation...
2009: Surgery Today
S Shah, Z Win, A Al-Nahhas
Functional imaging plays a central role in the evaluation of some of the clinical problems faced by diabetic patients. In cardiovascular disease, myocardial perfusion imaging, particularly when complemented by gated SPECT, is a powerful tool not only for establishing the diagnosis of coronary artery disease, but also for providing prognostic information in both the general and diabetic populations. Although promising, its role in screening of asymptomatic diabetic patients is yet to be established, and its role as a potential 'one-stop shop' also needs further study...
September 2009: Minerva Endocrinologica
Kuei-Pin Chung, Tzu-Hsiu Tsai, Yu-Tsung Huang, Po-Ren Hsueh
Bacteremic pneumonia caused by Mycobacterium simiae in non-human immunodeficiency virus (HIV)-infected patients has rarely been reported. We describe a non-HIV-infected adult with refractory bacteremia, osteomyelitis, and colonization of M. simiae in the respiratory tract who subsequently developed fatal bacteremic pneumonia. The isolate was confirmed as M. simiae by 16S rRNA gene analysis.
November 2009: Journal of Clinical Microbiology
C W Tew, F C Han, R Jureen, B H Tey
We present the first reported case of Aspergillus vertebral osteomyelitis and epidural abscess in Singapore in a 50-year-old man with post-tuberculous bronchiectasis. The patient presented with acute urinary retention and flaccid paraplegia. Despite surgical debridement and treatment with voriconazole, the patient developed multiorgan failure and died two weeks after presentation. Early diagnosis and prompt initiation of treatment are emphasised in the hope of improving the outcome of this aggressive condition...
April 2009: Singapore Medical Journal
Sascha Mann, Michael Schütze, Steffen Sola, Jürgen Piek
OBJECT: Pyogenic vertebral osteomyelitis is of special interest to neurosurgeons because it often results in acute neurological deterioration and requires a combination of adequate surgical and conservative treatment. The aim of the current study was to evaluate the strategy of a primary surgical approach to this disease. METHODS: A group of 24 patients with the clinical and radiological signs of acute pyogenic spondylodiscitis was prospectively followed from 1998 to 2004...
December 15, 2004: Neurosurgical Focus
Sandeep Vaishya, Manish Singh Sharma
BACKGROUND: Spinal extradural abscesses caused by Aspergillus species are rare and occur mostly in immunocompromised patients or in patients with Aspergillomas elsewhere in the body. In this report, the authors draw attention to a rapidly developing syndrome of extradural compressive myelopathy in an immunocompetent patient. Only four other cases have been reported previously. CASE DESCRIPTION: A 35-year-old female presented with rapidly progressive painful paraparesis progressing to paraplegia in 15 days despite adequate empiric antitubercular therapy...
June 2004: Surgical Neurology
D J Sexton
Access-related infections are the most important causes of the loss of vascular access for dialysis. These infections also may lead to devastating consequences, including sepsis with multiorgan failure; endocarditis; or metastatic infections such as vertebral osteomyelitis, epidural abscess, or endophthalmitis. A small percentage of these complications are fatal; overall, dialysis-related bloodstream infections are the second leading cause of death in patients undergoing hemodialysis, accounting for up to 10% of all deaths, and approximately three-fourths of all deaths caused by infection in patients undergoing dialysis...
September 2001: Infectious Disease Clinics of North America
A Rónai, L Olasz, D Mühl
The extraction of a tooth led to the acute exacerbation of existing chronic osteomyelitis then phlegmon, and sepsis as a result. Persisting coma developed after three reanimations of the patient, on account of septic shock. Finally, in more than two weeks following the extraction the patient died due to multiorgan failure. This case description wishes to call attention to the risks of complications of diabetes, to summarize the relevant documents of diagnosis and treatment of osteomyelitis and phlegmon and the data of mortality...
February 2001: Fogorvosi Szemle
S A Zimmerman, E E O'Branski, W F Rosse, R E Ware
Hemoglobin S/O(Arab) (Hb S/O(Arab)) is a rare compound heterozygous hemoglobinopathy characterized by the presence of two variant beta-globin chains: beta6Glu --> Val (Hb S) and beta121Glu --> Lys (Hb O(Arab)). The diagnosis of Hb S/O(Arab) requires electrophoresis on both cellulose acetate and citrate agar, since Hb O(Arab) co-migrates with Hb C at alkaline pH and close to Hb S at acidic pH. To date only case reports and small series of patients with Hb S/O(Arab) have been described. To better characterize the clinical and laboratory aspects of this unusual disorder, we reviewed the Duke University Medical Center experience...
April 1999: American Journal of Hematology
H B Ris, A Banic, M Furrer, M Caversaccio, A Cerny, P Zbären
BACKGROUND: Descending necrotizing mediastinitis requires an early and aggressive surgical approach to reduce the high morbidity and mortality associated with this disease. The clamshell incision has provided excellent exposure of the entire mediastinum and both pleural cavities and was assessed in patients suffering from descending necrotizing mediastinitis. METHODS: Three patients with descending necrotizing mediastinitis and bilateral pleural empyema due to invasive streptococcal infections were operated on with this method...
December 1996: Annals of Thoracic Surgery
D S Babcock, R A Kaufman
The use of diagnostic ultrasonography and CT in the investigation of the acutely ill pediatric patient has been steadily increasing because of the relative noninvasiveness of these imaging modalities and because of improvements in resolving capabilities and scanning speed of the latest equipment. In the examination of the pediatric patient, special emphasis must be given to immobilization, sedation, or both in those children too young or too ill to cooperate. Close monitoring and observation of the child throughout sedation is important and requires special personnel and equipment...
September 1983: Radiologic Clinics of North America
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