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The Gluten-Free Diet

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https://www.readbyqxmd.com/read/29146521/hla-dq-gluten-tetramer-blood-test-accurately-identifies-patients-with-and-without-celiac-disease-in-absence-of-gluten-consumption
#1
Vikas K Sarna, Knut E A Lundin, Lars Mørkrid, Shuo-Wang Qiao, Ludvig M Sollid, Asbjørn Christophersen
BACKGROUND & AIMS: Celiac disease is characterized by HLA-DQ2/8-restricted responses of CD4+ T cells to cereal gluten proteins. A diagnosis of celiac disease based on serologic and histologic evidence and duodenal histology requires patients to be on gluten-containing diets. The growing number of individuals adhering to a gluten-free diet (GFD) without exclusion of celiac disease complicates its detection. HLA-DQ-gluten tetramers can be used to detect gluten-specific T cells in blood of patients with celiac disease, even if they are on a GFD...
November 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29143803/use-of-novel-high-protein-functional-food-products-as-part-of-a-calorie-restricted-diet-to-reduce-insulin-resistance-and-increase-lean-body-mass-in-adults-a-randomized-controlled-trial
#2
Carol S Johnston, Barry Sears, Mary Perry, Jessica R Knurick
Significant reductions in insulin resistance (IR) can be achieved by either calorie restriction or by the increase of lean mass. However, calorie restriction usually results in significant loss of lean mass. A 6-week randomized controlled feeding trial was conducted to determine if a calorie-restricted, high-protein diet (~125 g protein/day consumed evenly throughout the day) using novel functional foods would be more successful for reducing IR in comparison to a conventional diet (~80 g protein/day) with a similar level of calorie restriction...
October 28, 2017: Nutrients
https://www.readbyqxmd.com/read/29142524/a-case-of-celiac-disease-with-neurologic-manifestations-misdiagnosed-as-amyotrophic-lateral-sclerosis
#3
Hyoju Ham, Bo-In Lee, Hyun Jin Oh, Se Hwan Park, Jin Su Kim, Jae Myung Park, Young Seok Cho, Myung-Gyu Choi
Celiac disease (CD) is an immune-mediated enteropathy and is a rare disease in Asia, including in Korea. However, the ingestion of wheat products, which can act as a precipitating factor of CD, has increased rapidly. CD is a common cause of malabsorption, but many patients can present with various atypical manifestations as first presented symptoms, including anemia, osteopenia, infertility, and neurological symptoms. Thus, making a diagnosis is challenging. We report a case of CD that mimicked amyotrophic lateral sclerosis (ALS)...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29141505/serum-zinc-copper-and-iron-status-of-children-with-coeliac-disease-on-three-months-of-gluten-free-diet-with-or-without-four-weeks-of-zinc-supplements-a-randomised-controlled-trial
#4
K Negi, R Kumar, L Sharma, S P Datta, M Choudhury, P Kumar
Data about the effect of zinc supplementation with gluten-free diet on normalisation of plasma zinc, copper and iron in patients with coeliac disease are scanty. We evaluated the effect of zinc supplementation on serum zinc, copper and iron levels in patients with coeliac disease, by randomising 71 children newly diagnosed with coeliac disease into two groups: Group A = gluten-free diet (GFD); and Group B = gluten-free diet with zinc supplements (GFD +Zn). The rise in iron and zinc was significantly higher in the latter, but the mean rise of copper levels was slightly higher in the former, but the difference was not significant...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29136587/management-of-eosinophilic-esophagitis-and-celiac-disease
#5
REVIEW
Rok Seon Choung, Jeffrey A Alexander, David A Katzka, Joseph A Murray
Eosinophilic esophagitis (EoE) and celiac disease (CeD) are chronic immune mediated gastrointestinal disorders characterized by mucosal inflammation, both of which are related to food antigens, but with differences in clinical and histopathological features. When untreated, both diseases lead to destruction of the epithelium. While a strict gluten-free diet is the only effective therapy for CeD, several therapeutic options, such as proton pump inhibitors, topical steroids and diet elimination therapy are available for EoE...
November 10, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29132967/unexplained-infertility-and-undiagnosed-celiac-disease-study-of-a-multiethnic-canadian-population
#6
Beth Gunn, Kellie E Murphy, Ellen M Greenblatt
OBJECTIVE: The aims of this study were to examine the prevalence of Celiac disease (CD) in Canadian women with unexplained infertility versus women with an identifiable cause of infertility and to assess the sensitivity of the point-of-care Biocard Celiac Test Kit versus standard serum serologic testing. METHODS: In this prospective cohort study, women aged 18 to 44 who were evaluated for infertility between February 2010 and May 2012 at a tertiary academic care fertility clinic in Toronto, ON, were invited to participate...
November 10, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29132758/gluten-free-diets-the-grain-of-truth
#7
Talha Khan Burki
No abstract text is available yet for this article.
December 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29132529/celiac-disease-and-gluten-sensitivity
#8
REVIEW
Katharine C DeGeorge, Jeanetta W Frye, Kim M Stein, Lisa K Rollins, Daniel F McCarter
Celiac disease is an immune-mediated enteropathy triggered by gluten that affects genetically predisposed individuals, typically causing intestinal symptoms and malabsorption. Diagnosis requires stepwise evaluation with anti-tissue transglutaminase IgA and histologic analysis of the small bowel. Strict adherence to a gluten-free diet is the primary treatment. Patients with symptoms thought to be related to gluten but without evidence of celiac disease are difficult to diagnose and treat. Consider first advising general nutritional improvements...
December 2017: Primary Care
https://www.readbyqxmd.com/read/29131356/gluten-sensitivities-and-the-allergist-threshing-the-grain-from-the-husks
#9
REVIEW
J G Burkhardt, A Chapa-Rodriguez, S L Bahna
"Gluten sensitivity" has become commonplace among the public. Wheat allergy (WA) and celiac disease (CD) are well-defined entities, but are becoming a fraction of individuals following a gluten-free diet. WA has a prevalence of <0.5%. Wheat, specifically its omega-5 gliadin fraction, is the most common allergen implicated in food-dependent, exercise-induced anaphylaxis. CD is a non-IgE hypersensitivity to certain cereal proteins: gluten in wheat, secalin in rye, hordein in barley, and to a lesser extent avenin in oat...
November 13, 2017: Allergy
https://www.readbyqxmd.com/read/29127130/eosinophilic-oesophagitis-and-coeliac-disease-is-there-an-association
#10
Ana Margarida Vaz, Antonio Jesus Cadilla, Diamantino Sousa, Horácio Guerreiro
A 25-year-old man was seen in outpatient clinic for progressive solid food dysphagia. He was already medicated with a proton pump inhibitor with no improvement. His blood tests showed a slight microcytic anaemia and peripheral eosinophilia. The oesophago-gastro-duodenoscopy showed longitudinal furrows in the distal two-thirds of the oesophagus and a concentric distal stenosis. The biopsies taken showed eosinophilic infiltrates consistent with eosinophilic oesophagitis. There was no improvement with topical fluticasone, so the patient was started on a systemic corticosteroid with resolution of dysphagia and of the oesophageal stenosis...
November 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29120789/laser-induced-breakdown-spectroscopy-libs-for-rapid-analysis-of-ash-potassium-and-magnesium-in-gluten-free-flours
#11
Maria Markiewicz-Keszycka, Maria P Casado-Gavalda, Xavier Cama-Moncunill, Raquel Cama-Moncunill, Yash Dixit, Patrick J Cullen, Carl Sullivan
Gluten free (GF) diets are prone to mineral deficiency, thus effective monitoring of the elemental composition of GF products is important to ensure a balanced micronutrient diet. The objective of this study was to test the potential of laser-induced breakdown spectroscopy (LIBS) analysis combined with chemometrics for at-line monitoring of ash, potassium and magnesium content of GF flours: tapioca, potato, maize, buckwheat, brown rice and a GF flour mixture. Concentrations of ash, potassium and magnesium were determined with reference methods and LIBS...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29119084/gluten-free-diet-among-school-age-children-in-olmsted-county-minnesota
#12
Eyad Almallouhi, Imad Absah
Objective: To assess the prevalence of gluten-free diet (GFD) among school-age children in Olmsted County, Minnesota, and compare it with the prevalence of celiac disease (CD) in the same age group. Methods: We performed a population-based study in Olmsted County using a survey to collect information from the six school districts in the county for the academic year 2014-2015. The survey contained questions to (1) assess the prevalence of GFD among school-age children in the public schools of Olmsted County; (2) assess the prevalence of CD among school-age children in Olmsted County; and (3) determine the indications for GFD in these children...
October 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29113008/-drug-therapy-in-coeliac-disease-from-bench-to-bedside
#13
Jürgen Stein, Jörg-Dieter Schulzke, Detlef Schuppan
Coeliac disease is one of the most common diseases worldwide, with an estimated global prevalence of 0.5 - 1 %. The disease is triggered by a combination of environmental (gluten proteins from wheat, rye or barley) and genetic factors (mainly the human leucocyte antigens HLA-DQ2 or -DQ8). At present, a strict gluten-free diet (GFD) represents the only treatment option. However, strict adherence to a GFD is challenging, since even highly motivated patients may be subject to inadvertent or background exposure to gluten...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29113007/-gluten-free-diet-update-2017
#14
Ottmar Leiß
Since sixty years, the gluten-free diet (GFD) is the only therapeutic option for patients with celiac disease or dermatitis herpetitormis to normalize symptoms and prevent complications. In recent years, the use of a gluten-free diet is rapidly growing because of presumed effects on well-being and control of body weight. GFD is becoming a popular health choice for everybody.In the present review, evidence-based indications for a gluten-free diet are stressed, the need for profound dietary counselling and education of the patient is underlined, problems and pitfalls of the implementation of a gluten-free diet in daily practice and possible side effects of long-term gluten-free diets are mentioned...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29105146/the-effect-of-the-gluten-free-diet-on-cardiovascular-risk-factors-in-patients-with-coeliac-disease-a-systematic-review
#15
M D E Potter, S C Brienesse, M M Walker, A Boyle, N J Talley
INTRODUCTION: A gluten free diet (GFD), the mainstay of treatment for celiac disease, is being increasingly adopted by people without this condition. The long-term health effects of this diet, apart from its beneficial effect on enteropathy in celiac disease, are unclear. Concerns exist that the GFD may result in micronutrient deficiencies, increased exposure to toxins such as arsenic, and an increased cardiovascular risk. This systematic review addresses the effect of the GFD on several modifiable cardiovascular risk factors...
November 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29102613/fructan-rather-than-gluten-induces-symptoms-in-patients-with-self-reported-non-celiac-gluten-sensitivity
#16
Gry I Skodje, Vikas K Sarna, Ingunn H Minelle, Kjersti L Rolfsen, Jane G Muir, Peter R Gibson, Marit B Veierød, Christine Henriksen, Knut E A Lundin
BACKGROUND & AIMS: Non-celiac gluten sensitivity is characterized by symptom improvement after gluten withdrawal in absence of celiac disease. The mechanisms of non-celiac gluten sensitivity are unclear, and there are no biomarkers for this disorder. Foods with gluten often contain fructans, a type of fermentable oligo-, di-, monosaccharides and polyols. We aimed to investigate the effect of gluten and fructans separately in individuals with self-reported gluten sensitivity. METHODS: We performed a double-blind crossover challenge of 59 individuals on a self-instituted gluten-free diet, for whom celiac disease had been excluded...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29096013/topical-review-adherence-interventions-for-youth-on-gluten-free-diets
#17
Christina E Holbein, Julia K Carmody, Kevin A Hommel
Objective: To summarize gluten-free diet (GFD) nonadherence risk factors, nonadherence rates, and current intervention research within an integrative framework and to develop a research agenda for the development and implementation of evidence-based GFD adherence interventions. Methods: Topical review of literature published since 2008 investigating GFD adherence in pediatric samples. Results: Reviews of pediatric studies indicate GFD nonadherence rates ranging from 19 to 56%...
October 31, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29095937/younger-age-at-diagnosis-predisposes-to-mucosal-recovery-in-celiac-disease-on-a-gluten-free-diet-a-meta-analysis
#18
Zsolt Szakács, Péter Mátrai, Péter Hegyi, Imre Szabó, Áron Vincze, Márta Balaskó, Bernadett Mosdósi, Patrícia Sarlós, Mária Simon, Katalin Márta, Alexandra Mikó, Dániel Pécsi, Alexandra Demcsák, Judit Bajor
BACKGROUND AND AIMS: Persistent intestinal damage is associated with higher complication rates in celiac disease. We aimed to assess the potential modifiers of mucosal recovery. MATERIALS AND METHODS: We screened databases (PubMed, Embase, Cochrane Trials, and Web of Science) for papers on celiac disease. Papers discussing (1) celiac patients (2) follow-up biopsy and (3) mucosal recovery after commencement of a gluten-free diet were included. The primary outcome was to produce a comprehensive analysis of complete mucosal recovery (i...
2017: PloS One
https://www.readbyqxmd.com/read/29094324/a-caucasian-american-patient-with-celiac-disease-diagnosed-in-japan-and-successfully-treated-with-a-gluten-free-diet
#19
Haruka Wada, Mari Hayashida, Taro Sato, Shintaro Minowa, Osamu Ikezaki, Tatsuya Mitsui, Miki Miura, Yoshihiko Ohmori, Daisuke Saito, Akihito Sakuraba, Hideo Kamiichi, Kengo Tokunaga, Makoto Mochizuki, Junji Shibahara, Hideaki Mori, Tadakazu Hisamatsu
We report the case of a 33-year-old Caucasian American man diagnosed with celiac disease in Japan. He presented to a community hospital because of chronic watery diarrhea and weight loss for 6 months. The laboratory data showed low serum albumin and serum cholesterol. A colonoscopy was normal. He was referred to our hospital for further work-up. Serum tissue transglutaminase immunoglobulin A (IgA) and endomysial antibody were positive. The HLA type was DQ2. Esophagogastroduodenoscopy (EGD) revealed nodular and mosaic-patterned mucosa from the bulb to the second part of the duodenum...
November 1, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29093615/less-common-etiologies-of-exocrine-pancreatic-insufficiency
#20
REVIEW
Vikesh K Singh, Mark E Haupt, David E Geller, Jerry A Hall, Pedro M Quintana Diez
Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases (diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin (CCK); celiac or inflammatory bowel disease (IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery (asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food)...
October 21, 2017: World Journal of Gastroenterology: WJG
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