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https://www.readbyqxmd.com/read/27917035/polyglandular-autoimmune-syndrome-in-pregnancy-case-report
#1
Basilio Pecorino, Maria Cristina Teodoro, Paolo Scollo
Type III Polyglandular Autoimmune Syndrome is a multiple endocrine disorders disease determined by autoimmunity; it can be diagnosed if a patient is affected by Type 1 Diabetes Mellitus and another autoimmune disease, except Addison Disease, for example Autoimmune Hashimoto Thyroiditis or Celiac Disease. R.D., 34-year-old woman (gravida 2 para 1), was referred to the High Risk Pregnancy Outpatient Clinic at Cannizzaro Hospital in Catania at 8 weeks' gestation. She was affected from type III Polyglandular Autoimmune Disease (Type 1 Diabetes Mellitus, Autoimmune Hashimoto Thyroiditis and Celiac Disease)...
September 2016: Italian Journal of Gynaecology & Obstetrics: Official Publication of the Societa Italiana di Ginecologia e Ostetricia (SIGO)
https://www.readbyqxmd.com/read/27908520/diagnosis-and-updates-in-celiac-disease
#2
REVIEW
Sarah Shannahan, Daniel A Leffler
Celiac disease is an autoimmune disorder induced by gluten in genetically susceptible individuals. It can result in intraintestinal and extraintestinal manifestations of disease including diarrhea, weight loss, anemia, osteoporosis, or lymphoma. Diagnosis of celiac disease is made through initial serologic testing and then confirmed by histopathologic examination of duodenal biopsies. Generally celiac disease is a benign disorder with a good prognosis in those who adhere to a gluten-free diet. However, in refractory disease, complications may develop that warrant additional testing with more advanced radiologic and endoscopic methods...
January 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/27908207/anti-sulfatide-reactivity-in-patients-with-celiac-disease
#3
Domenica Saccomanno, Carolina Tomba, Francesca Magri, Philippe Backelandt, Leda Roncoroni, Luisa Doneda, Maria Teresa Bardella, Giacomo Pietro Comi, Nereo Bresolin, Dario Conte, Luca Elli
OBJECTIVE: To explore a possible significance of the presence of anti-ganglioside and anti-sulfatide antibodies in sera of adult patients with celiac disease (CD) in different clinical scenario. METHODS: We selected 22 adult patients with newly diagnosed CD and 20 age-sex matched non-CD controls. Patients' serum was tested - before and after at least 6 months on a gluten-free diet (GFD) - for anti-GM1, GM2, GM3, GD1a, GD1b, GD3, GT1a, GT1b, GQ1b and sulfatide IgM, IgG and IgA auto-antibodies, by means of a dot blot technique and enzyme-linked immunosorbent assay (ELISA)...
December 1, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27906802/anti-tissue-transglutaminase-normalization-post-diagnosis-in-children-with-celiac-disease
#4
Daniela Migliarese Isaac, Seema Rajani, Maryna Yaskina, Hien Q Huynh, Justine M Turner
OBJECTIVES: Limited pediatric data exist examining the trend and predictors of anti-tissue transglutaminase (atTG) normalization over time in children with celiac disease (CD). We aimed to evaluate time to normalization of atTG in children after CD diagnosis, and to assess for independent predictors impacting this duration. METHODS: A retrospective chart review was completed in pediatric CD patients diagnosed from 2007 to 2014 at the Stollery Children's Hospital Celiac Clinic (Edmonton, Alberta)...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27895976/microscopic-colitis-in-patients-with-mild-duodenal-damage-a-new-clinical-and-pathological-entity-lymphocytic-enterocolitis
#5
Gabriele Antonio Bonagura, Davide Giuseppe Ribaldone, Sharmila Fagoonee, Nicoletta Sapone, Gian Paolo Caviglia, Giorgio Maria Saracco, Marco Astegiano, Rinaldo Pellicano
AIM: To evaluate the potential association between mild duodenal damage and microscopic colitis (MC). METHODS: We retrospectively included 105 consecutive patients with type I Marsh-Oberhuber duodenal damage and negativity for immunoglobulin A anti-endomysium and anti-tissue transglutaminase. The following parameters were analyzed: Sex, age at execution of esophagogastroduodenoscopy, duodenal damage, and number of intraepithelial lymphocytes at biopsies, prevalence of Helicobacter pylori infection, age at execution of colonoscopy, macroscopic and microscopic features of colonoscopy, family history of gastrointestinal and autoimmune diseases, smoking habits, biochemical parameters of inflammation and autoimmunity, use of proton pump inhibitors or nonsteroidal anti-inflammatory drugs, adverse reactions to drugs or foods, pathologies known to be associated with celiac disease or MC, living on a gluten-free diet or on a gluten-low diet for at least 1 mo...
November 15, 2016: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/27887897/nomenclature-and-diagnosis-of-gluten-related-disorders-a-position-statement-by-the-italian-association-of-hospital-gastroenterologists-and-endoscopists-aigo
#6
REVIEW
Luca Elli, Danilo Villalta, Leda Roncoroni, Donatella Barisani, Stefano Ferrero, Nicoletta Pellegrini, Maria Teresa Bardella, Flavio Valiante, Carolina Tomba, Antonio Carroccio, Massimo Bellini, Marco Soncini, Renato Cannizzaro, Gioacchino Leandro
BACKGROUND: "Gluten-related disorders" is a term that encompasses different diseases induced by the ingestion of gluten-containing food. Because of their incidence the scientific community has been intensively studying them. AIM: To support gastroenterologists with a correct nomenclature and diagnostic approach to gluten-related disorders in adulthood. METHODS: The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) commissioned a panel of experts to prepare a position statement clarifying the nomenclature and diagnosis of gluten-related disorders, focusing on those of gastroenterological interest...
November 4, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27878833/presence-of-intraepithelial-food-antigen-in-patients-with-active-eosinophilic-oesophagitis
#7
E V Marietta, D M Geno, T C Smyrk, A Becker, J A Alexander, M Camilleri, J A Murray, D A Katzka
BACKGROUND: Although eosinophilic oesophagitis (EoE) is putatively mediated by an abnormal response to food antigen, the oesophagus is considered relatively impermeable to large molecules. AIM: To assess whether food antigens penetrate the oesophageal mucosa in patients with EoE. METHODS: Anti-gliadin staining was performed in three groups: active EoE, inactive EoE and EoE patients on a low or gluten free diet. To appraise the specificity of our results, we also performed gliadin staining on six patients without oesophageal disease who were consuming gluten...
November 22, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27869798/gluten-induced-symptoms-in-diarrhea-predominant-irritable-bowel-syndrome-are-associated-with-increased-myosin-light-chain-kinase-activity-and-claudin-15-expression
#8
Richard L Wu, Maria I Vazquez-Roque, Paula Carlson, Duane Burton, Madhusudan Grover, Michael Camilleri, Jerrold R Turner
The mechanisms underlying diarrhea-predominant irritable bowel syndrome (IBS-D) are poorly understood, but increased intestinal permeability is thought to contribute to symptoms. A recent clinical trial of gluten-free diet (GFD) demonstrated symptomatic improvement, relative to gluten-containing diet (GCD), which was associated with reduced intestinal permeability in non-celiac disease IBS-D patients. The aim of this study was to characterize intestinal epithelial tight junction composition in IBS-D before and after dietary gluten challenge...
November 21, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27864127/no-difference-between-latiglutenase-and-placebo-in-reducing-villous-atrophy-or-improving-symptoms-in-patients-with-symptomatic-celiac-disease
#9
Joseph A Murray, Ciarán P Kelly, Peter H R Green, Annette Marcantonio, Tsung-Teh Wu, Markku Mäki, Daniel C Adelman
BACKGROUND & AIMS: Gluten ingestion leads to symptoms and small intestinal mucosal injury in patients with celiac disease. The only option is the strict lifelong exclusion of dietary gluten, which is difficult to accomplish. Many patients following a gluten-free diet continue to have symptoms and have small intestinal mucosal injury. Non-dietary therapies are needed. We performed a phase 2 study of the ability of latiglutenase, an orally administered mixture of 2 recombinant gluten-targeting proteases, to reduce mucosal morphometric measures in biopsies from patients with celiac disease...
November 15, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27861825/high-smad7-sustains-inflammatory-cytokine-response-in-refractory-celiac-disease
#10
Silvia Sedda, Veronica De Simone, Irene Marafini, Gerolamo Bevivino, Roberta Izzo, Omero Alessandro Paoluzi, Alfredo Colantoni, Angela Ortenzi, Paolo Giuffrida, Gino R Corazza, Alessandro Vanoli, Antonio Di Sabatino, Francesco Pallone, Giovanni Monteleone
Refractory celiac disease (RCD) is a form of celiac disease (CD) resistant to gluten-free diet and associated with elevated risk of complications. Many effector cytokines over-produced in the gut of RCD patients are supposed to amplify the tissue-destructive immune response, but it remains unclear if the RCD-associated mucosal inflammation is sustained by defects in counter-regulatory mechanisms. The aim of the present study was to determine whether RCD-related inflammation is marked by high Smad7, an intracellular inhibitor of transforming growth factor (TGF)-β1 activity...
November 14, 2016: Immunology
https://www.readbyqxmd.com/read/27849120/review-gut-microbiota-and-functional-diseases-of-the-gastrointestinal-tract
#11
Nicola Imperatore, Raffaella Tortora, Filomena Morisco, Nicola Caporaso
INTRODUCTION: Functional gastrointestinal disorders (FGIDs) are a common group of chronic gastrointestinal (GI) diseases defined by symptom-based diagnostic criteria, which consider chronic or recurrent symptoms of the GI tract in the absence of other organic or biochemical reasons. Recent evidences have been highlighted the role of gut microbiota in the pathophysiology of the FGIDs. EVIDENCE ACQUISITION: We focused our attention on critically analysis of the existing literature on the role of gut microbiota in FGIDs, by evaluating the differences of composition, functions and role of intestinal flora in FGIDs of the upper and lower gastrointestinal tract...
November 16, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27845514/are-anti-epidermal-transglutaminase-etg-antibodies-titre-correlated-with-dermatitis-herpetiformis-lesions-during-the-disease-follow-up
#12
Emanuele Cozzani, Fabrizio Pappalardo, Giulia Gasparini, Fabio Gallo, Francesco Drago, Aurora Parodi
BACKGROUND: Dermatitis herpetiformis (DH) is characterized by the presence of anti-tissue transglutaminase (tTG) IgA antibodies in patient sera. In 2002, anti-epidermal transglutaminase (eTG) antibodies have been identified in DH patients. Nowadays, their role is still controversial. AIM: To evaluate any association between presence/absence of anti-eTG antibodies and cutaneous manifestations during the follow-up. METHODS: Anti-eTG and anti-tTG antibodies from 13 patients on gluten-free diet (GFD) were studied during follow-up on ELISA...
November 15, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27834802/prevalence-and-characterization-of-self-reported-gluten-sensitivity-in-the-netherlands
#13
Tom van Gils, Petula Nijeboer, Catharina E IJssennagger, David S Sanders, Chris J J Mulder, Gerd Bouma
BACKGROUND: A growing number of individuals reports symptoms related to the ingestion of gluten-containing food in the absence of celiac disease. Yet the actual prevalence is not well established. METHODS: Between April 2015 and March 2016, unselected adults visiting marketplaces, dental practices and a university in The Netherlands were asked to complete a modified validated questionnaire for self-reported gluten sensitivity (srGS). RESULTS: Among the 785 adults enquired, two had celiac disease...
November 8, 2016: Nutrients
https://www.readbyqxmd.com/read/27830928/oral-iron-absorption-test-with-ferrous-bisglycinate-chelate-in-children-with-celiac-disease-preliminary-results
#14
Giuseppe A Mazza, Luisa Pedrelli, Elisabetta Battaglia, Laura Giancotti, Roberto Miniero
BACKGROUND: Celiac disease (CD) is an immunologically-mediated enteropathy resulting in small-bowel mucosal villous atrophy with crypt hyperplasia. Iron malabsorption is usually observed in CD. Only few studies investigated oral iron absorption in subjects with gastrointestinal diseases and Iron Deficiency Anemia (IDA), using the oral iron absorption test (OIAT). We considered useful to investigate the OIAT, using Ferrous Bisglycinate Chelate (FBC), in patients with CD at diagnosis or on Gluten Free Diet (GFD) from at least 1 year...
November 10, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27825568/osteoarticular-manifestations-of-celiac-disease-and-non-celiac-gluten-hypersensitivity
#15
Stéphanie Dos Santos, Frédéric Lioté
Celiac disease is a chronic inflammatory autoimmune enteropathy based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. The global prevalence of 1% to 2% represents only the tip of the iceberg. The diagnosis is confirmed by positive specific antibody, anti-transglutaminase or anti-endomysium, specific lesions of the small intestine and a response to strict gluten-free diet. The diagnosis is difficult and often delayed because the clinical variability is very large, ranging from digestive clinical presentation "classic" to "atypical" symptoms, often extra-intestinal, that are sometimes attributed to a concomitant disease or a complication...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27821042/two-jenuno-jenunal-intussusceptions-in-a-patient-with-coeliac-disease
#16
K Moubax, F Mana, H Reynaert, D Urbain
We present a case of a 41-year-old woman with severe abdominal pain caused by two jejuno-jejunal intussusceptions. Further investigation showed coeliac disease as the underlying cause. The patient recovered rapidly on a gluten-free diet. So coeliac disease could be the underlying cause of idiopathic intussusception more often than previously thought and intussusception should be suspected in patients with known coeliac disease presenting with abdominal pain. (Acta gastro-enterol. belg., 2016, 79, 000-000).
July 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/27803820/seronegative-intestinal-villous-atrophy-a-diagnostic-challenge
#17
Cláudio Martins, Cristina Teixeira, Suzane Ribeiro, Daniel Trabulo, Cláudia Cardoso, João Mangualde, Ricardo Freire, Ana Luísa Alves, Élia Gamito, Isabelle Cremers, Ana Paula Oliveira
Celiac disease is the most important cause of intestinal villous atrophy. Seronegative intestinal villous atrophy, including those that are nonresponsive to a gluten-free diet, is a diagnostic challenge. In these cases, before establishing the diagnosis of seronegative celiac disease, alternative etiologies of atrophic enteropathy should be considered. Recently, a new clinical entity responsible for seronegative villous atrophy was described-olmesartan-induced sprue-like enteropathy. Herein, we report two uncommon cases of atrophic enteropathy in patients with arterial hypertension under olmesartan, who presented with severe chronic diarrhea and significant involuntary weight loss...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27801835/dietary-gluten-induced-gut-dysbiosis-is-accompanied-by-selective-upregulation-of-micrornas-with-intestinal-tight-junction-and-bacteria-binding-motifs-in-rhesus-macaque-model-of-celiac-disease
#18
Mahesh Mohan, Cheryl-Emiliane T Chow, Caitlin N Ryan, Luisa S Chan, Jason Dufour, Pyone P Aye, James Blanchard, Charles P Moehs, Karol Sestak
The composition of the gut microbiome reflects the overall health status of the host. In this study, stool samples representing the gut microbiomes from 6 gluten-sensitive (GS) captive juvenile rhesus macaques were compared with those from 6 healthy, age- and diet-matched peers. A total of 48 samples representing both groups were studied using V4 16S rRNA gene DNA analysis. Samples from GS macaques were further characterized based on type of diet administered: conventional monkey chow, i.e., wheat gluten-containing diet (GD), gluten-free diet (GFD), barley gluten-derived diet (BOMI) and reduced gluten barley-derived diet (RGB)...
October 28, 2016: Nutrients
https://www.readbyqxmd.com/read/27799885/symptomatic-improvement-with-gluten-restriction-in-irritable-bowel-syndrome-a-prospective-randomized-double-blinded-placebo-controlled-trial
#19
Vinay G Zanwar, Sunil V Pawar, Pravir A Gambhire, Samit S Jain, Ravindra G Surude, Vinaya B Shah, Qais Q Contractor, Pravin M Rathi
BACKGROUND/AIMS: The existence of non-celiac gluten sensitivity has been debated. Indeed, the intestinal and extra-intestinal symptoms of many patients with irritable bowel syndrome (IBS) but without celiac disease or wheat allergy have been shown to improve on a gluten-free diet. Therefore, this study set out to evaluate the effects of gluten on IBS symptoms. METHODS: We performed a double-blind randomized placebo-controlled rechallenge trial in a tertiary care hospital with IBS patients who fulfilled the Rome III criteria...
October 2016: Intestinal Research
https://www.readbyqxmd.com/read/27799282/disease-activity-indices-in-coeliac-disease-systematic-review-and-recommendations-for-clinical-trials
#20
Pieter Hindryckx, Barrett G Levesque, Tom Holvoet, Serina Durand, Ceen-Ming Tang, Claire Parker, Reena Khanna, Lisa M Shackelton, Geert D'Haens, William J Sandborn, Brian G Feagan, Benjamin Lebwohl, Daniel A Leffler, Vipul Jairath
OBJECTIVE: Although several pharmacological agents have emerged as potential adjunctive therapies to a gluten-free diet for coeliac disease, there is currently no widely accepted measure of disease activity used in clinical trials. We conducted a systematic review of coeliac disease activity indices to evaluate their operating properties and potential as outcome measures in registration trials. DESIGN: MEDLINE, EMBASE and the Cochrane central library were searched from 1966 to 2015 for eligible studies in adult and/or paediatric patients with coeliac disease that included coeliac disease activity markers in their outcome measures...
October 31, 2016: Gut
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