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Citicoline AND Cognition

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https://www.readbyqxmd.com/read/27769579/molecular-structure-and-differential-function-of-choline-kinases-chk%C3%AE-and-chk%C3%AE-in-musculoskeletal-system-and-cancer
#1
Xi Chen, Heng Qiu, Chao Wang, Yu Yuan, Jennifer Tickner, Jiake Xu, Jun Zou
Choline, a hydrophilic cation, has versatile physiological roles throughout the body, including cholinergic neurotransmission, memory consolidation and membrane biosynthesis and metabolism. Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). PC is a major constituent of the phospholipid bilayer which constitutes the eukaryotic cell membrane, and regulates cell signal transduction...
October 8, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27587069/the-citirivad-study-citicoline-plus-rivastigmine-in-elderly-patients-affected-with-dementia-study
#2
Alberto Castagna, Antonino Maria Cotroneo, Giovanni Ruotolo, Pietro Gareri
BACKGROUND: Acetylcholinesterase inhibitors (AchEIs), such as rivastigmine, coadministered with cholinergic precursors, such as citicoline, could be effective in Alzheimer's disease (AD) and in mixed dementia (MD), because they are able to increase the intrasynaptic levels of acetylcholine more than the single drugs given alone. OBJECTIVE: The aim of the present study was to show the effectiveness of oral citicoline plus rivastigmine in patients with AD and MD. METHODS: The CITIRIVAD study was a retrospective case-control study on 174 consecutive outpatients aged ≥65 years, affected with AD or MD, mean age 81...
September 1, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27539610/a-meta-analysis-of-the-effect-of-different-neuroprotective-drugs-in-management-of-patients-with-traumatic-brain-injury
#3
Iman El Sayed, Adel Zaki, Akram M Fayed, Gihan M Shehata, Sherif Abdelmonem
Traumatic brain injury is a major problem worldwide. Our objective is to synthesize available evidence in the literature concerning the effectiveness of neuroprotective drugs (cerebrolysin, citicoline, and piracetam) on Glasgow outcome score (GOS), cognitive performance, and survival in traumatic brain injury patients. Comprehensive search of electronic databases, search engines, and conferences proceedings; hand search journals; searching reference lists of relevant articles, theses, and local publications; and contact of authors for incomplete data were performed...
August 18, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27178312/protective-effect-of-citicoline-against-aluminum-induced-cognitive-impairments-in-rats
#4
Ahmed O Abdel-Zaher, Mostafa M Hamdy, Mahran S Abdel-Rahman, Doaa H Abd El-Hamid
The potential protective effect of citicoline on aluminum chloride-induced cognitive deficits was investigated in rats. In a Morris water maze, administration of aluminum chloride to rats for 90 days resulted in increased escape latency to reach the platform and decreased swimming speed in acquisition trials. Similarly, in probe trials, the time required to reach the hidden platform was increased and the time spent in the target quadrant was reduced. Also, administration of aluminum chloride to rats for 90 days increased the reference and working memory errors and time required to end the task in the radial arm maze...
May 13, 2016: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/27029452/-assessing-the-impact-of-citicoline-on-the-efficiency-of-rehabilitation-measures-in-patients-with-ischemic-stroke
#5
A V Mushba, D S Ivanova, O I Vinogradov
OBJECTIVE: To evaluate the effect of citicoline on the efficacy of rehabilitation measures in patients with ischemic stroke (IS). MATERIAL AND METHODS: Sixty patients were examined in the acute period of hemispheric IS. All patients underwent routine comprehensive treatment. The study group included 30 patients who received citicoline within the first 24 hours after IS onset. The control group consisted of 30 patients who were not treated with citicoline. The examination of patients included the assessment of neurological deficit, cognitive functions, P300 evoked potentials, head single photon emission computed tomography...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/26999113/long-term-treatment-with-citicoline-prevents-cognitive-decline-and-predicts-a-better-quality-of-life-after-a-first-ischemic-stroke
#6
Jose Alvarez-Sabín, Estevo Santamarina, Olga Maisterra, Carlos Jacas, Carlos Molina, Manuel Quintana
Stroke, as the leading cause of physical disability and cognitive impairment, has a very significant impact on patients' quality of life (QoL). The objective of this study is to know the effect of citicoline treatment in Qol and cognitive performance in the long-term in patients with a first ischemic stroke. This is an open-label, randomized, parallel study of citicoline vs. usual treatment. All subjects were selected 6 weeks after suffering a first ischemic stroke and randomized into parallel arms. Neuropsychological evaluation was performed at 1 month, 6 months, 1 year and 2 years after stroke, and QoL was measured using the EuroQoL-5D questionnaire at 2 years...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26979720/citicoline-retards-myopia-progression-following-form-deprivation-in-guinea-pigs
#7
Junfeng Mao, Shuangzhen Liu, Chunyan Fu
The retinal dopaminergic system is involved in the myopic shift following form deprivation. Citicoline has been demonstrated to stimulate the dopaminergic system in the brain and retina. Furthermore, citicoline has been used in many neurogenic diseases, such as senile cognitive impairment, stroke and Parkinson's disease as well as in amblyopia and glaucoma. Our aim was to investigate the effect of citicoline on the refractive state and retinal dopamine level in form deprivation myopia of guinea pigs. Guinea pigs, at an age of four weeks, were randomly divided into normal control, deprivation, deprived + citicoline and deprived + vehicle groups...
June 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/26978503/-the-activity-of-blood-serum-cholinesterases-and-neprilysin-as-potential-biomarkers-of-mild-cognitive-impairment-and-alzheimer-s-disease
#8
I A Zhuravin, N N Nalivaeva, D I Kozlova, E G Kochkina, Ya B Fedorova, S I Gavrilova
OBJECTIVE: To analyze the activity of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and neprilysin (NEP) in the blood serum in elderly people with different types of cognitive impairment and evaluate the effect of ceraxon on the biochemical parameters. MATERIAL AND METHODS: Three groups of patients: without cognitive disorders (controls--CG), with amnestic mild cognitive impairment (а-MCI) and with Alzheimer's disease (AD were studied). RESULTS AND CONCLUSION: The activity of AChE, BChE and NEP was reduced in the blood serum of patients with a-MCI and, to the greater extent, in patients with AD compared to CG and correlated with the level of cognitive dysfunction evaluated by MMSE, ADAS-cog, and other tests...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/26658924/citicoline-treatment-improves-measures-of-impulsivity-and-task-performance-in-chronic-marijuana-smokers-a-pilot-bold-fmri-study
#9
Staci A Gruber, Kelly A Sagar, Mary Kathryn Dahlgren, Atilla Gonenç, Nina A Conn, Jeffrey P Winer, David Penetar, Scott E Lukas
OBJECTIVE: Citicoline is an endogenous nucleotide that has historically been used to treat stroke, traumatic brain injury, and cognitive dysfunction. Research has also shown that citicoline treatment is associated with improved cognitive performance in substance-abusing populations. We hypothesized that marijuana (MJ) smokers who received citicoline would demonstrate improvement in cognitive performance as well as increased neural efficiency during tasks of cognitive control relative to those who received placebo...
September 30, 2015: International Journal of Neurology and Neurotherapy
https://www.readbyqxmd.com/read/26608705/electropharmacogram-of-sceletium-tortuosum-extract-based-on-spectral-local-field-power-in-conscious-freely-moving-rats
#10
Wilfried Dimpfel, Leonie Schombert, Nigel Gericke
ETHNOPHARMACOLOGICAL RELEVANCE: The endemic succulent South African plant, Sceletium tortuosum (L.) N.E. Br. (synonym Mesembryanthemum tortuosum L.), of the family Mesembryathemaceae, has an ancient oral tradition history of use by San and Khoikhoi people as an integral part of the indigenous culture and materia medica. A special standardized extract of Sceletium tortuosum (Zembrin®) has been developed and tested pre-clinically in rats, and clinically in healthy subjects. AIM OF THE STUDY: The present investigation aimed at the construction of electropharmacograms of Zembrin® in the presence of three dosages (2...
January 11, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26508844/erratum-the-role-of-citicoline-in-cognitive-impairment-pharmacological-characteristics-possible-advantages-and-doubts-for-an-old-drug-with-new-perspectives-corrigendum
#11
(no author information available yet)
No abstract text is available yet for this article.
2015: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/26366063/the-role-of-citicoline-in-cognitive-impairment-pharmacological-characteristics-possible-advantages-and-doubts-for-an-old-drug-with-new-perspectives
#12
REVIEW
Pietro Gareri, Alberto Castagna, Antonino Maria Cotroneo, Salvatore Putignano, Giovambattista De Sarro, Amalia Cecilia Bruni
BACKGROUND: Citicoline is able to potentiate neuroplasticity and is a natural precursor of phospholipid synthesis, or rather serves as a choline source in the metabolic pathways for biosynthesis of acetylcholine. Several studies have shown that it can have beneficial effects both in degenerative and in vascular cognitive decline. The aim of the present study was to review the pharmacokinetics and pharmacodynamics of this drug and its role in cognitive impairment according to the present medical literature...
2015: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/26293923/acute-traumatic-coagulopathy-accompanying-isolated-traumatic-brain-injury-is-associated-with-worse-long-term-functional-and-cognitive-outcomes
#13
Peter A Abdelmalik, David W Boorman, Joseph Tracy, Jack Jallo, Fred Rincon
BACKGROUND: Approximately one-third of patients with isolated traumatic brain injury (iTBI) present with acute traumatic coagulopathy (ATC). ATC is associated with increased morbidity and mortality. Its effects on long-term functional and cognitive outcomes are not as well characterized. METHODS: Data from the Citicoline Brain Injury Treatment Trial (COBRIT) were analyzed retrospectively. Exclusion criteria were renal failure or malignancy, and any extracranial injury severity score >3...
June 2016: Neurocritical Care
https://www.readbyqxmd.com/read/26151475/-brain-specific-nutrients-a-memory-cure
#14
Mark A McDaniel, Steven F Maier, Gilles O Einstein
We review the experimental evaluations of several widely marketed nonprescription compounds claimed to be memory enhancers and treatments for age-related memory decline. We generally limit our review to double-blind placebo-controlled studies. The compounds examined are phos-phatidylserine (PS), phosphatidylcholine (PC), citicoline, piracetam, vinpocetine, acetyl-L-carnitine (ALC), and antiox-idants (particularly vitamin E). In animals, PS has been shown to attenuate many neuronal effects of aging, and to restore normal memory on a variety of tasks...
May 2002: Psychological Science in the Public Interest: a Journal of the American Psychological Society
https://www.readbyqxmd.com/read/25898541/-role-of-functional-state-of-neuronal-mitochondria-of-cerebral-cortex-in-mechanisms-of-nootropic-activity-of-neuroprotectors-in-rats-with-alloxan-hyperglycemia
#15
V I Zhiliuk, V I Mamchur, S V Pavlov
The influence of citicoline, phenylpiracetam, pentoxifylline and N-phenylacetyl-L-prolylglycine on cognitive processes and functional state of mitochondria in the neocortex of alloxan-diabetic rats has been studied. The drug effects on cognitive processes were assessed using passive avoidance tests in the dark-light camera. Latent period and the number of animals with amnesia skill on 6th and 20th days of drug administration were recorded. Functional status of mitochondria was assessed by mitochondrial pore opening and mitochondrial transmembrane potential (Y) on 20th day...
2015: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/25633559/association-of-a-common-genetic-variant-within-ankk1-with-six-month-cognitive-performance-after-traumatic-brain-injury
#16
MULTICENTER STUDY
John K Yue, Angela M Pronger, Adam R Ferguson, Nancy R Temkin, Sourabh Sharma, Jonathan Rosand, Marco D Sorani, Thomas W McAllister, Jason Barber, Ethan A Winkler, Esteban G Burchard, Donglei Hu, Hester F Lingsma, Shelly R Cooper, Ava M Puccio, David O Okonkwo, Ramon Diaz-Arrastia, Geoffrey T Manley
Genetic association analyses suggest that certain common single nucleotide polymorphisms (SNPs) may adversely impact recovery from traumatic brain injury (TBI). Delineating their causal relationship may aid in development of novel interventions and in identifying patients likely to respond to targeted therapies. We examined the influence of the (C/T) SNP rs1800497 of ANKK1 on post-TBI outcome using data from two prospective multicenter studies: the Citicoline Brain Injury Treatment (COBRIT) trial and Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot)...
July 2015: Neurogenetics
https://www.readbyqxmd.com/read/25591513/-the-possibilities-of-increase-of-efficacy-of-rehabilitation-of-stroke-patients-with-neglect-syndrome
#17
A S Galkin, E R Barantsevich, A O Gusev, T I Minnullin, V V Kovalchuk, N L Samus, S B Fokina, M D Bogatyryova, M A Stepanenko
OBJECTIVE: To evaluate different treatment schemes for post stroke patients with neglect syndrome (NS). MATERIAL AND METHODS: We studied management rules for patients with NS and the effect of ceraxon (citicoline) on the functional rehabilitation and removal of the neglect syndrome. We analyzed treatment results of 120 stroke patients. The functional rehabilitation was followed up using Barthel, Lindmark and Merton and Sutton scales, cognitive functions were assessed with the MMSE scale and the battery of frontal dysfunction, psychoemotional condition with the Beck Depression Questionnaire...
2014: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/25391431/effect-of-acupuncture-treatment-on-vascular-cognitive-impairment-without-dementia-study-protocol-for-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Bo-Feng Yang, Xiang-Hong Zeng, Yan Liu, Qing-Nan Fu, Tian He, Fang Li, Guang-Xia Shi, Bao-Zhen Liu, San-Feng Sun, Jun Wang, Lei Xiao, Yan-Mei Deng, Cun-Zhi Liu
BACKGROUND: Vascular cognitive impairment, no dementia (VCIND) is a condition at risk for future dementia and should be the target of preventive strategies. Preliminary evidence suggests that acupuncture may be a clinically effective intervention for people with early-stage vascular cognitive impairment. We will do a multicenter, 6-month, drug-controlled, nonblinded, randomized, parallel-group trial to determine whether acupuncture is effective for improving cognitive function and quality of life for patients with VCIND...
2014: Trials
https://www.readbyqxmd.com/read/25315828/cdp-choline-effects-of-the-procholine-supplement-on-sensory-gating-and-executive-function-in-healthy-volunteers-stratified-for-low-medium-and-high-p50-suppression
#19
RANDOMIZED CONTROLLED TRIAL
Verner Knott, Dylan Smith, Sara de la Salle, Danielle Impey, Joelle Choueiry, Elise Beaudry, Meaghan Smith, Salman Saghir, Vadim Ilivitsky, Alain Labelle
Diminished auditory sensory gating and associated neurocognitive deficits in schizophrenia have been linked to altered expression and function of the alpha-7 nicotinic acetycholinergic receptor (α7 nAChR), the targeting of which may have treatment potential. Choline is a selective α7 nAChR agonist and the aim of this study was to determine whether cytidine 5'-diphosphocholine (CDP-choline), or citicoline, a dietary source of choline, increases sensory gating and cognition in healthy volunteers stratified for gating level...
December 2014: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/25046515/improvements-in-concentration-working-memory-and-sustained-attention-following-consumption-of-a-natural-citicoline-caffeine-beverage
#20
RANDOMIZED CONTROLLED TRIAL
Steven E Bruce, Kimberly B Werner, Brittany F Preston, Laurie M Baker
This study examined the neurocognitive and electrophysiological effects of a citicoline-caffeine-based beverage in 60 healthy adult participants enrolled in a randomized, double-blind, placebo-controlled trial. Measures of electrical brain activity using electroencephalogram (EEG) and neuropsychological measures examining attention, concentration and reaction time were administered. Compared to placebo, participants receiving the citicoline-caffeine beverage exhibited significantly faster maze learning times and reaction times on a continuous performance test, fewer errors in a go/no-go task and better accuracy on a measure of information processing speed...
December 2014: International Journal of Food Sciences and Nutrition
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