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Cognitive enhancement

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https://www.readbyqxmd.com/read/28538627/early-heparin-administration-after-tbi-prolonged-cognitive-recovery-associated-with-reduced-cerebral-edema-and-neutrophil-sequestration
#1
Katsuhiro Nagata, Kevin D Browne, Yujin Suto, Kenichiro Kumasaka, John Cognetti, Victoria E Johnson, Joshua Marks, Douglas H Smith, Jose L Pascual
BACKGROUND: Early administration of unfractionated heparin (UFH) after TBI reduces early in vivo circulating leukocytes (LEU) in peri-injury penumbral brain tissue, enhancing cognitive recovery 2 days after injury. It remains unclear how long this effect lasts and if this is related to persistently accumulating LEU in penumbral brain tissue. We hypothesized that UFH reduces LEU brain tissue sequestration resulting in prolonged cognitive recovery. METHODS: CD1 male mice underwent either TBI by controlled cortical impact (CCI) or sham craniotomy...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538161/that-certain-something-focusing-on-similarities-reduces-judgmental-uncertainty
#2
Ann-Christin Posten, Thomas Mussweiler
Comparative thinking is an efficient cognitive strategy that reduces judgmental uncertainty. However, comparisons may be conducted with a focus on similarities or differences. Similarity-focused comparisons seem to facilitate information-transfer, which has been suggested to drive the uncertainty-reducing effect of comparisons. This implies that similarity-focused comparisons reduce uncertainty more than dissimilarity-focused comparisons. Two experiments examine this assumption. In Study 1, a similarity-focus (compared to a difference-focus and a neutral control condition) increased judgmental certainty when the comparison was based on confident standard-knowledge...
May 21, 2017: Cognition
https://www.readbyqxmd.com/read/28535272/measures-of-financial-capacity-a-review
#3
Angela R Ghesquiere, Caitlin McAfee, Jason Burnett
Purpose of the Study: Capacity to manage finances and make financial decisions can affect risk for financial exploitation and is often the basis for legal determinations of conservatorship/guardianship. Several structured assessments of financial capacity have been developed, but have not been compared regarding their focus, validity, or reliability. Therefore, we conducted a review of financial capacity measures to examine these factors. Design and Methods: We searched electronic databases, reference lists in identified articles, conference proceedings and other grey literature for measures of financial capacity...
May 23, 2017: Gerontologist
https://www.readbyqxmd.com/read/28535081/advances-in-antidepressants-for-treating-post-stroke-depression
#4
Stefano Paolucci
Introduction Post-stroke depression (PSD) is a common and serious complication after stroke, occurring in nearly one third of stroke survivors, and affecting mortality rate, functional outcome, rehabilitation results and quality of life. However, in the common clinical practice only a minority of patients are properly treated. A relatively small number of scientific reports are available on clinical usefulness and safety of antidepressants (ADs) in PSD. Areas Covered This report provides an updated review about pharmacological state of art of PSD, including efficacy and safety of different drugs and their role on prevention, treatment and functional outcome...
May 23, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28534735/the-use-of-the-gaps-in-noise-test-as-an-index-of-the-enhanced-left-temporal-cortical-thinning-associated-with-the-transition-between-mild-cognitive-impairment-and-alzheimer-s-disease
#5
Vasiliki Vivian Iliadou, Doris-Eva Bamiou, Christos Sidiras, Nikolaos P Moschopoulos, Magda Tsolaki, Ioannis Nimatoudis, Gail D Chermak
BACKGROUND: The known link between auditory perception and cognition is often overlooked when testing for cognition. PURPOSE: To evaluate auditory perception in a group of older adults diagnosed with mild cognitive impairment (MCI). RESEARCH DESIGN: A cross-sectional study of auditory perception. STUDY SAMPLE: Adults with MCI and adults with no documented cognitive issues and matched hearing sensitivity and age. DATA COLLECTION: Auditory perception was evaluated in both groups, assessing for hearing sensitivity, speech in babble (SinB), and temporal resolution...
May 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28534720/spatial-and-visual-reasoning-do-these-abilities-improve-in-first-year-veterinary-medical-students-exposed-to-an-integrated-curriculum
#6
J Claudio Gutierrez, Munashe Chigerwe, Jan E Ilkiw, Patricia Youngblood, Steven D Holladay, Sakti Srivastava
Spatial visualization ability refers to the human cognitive ability to form, retrieve, and manipulate mental models of spatial nature. Visual reasoning ability has been linked to spatial ability. There is currently limited information about how entry-level spatial and visual reasoning abilities may predict veterinary anatomy performance or may be enhanced with progression through the veterinary anatomy content in an integrated curriculum. The present study made use of two tests that measure spatial ability, and one test that measures visual reasoning ability in veterinary students: Guay's Visualization of Views Test, adapted version (GVVT), the Mental Rotations Test (MRT), and Raven's Advanced Progressive Matrices Test, short form (RavenT)...
May 23, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28533954/exercise-and-dietary-program-induced-weight-reduction-is-associated-with-cognitive-function-among-obese-adolescents-a-longitudinal-study
#7
Chun Xie, Xiaochun Wang, Chenglin Zhou, Chang Xu, Yu-Kai Chang
OBJECTIVE: The present study was to determine the effect of a combined exercise and dietary program on cognitive function as well as the relationship between the program-induced weight change and cognitive function alterations. DESIGN: The study applies a quasi-experimental design. METHODS: Fifty-eight adolescents with obese status (body mass index, BMI >28 kg/m(2)) were assigned to either an experiment (n = 30) or control group (n = 28)...
2017: PeerJ
https://www.readbyqxmd.com/read/28533615/effects-of-taekwondo-intervention-on-cognitive-function-and-academic-self-efficacy-in-children
#8
Su Youn Cho, Young Il Kim, Hee Tae Roh
[Purpose] The purpose of this study was to investigate the effects of taekwondo training on cognitive function and academic self-efficacy in children. [Subjects and Methods] Thirty-five children participated in the study. Seventeen children were randomly selected to undergo taekwondo training for 16 weeks (5 times per week). As controls, 18 children received no training. Cognitive function and academic self-efficacy were measured using the Stroop Color and Word Test (Word, Color, and Color-Word) and academic self-efficacy scale (Self-confidence, Self-regulatory Efficacy, and Task Difficulty Preference), respectively...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533388/selective-lowering-of-synapsins-induced-by-oligomeric-%C3%AE-synuclein-exacerbates-memory-deficits
#9
Megan E Larson, Susan J Greimel, Fatou Amar, Michael LaCroix, Gabriel Boyle, Mathew A Sherman, Hallie Schley, Camille Miel, Julie A Schneider, Rakez Kayed, Fabio Benfenati, Michael K Lee, David A Bennett, Sylvain E Lesné
Mounting evidence indicates that soluble oligomeric forms of amyloid proteins linked to neurodegenerative disorders, such as amyloid-β (Aβ), tau, or α-synuclein (αSyn) might be the major deleterious species for neuronal function in these diseases. Here, we found an abnormal accumulation of oligomeric αSyn species in AD brains by custom ELISA, size-exclusion chromatography, and nondenaturing/denaturing immunoblotting techniques. Importantly, the abundance of αSyn oligomers in human brain tissue correlated with cognitive impairment and reductions in synapsin expression...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28533042/-social-and-mood-enhancement-benefits-of-a-cognitive-remediation-workshop
#10
Karine Auffret, Céline Jacolot
A workshop focused on memory aimed at people with degenerative diseases like Alzheimer's disease can evolve into a social-therapeutic group for people also suffering from mood disorders. Cognitive remediation is therefore orientated towards social-mood mediation.
May 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28532665/evaluation-of-the-behavioral-characteristics-of-the-mdx-mouse-model-of-duchenne-muscular-dystrophy-through-operant-conditioning-procedures
#11
Matthew Lewon, Christina M Peters, Pam M Van Ry, Dean J Burkin, Kenneth W Hunter, Linda J Hayes
The mdx mouse is an important nonhuman model for Duchenne muscular dystrophy (DMD) research. Characterizing the behavioral traits of the strain relative to congenic wild-type (WT) mice may enhance our understanding of the cognitive deficits observed in some humans with DMD and contribute to treatment development and evaluation. In this paper we report the results of a number of experiments comparing the behavior of mdx to WT mice in operant conditioning procedures designed to assess learning and memory. We found that mdx outperformed WT in all learning and memory tasks involving food reinforcement, and this appeared to be related to the differential effects of the food deprivation motivating operation on mdx mice...
May 19, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28532283/the-feasibility-of-an-automated-eye-tracking-modified-fagan-test-of-memory-for-human-faces-in-younger-ugandan-hiv-exposed-children
#12
Ronak Chhaya, Jonathan Weiss, Victoria Seffren, Alla Sikorskii, Paula M Winke, Julius C Ojuka, Michael J Boivin
OBJECTIVE: The Fagan Test of Infant Intelligence (FTII) uses longer gaze length for unfamiliar versus familiar human faces to gauge visual-spatial encoding, attention, and working memory in infants. Our objective was to establish the feasibility of automated eye tracking with the FTII in HIV-exposed Ugandan infants. METHOD: The FTII was administered to 31 perinatally HIV-exposed noninfected (HEU) Ugandan children 6-12 months of age (11 boys; M = 0.69 years, SD = 0...
May 22, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28532200/spinal-analgesia-improves-surgical-outcome-after-open-nephrectomy-for-renal-cell-carcinoma-a-randomized-controlled-study
#13
Mascha Thurm, Britt-Inger Kröger Dahlin, Ola Winsö, Börje Ljungberg
OBJECTIVE: This study evaluated whether more effective perioperative analgesia can be part of a multimodal approach to minimizing morbidity and improving postoperative management after the open surgical approaches frequently used in the treatment of renal cell carcinoma (RCC). The aim of the study was to determine whether spinal anesthesia with clonidine can enhance postoperative analgesia, speed up mobilization and reduce the length of hospital stay (LOS). MATERIALS AND METHODS: Between 2012 and 2015, 135 patients with RCC were randomized, in addition to general anesthesia, to receive either spinal analgesia with clonidine or epidural analgesia, stratified to surgical technique...
May 22, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28529492/depression-in-men-and-women-one-year-following-traumatic-brain-injury-tbi-a-tbi-model-systems-study
#14
Sarah Lavoie, Samantha Sechrist, Nhung Quach, Reza Ehsanian, Thao Duong, Ian H Gotlib, Linda Isaac
In the general population, females experience depression at significantly higher rates than males. Individuals with traumatic brain injury (TBI) are at substantially greater risk for depression compared to the overall population. Treatment of, and recovery from, TBI can be hindered by depression; comorbid TBI and depression can lead to adverse outcomes and negatively affect multiple aspects of individuals' lives. Gender differences in depression following TBI are not well understood, and relevant empirical findings have been mixed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28528772/early-interleukin-6-enhances-hepatic-ketogenesis-in-appswe-psen1de9-mice-via-3-hydroxy-3-methylglutary-coa-synthase-2-signaling-activation-by-p38-nuclear-factor-%C3%AE%C2%BAb-p65
#15
Le Shi, Daina Zhao, Chen Hou, Yunhua Peng, Jing Liu, Shuangxi Zhang, Jiankang Liu, Jiangang Long
Alzheimer's disease (AD) is considered a multifactorial disease that affects the central nervous system and periphery. A decline in brain glucose metabolism is an early feature of AD and is accompanied by a phenotypic shift from aerobic glycolysis to ketogenesis. The liver is responsible for the generation of the ketone body. However, the mechanism that underlies hepatic ketogenesis in AD remains unclear. Here, we investigated hepatic ketogenesis during the early stage of AD pathogenesis in amyloid precursor protein (APPSWE) and presenilin (PSEN1dE9) (APP/PS1) mice...
April 26, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28528023/medication-management-activities-performed-by-informal-caregivers-of-older-adults
#16
Kevin A Look, Jamie A Stone
BACKGROUND: Medication management is commonly performed by informal caregivers, yet they are often unprepared and ill-equipped to manage complex medication regimens for their older adult care recipients. In order to develop interventions that will enhance the caregiver's ability to safely and confidently manage medications, it is critical to first understand caregiver challenges and unmet needs related to medication management. OBJECTIVES: To explore how informal caregivers manage medications for their older adult care recipients by identifying the activities involved in medication management and the tools or strategies used to facilitate these activities...
May 16, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28527318/activating-analytic-thinking-enhances-the-value-given-to-individualizing-moral-foundations
#17
Onurcan Yilmaz, S Adil Saribay
Two central debates within Moral Foundations Theory concern (1) which moral foundations are core and (2) how conflict between ideological camps stemming from valuing different moral foundations can be resolved. Previous studies have attempted to answer the first question by imposing cognitive load on participants to direct them toward intuitive and automatic thought. However, this method has limitations and has produced mixed findings. In the present research, in two experiments, instead of directing participants toward intuitive thought, we tested the effects of activating high-effort, analytic thought on participants' moral foundations...
May 17, 2017: Cognition
https://www.readbyqxmd.com/read/28527057/behavioral-therapy-emotion-and-pain-a-common-anatomical-background
#18
Lauren A-M Dahlke, Jeffrey J Sable, Frank Andrasik
Emotion and pain are closely intertwined in the brain, as the human experience of pain includes both affective and nociceptive components. Although each of these components relies on a different system in the brain, the two systems converge on the anterior cingulate and insular cortices, which interact with the prefrontal cortex and other frontal structures to influence behavior. Both emotional and physical pain elicit activity in these common areas, and conditions that affect one system (e.g., drugs, neural plasticity) may affect the function of the other-ultimately altering the experience of pain...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28525796/beneficial-effects-of-training-in-self-distancing-and-perspective-broadening-for-people-with-a-history-of-recurrent-depression
#19
Emma Travers-Hill, Barnaby D Dunn, Laura Hoppitt, Caitlin Hitchcock, Tim Dalgleish
Cognitive training designed to recalibrate maladaptive aspects of cognitive-affective processing associated with the presence of emotional disorder can deliver clinical benefits. This study examined the ability of an integrated training in self-distancing and perspective broadening (SD-PB) with respect to distressing experiences to deliver such benefits in individuals with a history of recurrent depression (≥3 prior episodes), currently in remission. Relative to an overcoming avoidance (OA) control condition, SD-PB: a) reduced distress to upsetting memories and to newly encountered events, both during training when explicitly instructed to apply SD-PB techniques, and after-training in the absence of explicit instructions; b) enhanced capacity to self-distance from and broaden perspectives on participants' experiences; c) reduced residual symptoms of depression...
May 11, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28525569/comparative-effects-of-methylphenidate-modafinil-and-mdma-on-response-inhibition-neural-networks-in-healthy-subjects
#20
André Schmidt, Felix Müller, Patrick C Dolder, Yasmin Schmid, Davide Zanchi, Matthias E Liechti, Stefan Borgwardt
Background: Psychostimulants such as methylphenidate (MPH) and modafinil are increasingly used by healthy people for cognitive enhancement purposes, whereas the acute effect of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) on cognitive functioning in healthy subjects remains unclear. This study directly compared the acute effects of MPH, modafinil and MDMA on the neural mechanisms underlying response inhibition in healthy subjects. Methods: Using a double-blind within-subject placebo-controlled cross-over design, MPH, modafinil and MDMA were administrated to 21 healthy subjects, while performing a Go/No-Go event-related functional magnetic resonance imaging task to assess brain activation during motor response inhibition...
May 19, 2017: International Journal of Neuropsychopharmacology
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