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https://www.readbyqxmd.com/read/28749358/a-new-neural-dynamic-classification-algorithm
#1
Mohammad Hossein Rafiei, Hojjat Adeli
The keys for the development of an effective classification algorithm are: 1) discovering feature spaces with large margins between clusters and close proximity of the classmates and 2) discovering the smallest number of the features to perform accurate classification. In this paper, a new supervised classification algorithm, called neural dynamic classification (NDC), is presented with the goal of: 1) discovering the most effective feature spaces and 2) finding the optimum number of features required for accurate classification using the patented robust neural dynamic optimization model of Adeli and Park...
July 25, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28749318/probabilistic-linkage-to-enhance-deterministic-algorithms-and-reduce-data-linkage-errors-in-hospital-administrative-data
#2
Gareth Hagger-Johnson, Katie Harron, Harvey Goldstein, Robert Aldridge, Ruth Gilbert
 BACKGROUND: The pseudonymisation algorithm used to link together episodes of care belonging to the same patients in England (HESID) has never undergone any formal evaluation, to determine the extent of data linkage error. OBJECTIVE: To quantify improvements in linkage accuracy from adding probabilistic linkage to existing deterministic HESID algorithms. METHODS: Inpatient admissions to NHS hospitals in England (Hospital Episode Statistics, HES) over 17 years (1998 to 2015) for a sample of patients (born 13/28th of months in 1992/1998/2005/2012)...
June 30, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749195/hippo-pathway-contributes-to-cisplatin-resistant-induced-emt-in-nasopharyngeal-carcinoma-cells
#3
Shuo Li, Xiaomeng Zhang, Rongkai Zhang, Zibin Liang, Wei Liao, Zhengde Du, Chunsheng Gao, Fei Liu, Yunping Fan, Haiyu Hong
Nasopharyngeal carcinoma (NPC) is a kind of head-neck malignant tumor derived from the nasopharyngeal epithelium and is mainly prevalent in Southern China and Southeast Asia countries. Cisplatin (DDP) provides the first-line therapeutic administration in NPC patients. However, chemoresistance has been a main barrier and caused bad treatment outcome in NPC therapy. To understand the molecular mechanism of acquired resistance to DDP, multiple methods were performed to examine the morphocytology and molecular changes in DDP-resistant NPC cells...
July 27, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28749189/improved-oral-bioavailability-for-lutein-by-nanocrystal-technology-formulation-development-in-vitro-and-in-vivo-evaluation
#4
Daoxiao Chang, Yanni Ma, Guoyu Cao, Jianhuan Wang, Xia Zhang, Jun Feng, Wenping Wang
Lutein is a kind of natural carotenoids possessing many pharmacological effects. The application of lutein was limited mainly due to its low oral bioavailability caused by poor aqueous solubility. Nanocrystal formulation of lutein was developed to improve the oral bioavailability in this study. The nanosuspension was prepared by the anti-solvent precipitation-ultrasonication method and optimized by Box-Behnken design, followed by freeze-drying to obtain lutein nanocrystals. The nanocrystals were characterized on their physical properties, in vitro dissolution and in vivo absorption performance...
July 27, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28749167/diagnostic-value-of-semiquantitative-and-quantitative-analysis-of-functional-parameters-in-multiparametric-mri-of-the-prostate
#5
Elke Hauth, Daniela Halbritter, Horst Jaeger, Horst Hohmuth, Meinrad Beer
OBJECTIVES: To determine the diagnostic value of semiquantitative and quantitative parameters of three functional techniques in multiparametric (mp)-MRI of the prostate. METHODS: Mp-MRI was performed in 110 patients with suspicion of prostate cancer (PCA) before TRUS-guided core biopsy. Peak-enhancement, initial and post-initial enhancement, iAUGC (initial area under gadolinium curve), Ktrans (forward rate constant), Kep (efflux rate constant), Ve (extracellular volume), ADC (apparent diffusion coefficient), and MR spectroscopy ratio were obtained for malignant and benign lesions...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28749149/diversity-shrinkage-cross-validating-pareto-optimal-weights-to-enhance-diversity-via-hiring-practices
#6
Q Chelsea Song, Serena Wee, Daniel A Newman
To reduce adverse impact potential and improve diversity outcomes from personnel selection, one promising technique is De Corte, Lievens, and Sackett's (2007) Pareto-optimal weighting strategy. De Corte et al.'s strategy has been demonstrated on (a) a composite of cognitive and noncognitive (e.g., personality) tests (De Corte, Lievens, & Sackett, 2008) and (b) a composite of specific cognitive ability subtests (Wee, Newman, & Joseph, 2014). Both studies illustrated how Pareto-weighting (in contrast to unit weighting) could lead to substantial improvement in diversity outcomes (i...
July 27, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28749136/high-performance-pyrochlore-type-yttrium-ruthenate-electrocatalyst-for-oxygen-evolution-reaction-in-acidic-media
#7
Jaemin Kim, Pei-Chieh Shih, Kai-Chieh Tsao, Yung-Tin Pan, Xi Yin, Cheng-Jun Sun, Hong Yang
Development of acid-stable electrocatalysts with low overpotential for oxygen evolution reaction (OER) is a major challenge to produce of hydrogen directly from water. We report in this paper a pyrochlore yttrium ruthenate (Y2Ru2O7-δ) electrocatalyst that has significantly enhanced performance towards OER in acid media over the best-known catalysts, with an onset overpotential of 190 mV and high stability in 0.1-M perchloric acid solution. X-ray absorption near-edge structure (XANES) indicates Y2Ru2O7-δ electrocatalyst had a low valence state that favors the high OER activity...
July 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28749094/superiority-of-ultrasound-guided-shamrock-lumbar-plexus-block
#8
Martin V Nielsen, Thomas F Bendtsen, Jens Børglum
BACKGROUND: Ultrasound-guided lumbar plexus block performed with the Shamrock approach has received much interest since the technique was first described in 2013. The technique is believed to be faster and easier to perform and possibly safer in regards to potential complications compared with other lumbar plexus blocks. METHODS: In order to outline some favorable characteristics of the Shamrock lumbar plexus block, we performed an exhaustive search of the current literature; even though it is rather limited...
July 26, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28749049/mineral-trioxide-aggregate-enhances-the-osteogenic-capacity-of-periodontal-ligament-stem-cells-via-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#9
Yanqiu Wang, Yixiang Zhou, Lin Jin, Xiyao Pang, Yadie Lu, Zilu Wang, Yan Yu, Jinhua Yu
INTRODUCTION: Mineral trioxide aggregate (MTA), as a bioactive material, has a widespread application in clinical practice. To date, the effects of MTA on the proliferation and differentiation of human periodontal ligament stem cells (hPDLSCs) remain unclear. MATERIALS AND METHODS: hPDLSCs were isolated from human periodontal ligament tissues and cultured with MTA conditioned media. Cell counting kit-8 (CCK-8) assay was performed to assess the proliferation capacity of MTA-treated hPDLSCs...
July 27, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28748991/-analysis-of-incident-reports-in-an-anesthesiology-unit-of-a-university-hospital
#10
Luis Marfán, Juan C Pedemonte, Daniela Sandoval, Constanza Ferdinand, Lorena Camus, Héctor J Lacassie
BACKGROUND: Incident reporting is an effective strategy used to enhance patient safety. An incident is an event that could eventually result in harm to a patient. AIM: To classify and analyze incidents reported by an Anesthesiology division at a University hospital in Chile. MATERIAL AND METHODS: A retrospective analysis of the reported incidents registered in our institutional database from January 2008 to January 2014. They were classified according to three variables proposed by the World Health Organization system to determine the type of incident and patients’ potential harm...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748956/thermally-stable-single-atom-pt-m-al2o3-for-selective-hydrogenation-and-co-oxidation
#11
Zailei Zhang, Yihan Zhu, Hiroyuki Asakura, Bin Zhang, Jiaguang Zhang, Maoxiang Zhou, Yu Han, Tsunehiro Tanaka, Aiqin Wang, Tao Zhang, Ning Yan
Single-atom metal catalysts offer a promising way to utilize precious noble metal elements more effectively, provided that they are catalytically active and sufficiently stable. Herein, we report a synthetic strategy for Pt single-atom catalysts with outstanding stability in several reactions under demanding conditions. The Pt atoms are firmly anchored in the internal surface of mesoporous Al2O3, likely stabilized by coordinatively unsaturated pentahedral Al(3+) centres. The catalyst keeps its structural integrity and excellent performance for the selective hydrogenation of 1,3-butadiene after exposure to a reductive atmosphere at 200 °C for 24 h...
July 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28748909/von-hippel-lindau-disease-when-neurosurgery-meets-nephrology-ophthalmology-and-genetics
#12
Francesco Signorelli, Giovanni Piscopo, Sophie Giraud, Silvana Guerriero, Antonio Laborante, Maria E Latronico, Gennaro Chimenti, Rodolfo Maduri, Domenico Chirchiglia, Angelo Lavano, Jacques Guyotat, Giovanni Alessio, Loreto Gesualdo
INTRODUCTION: Von Hippel-Lindau (VHL) disease is a dominantly inherited condition associated with tumors in multiple organs, whose treatment requires heightened multidisciplinary teamwork. Therefore, a document summarizing all the pertinent knowledge is needed to enhance coordination of care. EVIDENCE ACQUISITION: A systematic review of the literature from the Medline, Embase and Cochrane Central databases was performed. From 1970 to 2017, all articles meeting specific inclusion criteria were included by at least one specialist physician for each field...
July 26, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28748855/clinical-characteristics-and-endoscopic-endonasal-removal-of-foreign-bodies-within-sinuses-orbit-and-skull-base
#13
Yi-Hui Wen, Wei-Jian Hou, Wen-Bin Lei, Feng-Hong Chen, Xiao-Lin Zhu, Zhang-Feng Wang, Ren-Qiang Ma, Wei-Ping Wen
BACKGROUND: Foreign bodies within the sinuses, orbit, and skull base (FBSOS) are rare; hence, diagnosis and management guidelines are lacking. Endoscopic sinus surgery (ESS) removal is preferred because of the less invasiveness and minimal morbidity. This study was designed to summarize clinical experience with ESS management of FBSOS. METHODS: We retrospectively reviewed clinical manifestations, imaging findings, treatment, and outcomes in consecutive patients with ESS removal of FBSOS between 2004 and 2015 at a tertiary academic medical center...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28748701/mesoporous-zro2-nanoframes-for-biomass-upgrading
#14
Haiqing Wang, Hao Chen, Bing Ni, Kai Wang, Ting He, Yulong Wu, Xun Wang
The rational design and preparation of high-performance catalyst for biomass upgrading are of great significance and remain a great challenge. In this work, mesoporous ZrO2 nanoframe, hollow ring, sphere and core-shell nanostructures have been developed through a surfactant-free route for upgrading biomass acids into liquid alkane fuels. The obtained ZrO2 nanostructures possess well-defined hollow features, high surface areas and mesopores. The diversity of resultant ZrO2 nanostructures should be arising from the discrepant hydrolysis of two different ligands in zirconocene dichloride (Cp2ZrCl2) as zirconium precursor...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748579/new-approach-applying-a-pet-fish-air-pump-in-liquid-phase-microextraction-for-the-determination-of-sudan-dyes-in-food-samples-by-hplc
#15
Phitchan Sricharoen, Nunticha Limchoowong, Suchila Techawongstien, Saksit Chanthai
A new approach applying a pet fish air pump is introduced to develop an extraction method, namely, air-pump-enhanced emulsion, followed by salt-assisted emulsion breaking based on solidified floating organic drop microextraction for the extraction and preconcentration of Sudan I-IV before high-performance liquid chromatography. The applicability of this method was successfully demonstrated by the determination of these dyes in four chili products that include chili powder, chili oil, chili sauce and chili paste...
July 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28748559/introduction-of-2-6-diaminopurines-into-serinol-nucleic-acid-sna-improves-anti-mirna-performance
#16
Yukiko Kamiya, Yuka Donoshita, Hiroshi Kamimoto, Keiji Murayama, Jumpei Ariyoshi, Hiroyuki Asanuma
MicroRNAs (miRNAs) are endogenous small RNAs that regulate gene expression at the post-transcriptional level by sequence-specific hybridization. Anti-miRNA oligonucleotides (AMOs) are inhibitors of miRNA activity. Chemical modifications of AMOs are required to increase binding affinity and stability in serum and cells. In this study we synthesized AMOs with our original acyclic nucleic acid, serinol nucleic acid (SNA) backbone and with an artificial nucleobase 2,6-diaminopurine. The AMO composed of only SNA had strong nuclease resistance and blocked endogenous miRNA activity...
July 26, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28748542/pediatric-intracerebral-histiocytic-sarcoma-with-rhabdoid-features-case-report-and-literature-review
#17
Young Hye Kim, Gie-Taek Yie, Na Rae Kim, In-Sang Jeon, Hyun Yee Cho, Jae Yeon Seok, Eung Yeop Kim, Kyu Chan Lee
A 16-year-old boy presented with marked weight loss, weakness of the left extremities and dizziness of 2 months duration and vomiting for 2 days. Brain MRI showed an approximately 6.5 × 5.3 cm-sized huge heterogeneous enhancing mass located in the corpus callosum, extending into the lateral ventricle. Open biopsy showed that the lesion consisted of lymphoplasmacytes and plump histiocytes with rhabdoid morphology, which were stained with S-100 protein, CD68 (KP1) and negative for CD1a. Histiocytic tumor was initially diagnosed...
July 27, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28748532/rdxa-frxa-and-efflux-pump-in-metronidazole-resistant-helicobacter-pylori-their-relation-to-clinical-outcomes
#18
Sun Min, Nayoung Kim, Yong Hwan Kwon, Ryoung Hee, Jung Mogg Kim, Jong Youn, Yeon Suk Lee, Dong Ho Lee
BACKGROUND AND AIM: rdxA and frxA mutations and enhancement of efflux pump have been suggested as the cause of metronidazole resistance in Helicobacter pylori. This study was performed to investigate the resistance mechanisms related to clinical eradication outcome, and to examine direct involvement of hefA in metronidazole-resistant isolates with intact rdxA and frxA. METHODS: A total of 53 H. pylori-positive patients who were treated with metronidazole-containing sequential or quadruple therapy from 2011 to 2015 were enrolled...
July 27, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28748480/investigation-of-the-effects-of-starch-on-the-physical-and-biological-properties-of-polyacrylamide-paam-starch-nanofibers
#19
Hadi Taghavian, Seyed-Omid Ranaei-Siadat, Mohammad Reza Kalaee, Saeedeh Mazinani
Here, we report the development of a new polyacrylamide (PAAm)/starch nanofibers' blend system and highlight its potential as substrate for efficient enzyme immobilization. PAAm was synthesized and blended with starch. The final blend was then electrospun into nanofibers. The response surface methodology was used to analyze the parameters that control nanofiber's diameter. Electrospun mat was then modified either by cross-linking or phytase immobilization using silane coupling agent and glutaraldehyde chemistry...
July 26, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/28748373/novel-combination-of-salinomycin-and-resveratrol-synergistically-enhances-the-anti-proliferative-and-pro-apoptotic-effects-on-human-breast-cancer-cells
#20
Jayant Dewangan, Divya Tandon, Sonal Srivastava, Ajeet Kumar Verma, Ashok Yapuri, Srikanta Kumar Rath
Resveratrol (RES) is a natural polyphenol having anti-proliferative activity against breast cancer cells. RES in combination with other chemo modulatory agents, minimizes toxicity and increases efficacy of the treatment. Salinomycin (SAL), a monocarboxylic polyether ionophore is known for selectively targeting breast cancer stem cells. Purpose of the present study was to investigate whether RES in combination with SAL exerts synergistic anti-proliferative activity on breast cancer cells. We further evaluated the molecular mechanism behind SAL and RES mediated cell death...
July 26, 2017: Apoptosis: An International Journal on Programmed Cell Death
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