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Hypocalcaemia

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https://www.readbyqxmd.com/read/27889760/pamidronate-attenuates-oxidative-stress-and-energetic-metabolism-changes-but-worsens-functional-outcomes-in-acute-doxorubicin-induced-cardiotoxicity-in-rats
#1
Paula Bernardo de Carvalho, Andréa de Freitas Gonçalves, Patrícia Helena Correa Alegre, Paula Schmidt Azevedo, Meliza Goi Roscani, Carolina Marabesi Bergamasco, Pamela N Modesto, Ana Angélica Fernandes, Marcos Ferreira Minicucci, Sergio Alberto Rupp Paiva, Leonardo Antonio, Mamede Zornoff, Bertha Furlan Polegato
BACKGROUND: Cardiotoxicity is the major side effect of doxorubicin. As mechanisms that are involved in cardiotoxicity are ambiguous, new methods for attenuating cardiotoxicity are needed. Recent studies have shown that bisphosphonates can decrease oxidative stress. Therefore, the objective of this study was to evaluate the effect of pamidronate on preventing acute doxorubicin-induced cardiotoxicity. METHODS: Sixty-four male Wistar rats were allocated into four groups: the control group (C), the pamidronate group (P), the doxorubicin group (D) and the doxorubicin/pamidronate group (DP)...
November 25, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27871293/genetic-and-epigenetic-alterations-in-the-gnas-locus-and-clinical-consequences-in-pseudohypoparathyroidism-italian-common-healthcare-pathways-adoption
#2
L de Sanctis, F Giachero, G Mantovani, G Weber, M Salerno, G I Baroncelli, M F Elli, P Matarazzo, M Wasniewska, L Mazzanti, G Scirè, D Tessaris
BACKGROUND: Genetic and epigenetic alterations in the GNAS locus are responsible for the Gsα protein dysfunctions causing Pseudohypoparathyroidism (PHP) type Ia/c and Ib, respectively. For these heterogeneous diseases characterized by multiple hormone resistances and Albright's Hereditary Osteodystrophy (AHO) the current classification results inadequate because of the clinical overlap between molecular subtypes and a standard clinical approach is still missing. In the present paper several members of the Study Group Endocrine diseases due to altered function of Gsα protein of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED) have reviewed and updated the clinical-molecular data of the largest case series of (epi)/genetically characterized AHO/PHP patients; they then produced a common healthcare pathway for patients with these disorders...
November 21, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27863287/bone-health-in-the-elderly-cancer-patient-a-siog-position-paper
#3
REVIEW
J J Body, E Terpos, B Tombal, P Hadji, A Arif, A Young, M Aapro, R Coleman
More than a third of cancers are diagnosed in people over the age of 75. Androgen deprivation for prostate cancer and aromatase inhibitors in breast cancer accelerate age-related bone loss and increase fracture rates. BMD should be checked by dual energy X-ray absorptiometry at baseline and, dependent on risk, every 12-24months. Sufficient calcium, vitamin D and exercise are part of primary fracture prevention. Resistance exercise in particular may improve functional activity and bone density. In men at increased fracture risk and women with postmenopausal early breast cancer, antiresorptive treatment is warranted to reduce fracture rate and to increase overall survival in breast cancer...
December 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27862983/denosumab-prevention-and-management-of-hypocalcemia-osteonecrosis-of-the-jaw-and-atypical-fractures
#4
REVIEW
Kenneth Pittman, Yoland C Antill, Amanda Goldrick, Jeffrey Goh, Richard H de Boer
Denosumab, a bone-modifying agent, reduces the risk of skeletal-related events in patients with bone metastases from solid tumors and is generally well tolerated. However, hypocalcemia, osteonecrosis of the jaw (ONJ) and atypical fracture are potential and important toxicities of denosumab therapy that require attention. In pivotal phase III trials in patients with bone metastases from solid tumors, the incidence of hypocalcemia was 9.6% in denosumab-treated patients, with most events being asymptomatic, grade 2 and resolving by week 4...
November 10, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27784623/clinical-and-pathological-results-of-denosumab-treatment-for-giant-cell-tumors-of-bone-prospective-study-of-14-cases
#5
Mehmet Ali Deveci, Semra Paydaş, Gülfiliz Gönlüşen, Cenk Özkan, Ömer Sunkar Biçer, Mustafa Tekin
OBJECTIVE: Giant cell tumor of bone (GCT) is a primary, osteolytic, benign tumor of the bone. Surgery is the commonly used treatment; however, recurrence remains a problem. Receptor activator of nuclear factor kappa B (RANKL) is responsible for the formation of osteoclastic cells. Discovery of RANKL and its human monoclonal antibody, denosumab, led to use of denosumab for treatment of GCT. The aim of this study was to evaluate clinical and pathological results of treatment of GCT with denosumab and to assess adverse effect profile and recurrence rate...
October 24, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27781034/generalized-epilepsy-and-myoclonic-seizures-in-22q11-2-deletion-syndrome
#6
Vincent Strehlow, Marielle E M Swinkels, Rhys H Thomas, Nora Rapps, Steffen Syrbe, Thomas Dorn, Johannes R Lemke
Prompted by the observations of juvenile myoclonic epilepsy (JME) in 22q11.2 deletion syndrome (22q11DS) and recurrent copy number variants in genetic generalized epilepsy (GGE), we searched for further evidence supporting a possible correlation of 22q11DS with GGE and with myoclonic seizures. Through routine diagnostics, we identified 3 novel individuals with the seemingly uncommon combination of 22q11DS and JME. We subsequently screened the literature for reports focussing on the epilepsy phenotype in 22q11DS...
September 2016: Molecular Syndromology
https://www.readbyqxmd.com/read/27753627/minimally-symptomatic-hypocalcaemia-unmasking-celiac-disease
#7
A Lazaridis, M E Drosou, A Fontalis, E Prousali, S E Hadwe, O Giouleme, K Petidis
INTRODUCTION: Celiac disease is an autoimmune disease of the small intestine which occurs in genetically predisposed people of all ages. A large clinical spectrum of manifestations accompanies the onset of the disease with diarrhoea, flatulence and weight loss being the most common. However, findings like osteoporosis, iron deficiency, anaemia and hypocalcaemia could also insinuate the existence of the disease. CASE PRESENTATION: We report the case of a 55-year-old man with numbness and tingling of the upper extremities due to hypocalcaemia that proved to be an uncommon case of celiac disease...
November 2016: Scottish Medical Journal
https://www.readbyqxmd.com/read/27710917/primary-hyperparathyroidism-may-masquerade-as-rickets-osteomalacia-in-vitamin-d-replete-children
#8
Mohd Ashraf Ganie, Nishant Raizada, Himika Chawla, Arun Kumar Singh, Sandeep Aggarwala, Chandra Sekhar Bal
Primary hyperparathyroidism, typically a disease of the middle aged and the old, is less commonly seen in children. In children the disease has a bimodal age distribution with calcium sensing receptor mutation presenting in infancy as hypercalcemic crises and parathyroid adenoma or hyperplasia presenting later in childhood with bone disease. The childhood parathyroid adenomas are often familial with multiglandular disease and manifest with severe bone disease unlike adults. We report a series of four male patients with juvenile primary hyperparathyroidism, three of whom presented with bone disease masquerading as rickets-osteomalacia...
October 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27689826/natpara-for-the-treatment-of-hypoparathyroidism
#9
Gemma Marcucci, Giuseppe Della Pepa, Maria Luisa Brandi
INTRODUCTION: Hypoparathyroidism is a rare endocrine disorder characterized by hypocalcaemia and hyperphosphatemia, due to absent or inappropriately low parathyroid hormone levels. For management of chronic hypoparathyroidism, current treatment options involve oral calcium and vitamin D. This standard treatment cannot resolve all problematic aspects of the disease, such as abnormal bone remodeling and reduced quality of life, and is associated with long-term complications, including nephrolithiasis, nephrocalcinosis, renal impairment, cataracts and cerebral calcifications...
November 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27682264/intraoperative-neuromonitoring-in-thyroidectomy-the-learning-curve
#10
Paolo Del Rio, Piercosimo Nisi, Sara Benedicenti, Elisa Bertocchi, Enrico Luzietti, Mario Sianesi
AIM: To evaluate the learning curve in the use of intraoperative neuromonitoring of recurrent laryngeal nerve and vagus in thyroid surgery. MATERIALS OF THE STUDY: We analyzed 140 pts treated consecutively for thyroid disease. All the patients were neuromonitored with Intraoperative neuromonitoring of recurrent laryngeal nerve and vagus. We divided these patients in 7 groups to collect the adverse events during our learning curve. RESULTS: We monitored consecutively 271 nerves...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27682248/hypocalcaemia-after-denosumab-in-older-people-following-fracture
#11
Jessica Chen, Peter Smerdely
: Hypocalcaemia following denosumab therapy can be observed in older adults. This is more common if their pre-treatment corrected serum calcium concentrations are less than 2.28 mmol/L. Denosumab remains a safe treatment in older people but we recommend a cautious approach in people at risk. INTRODUCTION: Previous studies have indicated that denosumab, an anti-RANK ligand (RANKL) monoclonal antibody, for treatment of osteoporosis is well-tolerated. There is little data specifically regarding its adverse effect profile in a hospitalised older person...
September 28, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27663953/autosomal-dominant-hypocalcaemia-a-novel-mutation
#12
Lidia Urbón López de Linares, Cristina Crespo Soto, Luis Cuellar Olmedo, Maria Piedra León
No abstract text is available yet for this article.
November 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/27647839/disorders-of-the-calcium-sensing-receptor-and-partner-proteins-insights-into-the-molecular-basis-of-calcium-homeostasis
#13
REVIEW
Fadil M Hannan, Valerie N Babinsky, Rajesh V Thakker
The extracellular calcium (Ca(2+) o)-sensing receptor (CaSR) is a family C G protein-coupled receptor, which detects alterations in Ca(2+) o concentrations and modulates parathyroid hormone secretion and urinary calcium excretion. The central role of the CaSR in Ca(2+) o homeostasis has been highlighted by the identification of mutations affecting the CASR gene on chromosome 3q21.1. Loss-of-function CASR mutations cause familial hypocalciuric hypercalcaemia (FHH), whereas gain-of-function mutations lead to autosomal dominant hypocalcaemia (ADH)...
October 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27645473/the-incidence-and-risk-factors-for-central-lymph-node-metastasis-in-cn0-papillary-thyroid-microcarcinoma-a-meta-analysis
#14
Liang-Sen Liu, Jia Liang, Jun-Hong Li, Xue Liu, Li Jiang, Jian-Xiong Long, Yue-Ming Jiang, Zhi-Xiao Wei
Although there have been many studies identifying clinical and pathologic factors that may predict central lymph node metastases (CLNM) in papillary thyroid microcarcinoma (PTMC) patients without clinically cervical lymph node metastasis (cN0), the results were inconsistent. And whether prophylactic central lymph node dissection (pCLND) should be performed in cN0 PTMC remains controversial. The EMBASE, PubMed, MEDLINE and the Cochrane Library were searched until Oct 2015 to identify relevant studies. Primary outcomes were clinical and pathologic factors for CLNM...
September 19, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27624449/familial-hypomagnesaemia-with-secondary-hypocalcaemia
#15
Sabina Patel, Girish Rayanagoudar, Susan Gelding
Magnesium is the second most abundant intracellular cation and plays an essential role in neuronal, skeletal and cardiac tissue. Hypomagnesaemia can cause hypocalcaemia by inhibiting parathyroid hormone release and inducing resistance at its receptor sites. Untreated hypomagnesaemia can lead to tetany, recurrent seizures, status epilepticus and life-threatening arrhythmias. Primary hypomagnesaemia with secondary hypocalcaemia (HSH) is a rare metabolic disorder of intestinal magnesium absorption. The condition typically presents in the neonatal period with neuromuscular excitability and seizures refractory to antiepileptic therapy...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27618554/the-impact-of-different-thyroid-surgery-routes-on-the-function-of-parathyroid
#16
G Zhu, X Zou
Objective: To explore the impact of three different surgery routes for thyroid cancer on the function of parathyroid. Methods: Three groups were included: group A-gland lobe removal of one side + ipsilateral lymph nodes dissection at the central neck area (n = 62); group B-total thyroid removal + unilateral lymph nodes dissection at neck IV area with/without ipsilateral dissection of neck II-V area (n = 193); group C-total thyroid removal + bilateral neck VI dissections with/without lymph nodes dissection of ipsilateral neck II-V area (n = 60)...
December 18, 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/27608686/clinical-profile-of-patients-requiring-prolonged-mechanical-ventilation-and-their-outcome-in-a-tertiary-care-medical-icu
#17
Chakor S Vora, Niteen D Karnik, Vishal Gupta, Milind Y Nadkar, Jaimala V Shetye
INTODUCTION: An increasing number of patients require mechanical ventilation and there has been a proportional increase in patients needing prolonged mechanical ventilation (ventilated for ≥ 21 days, for atleast 6 hours per day). It accounts for about 10% of all mechanically ventilated patients. Although these patients represent a smaller proportion of intensive care unit (ICU) patients, they consume substantial ICU resources. We studied etiology, metabolic and clinical profile, complications and outcome of these patients...
October 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27608168/low-levels-of-calcium-or-vitamin-d-which-is-more-important-in-systemic-lupus-erythematosus-patients-an-extensive-data-analysis
#18
Abdulla Watad, Shmuel Tiosano, Shir Azrielant, Aaron Whitby, Doron Comaneshter, Arnon D Cohen, Yehuda Shoenfeld, Howard Amital
OBJECTIVES: Several reports have indicated an association between systemic lupus erythematosus (SLE) and low levels of vitamin D. We examined several blood work parameters in SLE patients and controls and performed an extensive data analysis in order to investigate the links between blood levels of calcium, vitamin D, and SLE disease. METHODS: 4,278 SLE patients and 16,443 age and sex-matched controls were selected from a national health insurer database in Israel...
August 31, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27600961/pre-calving-feeding-of-rumen-protected-rice-bran-to-multiparous-dairy-cows-improves-recovery-of-calcaemia-after-calving
#19
Javier Martín-Tereso, Holger Martens, Carolin Deiner, Harmen van Laar, Leo A den Hartog, Martin W A Verstegen
Dairy cows can have different degrees of hypocalcaemia around calving. Lowering dietary Ca availability before calving can prevent it. Rice bran, treated for lower rumen degradability of phytic acid can reduce dietary availability of Ca. During 3 periods of 3 weeks, 113 multiparous cows calved in a single close-up group, which was fed first a control diet, then 140 g/kg DM of rumen-protected rice bran, and at last the control diet again. Cows joined the group 3 weeks before expected calving date and left it at calving...
August 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27588942/effectiveness-of-cinacalcet-in-patients-with-chronic-kidney-disease-and-secondary-hyperparathyroidism-not-receiving-dialysis
#20
Ariadna Pérez-Ricart, Maria Galicia-Basart, Maria Alcalde-Rodrigo, Alfons Segarra-Medrano, Josep-Maria Suñé-Negre, José-Bruno Montoro-Ronsano
BACKGROUND: Secondary hyperparathyroidism (SHPT) is a common complication in chronic kidney disease (CKD) patients. Cinacalcet could be a therapeutic option although its use is controversial in patients not receiving dialysis. Thus, the aim of this study is to assess the effectiveness and safety of cinacalcet in patients with CKD and SHPT without renal replacement treatment (RRT) and without renal transplantation (RT). METHODS: A retrospective observational study was conducted...
2016: PloS One
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