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https://www.readbyqxmd.com/read/29684875/toxicoproteomic-analysis-of-human-lung-epithelial-cells-exposed-to-steel-industry-ambient-particulate-matter-pm-reveals-possible-mechanism-of-pm-related-carcinogenesis
#1
S Senthil Kumar, P Muthuselvam, V Pugalenthi, N Subramanian, K M Ramkumar, T Suresh, T Suzuki, P Rajaguru
Toxicoproteomic analysis of steel industry ambient particulate matter (PM) that contain high concentrations of PAHs and metals was done by treating human lung cancer cell-line, A549 and the cell lysates were analysed using quantitative label-free nano LC-MS/MS. A total of 18,562 peptides representing 1576 proteins were identified and quantified, with 196 proteins had significantly altered expression in the treated cells. Enrichment analyses revealed that proteins associated to redox homeostsis, metabolism, and cellular energy generation were inhibited while, proteins related to DNA damage and repair and other stresses were over expressed...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684852/polysaccharide-from-rhizopus-nigricans-inhibits-the-invasion-and-metastasis-of-colorectal-cancer
#2
Zhidan Yu, Qingjie Sun, Jing Liu, Xiujuan Zhang, Ge Song, Guodong Wang, Pengying Zhang, Kaoshan Chen
Polysaccharide (EPS1-1) extracted from fermentation liquor of Rhizopus nigricans possesses antitumor and immune-enhancing activities. The study was the first to investigate the anti-metastasis effects of EPS1-1 in vitro and in vivo. Results suggested that EPS1-1 dose-dependently suppressed the migration, invasion and adhesion abilities of CT26 cells. Furthermore, EPS1-1 dramatically inhibited the enzyme activity and expression levels of matrix metalloproteinases (MMPs) in CT26 cells, as well as the tube formation of HUVECs...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684520/phosphate-toxicity-and-tumorigenesis
#3
REVIEW
Ronald B Brown, Mohammed S Razzaque
In this brief opinion article, we briefly summarized evidence that cellular phosphate burden from phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells express more phosphate cotransporters and store more inorganic phosphate than normal cells, and dysregulated phosphate homeostasis is associated with the genesis of various human tumors. High dietary phosphate consumption causes the growth of lung and skin tumors in experimental animal models. Experimental studies show that excessive phosphate burden induces growth-promoting cell signaling, stimulates neovascularization, and is associated with chromosome instability and metastasis...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684384/knockdown-of-poldip2-suppresses-tumor-growth-and-invasion-capacity-and-is-linked-to-unfavorable-transformation-ability-and-metastatic-feature-in-non-small-cell-lung-cancer
#4
Ying-Chieh Chen, Chih-Chi Kuo, Chih-Feng Chian, Ching Tzao, Shan-Yueh Chang, Yu-Lueng Shih, Ya-Wen Lin, Mu-Hsien Yu, Her-Young Su
The main problem in the treatment of non-small cell lung cancer (NSCLC) is metastasis. Epithelial-mesenchymal transition (EMT) is known as the critical signaling in tumor progression, metastasis, and also the drug resistance. In this study, we reported a novel gene Polymerase delta-interacting protein 2 (POLDIP2) was downregulated in NSCLC tissues and first demonstrated that overexpression of POLDIP2 increased the anchorage-independent growth (AIG) and invasiveness of H1299 cells. In addition, we examined that knockdown of POLDIP2 in H1299 and A549 cells reduced tumorigenicity and metastatic capacity in vitro and also in vivo...
April 20, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29684350/down-regulation-of-traf4-targeting-rsk4-inhibits-proliferation-invasion-and-metastasis-in-breast-cancer-xenografts
#5
Lingyu Zhu, Suisui Zhang, Xuejie Huan, Yan Mei, Huawei Yang
Ribosomal S6 protein kinase 4 (RSK4) was known as a novel tumor suppressor gene, and the tumor necrosis factor receptor-associated factor 4 (TRAF4) was linked to carcinogenesis. The purpose of this study is to further investigate the effect of the TRAF4 gene on cell proliferation, invasion and metastasis in vivo and explore whether there is an interaction between TRAF4 and RSK4 in breast cancer. MDA-MB-231 cells were transfected with lentivirus TRAF4-shRNA to specifically block the expression of TRAF4, or transfected with lentivirus negative-shRNA as a negative control...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29684314/efficacy-of-endosonographic-procedures-in-mediastinal-re-staging-of-lung-cancer-after-neoadjuvant-therapy-a-systematic-review-and-diagnostic-accuracy-meta-analysis
#6
Valliappan Muthu, Inderpaul Singh Sehgal, Sahajal Dhooria, Ashutosh N Aggarwal, Ritesh Agarwal
BACKGROUND AND AIM: The optimal modality for re-staging the mediastinum following neoadjuvant therapy for lung cancer remains unclear. Surgical methods are currently considered the reference standard. Herein, we evaluate the role of endosonographic techniques for mediastinal re-staging in lung cancer. METHODS: Systematic review of PubMed and EmBase databases was performed to identify studies utilizing endoscopic ultrasound (EUS), endobronchial ultrasound (EBUS) or a combination (CUS) for mediastinal re-staging following induction therapy for stage III lung cancer...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29684288/endobronchial-ultrasound-for-nodal-staging-of-non-small-cell-lung-cancer-patients-with-radiologically-normal-mediastinum-a-meta-analysis
#7
Hazem El-Osta, Pushan Jani, Ali Mansour, Philip Rascoe, Syed Jafri
RATIONALE: An accurate assessment of the mediastinal lymph nodes status is essential in the staging and treatment planning of potentially resectable non-small cell lung cancer (NSCLC). OBJECTIVES: We performed this meta-analysis to evaluate the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in detecting occult mediastinal disease in NSCLC with no radiologic mediastinal involvement. METHODS: The PubMed, Embase, and Cochrane libraries were searched for studies describing the role of EBUS-TBNA in lung cancer patients with radiologically negative mediastinum...
April 23, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29684234/systemic-treatment-options-for-brain-metastases-from-non-small-cell-lung-cancer
#8
REVIEW
Ajaz Bulbul, Patrick M Forde, Ayesha Murtuza, Brian Woodward, Hannah Yang, Ingmar Bastian, Parissa K Ferguson, Fernando Lopez-Diaz, David S Ettinger, Hatim Husain
Brain metastases are common in patients with non-small-cell lung cancer (NSCLC). Because of associated poor prognosis and limited specific treatment options, there is a real need for the development of medical therapies and strategies for affected patients. Novel compounds for epidermal growth factor receptor-dependent and anaplastic lymphoma kinase-dependent lung cancer have demonstrated blood-brain barrier permeability and have led to important improvements in central nervous system outcomes. Studies of targeted therapies for oncogene-driven tumors and of immunotherapies in patients with brain metastases have shown promise and, allied with novel radiation techniques, are driving a rapid evolution in treatment and prognosis for NSCLC brain metastases...
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684106/urine-antigen-detection-as-an-aid-to-diagnose-invasive-aspergillosis
#9
Kieren A Marr, Kausik Datta, Seema Mehta, Darin B Ostrander, Michelle Rock, Jesse Francis, Marta Feldmesser
Background: Establishing rapid diagnoses of invasive aspergillosis (IA) is priority, given poor outcomes of late therapy. Non-culture based tests that detect galactomannan and β-D glucan are available, but are technically cumbersome and rely on invasive sampling (blood or bronchoalveolar lavage). Methods: We optimized a lateral flow dipstick assay using the galactofuranose -specific monoclonal antibody (mAb476), which was previously shown to recognize urine antigens after Aspergillus fumigatus pulmonary infection in an`imals...
April 19, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29684049/clinical-factors-associated-with-early-progression-and-grade-3-4-toxicity-in-patients-with-advanced-non-small-cell-lung-cancers-treated-with-nivolumab
#10
Coraline Dumenil, Marie-Ange Massiani, Jennifer Dumoulin, Violaine Giraud, Sylvie Labrune, Thierry Chinet, Etienne Giroux Leprieur
INTRODUCTION: The prognosis of advanced non-small-cell lung cancer (NSCLC) has been improved by development of immune checkpoint inhibitors (ICIs) such as nivolumab for second-line treatment. As phase III trials include only selected patients, we here investigated the clinical factors associated with efficacy and safety of nivolumab in 'real life' patients with advanced NSCLC. METHODS: Clinical and histological characteristics, therapies and survival data of all consecutive patients with advanced NSCLC included prospectively and treated by nivolumab in two French academic hospitals between February 2015 and December 2016 were examined...
2018: PloS One
https://www.readbyqxmd.com/read/29683890/characteristics-and-predictive-value-of-pd-l1-status-in-real-world-non-small-cell-lung-cancer-patients
#11
Jeng-Sen Tseng, Tsung-Ying Yang, Chih-Ying Wu, Wen-Hui Ku, Kun-Chieh Chen, Kuo-Hsuan Hsu, Yen-Hsiang Huang, Kang-Yi Su, Sung-Liang Yu, Gee-Chen Chang
Immunotherapy targeting the programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) pathway has emerged as an effective treatment for lung cancer patients. It is important to evaluate the practicality of PD-L1 testing in real-world practice. A total of 211 non-small cell lung cancer patients were enrolled to detect 5 driver mutations and PD-L1 status (22C3 and SP263 assays) and to evaluate the characteristics of PD-L1 expression and its predictive value of immunotherapy. The PD-L1 positive (≥1%) and strong positive (≥50%) rate by SP263 assay was 27...
April 20, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29683843/benefits-and-harms-of-lung-cancer-screening-in-hiv-infected-individuals-with-cd4-%C3%A2-500-a-simulation-study
#12
Chung Yin Kong, Keith Sigel, Steven D Criss, Deirdre F Sheehan, Matthew Triplette, Michael J Silverberg, Claudia I Henschke, Amy Justice, R Scott Braithwaite, Juan Wisnivesky, Kristina Crothers
OBJECTIVE: Lung cancer is the leading cause of non-AIDS-defining cancer deaths among HIV-infected individuals. Although lung cancer screening with low-dose computed tomography (LDCT) is endorsed by multiple national organizations, whether HIV-infected individuals would have similar benefit as uninfected individuals from lung cancer screening is unknown. Our objective was to determine the benefits and harms of lung cancer screening among HIV-infected individuals. DESIGN: We modified an existing simulation model, the Lung Cancer Policy Model, for HIV-infected patients...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683761/circulating-micrornas-associated-with-prolonged-overall-survival-in-lung-cancer-patients-treated-with-nivolumab
#13
Ann Rita Halvorsen, Vandana Sandhu, Mette Sprauten, Vidar G Flote, Elin H Kure, Odd Terje Brustugun, Åslaug Helland
BACKGROUND: The introduction of immune check-point inhibition in non-small cell lung cancer (NSCLC) therapy represents improved prospects for the patients. The response rates to check-point inhibitors are approximately 20% in unselected NSCLC patients. Increasing levels of tumor PD-L1 expression are associated with higher response rates. However, patients with low PD-L1 levels may also have durable responses, and improved strategies for patient stratification are needed. MATERIAL AND METHODS: In this study, we investigated circulating microRNAs aiming to identify circulating predictive biomarkers associated with increased overall survival after immune check-point treatment...
April 23, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29683727/bone-turnover-markers-and-novel-biomarkers-in-lung-cancer-bone-metastases
#14
Jiangli Lang, Qian Zhao, Yuedong He, Xijie Yu
CONTEXT: Lung cancer still remains the leading cause of cancer-related mortality worldwide. Bone is one of preferred metastatic sites for lung cancer cells. So far, both accurate diagnosis and effective treatment of lung cancer bone metastases are difficult. OBJECTIVE: This review aimed to evaluate roles of bone turnover markers (BTMs), microRNAs (miRNAs), dickkopf1 (DKK1) and insulin like growth factor binding protein 3 (IGFBP-3) in lung cancer bone metastases...
April 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29683344/a-new-sterol-from-the-vietnamese-marine-sponge-xestospongia-testudinaria-and-its-biological-activities
#15
Hien Minh Nguyen, Takuya Ito, Nwet Nwet Win, Hung Quoc Vo, Hoai Thi Nguyen, Hiroyuki Morita
A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC50 values ranging from 29...
April 23, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29683112/a-panel-of-serum-noncoding-rnas-for-the-diagnosis-and-monitoring-of-response-to-therapy-in-patients-with-breast-cancer
#16
Sheng-Kai Huang, Qing Luo, Hua Peng, Jia Li, Mei Zhao, Jia Wang, Yu-Yu Gu, Yan Li, Peng Yuan, Guo-Hua Zhao, Chang-Zhi Huang
BACKGROUND The aim of this study was to identify a panel of serum noncoding RNAs (ncRNAs) as potential diagnostic and prognostic biomarkers for breast cancer. MATERIAL AND METHODS Patients with breast cancer (n=30), and normal controls (n=30) were included in the 'training set.' A 'validation set' included cases of breast cancer (n=128) and controls (n=77). All cases provided blood samples for serum analysis. All cases of breast cancer were confirmed histologically and were staged. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the expression of 11 candidate ncRNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), in the serum...
April 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29683065/anaplastic-lymphoma-kinase-immunohistochemistry-scores-do-not-predict-sensitivity-to-crizotinib-in-fluorescence-in-situ-hybridization-positive-non-small-cell-lung-cancer-patients
#17
Giulio Metro, Diana Giannarelli, Angelo Sidoni, Rita Chiari, Guido Bellezza
No abstract text is available yet for this article.
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29682899/generalization-and-representativeness-of-phase-iii-immune-checkpoint-blockade-trials-in-non-small-cell-lung-cancer
#18
Shin Hye Yoo, Bhumsuk Keam, Miso Kim, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo
BACKGROUND: Strict eligibility criteria for patient enrollment in phase III trials raise questions regarding generalization to ineligible patients. We evaluated whether pivotal phase III trials of immune checkpoint blockades (ICBs) represent the overall population of non-small cell lung cancer (NSCLC) patients. METHODS: We reviewed the inclusion and exclusion criteria of three phase III trials (CheckMate057, CheckMate017, and KEYNOTE-010). Stage IIIB or IV NSCLC patients diagnosed from 2011 to 2013 at Seoul National University Hospital (cohort 1) were reviewed...
April 22, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29682554/differential-expression-patterns-of-eph-receptors-and-ephrin-ligands-in-human-cancers
#19
REVIEW
Chung-Ting Jimmy Kou, Raj P Kandpal
Eph receptors constitute the largest family of receptor tyrosine kinases, which are activated by ephrin ligands that either are anchored to the membrane or contain a transmembrane domain. These molecules play important roles in the development of multicellular organisms, and the physiological functions of these receptor-ligand pairs have been extensively documented in axon guidance, neuronal development, vascular patterning, and inflammation during tissue injury. The recognition that aberrant regulation and expression of these molecules lead to alterations in proliferative, migratory, and invasive potential of a variety of human cancers has made them potential targets for cancer therapeutics...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682534/the-progress-of-t-cell-immunity-related-to-prognosis-in-gastric-cancer
#20
REVIEW
Ming Wei, Duo Shen, Sachin Mulmi Shrestha, Juan Liu, Junyi Zhang, Ying Yin
Gastric cancer is the fifth most common malignancy all over the world, and the factors that can affect progress and prognosis of the gastric cancer patients are various, such as TNM stages, invasive depth, and lymph node metastasis ratio. T cell immunity is important component of human immunity system and immunity responding to tumor and dysfunction or imbalance of T cell immunity will lead to serious outcomes for body. T cell immunity includes many different types of cells, CD4+ T cell, CD8+ T cell, memory cell, and so on, and each of them has special function on antitumor response or tumor immune escape which is revealed in lung cancer, colorectal cancer, breast cancer, ovarian cancer, and so on...
2018: BioMed Research International
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