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Type 1 diabetes pediatric

Ivana Rabbone, Nicola Minuto, Sonia Toni, Fortunato Lombardo, Dario Iafusco, Marco Marigliano, Riccardo Schiaffini, G Maltoni, Anna Paola Frongia, Marco Scardapane, Antonio Nicolucci, Valentino Cherubini, Riccardo Bonfanti, Andrea E Scaramuzza
AIMS: Incidence of insulin pump failures in a cohort of children and adolescents with type 1 diabetes was evaluated prospectively during a 1-yr follow-up. MATERIALS AND METHODS: Insulin pump breakdown and infusion set failures were prospectively registered in a cohort of 1046 children and adolescents from 25 tertiary pediatric diabetes centers (50% males, mean age 12.2±4.1 yrs), with type 1 diabetes since 6.7±3.6 yrs, and using insulin pump since 3.3±2.2 yrs...
June 12, 2018: Diabetes, Obesity & Metabolism
Brandy A Wicklow, Elizabeth A C Sellers, Atul K Sharma, Kristine Kroeker, Nathan C Nickel, Wanda Philips-Beck, Garry X Shen
Importance: Type 2 diabetes is increasing worldwide, disproportionately affecting First Nations (FN) people. Identifying early-life determinants of type 2 diabetes is important to address the intergenerational burden of illness. Objective: To investigate the association of in utero exposure to gestational diabetes and type 2 diabetes, stratified by FN status, with the development of type 2 diabetes in offspring. Design, Setting, and Participants: This cohort study was derived from the linkage of a pediatric diabetes clinical database and a population-based research data repository in Manitoba, Canada...
June 11, 2018: JAMA Pediatrics
Katharine Garvey, Lori Laffel
Adolescence and young adulthood are times of multiple developmental changes, including physiological, social, emotional, cognitive, and behavioral transformations. The adolescent or young adult living with type 1 or type 2 diabetes must navigate the vicissitudes of these developmental stages while managing the rigors and self-care demands of these conditions. Diabetes in children is managed by adults, mainly by parents. As the child matures, diabetes management tasks transition from parents to the developing teen...
2018: Endocrine Development
Debora N Setoue, Ana C Pitta, Fernanda J Fiorot, Mariana M Nastri, Glaucia V Novak, Beatriz C Molinari, Juliana C Oliveira, Natali W Gormezano, Ana P Sakamoto, Maria T Terreri, Rosa M Pereira, Claudia Saad-Magalhães, Adriana M Sallum, Katia Kozu, Melissa M Fraga, Daniela P Piotto, Gleice Clemente, Roberto Marini, Hugo R Gomes, Carlos N Rabelo-Junior, Marta M Felix, Maria C Ribeiro, Rozana G Almeida, Ana P Assad, Silvana B Sacchetti, Leandra C Barros, Eloisa Bonfá, Clovis A Silva
OBJECTIVE: To evaluate symptomatic polyautoimmunity (PA) at childhood-onset systemic lupus erythematosus(cSLE) diagnosis, and its association with demographic data, disease activity, clinical manifestations and laboratorial abnormalities in a large Brazilian cSLE population. METHODS: A multicenter retrospective study was performed in 1463 cSLE(ACR criteria) patients from 27 Pediatric Rheumatology services. Symptomatic PA was defined according to the presence of more than one concomitant autoimmune disease(AD) and symptomatic multiple autoimmune syndrome(MAS) was defined as three or more AD...
June 7, 2018: Autoimmunity Reviews
Annalise N vonderEmbse, Jamie C DeWitt
Immune-based childhood diseases and conditions, including allergic diseases and asthma, recurrent otitis media, pediatric celiac disease, and type 1 diabetes have been on the rise over the past decades. As a result, the use of developmental immunotoxicity (DIT) testing to identify potential environmental risk factors contributing to these and other diseases has become a priority for scientists across sectors. This chapter serves to provide insight into the scientific basis for DIT and determining the necessity of DIT testing and offers recommendations for DIT testing parameters to optimize sensitivity, power, and concordance among DIT assays...
2018: Methods in Molecular Biology
Maaret Turtinen, Taina Härkönen, Anna Parkkola, Jorma Ilonen, Mikael Knip
OBJECTIVE: This study tested the hypothesis that girls have a more aggressive disease process than boys at the diagnosis of type 1 diabetes (T1D). SUBJECTS AND METHODS: Demographic and clinical characteristics, the humoral autoantibody profile and the genetic risk assessed by the presence of HLA DR-DQ haplotypes were analyzed by sex in 4993 children and adolescents diagnosed with T1D between January 2003 and December 2016. RESULTS: A clear male preponderance (56...
June 3, 2018: Pediatric Diabetes
Magdalena Zurawek, Agnieszka Dzikiewicz-Krawczyk, Katarzyna Izykowska, Iwona Ziolkowska-Suchanek, Bogda Skowronska, Maria Czainska, Marta Podralska, Piotr Fichna, Grzegorz Przybylski, Marta Fichna, Jerzy Nowak
AIMS: Type 1 diabetes (T1D) is an autoimmune disorder caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. T1D is a consequence of complex processes, influenced by genetic, epigenetic and environmental factors. MicroRNAs (miRNAs) are small non-coding RNAs that target multiple mRNAs and regulate gene expression. The implication of miRNAs in T1D pathogenesis, as potential modulators of immune response genes, remains poorly defined. The aim of this study was to investigate the expression profile of miRNAs in new onset T1D and the impact of deregulated miRNAs on target genes...
May 30, 2018: Diabetes Research and Clinical Practice
Jacob C Hartz, Sarah de Ferranti, Samuel Gidding
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). It is estimated that the risk of CVD in diabetes mellitus (DM) is 2 to 10 times higher than in the general population. Much of this increased risk is thought to be related to the development of an atherogenic lipid profile, in which hypertriglyceridemia is an essential component. Recent studies suggest that dyslipidemia may be present in children and adolescents with DM, particularly in T2DM and in association with poor control in T1DM...
June 1, 2018: Journal of the Endocrine Society
Kristina M Derrick, Rubina A Heptulla
No abstract text is available yet for this article.
May 1, 2018: Journal of Diabetes Science and Technology
Balsam Noueiri, Nahla Nassif, Abbas Ollek
Introduction: Diabetes mellitus type I (DM1) has been increasing at an alarming rate worldwide. Children suffering from this chronic disease are subject to a high risk of systemic and oral complications, due to their young age and the lack of awareness of the relation between diabetes and oral health. Objective: The aim of this study is to evaluate the impact of oral and general complications of DM1 on the Lebanese children's quality of life. The goal was to assess the child's behavioral issues on the one hand and the oral issues on the other...
January 2018: International Journal of Clinical Pediatric Dentistry
Zahra Razavi, Saba Maher, Javad Fredmal
PURPOSE: To compare the safety/efficacy of intermittent subcutaneous rapid-acting insulin aspart with the standard low-dose intravenous infusion protocol of regular insulin for treatment of pediatric diabetic-ketoacidosis. METHODS: For a prospective randomized-controlled clinical trial on 50 children/adolescents with mild/moderate diabetic-ketoacidosis, the diagnostic criteria for ketoacidosis included: blood glucose level >250 mg/dl, ketonuria>++, venous pH <7...
May 24, 2018: Endocrine
Kentaro Shiga, Tatsuhiko Urakami, Junichi Suzuki, Yasuhiro Igarashi, Hanako Tajima, Shin Amemiya, Shigetaka Sugihara
Fulminant type 1 diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus characterized by a remarkably abrupt onset. In Japan, FT1DM accounts for approximately 20% of acute-onset adult type 1 diabetes mellitus cases; however, reports of pediatric-onset FT1DM are rare. We aimed to determine the frequency and clinical characteristics of FT1DM in Japanese children and adolescents by conducting a 2-phase questionnaire survey among the members of the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT) regarding their clinical experience with FT1DM...
May 22, 2018: Endocrine Journal
Shuodan Zhang, Emily Hamburger, Sachini Kahanda, Morgan Lyttle, Rodayne Williams, Sarah S Jaser
Adherence to diabetes management is a challenge for adolescents with type 1 diabetes (T1D). Positive psychology interventions have improved adherence to treatment recommendations in adults with chronic health conditions but have not been widely tested in pediatric populations. We hypothesized that higher engagement with a text-messaging intervention to promote positive affect would increase the effects on diabetes management among adolescents with T1D. Adolescents with T1D (n = 48) and their caregivers were randomized to either an attention control condition or a novel positive psychology intervention delivered through personalized automated text messaging...
May 2018: Diabetes Technology & Therapeutics
James W Varni, Alan M Delamater, Korey K Hood, Jennifer K Raymond, Kimberly A Driscoll, Jenise C Wong, Saleh Adi, Joyce P Yi-Frazier, Ellen K Grishman, Melissa A Faith, Sarah D Corathers, Jessica C Kichler, Jennifer L Miller, Elena M Doskey, Vincent P Aguirre, Robert W Heffer, Don P Wilson
OBJECTIVES: The objective was to investigate the patient-reported diabetes symptoms predictors of generic health-related quality of life (HRQOL) in adolescents and young adults (AYA) with type 1 or type 2 diabetes. METHODS: The 15-item PedsQL™ 3.2 Diabetes Module Diabetes Symptoms Summary Score and PedsQL™ 4.0 Generic Core Scales were completed in a 10-site national field test study by 513 AYA ages 13-25 years with type 1 (n = 424) or type 2 (n = 89) diabetes...
May 21, 2018: Quality of Life Research
Dexter M Thomas, Leah M Lipsky, Aiyi Liu, Tonja R Nansel
OBJECTIVE: Informed by the family stress and family investment models, this study investigated whether income is indirectly related to adherence and glycemic control through parenting constructs among youth with type 1 diabetes (TID). METHODS: Youth and their families (n = 390) from 4 geographically dispersed pediatric endocrinology clinics in the United States were participants in a multisite clinical trial from 2006 to 2009 examining the efficacy of a clinic-integrated behavioral intervention targeting family disease management for youth with TID...
May 17, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
Rade Vukovic, Maja D Jesic, Ivana Vorgucin, Sandra Stankovic, Nevena Folic, Tatjana Milenkovic, Silvija Sajic, Dragan Katanic, Sasa Zivic, Slavica Markovic, Ivan Soldatovic
Data regarding incidence of type 1 diabetes (T1DM), as well as data on frequency and severity of diabetic ketoacidosis (DKA) at the time of T1DM diagnosis is of paramount importance for national and regional healthcare planning. The aim of present multicenter study was to provide the first report regarding nationwide annual incidence rates for T1DM in youth in Serbia, as well as prevalence of DKA at the time of diagnosis. Data on all pediatric patients with newly diagnosed T1DM was retrospectively collected from all 15 regional centers for pediatric diabetes in Serbia during the period 2007-2017...
May 17, 2018: European Journal of Pediatrics
Marko Šimunović, Martina Paradžik, Roko Škrabić, Ivana Unić, Kajo Bućan, Veselin Škrabić
Cataract is a rare manifestation of ocular complication at an early phase of T1DM in the pediatric population. The pathophysiological mechanism of early diabetic cataract has not been fully understood; however, there are many theories about the possible etiology including osmotic damage, polyol pathway, and oxidative stress. The prevalence of early diabetic cataract in the population varies between 0.7 and 3.4% of children and adolescents with T1DM. The occurrence of diabetic cataract in most pediatric patients is the first sign of T1DM or occurs within 6 months of diagnosis of T1DM...
2018: International Journal of Endocrinology
Eftychia Pappa, Heleni Vastardis, George Mermelekas, Andriani Gerasimidi-Vazeou, Jerome Zoidakis, Konstantinos Vougas
The composition of the salivary proteome is affected by pathological conditions. We analyzed by high resolution mass spectrometry approaches saliva samples collected from children and adolescents with type 1 diabetes and healthy controls. The list of more than 2000 high confidence protein identifications constitutes a comprehensive characterization of the salivary proteome. Patients with good glycemic regulation and healthy individuals have comparable proteomic profiles. In contrast, a significant number of differentially expressed proteins were identified in the saliva of patients with poor glycemic regulation compared to patients with good glycemic control and healthy children...
2018: Frontiers in Physiology
Cíntia Castro-Correia, Rita Santos-Silva, Marta Pinheiro, Carla Costa, Manuel Fontoura
BACKGROUND: The incidence of pediatric metabolic syndrome (MS) has progressively increased. The incidence of type 1 diabetes mellitus (T1DM) has also increased. Thus, some children and adolescents with T1DM exhibit MS parameters. The aim of the study was to evaluate the presence of MS parameters in female adolescents with T1DM based on their nutritional status. METHODS: We evaluated 44 adolescents with T1DM (consecutive non-randomized sample) aged between 14 and 18 years, who were on intensive therapy with insulin...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Rania N Sabry, Maged A El Wakeel, Ghada M El-Kassas, Ahmed F Amer, Wael H El Batal, Salwa Refat El-Zayat, Mohamed Abou-El-Asrar
INTRODUCTION: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be complicated by micro or macrovascular complications. Measurement of the carotid intima-media thickness (CIMT) allows the early detection of atherosclerotic alterations of blood vessels that may complicate T1DM. SUBJECTS AND METHODS: This study is a case-control study. Participants were classified into two groups. The first group included 40 children with T1DM and the second group included 30 matched healthy controls...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
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