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https://www.readbyqxmd.com/read/27926876/potentiation-of-synaptic-glun2b-nmdar-currents-by-fyn-kinase-is-gated-through-bdnf-mediated-disinhibition-in-spinal-pain-processing
#1
Michael E Hildebrand, Jian Xu, Annemarie Dedek, Yi Li, Ameet S Sengar, Simon Beggs, Paul J Lombroso, Michael W Salter
In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the output of lamina I spinal neurons by decreasing synaptic inhibition. Pain hypersensitivity also depends on N-methyl-D-aspartate receptors (NMDARs) and Src-family kinases, but the locus of NMDAR dysregulation remains unknown. Here, we show that NMDAR-mediated currents at lamina I synapses are potentiated in a peripheral nerve injury model of neuropathic pain. We find that BDNF mediates NMDAR potentiation through activation of TrkB and phosphorylation of the GluN2B subunit by the Src-family kinase Fyn...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27922332/effect-of-moderate-and-high-intensity-chronic-exercise-on-the-pancreatic-islet-morphometry-in-healthy-rats-bdnf-receptor-participation
#2
Alberto Jiménez-Maldonado, Adolfo Virgen-Ortiz, Valery Melnikov, Alejandrina Rodríguez-Hernández, Armando Gamboa-Domínguez, Sergio Montero, Jesús Muñiz-Murguía, Mónica Lemus, Elena Roces de Álvarez-Buylla
A B S T R A C T The function and morphology of β-cells is largely dependent on insulin demand. As β-cells cover a bigger cell proportion in pancreas islets, changes of insulin producer cells affect the whole pancreatic islet morphology. Growth factors as the neurotrophins regulate the pancreas physiology, besides; physical exercise increases insulin sensitivity, and further modifies brain derived neurotrophic factor (BDNF) concentration in plasma. The aim of this study was to investigate the effects of chronic exercise (running in a treadmill for eight weeks) intensity on pancreatic islet morphometry in healthy state...
December 6, 2016: Islets
https://www.readbyqxmd.com/read/27915043/involvement-of-bdnf-trkb-signaling-in-the-effect-of-diphenyl-diselenide-on-motor-function-in-a-parkinson-s-disease-rat-model
#3
Tuane Bazanella Sampaio, Simone Pinton, Juliana Trevisan da Rocha, Bibiana Mozzaquatro Gai, Cristina Wayne Nogueira
Parkinson's disease is a progressive neurodegenerative disorder characterized by degeneration of nigrostriatal dopaminergic neurons. Diphenyl diselenide [(PhSe)2] is a compound with pharmacological proprieties, such as antidepressant and neuroprotective. Therefore, this study investigated whether (PhSe)2 reverses motor impairment and neurochemical alterations in a model of Parkinson's disease induced by 6-hydroxydopamine (6-OHDA) in rats. For this, male Wistar rats received 20μg/3μl of 6-OHDA or vehicle into the right striatum...
November 30, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27908981/neurotrophin-signalling-novel-insights-into-mechanisms-and-pathophysiology
#4
REVIEW
Mariela Mitre, Abigail Mariga, Moses V Chao
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators of neuronal survival, growth and differentiation during development. While trophic factors are viewed as well-understood but not innovative molecules, there are many lines of evidence indicating that BDNF plays an important role in the pathophysiology of many neurodegenerative disorders, depression, anxiety and other psychiatric disorders. In particular, lower levels of BDNF are associated with the aetiology of Alzheimer's and Huntington's diseases...
January 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27904490/antidepressant-effect-of-electroacupuncture-regulates-signal-targeting-in-the-brain-and-increases-brain-derived-neurotrophic-factor-levels
#5
Dong-Mei Duan, Ya Tu, Ping Liu, Shuang Jiao
Electroacupuncture improves depressive behavior faster and with fewer adverse effects than antidepressant medication. However, the antidepressant mechanism of electroacupuncture remains poorly understood. Here, we established a rat model of chronic unpredicted mild stress, and then treated these rats with electroacupuncture at Yintang (EX-HN3) and Baihui (DU20) with sparse waves at 2 Hz and 0.6 mA for 30 minutes, once a day. We found increased horizontal and vertical activity, and decreased immobility time, at 2 and 4 weeks after treatment...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27894797/roles-of-the-serotonin-5-ht4-receptor-in-dendrite-formation-of-the-rat-hippocampal-neurons-in-vitro
#6
Naoki Kozono, Akiko Ohtani, Takashi Shiga
Serotonin (5-HT) is involved in various aspects of hippocampal development, although the specific roles of 5-HT receptors are poorly understood. We investigated the roles of 5-HT receptors in the dendrite formation of hippocampal neurons. We focused on the 5-HT4 receptor, which is coupled with Gs protein, and compared the effects with those of the Gi-coupled 5-HT1A receptor. Neurons from rat hippocampi at embryonic day 18 were dissociated and treated for 4 days with the 5-HT4 receptor agonist BIMU8 or the 5-HT1A receptor agonist 8-OH DPAT...
November 25, 2016: Brain Research
https://www.readbyqxmd.com/read/27882154/kai-xin-san-a-traditional-chinese-medicine-formulation-exerts-antidepressive-and-neuroprotective-effects-by-promoting-pcreb-upstream-pathways
#7
Xian-Zhe Dong, Dong-Xiao Wang, Bing-Ying Yu, Ping Liu, Yuan Hu
Kai-Xin-San (KXS) is a traditional Chinese medicine that has been widely used for the treatment of emotion-related disease. However, the underlying mechanism remains largely unknown. The present study aimed to examine whether phospho-cAMP response element-binding protein (pCREB) and upstream components, such as extracellular signal-regulated kinase (ERK), phospho-ERK (pERK), phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt), glycogen synthase kinase 3β (GSK3β) and pGSK3β are associated with the antidepressive effect of KXS...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27876812/corrigendum-flux-of-signalling-endosomes-undergoing-axonal-retrograde-transport-is-encoded-by-presynaptic-activity-and-trkb
#8
Tong Wang, Sally Martin, Tam H Nguyen, Callista B Harper, Rachel S Gormal, Ramon Martínez-Mármol, Shanker Karunanithi, Elizabeth J Coulson, Nick R Glass, Justin J Cooper-White, Bruno van Swinderen, Frédéric A Meunier
No abstract text is available yet for this article.
November 23, 2016: Nature Communications
https://www.readbyqxmd.com/read/27875242/involvement-of-bdnf-trkb-and-erk-creb-axes-in-nitroglycerin-induced-rat-migraine-and-effects-of-estrogen-on-these-signals-in-the-migraine
#9
Jiu-Qing Guo, Hui-Hui Deng, Xiao Bo, Xiao-Su Yang
Migraine is a highly prevalent headache disorder especially in women. Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin receptor kinases (TrkB), as well as extracellular signal-regulated kinase (ERK) and its downstream target c-AMP-responsive element binding protein (CREB) are strongly associated with the transmission of nociceptive information. However, the involvement of these substances in migraine has rarely been examined. In the present study, intraperitoneal injection of nitroglycerin (NTC) successfully induced rat migraine attack, as evidenced by the behavioral testing...
November 14, 2016: Biology Open
https://www.readbyqxmd.com/read/27864043/maternal-trans-fat-intake-during-pregnancy-or-lactation-impairs-memory-and-alters-bdnf-and-trkb-levels-in-the-hippocampus-of-adult-offspring-exposed-to-chronic-mild-stress
#10
Camila Simonetti Pase, Karine Roversi, Katiane Roversi, Luciana Taschetto Vey, Verônica Tironi Dias, Juliana Cristiana Veit, Luana Haselein Maurer, Thiago Duarte, Tatiana Emanuelli, Marta Duarte, Marilise Escobar Bürger
This study aimed to assess the influence of maternal dietary fat intake during pregnancy or lactation on memory of adult offspring after chronic mild stress (CMS) exposure. Female Wistar rats were supplemented daily with soybean oil/fish oil (SO/FO) or hydrogenated vegetable fat (HVF) by oral gavage (3.0g/kg body weight) during pregnancy or lactation. On post-natal day (PND) 60, half of the animals were exposed to CMS following behavioral assessments. While the adult offspring born under influence of SO/FO and HVF supplementations during pregnancy showed higher levels of n-3 and n-6 fatty acids (FA) series DHA and ARA metabolites, respectively, in the hippocampus, adult offspring born from supplemented dams during lactation showed higher levels of their precursors: ALA and LA...
November 15, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27855137/garcinol-upregulates-gabaa-and-gad65-expression-modulates-bdnf-trkb-pathway-to-reduce-seizures-in-pentylenetetrazole-ptz-induced-epilepsy
#11
Fang Hao, Li-Hua Jia, Xiao-Wan Li, Ying-Rui Zhang, Xue-Wu Liu
BACKGROUND Epilepsy is the most predominant neurological disorder characterized by recurrent seizures. Despite treatment with antiepileptic drugs, epilepsy still is a challenge to treat, due to the associated adverse effects of the drugs. Previous investigations have shown critical roles of BDNF-TrkB signalling and expression of glutamic acid decarboxylase 65 (GAD65) and GABAA in the brain during epilepsy. Thus, drugs that could modulate BDNF-TrkB signal and expression of GAD65 and GABAA could aid in therapy...
November 17, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27844095/antidepressant-effects-of-combination-of-brexpiprazole-and-fluoxetine-on-depression-like-behavior-and-dendritic-changes-in-mice-after-inflammation
#12
Min Ma, Qian Ren, Chun Yang, Ji-Chun Zhang, Wei Yao, Chao Dong, Yuta Ohgi, Takashi Futamura, Kenji Hashimoto
RATIONALE: Addition of low doses of atypical antipsychotic drugs with selective serotonin reuptake inhibitors (SSRIs) could promote a rapid antidepressant effect in treatment-resistant patients with major depression. Brexpiprazole, a new atypical antipsychotic drug, has been used as adjunctive therapy for the treatment of major depression. OBJECTIVES: The present study was undertaken to examine whether brexpiprazole could augment antidepressant effects of the SSRI fluoxetine in an inflammation model of depression...
November 15, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27843590/ntrk-gene-fusions-as-novel-targets-of-cancer-therapy-across-multiple-tumour-types
#13
REVIEW
Alessio Amatu, Andrea Sartore-Bianchi, Salvatore Siena
The tropomyosin receptor kinase (Trk) receptor family comprises 3 transmembrane proteins referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the NTRK1, NTRK2 and NTRK3 genes, respectively. These receptor tyrosine kinases are expressed in human neuronal tissue and play an essential role in the physiology of development and function of the nervous system through activation by neurotrophins. Gene fusions involving NTRK genes lead to transcription of chimeric Trk proteins with constitutively activated or overexpressed kinase function conferring oncogenic potential...
2016: ESMO Open
https://www.readbyqxmd.com/read/27843294/mimetics-of-brain-derived-neurotrophic-factor-loops-1-and-4-are-active-in-a-model-of-ischemic-stroke-in-rats
#14
Tatyana A Gudasheva, Polina Povarnina, Ilya O Logvinov, Tatyana A Antipova, Sergey B Seredenin
BACKGROUND: Two dimeric dipeptides, bis-(N-monosuccinyl-l-seryl-l-lysine)hexamethylenediamide (GSB-106) and bis-(N-monosuccinyl-l-methionyl-l-serine) heptamethylenediamide (GSB-214), were designed based on the brain-derived neurotrophic factor (BDNF) loop 4 and loop 1 β-turn sequences, respectively. Earlier, both of these dipeptides were shown to exhibit neuroprotective activity in vitro (10(-5)-10(-8) M). The present study aimed to investigate the mechanisms of action of these peptides and their neuroprotective activity in an experimental stroke model...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27830679/-effects-of-ischemia-on-the-expression-of-neurotrophins-and-their-receptors-in-rat-brain-structures-outside-the-lesion-site-including-on-the-opposite-hemisphere
#15
V G Dmitrieva, V V Stavchansky, O V Povarova, V I Skvortsova, S A Limborska, L V Dergunova
Neurotrophins stimulate the regeneration of neural tissue after lesions. It is also known that the sources of neurogenesis and cerebral function recovery are predominantly located in subcortical brain structures. The effects of ischemia on the expression of genes that encode neurotrophins (Bdnf, Ngf, Nt-3) and their receptors (TrkB, TrkA, TrkC, p75) in brain structures outside the lesion site were studied 3, 24, and 72 h after irreversible unilateral occlusion of the middle cerebral artery in rats. Changes in the mRNA expression of these genes were assessed by relative quantification using real-time RT-PCR...
September 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27826105/klf7-transfected-schwann-cell-graft-transplantation-promotes-sciatic-nerve-regeneration
#16
Ying Wang, Wen-Yuan Li, Hua Jia, Feng-Guo Zhai, Wen-Rui Qu, Yong-Xia Cheng, Yan-Cui Liu, Ling-Xiao Deng, Su-Fen Guo, Zai-Shun Jin
Our former study demonstrated that Krüppel-like Factor 7 (KLF7) is a transcription factor that stimulates axonal regeneration after peripheral nerve injury. Currently, we used a gene therapy approach to overexpress KLF7 in Schwann cells (SCs) and assessed whether KLF7-transfected SCs graft could promote sciatic nerve regeneration. SCs were transfected by adeno-associated virus 2 (AAV2)-KLF7 in vitro. Mice were allografted by an acellular nerve (ANA) with either an injection of DMEM (ANA group), SCs (ANA+SCs group) or AAV2-KLF7-transfected SCs (ANA+KLF7-SCs group) to assess repair of a sciatic nerve gap...
November 5, 2016: Neuroscience
https://www.readbyqxmd.com/read/27824119/intake-of-7-8-dihydroxyflavone-during-juvenile-and-adolescent-stages-prevents-onset-of-psychosis-in-adult-offspring-after-maternal-immune-activation
#17
Mei Han, Ji-Chun Zhang, Wei Yao, Chun Yang, Tamaki Ishima, Qian Ren, Min Ma, Chao Dong, Xu-Feng Huang, Kenji Hashimoto
Prenatal infection and subsequent abnormal neurodevelopment of offspring is involved in the etiology of schizophrenia. Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the neurodevelopment. Pregnant mice exposed to polyriboinosinic-polyribocytidylic acid [poly(I:C)] causes schizophrenia-like behavioral abnormalities in their offspring at adulthood. Here we found that the juvenile offspring of poly(I:C)-treated mice showed cognitive deficits, as well as reduced BDNF-TrkB signaling in the prefrontal cortex (PFC)...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822668/chronic-intermittent-hypobaric-hypoxia-pretreatment-ameliorates-ischemia-induced-cognitive-dysfunction-through-activation-of-erk1-2-creb-bdnf-pathway-in-anesthetized-mice
#18
Jintian Wang, Shixiao Zhang, Huijuan Ma, Shijie Yang, Zhao Liu, Xiaolei Wu, Sheng Wang, Yi Zhang, Yixian Liu
Chronic intermittent hypobaric hypoxia (CIHH) has protective effects on heart and brain against ischemia injury through mobilizing endogenous adaptive mechanisms. However, whether CIHH prevents against cognitive impairment was not elucidated. The present study aimed to investigate the effect and mechanism of CIHH treatment on ischemia/reperfusion (IR)-induced cognitive dysfunction. Mice were randomly divided into 8 groups: Control, Sham, CIHH (simulating 5000 m high-altitude for 28 days, 6 h per day), IR (three 16-min occlusions of bilateral common carotid arteries interrupted by two 10-min intervals), CIHH + IR, PD98059 (inhibitor of MEK1/2) + CIHH + IR, PD98059 + Sham and PD98059 + IR group...
November 8, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27822288/xiao-yao-san-against-corticosterone-induced-stress-injury-via-upregulating-glucocorticoid-receptor-reaction-element-transcriptional-activity
#19
Guoping Cao, Shenglan Gong, Fengxue Zhang, Wenjun Fu
Previous studies have revealed that uncontrollable stress can impair the synaptic plasticity and firing property of hippocampal neurons, which influenced various hippocampal-dependent tasks including memory, cognition, behavior, and mood. In this work, we had investigated the effects and mechanisms of the Chinese herbal medicine Xiao Yao San (XYS) against corticosterone-induced stress injury in primary hippocampal neurons (PHN) cells. We found that XYS and RU38486 could increase cell viabilities and decrease cell apoptosis by MTT, immunofluorescence, and flow cytometry assays...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27821848/depression-like-phenotype-by-deletion-of-%C3%AE-7-nicotinic-acetylcholine-receptor-role-of-bdnf-trkb-in-nucleus-accumbens
#20
Ji-Chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma, Jin Wu, Kenji Hashimoto
The α7 subtype of nicotinic acetylcholine receptor (nAChR) plays a role in the inflammation which is implicated in depression. This study was undertaken to examine the role of α7 nAChR in depression using α7 nAChR knock-out (KO) mice. Serum levels of tumor necrosis factor-α and interlukin-1β in KO mice were higher than wild-type mice, suggesting an inflammatory process in KO mice. α7 nAChR KO mice showed depression-like phenotype. Furthermore, KO mice showed increased brain-derived neurotrophic factor (BDNF) and its receptor TrkB signaling, as well as increased synaptogenesis and spine density in the nucleus accumbens (NAc), although BDNF-TrkB signaling and synaptogenesis were not altered in the prefrontal cortex and hippocampus...
November 8, 2016: Scientific Reports
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