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https://www.readbyqxmd.com/read/28227485/augmented-reality-for-breast-tumors-visualization
#1
Mohammad Ali Ghaderi, Mehrdad Heydarzadeh, Mehrdad Nourani, Gopal Gupta, Lakshman Tamil, Mohammad Ali Ghaderi, Mehrdad Heydarzadeh, Mehrdad Nourani, Gopal Gupta, Lakshman Tamil, Gopal Gupta, Mehrdad Heydarzadeh, Lakshman Tamil, Mehrdad Nourani
3D visualization of breast tumors are shown to be effective by previous studies. In this paper, we introduce a new augmented reality application that can help doctors and surgeons to have a more accurate visualization of breast tumors; this system uses a marker-based image-processing technique to render a 3D model of the tumors on the body. The model can be created using a combination of breast 3D mammography by experts. We have tested the system using an Android smartphone and a head-mounted device. This proof of concept can be useful for oncologists to have a more effective screening, and surgeons to plan the surgery...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227361/kinect2-respiratory-movement-detection-study
#2
Sandy Rihana, Elie Younes, Dimitris Visvikis, Hadi Fayad, Sandy Rihana, Elie Younes, Dimitris Visvikis, Hadi Fayad, Sandy Rihana, Elie Younes, Dimitris Visvikis, Hadi Fayad
Radiotherapy is one of the main cancer treatments. It consists in irradiating tumor cells to destroy them while sparing healthy tissue. The treatment is planned based on Computed Tomography (CT) and is delivered over fractions during several days. One of the main challenges is replacing patient in the same position every day to irradiate the tumor volume while sparing healthy tissues. Many patient positioning techniques are available. They are both invasive and not accurate performed using tattooed marker on the patient's skin aligned with a laser system calibrated in the treatment room or irradiating using X-ray...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227042/advanced-inside-out-tracking-approach-for-real-time-combination-of-mri-and-us-images-in-the-radio-frequency-shielded-room-using-combination-markers
#3
Yeshaswini Nagaraj, Christian Benedicks, Philipp Matthies, Michael Friebe, Yeshaswini Nagaraj, Christian Benedicks, Philipp Matthies, Michael Friebe
For the real-time fusion of different modalities, a variety of tracking methods are available including the optical, electromagnetic (EM) and image-based tracking. But as a drawback optical tracking suffers from line of sight issues and EM tracking requires the manual referencing for the fusion procedure and is not usable in Magnetic Resonance Imaging (MRI) environment. To avoid these issues, we propose a real-time setup containing a camera capable of inside-Out tracking using combined circular markers attached to Ultrasound (US) probe and a suitable platform for automatic overlay of MRI and US image using markers...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227003/automated-segmentation-and-classification-of-cell-nuclei-in-immunohistochemical-breast-cancer-images-with-estrogen-receptor-marker
#4
Julio Oscanoa, Franco Doimi, Richard Dyer, Jhahaira Araujo, Joseph Pinto, Benjamin Castaneda, Julio Oscanoa, Franco Doimi, Richard Dyer, Jhahaira Araujo, Joseph Pinto, Benjamin Castaneda, Jhahaira Araujo, Franco Doimi, Julio Oscanoa, Richard Dyer, Benjamin Castaneda, Joseph Pinto
Breast cancer is the most common malignant tumor in women worldwide. In recent years, there has been an increasing use of immunohistochemistry (the process of detecting the expression of certain proteins in cytological images) to obtain useful information for diagnosis. This paper presents an efficient algorithm that automatically detects breast cancer cell nuclei and divides them into two groups: those that express the ER marker and those that do not. First, the areas that belong to the carcinoma are automatically identified...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226773/biclustering-strategies-for-genetic-marker-selection-in-gynecologic-tumor-cell-lines
#5
A Alevyzaki, S Sfakianakis, E S Bei, E Obermayr, R Zeillinger, D Fotiadis, M Zervakis, A Alevyzaki, S Sfakianakis, E S Bei, E Obermayr, R Zeillinger, D Fotiadis, M Zervakis, R Zeillinger, D Fotiadis, E S Bei, S Sfakianakis, M Zervakis, A Alevyzaki, E Obermayr
Over the past few decades great interest has been focused on cell lines derived from tumors, because of their usability as models to understand the biology of cancer. At the same time, advanced technologies such as DNA-microarrays have been broadly used to study the expression level of thousands of genes in primary tumors or cancer cell lines in a single experiment. Results from microarray analysis approaches have provided valuable insights into the underlying biology and proven useful for tumor classification, prognostication and prediction...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226354/-prognostic-factors-of-lymph-node-negative-metastasis-gastric-cancer
#6
Ding Sun, Huimian Xu, Jinyu Huang
OBJECTIVE: To investigate the prognostic factors of patients with lymph node-negative metastasis gastric cancer (pN0). METHODS: Clinicopathological data of patients with pN0 gastric cancer who underwent radical operation at the Department of Surgical Oncology, The First Hospital of China Medical University from May 1980 to August 2012 were collected and analyzed retrospectively. INCLUSION CRITERIA: (1) Patients were diagnosed as gastric adenocarcinoma; (2) Postoperative pathology confirmed T1a to 4bN0M0 gastric cancer; (3) Total number of harvested lymph node was more than 15...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28225768/anti-rheumatic-treatment-is-not-associated-with-reduction-of-pentraxin-3-in-rheumatoid-arthritis-psoriatic-arthritis-and-ankylosing-spondylitis
#7
Gia Deyab, Ingrid Hokstad, Jon Elling Whist, Milada Cvancarova Småstuen, Stefan Agewall, Torstein Lyberg, Barbara Bottazzi, Pier Luigi Meroni, Roberto Leone, Gunnbjorg Hjeltnes, Ivana Hollan
BACKGROUND: Pentraxin 3 is proposed to be a marker of inflammation and cardiovascular risk, but its role in inflammatory rheumatic diseases (IRDs) is still uncertain. Therefore, we wanted to examine if anti-rheumatic treatment reduced serum PTX3 (s-PTX3) levels in IRDs, and if s-PTX3 levels were related to other markers of inflammation and to endothelial function (EF). METHODS: We examined s-PTX3, EF and established inflammatory biomarkers in 114 IRD patients from the PSARA study before and after 6 weeks and 6 months of treatment with methotrexate (MTX) or anti-tumor necrosis factor alpha (anti-TNF) therapy with or without MTX co-medication...
2017: PloS One
https://www.readbyqxmd.com/read/28225655/mnte-2-pyp-treatment-or-nox4-inhibition-protects-against-radiation-induced-damage-in-mouse-primary-prostate-fibroblasts-by-inhibiting-the-tgf-beta-1-signaling-pathway
#8
Arpita Chatterjee, Elizabeth A Kosmacek, Rebecca E Oberley-Deegan
Prostate cancer patients who undergo radiotherapy frequently suffer from side effects caused by radiation-induced damage to normal tissues adjacent to the tumor. Exposure of these normal cells during radiation treatment can result in tissue fibrosis and cellular senescence, which ultimately leads to postirradiation-related chronic complications including urinary urgency and frequency, erectile dysfunction, urethral stricture and incontinence. Radiation-induced reactive oxygen species (ROS) have been reported as the most potent causative factor for radiation damage to normal tissue...
February 22, 2017: Radiation Research
https://www.readbyqxmd.com/read/28225051/low-muscle-mass-at-initiation-of-anti-tnf-therapy-for-inflammatory-bowel-disease-is-associated-with-early-treatment-failure-a-retrospective-analysis
#9
D Q Holt, P Varma, B J G Strauss, A S Rajadurai, G T Moore
BACKGROUND/OBJECTIVES: Delayed treatment failure occurs in a significant proportion of inflammatory bowel disease (IBD) patients treated with tumor necrosis factor-alpha (TNF) antagonists. Identification of predictors of loss of response (LOR) may help to optimize therapy. We sought to determine whether body composition parameters at the commencement of anti-TNF therapy were associated with earlier treatment failure. SUBJECTS/METHODS: A retrospective cohort study was performed on 68 patients who had undergone cross-sectional abdominal imaging coincident with the commencement of anti-TNF drugs...
February 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28224680/aberrant-expressions-of-endometrial-id3-and-ctla-4-are-associated-with-unexplained-repeated-implantation-failure-and-recurrent-miscarriage
#10
Jin-Li Ding, Liang-Hui Diao, Tai-Lang Yin, Chun-Yu Huang, Biao Yin, Cong Chen, Yi Zhang, Jie Li, Yan-Xiang Cheng, Yong Zeng, Jing Yang
Inhibitor of DNA-binding protein 3 (Id3) is required for tumor angiogenesis and regulatory T-cell generation. However, the involvement of Id3 in unexplained repeated implantation failure (RIF) and recurrent miscarriage (RM) remains poorly understood. Immunohistochemistry was used to identify Id3, CD34, CTLA-4, and FOXP3 in the endometrium taken from the women with RIF (n=16), RM (n=16) and matched controls (n=8). The images were acquired and analyzed by the Vectra(®) automated quantitative pathology imaging system...
February 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28224663/loss-of-mlh1-sensitizes-colon-cancer-cells-to-dna-pkcs-inhibitor-ku60648
#11
Inga Hinrichsen, Anne Ackermann, Tonja Düding, Annika Graband, Natalie Filmann, Guido Plotz, Stefan Zeuzem, Angela Brieger
Germline mutations of MLH1 are responsible for tumor generation in nearly 50% of patients with Lynch Syndrome, and around 15% of sporadic colorectal cancers show MLH1-deficiency due to promotor hypermethylation. Although these tumors are of lower aggressiveness the benefit for these patients from standard chemotherapy is still under discussion. Recently, it was shown that the sensitivity to the DNA-PKcs inhibitor KU60648 is linked to loss of the MMR protein MSH3. However, loss of MSH3 is rather secondary, as a consequence of MMR-deficiency, and frequently detectable in MLH1-deficient tumors...
February 22, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28224423/prognostic-significance-of-autophagy-related-proteins-expression-in-resected-human-gastric-adenocarcinoma
#12
Bing Qu, Lei Yao, Hua-Ling Ma, Hong-Lei Chen, Zhi Zhang, Jiang Xie
Gastric adenocarcinoma (GC) is one of the most common malignancies in the world and one of the most frequent causes of cancer-related death. Autophagy is a highly regulated catabolic pathway responsible for the degradation of long-lived proteins and damaged intracellular organelles. However, the mechanism and guiding significance of autophagy in the development and progression of GC have remained to be elucidated. This study aimed to explore the clinicopathological significances and prognostic values of autophagy-related proteins AMBRA1 and Beclin-1 in GC...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28223823/prognostic-implications-of-kindlin-proteins-in-human-osteosarcoma
#13
Kai Ning, Haoshaqiang Zhang, Zhigang Wang, Kun Li
The Kindlin protein family, comprising Kindlin-1, Kindlin-2 and Kindlin-3, play important roles in various human cancers. Here, to explore the clinical significance of Kindlins in human osteosarcomas, quantitative real-time PCR and Western blot analyses were performed to detect the expression of Kindlin-1, Kindlin-2 and Kindlin-3 mRNAs and proteins in 20 self-pairs of osteosarcoma and adjacent noncancerous tissues. Then, immunohistochemistry was performed to examine subcellular localizations and expression patterns of Kindlin proteins in 100 osteosarcoma and matched adjacent noncancerous tissues...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28223541/targeting-growth-hormone-receptor-in-human-melanoma-cells-attenuates-tumor-progression-and-epithelial-mesenchymal-transition-via-suppression-of-multiple-oncogenic-pathways
#14
Reetobrata Basu, Shiyong Wu, John J Kopchick
Recent reports have confirmed highest levels of growth hormone (GH) receptor (GHR) transcripts in melanoma, one of the most aggressive forms of human cancer. Yet the mechanism of GH action in melanoma remains mostly unknown. Here, using human malignant melanoma cells, we examined the effects of GH excess or siRNA mediated GHR knock-down (GHRKD) on tumor proliferation, migration and invasion. GH promoted melanoma progression while GHRKD attenuated the same. Western blot analysis revealed drastic modulation of multiple oncogenic signaling pathways (JAK2, STAT1, STAT3, STAT5, AKT, mTOR, SRC and ERK1/2) following addition of GH or GHRKD...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28223536/preoperative-inflammation-markers-and-idh-mutation-status-predict-glioblastoma-patient-survival
#15
Peng-Fei Wang, Hong-Wang Song, Hong-Qing Cai, Ling-Wei Kong, Kun Yao, Tao Jiang, Shou-Wei Li, Chang-Xiang Yan
Recent studies suggest that inflammation response biomarkers are prognostic indicators of solid tumor outcomes. Here, we quantify the prognostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in glioblastomas (GBMs), taking into consideration the role of the isocitrate dehydrogenase (IDH) mutation status. We examined 141 primary glioblastomas (pGBMs) and 25 secondary glioblastomas (sGBMs). NLRs, PLRs, and LMRs were calculated before surgery...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28223431/changes-in-the-glycosylation-of-kininogen-and-the-development-of-a-kininogen-based-algorithm-for-the-early-detection-of-hcc
#16
Mengjun Wang, Miloslav Sanda, Mary Ann Comunale, Harmin Herrera, Charles Swindell, Yuko Kono, Amit G Singal, Jorge A Marrero, Timothy Block, Radoslav Goldman, Anand Mehta
BACKGROUND: Hepatocellular carcinoma (HCC) has the greatest increase in mortality among all solids tumors in the United States related to low rates of early tumor detection. Development of non-invasive biomarkers for early detection of HCC may reduce HCC-related mortality. METHODS: We have developed an algorithm that combines routinely observed clinical values into a single equation that in a study of > 3,000 patients from 5 independent sites, improved detection of HCC as compared to the currently used biomarker, alpha-feto-protein (AFP), by 4-20%...
February 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28223415/science-signaling-podcast-for-21-february-2017-pentraxin-3-in-basal-like-breast-cancer
#17
Antoine E Karnoub, Annalisa M VanHook
This Podcast features an interview with Antoine Karnoub, senior author of a Research Article that appears in the 21 February 2017 issue of Science Signaling, about how pentraxin-3 (PTX3) links increased phosphoinositide 3-kinase (PI3K) signaling to stem cell properties in basal-like breast cancer (BLBC). BLBC is an aggressive type of breast cancer in which the tumor cells exhibit increased PI3K signaling and have stem cell-like properties. Thomas et al found that aberrant PI3K signaling in BLBCs stimulated the expression of PTX3, which encodes a protein that functions in innate immunity...
February 21, 2017: Science Signaling
https://www.readbyqxmd.com/read/28223275/vascular-cxcr4-expression-promotes-vessel-sprouting-and-sensitivity-to-sorafenib-treatment-in-hepatocellular-carcinoma
#18
Jing Xu, Jing Liang, Ya-Ming Meng, Jing Yan, Xin-Juan Yu, Chao-Qun Liu, Li Xu, Shi-Mei Zhuang, Limin Zheng
PURPOSE: Chemokine receptor CXCR4 is known to be involved in both developmental and adult angiogenesis; however, its role in tumor angiogenesis remains largely unknown. Here the role of vascular CXCR4 in regulating vascular structure in HCC was assessed and the clinical value of CXCR4 was explored. EXPERIMENTAL DESIGN: The expression of CXCR4 in hepatocellular carcinoma (HCC) was determined by immunohistochemistry and immunofluorescence. Characteristics of CXCR4+ cells were determined by in vitro and mice experiments...
February 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28223108/tenascin-c-is-a-prognostic-determinant-and-potential-cancer-associated-fibroblasts-marker-for-breast-ductal-carcinoma
#19
Zhaoting Yang, Weidong Ni, Chunai Cui, Longyun Fang, Yanhua Xuan
Tenascin C (TNC) is a key of extracellular matrix glycoprotein and highly express in numerous human malignancies. Herein, we attempted to clarify the clinicopathological significance of TNC as a prognostic determinant of breast ductal carcinoma. Then, we investigated TNC immunohistochemical expression in 150 breast ductal carcinomas and 27 normal breast tissue samples. Clinical relevance of TNC expression and the association TNC expression with other factors related to cancer-associated fibroblasts were also examined...
February 18, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28222768/ki-67-as-a-controversial-predictive-and-prognostic-marker-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy
#20
Balázs Ács, Veronika Zámbó, Laura Vízkeleti, A Marcell Szász, Lilla Madaras, Gyöngyvér Szentmártoni, Tímea Tőkés, Béla Á Molnár, István Artúr Molnár, Stefan Vári-Kakas, Janina Kulka, Anna-Mária Tőkés
BACKGROUND: Studies have partly demonstrated the clinical validity of Ki-67 as a predictive marker in the neoadjuvant setting, but the question of the best cut-off points as well as the importance of this marker as a prognostic factor in partial responder/non-responder groups remains uncertain. METHODS: One hundred twenty patients diagnosed with invasive breast cancer and treated with neoadjuvant chemotherapy (NAC) between 2002 and 2013 were retrospectively recruited to this study...
February 21, 2017: Diagnostic Pathology
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