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https://www.readbyqxmd.com/read/29789410/a-randomised-open-label-parallel-group-phase-2-study-of-antisense-oligonucleotide-therapy-in-acromegaly
#1
Peter J Trainer, John Newell-Price, John Ayuk, Simon Aylwin, D Aled Rees, Wm Drake, Philippe Chanson, Thierry Brue, Susan M Webb, Carmen Fajardo Montañana, Javier Aller, Ann I McCormack, David J Torpy, George Tachas, Lynne Atley, David Ryder, Martin Bidlingmaier
OBJECTIVE: ATL1103 is a second-generation antisense oligomer targeting the human GH receptor. This phase 2 randomised, open-label, parallel-group study assessed the potential of ATL1103 as a treatment for acromegaly. DESIGN: 26 patients with active acromegaly (IGF-I >130% upper limit of normal) were randomised to subcutaneous ATL1103 200 mg either once- or twice-weekly for 13 weeks, and monitored for a further 8-week washout period. METHODS: The primary efficacy measures were change in IGF-I at week 14, compared to baseline and between cohorts...
May 22, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29726627/relationship-between-patient-reported-swelling-and-mri-defined-effusion-synovitis-in-patients-with-meniscus-tears-and-knee-osteoarthritis
#2
Lindsey A MacFarlane, Heidi Yang, Jamie E Collins, Ali Guermazi, Lisa A Mandl, Brue A Levy, Robert G Marx, Clare E Safran-Norton, Elena Losina, Jeffrey N Katz
OBJECTIVE: Synovitis is a prevalent feature in patients with knee osteoarthritis (OA) and meniscal tear and is associated with pain and cartilage damage. Patient-reported swelling is also prevalent in this population. We aimed to investigate the cross-sectional association between patient-reported swelling and effusion-synovitis on magnetic resonance imaging (MRI) in patients with OA and meniscal tear. METHODS: We used baseline data from a multicenter randomized controlled trial, Meniscal Tear in Osteoarthritis Research (MeTeOR)...
May 4, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29689852/new-distribution-data-for-some-charismatic-tramp-species-of-platygastroidea-hymenoptera
#3
Ovidiu Alin Popovici, LubomÍr Masner, MĂdĂlina Viciriuc, Alexandru Pintilioaie, David G Notton, Elijah Talamas
This paper documents what we consider to be expanding distributions in three genera of Platygastroidea: Platyscelio Kieffer (Scelionidae), Aphanomerus Perkins (Platygastridae) and Tetrabaeus Kieffer (Platygastridae). Platyscelio africanus Risbec is the first record of Platyscelio in the Western Hemisphere (French Guiana). Aphanomerus is a new record for the continental Nearctic region (USA, Los Angeles) and Tetrabaeus is a new record for the Palaearctic (Ukraine, Georgia, and South Korea) and Sino-Japanese (Japan) regions...
January 9, 2018: Zootaxa
https://www.readbyqxmd.com/read/29676409/erratum-to-relationship-between-clinical-mri-and-arthroscopic-findings-a-guide-to-correct-diagnosis-of-meniscal-tears
#4
P Antinolfi, R Cristiani, F Manfreda, S Bruè, V Sarakatsianos, G Placella, M Bartoli, A Caraffa
[This corrects the article DOI: 10.1055/s-0037-1605583.].
March 2018: Joints
https://www.readbyqxmd.com/read/29524603/descending-aortopexy-and-posterior-tracheopexy-for-severe-tracheomalacia-and-left-mainstem-bronchomalacia
#5
Hester F Shieh, C Jason Smithers, Thomas E Hamilton, David Zurakowski, Gary A Visner, Michael A Manfredi, Russell W Jennings, Christopher W Baird
Posterior descending aortopexy can relieve posterior intrusion of the left mainstem bronchus that may limit the effectiveness of posterior tracheobronchopexy. We review outcomes of patients undergoing both descending aortopexy and posterior tracheopexy for severe tracheobronchomalacia with posterior intrusion and left mainstem compression to determine if there were resolution of clinical symptoms and bronchoscopic evidence of improvement in airway collapse. All patients who underwent both descending aortopexy and posterior tracheopexy from October 2012 to October 2016 were retrospectively reviewed...
March 7, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29523633/management-of-endocrine-disease-management-of-cushing-s-syndrome-during-pregnancy-solved-and-unsolved-questions
#6
REVIEW
Thierry Brue, Vincent Amodru, Frederic Castinetti
With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2- to 3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. Apart from gestational hypertension, differential diagnosis includes pheochromocytoma and primary aldosteronism...
June 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29440375/preoperative-medical-treatment-in-cushing-s-syndrome-frequency-of-use-and-its-impact-on-postoperative-assessment-data-from-ercusyn
#7
Elena Valassi, Holger Franz, Thierry Brue, Richard A Feelders, Romana Netea-Maier, Stylianos Tsagarakis, Susan M Webb, Maria Yaneva, Martin Reincke, Michael Droste, Irina Komerdus, Dominique Maiter, Darko Kastelan, Philippe Chanson, Marija Pfeifer, Christian J Strasburger, Miklós Tóth, Olivier Chabre, Michal Krsek, Carmen Fajardo, Marek Bolanowski, Alicia Santos, Peter J Trainer, John A H Wass, Antoine Tabarin
BACKGROUND: Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical treatment (PMT) affects postoperative outcome remains controversial. OBJECTIVE: (1) Evaluate how frequently PMT is given to CS patients across Europe; (2) examine differences in preoperative characteristics of patients who receive PMT and those who undergo primary surgery and (3) determine if PMT influences postoperative outcome in pituitary-dependent CS (PIT-CS)...
April 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29398048/risk-of-death-in-infants-who-have-experienced-a-brief-resolved-unexplained-event-a-meta-analysis
#8
Donald A Brand, Melissa J Fazzari
OBJECTIVE: To estimate an upper bound on the risk of death after a brief resolved unexplained event (BRUE), a sudden alteration in an infant's breathing, color, tone, or responsiveness, previously labeled "apparent life-threatening event" (ALTE). STUDY DESIGN: The meta-analysis incorporated observational studies of patients with ALTE that included data on in-hospital and post-discharge deaths with at least 1 week of follow-up after hospital discharge. Pertinent studies were identified from a published review of the literature from 1970 through 2014 and a supplementary PubMed query through February 2017...
February 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29380884/single-sub-species-then-and-now-an-examination-of-the-nonracial-perspective-of-c-loring-brace
#9
Shelley L Smith
C. Loring Brace's writings on the concept of race have been among the most influential within anthropology. A review of the development of Brace's perspective on race shows that his philosophical approaches to fossil and modern human variation are consistent and integrated. Brace's views on race are compared with those of Ashley Montagu and Frank Livingstone, who also proposed eliminating "race" from anthropology, and with those of Stanley Garn and Alice Brues, who accepted "racial" subdivisions of humans...
January 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29346555/data-resource-profile-expansion-of-the-rochester-epidemiology-project-medical-records-linkage-system-e-rep
#10
Walter A Rocca, Brandon R Grossardt, Scott M Brue, Cynthia M Bock-Goodner, Alanna M Chamberlain, Patrick M Wilson, Lila J Finney Rutten, Jennifer L St Sauver
No abstract text is available yet for this article.
January 16, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29233182/apparent-life-threatening-events-alte-italian-guidelines
#11
REVIEW
Raffaele Piumelli, Riccardo Davanzo, Niccolò Nassi, Silvia Salvatore, Cinzia Arzilli, Marta Peruzzi, Massimo Agosti, Antonella Palmieri, Maria Giovanna Paglietti, Luana Nosetti, Raffaele Pomo, Francesco De Luca, Alessandro Rimini, Salvatore De Masi, Simona Costabel, Valeria Cavarretta, Anna Cremante, Fabio Cardinale, Renato Cutrera
Five years after the first edition, we have revised and updated the guidelines, re-examining the queries and relative recommendations, expanding the issues addressed with the introduction of a new entity, recently proposed by the American Academy of Pediatrics: BRUE, an acronym for Brief Resolved Unexplained Events. In this manuscript we will use the term BRUE only to refer to mild, idiopathic cases rather than simply replace the acronym ALTE per se.In our guidelines the acronym ALTE is used for severe cases that are unexplainable after the first and second level examinations...
December 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29099422/short-article-the-endoscopic-and-histologic-findings-of-infants-who-have-experienced-brief-resolved-unexplained-events
#12
Chaowapong Jarasvaraparn, Maria B R Gallegos, Madhuri S Mulekar, Bin Wang, David A Gremse, Karen D Crissinger
INTRODUCTION: A brief resolved unexplained event (BRUE) describes an event associated with a change in muscle tone, color, respiration, and responsiveness that is unexplained after an appropriate examination. Some infants with higher risk BRUE may undergo endoscopy as part of their evaluation. OBJECTIVE: This retrospective study aimed to identify the endoscopic findings in infants who have experienced a higher risk BRUE. We also compared the characteristics, prenatal, natal, and postnatal risk factors between 23 infants who underwent endoscopic evaluation and 23 race-matched/sex-matched/term-matched/preterm-matched infants who did not undergo endoscopic evaluation...
February 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29093125/case-5-brue-in-an-infant-found-to-have-feeding-difficulties
#13
Nastassia Bommel, Samira Kannarkatt
No abstract text is available yet for this article.
November 2017: Pediatrics in Review
https://www.readbyqxmd.com/read/29077191/pegaptanib-choroidal-neovascularization-in-patients-with-age-related-macular-degeneration-and-previous-arterial-thromboembolic-events
#14
MULTICENTER STUDY
Maurizio Battaglia Parodi, Emanuele Di Bartolo, Claudia Brue, Ezio Cappello, Claudio Furino, Sebastiano Giuffrida, Manuela Imparato, Michele Reibaldi
PURPOSE: To evaluate the efficacy and the rate of side effects of the pegylated aptamer pegaptanib in the treatment of patients with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and a history of previous arterial thromboembolic events (ATEs). METHODS: Twenty-three eyes of 23 patients with subfoveal CNV due to AMD and cerebrovascular accidents (n = 12) and myocardial infarction (n = 11) in the previous 6 months received intravitreal pegaptanib 0...
January 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29019347/pituitary-gland-gamma-knife-for-cushing-disease-time-for-a-reappraisal
#15
Frederic Castinetti, Thierry Brue
No abstract text is available yet for this article.
October 11, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28918451/quantitative-18-f-dopa-pet-ct-in-pheochromocytoma-the-relationship-between-tumor-secretion-and-its-biochemical-phenotype
#16
Vincent Amodru, Carole Guerin, Sarkis Delcourt, Pauline Romanet, Anderson Loundou, Bruna Viana, Thierry Brue, Frédéric Castinetti, Frédéric Sebag, Karel Pacak, David Taïeb
INTRODUCTION: 18 F-FDOPA illustrates the properties of uptake and storage of catecholamines in pheochromocytomas (PHEOs). Until now, the relationship between 18 F-FDOPA quantitative parameters and a PHEO secretory profile has not been specifically evaluated. MATERIALS AND METHODS: Fifty-six patients (56% females, median age: 47.5 yrs) with non-metastatic PHEO, evaluated by 18 F-FDOPA PET/CT, were included in this retrospective study. Forty-five patients had negative genetic testing (80...
February 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28898885/pilot-neonatal-screening-program-for-central-congenital-hypothyroidism-evidence-of-significant-detection
#17
Débora Braslavsky, Maria Virginia Méndez, Laura Prieto, Ana Keselman, Rosa Enacan, Laura Gruñeiro-Papendieck, Nicolas Jullien, Alexandru Savenau, Rachel Reynaud, Thierry Brue, Ignacio Bergadá, Ana Chiesa
BACKGROUND/AIM: Congenital hypothyroidism (CH) is a heterogeneous entity. Neonatal screening programs based on thyrotropin (TSH) determination allow primary CH diagnosis but miss central CH (CCH). CCH causes morbidity, alerts to other pituitary deficiencies, and is more prevalent than previously thought. We aimed at developing a pilot neonatal screening program for CCH detection. PATIENTS AND METHODS: A prospective 2-year pilot neonatal screening study based on simultaneous dried blood specimen TSH and thyroxine (T4) measurements was implemented in term newborns aged 2-7 days...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28887782/development-of-acrodat%C3%A2-a-new-software-medical-device-to-assess-disease-activity-in-patients-with-acromegaly
#18
Aart J van der Lely, Roy Gomez, Andreas Pleil, Xavier Badia, Thierry Brue, Michael Buchfelder, Pia Burman, David Clemmons, Ezio Ghigo, Jens Otto Lunde Jørgensen, Anton Luger, Joli van der Lans-Bussemaker, Susan M Webb, Christian J Strasburger
PURPOSE: Despite availability of multimodal treatment options for acromegaly, achievement of long-term disease control is suboptimal in a significant number of patients. Furthermore, disease control as defined by biochemical normalization may not always show concordance with disease-related symptoms or patient's perceived quality of life. We developed and validated a tool to measure disease activity in acromegaly to support decision-making in clinical practice. METHODS: An international expert panel (n = 10) convened to define the most critical indicators of disease activity...
December 2017: Pituitary
https://www.readbyqxmd.com/read/28874394/looking-beyond-the-thyroid-advances-in-the-understanding-of-pheochromocytoma-and-hyperparathyroidism-phenotypes-in-men2-and-of-non-men2-familial-forms
#19
REVIEW
Carole Guerin, Pauline Romanet, David Taieb, Thierry Brue, André Lacroix, Frederic Sebag, Anne Barlier, Frederic Castinetti
Over the last years, the knowledge of MEN2 and non-MEN2 familial forms of pheochromocytoma (PHEO) has increased. In MEN2, PHEO is the second most frequent disease: the penetrance and age at diagnosis depend on the mutation of RET Given the prevalence of bilateral PHEO (50% by age 50), adrenal sparing surgery, aimed at sparing a part of the adrenal cortex to avoid adrenal insufficiency, should be systematically considered in patients with bilateral PHEO. Non-MEN2 familial forms of PHEO now include more than 20 genes: however, only small phenotypic series have been reported, suggesting that phenotypic features of isolated hereditary PHEO must be better explored, and follow-up series are needed to better understand the outcome of patients carrying mutations of these genes...
February 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28814262/update-on-the-evaluation-and-management-of-brief-resolved-unexplained-events-previously-apparent-life-threatening-events
#20
Eric Zwemer, Ilene Claudius, Joel Tieder
BACKGROUND: The thirty-year-old term "apparent life-threatening event" (ALTE) is difficult to apply in clinical practice and research. The American Academy of Pediatrics now defines these events as brief resolved unexplained events (BRUEs), stratifies infants based on the risk of recurrence or of a serious underlying condition, and offers evidence-based management recommendations for infants at lower-risk. OBJECTIVE: To review recent ALTE literature as it relates to BRUEs...
2017: Reviews on Recent Clinical Trials
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