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https://www.readbyqxmd.com/read/28814248/pediatric-abdominal-trauma
#1
Tim Lynch
Abdominal trauma is present in approximately 25% of pediatric patients with major trauma and is the most common cause of unrecognized fatal injury in children. Pediatric abdominal trauma is typically blunt in nature with the spleen being the most common organ injured. Non-operative management is employed in over 95% of patients. Penetrating injuries are less common but often require operative management. Knowledge of specific mechanisms of injury aids the clinician in the diagnosis of specific injuries. Computed tomography (CT) is the gold standard in the identification of intra-abdominal injury...
August 14, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28801804/a-comparison-of-the-characteristics-and-precision-of-needle-driving-for-right-handed-pediatric-surgeons-between-right-and-left-driving-using-a-model-of-infant-laparoscopic-diaphragmatic-hernia-repair
#2
Takamasa Ikee, Shun Onishi, Motoi Mukai, Takafumi Kawano, Koshiro Sugita, Tomoe Moriguchi, Koji Yamada, Waka Yamada, Ryuta Masuya, Seiro Machigashira, Kazuhiko Nakame, Tatsuru Kaji, Satoshi Ieiri
PURPOSE: We compared the characteristics and precision of right and left needle driving for right-handed pediatric surgeons using a laparoscopic diaphragmatic repair model. METHODS: Eighteen right-handed pediatric surgeons performed three needle driving maneuvers using both hands. We evaluated the required time and conducted an image analysis. The total path length, velocity, and acceleration of the needle driving were also evaluated. RESULTS: Obtained results show the findings for the required time (s, Rt 310...
August 11, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28800051/alternative-tests-versus-measurement-of-fasting-plasma-glucose-and-oral-glucose-tolerance-test-for-diagnosis-of-pediatric-type-2-pre-diabetes-a-systematic-review-protocol
#3
Dagmar Tučková, Miloslav Klugar, Tomasz Lasota, Jakub Lasák, Jared M Campbell, Zachary Munn
The gold standard for the diagnosis of pre-diabetes is the measurement of fasting plasma glucose and the oral glucose tolerance test. The objective of this systematic review is to identify all alternative tests currently in use for the diagnosis of type 2 pre-diabetes mellitus in children and establish their accuracy relative to this gold standard.
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28794661/focused-assessment-with-sonography-for-trauma-current-perspectives
#4
REVIEW
Sorravit Savatmongkorngul, Sirote Wongwaisayawan, Rathachai Kaewlai
Focused assessment with sonography for trauma (FAST) is a part of resuscitation of trauma patients recommended by international panel consensus. The purpose of FAST is to identify free fluid, which necessarily means blood in acute trauma patients. In this article, the authors focused on various aspects of FAST in the emergency department, prehospital care, pediatric setting, training and general pearls/pitfalls. Detailed techniques and interpretation of FAST are beyond the scope of this article.
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/28790477/pediatric-lumbar-pedicle-screw-placement-using-navigation-templates-a-cadaveric-study
#5
Xing Wang, Jun Shi, Shojie Zhang, Zhifeng Zhang, Xiaohe Li, Zhijun Li
BACKGROUND: Pedicle screw technique is commonly used treatment of adult spinal trauma, tumor, degeneration. The application of pedicle screws is very challenging in children because children have a fast growing spine and spinal pedicle morphology of children and adult has large difference. 3 D reconstruction individual navigation templates improve the success rate of pediatric pedicle screw system. This study is aimed to provide a precise method for lumbar spine pedicle screw placement in children using computer-aided design and rapid prototyping technology...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28781793/activation-of-the-arachidonic-acid-metabolic-pathway-and-induction-of-sleep-disturbance-by-sacral-osteoblastoma-a-case-report
#6
Mitsunori Ozaki, Kazuya Nishioka, Akihiko Kimura, Toshikazu Kondo, Naoyuki Nakao
Osteoblastomas are benign bone tumors that produce prostaglandin and promote inflammation. The aim of the present study was to describe the clinical and radiological characteristics of a pediatric osteoblastoma case over an 8-month postoperative follow-up. The case involved an 11-year-old female patient with normal somatic development, presenting with a chief complaint of sleep disturbance. The patient had no spontaneous pain or other readily evident possible causes. Magnetic resonance imaging (MRI) revealed a neoplastic lesion in the sacrum, with peritumoral edema...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28776642/diagnosis-of-monogenic-liver-diseases-in-childhood-by-next-generation-sequencing
#7
Amelie Stalke, Britta Skawran, Bernd Auber, Thomas Illig, Brigitte Schlegelberger, Norman Junge, Imeke Goldschmidt, Christoph Leiskau, Nils von Neuhoff, Ulrich Baumann, Eva-Doreen Pfister
Next-Generation Sequencing (NGS) has opened up novel diagnostic opportunities for children with unidentified, but suspected inherited diseases. We describe our single-center experience with NGS diagnostics in standard clinical scenarios in pediatric hepatology. We investigated 135 children with suspected inherited hepatopathies, where initially no causative pathogenic variant had been identified, with an amplicon-based NGS panel of 21 genes associated with acute and chronic hepatopathies. In 23 of these patients we detected pathogenic or likely pathogenic variants in ten different genes...
August 4, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28776526/common-bacterial-isolates-clinical-outcome-and-tb-meningitis-in-children-admitted-at-morogoro-regional-referral-hospital-tanzania
#8
Ramadhani Salum Chambuso, Mkhoi Lord Mkhoi, Evelyn Kaambo
BACKGROUND: Bacterial meningitis is still one of the major causes of deaths, disabilities, and mental retardation in children in Morogoro region. To study the current meningitis burden, we evaluated the common bacterial isolates and clinical outcome of the disease in the region. METHODS: We conducted a hospital-based prospective study on 1352 children aged between 7 days and 12 years admitted in pediatric wards at Morogoro Regional Referral Hospital for 7 months...
July 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28776381/insulin-resistance-and-the-metabolic-syndrome-are-related-to-the-severity-of-steatosis-in-the-pediatric-population-with-obesity
#9
Esther Ubiña-Aznar, Leopoldo Tapia-Ceballos, José Miguel Rosales-Zabal, Rocío Porcel-Chacón, Francisco Poveda-Gómez, Carmen Lozano-Calero, Carmen Ortiz-Cuevas, Francisco Rivas-Ruiz, Andrés Sánchez Cantos, José María Navarro Jarabo
BACKGROUND: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. METHODS: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. RESULTS: A total of 94 children (51 males) aged from six to 14 years were included...
August 4, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28765060/contemporary-management-and-surveillance-strategy-after-shunt-or-endoscopic-third-ventriculostomy-procedures-for-hydrocephalus
#10
REVIEW
M Burhan Janjua, Caitlin E Hoffman, Mark M Souweidane
The management of hydrocephalus can be challenging even in expert hands. Due to acute presentation, recurrence, accompanying complications, the need for urgent diagnosis; a robust management plan is an absolute necessity. We devised a novel time efficient surveillance strategy during emergency, and clinic follow up settings which has never been described in the literature. We searched all articles embracing management/surveillance protocol on pediatric hydrocephalus utilizing the terms "hydrocephalus follow up" or "surveillance protocol after hydrocephalus treatment"...
July 29, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28748713/qbd-for-pediatric-oral-lyophilisates-development-risk-assessment-followed-by-screening-and-optimization
#11
Tibor Casian, Sonia Iurian, Catalina Bogdan, Lucia Rus, Mirela Moldovan, Ioan Tomuta
OBJECTIVE: This study proposed the development of oral lyophilisates with respect to pediatric medicine development guidelines, by applying risk management strategies and DoE as an integrated QbD approach. METHODS: Product critical quality attributes were overviewed by generating Ishikawa diagrams for risk assessment purposes, considering process, formulation and methodology related parameters. Failure Mode Effect Analysis was applied to highlight critical formulation and process parameters with an increased probability of occurrence and with a high impact on the product performance...
August 16, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28731653/insulin-level-and-insulin-sensitivity-indices-among-healthy-children-and-adolescents
#12
María G Ballerini, Ignacio Bergadá, María E Rodríguez, Ana Keselman, Viviana S Bengolea, Viviana Pipman, Horacio M Domené, Héctor G Jasper, María G Ropelato
INTRODUCTION: Information on insulin reference values and insulin sensitivity indices in the field of pediatrics is scarce. OBJETIVE: To describe insulin range and insulin sensitivity surrogate indices during childhood. POPULATION AND METHODS: Fasting insulin level range and surrogate indices, such as the homeostasis model assessment of insulin resistance (HOMA-IR), among healthy children and adolescents by age, body mass index, pubertal stage (PS), insulin-like growth factor-1 (IGF-1), total cholesterol, and triglycerides...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28727480/pilot-study-of-propranolol-premedication-to-reduce-fdg-uptake-in-brown-adipose-tissue-on-pet-scans-of-adolescent-and-young-adult-oncology-patients
#13
Anil George, Partha Sinha, Gary Conrad, Aum A Memon, Emily V Dressler, Lars M Wagner
OBJECTIVE: Physiologic uptake of (18)F-fluorodeoxyglucose (FDG) in brown adipose tissue (adipose tissue) of cancer patients may confound interpretation of positron emission tomography (PET) scans. Uptake in adipose tissue occurs in up to half of pediatric oncology patients undergoing PET scans, and is especially common in adolescents. adipose tissue is innervated by the sympathetic nervous system, and beta blockers such as propranolol have shown efficacy in reducing adipose tissue uptake on PET scans done in older adult oncology patients...
July 20, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/28726111/glucokinase-mutations-in-pediatric-patients-with-impaired-fasting-glucose
#14
C Aloi, A Salina, N Minuto, R Tallone, F Lugani, A Mascagni, O Mazza, M Cassanello, M Maghnie, G d'Annunzio
AIMS: Our aim was to detect the frequency of glucokinase (GCK) gene mutations in a cohort of patients with impaired fasting glucose and to describe the clinical manifestations of identified variants. We also aimed at predicting the effect of the novel missense mutations by computational approach. METHODS: Overall 100 unrelated Italian families with impaired fasting glucose were enrolled and subdivided into two cohorts according to strict and to mild criteria for diagnosis of maturity-onset diabetes of the young (MODY)...
July 19, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28700540/clinical-and-radiological-presentations-and-management-of-blunt-splenic-trauma-a-single-tertiary-hospital-experience
#15
Gaby Jabbour, Ammar Al-Hassani, Ayman El-Menyar, Husham Abdelrahman, Ruben Peralta, Mohammed Ellabib, Hisham Al-Jogol, Mohammed Asim, Hassan Al-Thani
BACKGROUND Splenic injury is the leading cause of major bleeding after blunt abdominal trauma. We examined the clinical and radiological presentations, management, and outcome of blunt splenic injuries (BSI) in our institution. MATERIAL AND METHODS A retrospective study of BSI patients between 2011 and 2014 was conducted. We analyzed and compared management and outcome of different splenic injury grades in trauma patients. RESULTS A total of 191 BSI patients were identified with a mean (SD) age of 26.9 years (13...
July 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28700280/biologic-treatment-options-for-retinal-neovascularization-in-beh%C3%A3-et-s-disease
#16
Nikos N Markomichelakis, Evaggelia K Aissopou, Stelios Maselos, Ilknur Tugal-Tutkun, Petros P Sfikakis
PURPOSE: Relapsing ocular inflammation occurs in about 70% of patients with Behçet's disease (BD) and can lead to permanent loss of vision. Neovascularization of the optic disc (NVD) or elsewhere in the retina (NVE) is a relatively uncommon but severe complication that lacks standardized treatment. METHODS: We report on the therapeutic use of anti-TNF monoclonal antibodies for BD-associated NVD and NVE in one pediatric patient (subcutaneous adalimumab) and one young man (intravenous infliximab)...
July 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28698725/plasma-pyridoxal-5%C3%A1-phosphate-level-in-children-with-intractable-and-controlled-epilepsy
#17
Zahra Pirzadeh, Mohammad Ghofrani, Mohsen Mollamohammadi
OBJECTIVE: Intractable epilepsy is a serious neurologic problem with different etiologies. Decreased levels of pyridoxal phosphate in cerebral spinal fluid of patients with intractable epilepsy due to pyridoxine dependency epilepsy are reported. The aim of this study was to compare plasma pyridoxal 5´-phosphate level in patients with intractable and controlled epilepsy. MATERIALS & METHODS: This cross- sectional analytic study included 66 epileptic children, 33 patients with controlled and 33 patients with intractable epilepsy, after neonatal period up to 15 yr old of age...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28693787/secretin-enhanced-magnetic-resonance-cholangiopancreatography-for-assessing-pancreatic-secretory-function-in-children
#18
Andrew T Trout, Daniel B Wallihan, Suraj Serai, Maisam Abu-El-Haija
OBJECTIVE: To assess the accuracy and interrater reproducibility of measurements of pancreatic secretory function by magnetic resonance cholangiopancreatography in response to secretin administration and to describe our experience using the technique to noninvasively assess pancreatic secretory function in a pediatric population. STUDY DESIGN: In the accuracy study, phantoms with varying fluid volume (47-206 mL) were imaged using the clinical quantification sequence...
July 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28692864/serum-il-10-il-17-and-il-23-levels-as-bioumoral-bridges-between-dyslipidemia-and-atopy
#19
S Manti, S Leonardi, I Panasiti, T Arrigo, C Salpietro, C Cuppari
BACKGROUND: Although several studies suggest a possible link between dyslipidemia and atopy, literature findings are still unclear. OBJECTIVE: The aim of the study was to investigate the relationship between dyslipidemia and atopy in a pediatric population affected by dyslipidemia or dyslipidemia/atopic predisposition. MATERIALS AND METHODS: Children with dyslipidemia, dyslipidemia and atopy as well as healthy children were recruited. Serum total IgE, IL-10, IL-17, and IL-23 levels as well as fasting lipid values (total cholesterol, LDL, HDL and triglycerides) were performed on all enrolled children...
July 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28678222/the-impact-of-intrauterine-and-extrauterine-weight-gain-in-premature-infants-on-later-body-composition
#20
Miguel Saenz de Pipaon, Izaskun Dorronsoro, Laura Álvarez-Cuervo, Nancy F Butte, Rosario Madero, Vicente Barrios, Juan Coya, Miriam Martínez-Biarge, Gabriel Á Martos-Moreno, Mary S Fewtrell, Jesús Argente, José Quero
BackgroundThe impact of intrauterine and extrauterine growth on later insulin resistance and fat mass (FM) in very low birth weight (VLBW) infants is not well established. The aim of our study was to evaluate the effects of intrauterine and early/late extrauterine growth on later insulin resistance and body composition in VLBW infants from 6 months' corrected age (CA) to 36 months.MethodsProspective measurements of body composition by dual-energy X-ray absorptiometry and insulin resistance by homeostasis model assessment insulin resistance (HOMA-IR) along with other fasting plasma biochemistries were made in 95 VLBW infants at 6, 12, 18, and 24 months' CA and 36 months' postnatal age...
July 5, 2017: Pediatric Research
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