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https://www.readbyqxmd.com/read/28624713/aneuploidy-identification-in-pre-b-acute-lymphoblastic-leukemia-patients-at-diagnosis-by-multiplex-ligation-dependent-probe-amplification-mlpa
#1
A Vázquez-Reyes, L Bobadilla-Morales, C Barba-Barba, G Macías-Salcedo, G Serafín-Saucedo, M E Velázquez-Rivera, M C Almodóvar-Cuevas, A Márquez-Mora, H J Pimentel-Gutiérrez, C Ortega-de-la-Torre, R M Cruz-Osorio, S Nava-Gervasio, J Rivera-Vargas, F Sánchez-Zubieta, J R Corona-Rivera, A Corona-Rivera
Three-quarters of the patients with acute lymphoblastic leukemia (ALL), show numerical or structural chromosomal alterations, which are important factors in leukemogenesis. The use of Multiplex Ligation-dependent Probes Amplification (MLPA) has been mainly limited for searching copy number alterations of genes, suggesting that MLPA could detect numerical alterations in cancer. However, the use of MLPA in pediatrics to analyze subtelomeric sequences for aneuploidy detection has not been considered in previous studies...
June 1, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28624354/school-reintegration-of-pediatric-burn-survivors-an-integrative-literature-review
#2
REVIEW
Raquel Pan, Bruna Domingos Dos Santos, Lucila Castanheira Nascimento, Lídia Aparecida Rossi, Rinie Geenen, Nancy E Van Loey
BACKGROUND: The school is an essential context for children's social interaction with peers and to develop academic skills. Therefore, a fast reintegration can help children with burns to normalize their life. Thus, school reintegration is an important outcome after burns. The aim of this review was to systematically synthesize the literature addressing school reintegration programs of pediatric burns survivors. METHODS: Five electronic databases were searched independently by two reviewers...
June 14, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28619404/prevalence-of-pediatric-asthma-risk-in-santo-domingo-dominican-republic
#3
Wendy W Sun, Lipi Gupta, Andrew E Andreae, Kristin Romutis, Allison M Borda, Priya Sabu, Sean McKenna, Mark Ryan
BACKGROUND: Early detection and treatment of pediatric asthma could reduce morbidity and lessen burden on society. Currently there is no known research on the prevalence of pediatric asthma in the Dominican Republic (DR) and no known asthma risk assessment tool for one-time encounters in a fast-paced clinic. OBJECTIVES: To pilot a streamlined version of previously validated screening tools to estimate the prevalence of pediatric asthma risk in Santo Domingo Norte, DR...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28609517/abdominal-ultrasound-for-pediatric-blunt-trauma-fast-is-not-always-better
#4
EDITORIAL
David O Kessler
No abstract text is available yet for this article.
June 13, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28609322/thoracic-spine-growth-revisited-how-accurate-is-the-dimeglio-data
#5
Ozgur Dede, Kadir Büyükdoğan, Halil Gökhan Demirkıran, Erhan Akpınar, Muharrem Yazici
STUDY DESIGN: Cross-sectional descriptive study. OBJECTIVE: To describe the normal rate pattern of thoracic spine growth in children without any spinal deformity. SUMMARY OF BACKGROUND DATA: The knowledge of thoracic spine growth and height is important for growing spine treatment and the decision of final fusion. Currently, pediatric spinal deformity is approached as early onset and late onset with an understanding of the fast growth during the first 5 years of life...
June 15, 2017: Spine
https://www.readbyqxmd.com/read/28607639/effect-of-diode-laser-irradiation-on-compressive-strength-of-dental-amalgam
#6
Mitra Tabari, Reza Fekrazad, Homayoun Alaghemand, Mahtab Hamzeh
INTRODUCTION: One of the biggest disadvantages of dental amalgam is that gaining its ultimate strength is a slow process. The use of a rapid-setting amalgam with high early compressive strength could be a better option in preventing early fractures in pediatric dentistry. The aim of this study was to determine the effect of diode laser irradiation on compressive strength of dental amalgam. METHODS: A case-control study was performed on 180 amalgam samples made at the Tehran Dental Material Research Center in 2014...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28606575/good-adherence-to-the-mediterranean-diet-reduces-the-risk-for-nash-and-diabetes-in-pediatric-patients-with-obesity-the-results-of-an-italian-study
#7
Claudia Della Corte, Antonella Mosca, Andrea Vania, Arianna Alterio, Salvatore Iasevoli, Valerio Nobili
OBJECTIVE: In the last decade, it was demonstrated that the Mediterranean diet (MD) represents an ideal diet for all age groups and has an important role in the prevention of metabolic and cardiovascular diseases, as well as nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to analyze the association between adherence to the MD and NAFLD, with laboratory and histologic evaluation, in a group of children and adolescents with obesity. METHODS: We enrolled 243 patients with obesity referred to our department from March 2014 to November 2015...
July 2017: Nutrition
https://www.readbyqxmd.com/read/28603029/mechanical-microencapsulation-the-best-technique-in-taste-masking-for-the-manufacturing-scale-effect-of-polymer-encapsulation-on-drug-targeting
#8
REVIEW
Basheer Al-Kasmi, Mhd Bashir Alsirawan, Mais Bashimam, Hind El-Zein
Drug taste masking is a crucial process for the preparation of pediatric and geriatric formulations as well as fast dissolving tablets. Taste masking techniques aim to prevent drug release in saliva and at the same time to obtain the desired release profile in gastrointestinal tract. Several taste masking methods are reported, however this review has focused on a group of promising methods; complexation, encapsulation, and hot melting. The effects of each method on the physicochemical properties of the drug are described in details...
June 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28598548/eating-behavior-during-dexamethasone-treatment-in-children-with-acute-lymphoblastic-leukemia
#9
Lidewij T Warris, Erica L T van den Akker, Marc B Bierings, Cor van den Bos, Femke K Aarsen, Michel C Zwaan, Wim J E Tissing, Margreet A Veening, Rob Pieters, Marry M van den Heuvel-Eibrink
BACKGROUND AND AIM: Large prospective studies on dexamethasone-induced changes in eating behavior, energy, and nutrient intake are lacking in pediatric acute lymphoblastic leukemia (ALL). We prospectively studied eating behavior, energy, nutrient intake, and the effect on leptin and adiponectin levels during dexamethasone administration in children with ALL. PATIENTS: Parents of patients with ALL (3-16 years) completed a dietary diary for their child during 4 days of dexamethasone (6 mg/m(2) ) administration...
June 9, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28592095/-the-epidemic-status-of-metabolic-syndrome-among-chinese-adolescents-aged-10-17-years-in-2010-2012
#10
Y N He, W H Zhao, L Y Zhao, D M Yu, J Zhang, W T Yu, X G Yang, G G Ding
Objective: To invesigate the epidemic status of the metabolic syndrome (MS) among mainland Chinese adolescents aged 10-17 in 2010-2012. Methods: Data were collected from Chinese Nutrition and Health Surveillance in 2010-2012. Multi-stage stratified proportion to the population cluster random sampling method was conducted to determine 16 872 adolescents in 150 counties from 31 provinces in mainland China. The epidemic status of metabolic syndrome was analyzed by China criterion (defined by Chinese Pediatric Society, Chinese Medical Association) and Cook criterion, respectively...
June 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28590347/focused-assessment-with-sonography-for-trauma-fast-in-children-following-blunt-abdominal-trauma-a-multi-institutional-analysis
#11
Bennett W Calder, Adam M Vogel, Jingwen Zhang, Patrick D Mauldin, Eunice Y Huang, Kate B Savoie, Matthew T Santore, KuoJen Tsao, Tiffany G Ostovar-Kermani, Richard A Falcone, M Sidney Dassinger, John Recicar, Jeffrey H Haynes, Martin L Blakely, Robert T Russell, Bindi J Naik-Mathuria, Shawn D St Peter, David P Mooney, Chinwendu Onwubiko, Jeffrey S Upperman, Jessica A Zagory, Christian J Streck
INTRODUCTION: The utility of FAST in children is poorly defined with considerable practice variation. Our purpose was to investigate the role of FAST for intraabdominal injury (IAI) and IAI requiring acute intervention (IAI-I) in children following blunt abdominal trauma (BAT). METHODS: We prospectively enrolled children <16 years following BAT at 14 Level-One Pediatric Trauma Centers over a 1-year period. Patients who underwent FAST were compared to those that did not using descriptive statistics and univariate analysis; p<0...
June 6, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28589518/forty-years-of-sodium-channels-structure-function-pharmacology-and-epilepsy
#12
William A Catterall
Voltage-gated sodium channels initiate action potentials in brain neurons. In the 1970s, much was known about the function of sodium channels from measurements of ionic currents using the voltage clamp method, but there was no information about the sodium channel molecules themselves. As a postdoctoral fellow and staff scientist at the National Institutes of Health, I developed neurotoxins as molecular probes of sodium channels in cultured neuroblastoma cells. During those years, Bruce Ransom and I crossed paths as members of the laboratories of Marshall Nirenberg and Philip Nelson and shared insights about sodium channels in neuroblastoma cells from my work and electrical excitability and synaptic transmission in cultured spinal cord neurons from Bruce's pioneering electrophysiological studies...
June 7, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28588153/gastric-dilatation-and-abdominal-compartment-syndrome-in-a-child-with-prader-willi-syndrome
#13
Clara Blat, Elisenda Busquets, Teresa Gili, Assumpta Caixàs, Elisabeth Gabau, Raquel Corripio
BACKGROUND Prader-Willi syndrome (PWS) is a genetic disorder characterized by initial muscular hypotonia and feeding difficulties, and later an insatiable appetite, hyperphagia and obesity along with mild to moderate intellectual impairment. Affected individuals' food-seeking behavior and suspected delayed gastric emptying can lead to gastric dilatation with subsequent necrosis and perforation. CASE REPORT We present the case of a 5-year-old boy diagnosed with Prader-Willi syndrome at neonatal age due to muscular hypotonia, who started growth hormone therapy at 20 months...
June 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28583243/significant-factors-related-to-failed-pediatric-dental-general-anesthesia-appointments-at-a-hospital-based-residency-program
#14
John R Emhardt, Juan F Yepes, LaQuia A Vinson, James E Jones, John D Emhardt, Diana C Kozlowski, George J Eckert, Gerardo Maupome
PURPOSE: The purposes of this study were to: (1) evaluate the relationship between appointment failure and the factors of age, gender, race, insurance type, day of week, scheduled time of surgery, distance traveled, and weather; (2) investigate reasons for failure; and (3) explore the relationships between the factors and reasons for failure. METHODS: Electronic medical records were accessed to obtain data for patients scheduled for dental care under general anesthesia from May 2012 to May 2015...
May 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/28579059/neuroketotherapeutics-a-modern-review-of-a-century-old-therapy
#15
REVIEW
Scott J Koppel, Russell H Swerdlow
Neuroketotherapeutics represent a class of bioenergetic medicine therapies that feature the induction of ketosis. These therapies include medium-chain triglyceride supplements, ketone esters, fasting, strenuous exercise, the modified Atkins diet, and the classic ketogenic diet. Extended experience reveals persons with epilepsy, especially pediatric epilepsy, benefit from ketogenic diets although the mechanisms that underlie its effects remain unclear. Data indicate ketotherapeutics enhance mitochondrial respiration, promote neuronal long-term potentiation, increase BDNF expression, increase GPR signaling, attenuate oxidative stress, reduce inflammation, and alter protein post-translational modifications via lysine acetylation and β-hydroxybutyrylation...
June 1, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28577636/acculturation-and-pediatric-minority-oral-health-interventions
#16
REVIEW
Tamanna Tiwari, Judith Albino
Immigrant populations are growing at a fast pace in the United States. Cultural variations can have implications on oral health of children from immigrant households. Length of stay in the United States and language spoken at home, proxies for measuring acculturation, are some of the crucial factors determining the level of acculturation in families. Higher acculturation generally has a positive impact on oral health utilization. Improving cultural competency of dental teams and involving the stakeholders in intervention design and implementation are some strategies that may increase the trust of ethnic minority patients and reduce barriers to access to care...
July 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28571426/versatile-synchronized-real-time-meg-hardware-controller-for-large-scale-fast-data-acquisition
#17
Limin Sun, Menglai Han, Kevin Pratt, Douglas Paulson, Christoph Dinh, Lorenz Esch, Yoshio Okada, Matti Hämäläinen
Versatile controllers for accurate, fast, and real-time synchronized acquisition of large-scale data are useful in many areas of science, engineering, and technology. Here, we describe the development of a controller software based on a technique called queued state machine for controlling the data acquisition (DAQ) hardware, continuously acquiring a large amount of data synchronized across a large number of channels (>400) at a fast rate (up to 20 kHz/channel) in real time, and interfacing with applications for real-time data analysis and display of electrophysiological data...
May 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28569379/use-and-education-of-point-of-care-ultrasound-in-pediatric-emergency-medicine-in-saudi-arabia
#18
Abdullah Saad Alzayedi, Amani A Azizalrahman, Hamad A AlMadi, Ahmed M Althekair, Michael Blaivas, Dimitrios Karakitsos
OBJECTIVES: Point-of-care ultrasound (US) is an emerging tool used by pediatric emergency physicians in the last decade. Currently in the Middle East, point-of-care US use and education are at an early stage, with no designed curriculum or guidelines for its implementation in pediatric emergency medicine (EM). The objective of this article is to describe the clinical and educational uses of point-of-care US among certified pediatric EM physicians. METHODS: A 19-question survey was sent to all certified pediatric emergency physicians and fellows in pediatric emergency fellowships in Saudi Arabia in February 2016...
June 1, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28567283/dyslipidemia-management-in-overweight-or-obese-adolescents-a-mixed-methods-clinical-trial-of-motivational-interviewing
#19
Nita Chahal, Janet Rush, Cedric Manlhiot, Katherine M Boydell, Ahlexxi Jelen, Brian W McCrindle
BACKGROUND: Lifestyle management for dyslipidemic adolescents often occurs in the context of family-centered care, which necessitates adaptation of counseling strategies. OBJECTIVE: To determine the effectiveness of motivational interviewing for lifestyle behavior change for dyslipidemic adolescents in a dyad with a parent versus alone. METHODS: A total number of 32 adolescents were randomized 1:1 to receive a series of motivational interviewing sessions either together with a parent or alone for a 6-month intervention, with both quantitative and qualitative assessment of outcomes...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28556685/relationship-between-meeting-24-hour-movement-guidelines-and-cardiometabolic-risk-factors-in-children
#20
Peter T Katzmarzyk, Amanda E Staiano
BACKGROUND: The purpose was to evaluate the relationship between adherence to pediatric 24-hour movement guidelines (moderate-to-vigorous physical activity (MVPA), sedentary behavior and sleep) and cardiometabolic risk factors. METHODS: The sample included 357 white and African American children aged 5-18 years. Physical activity, TV viewing and sleep duration were measured using questionnaires, and the 24-hour guidelines were defined as: ≥60 min/day of MVPA on ≥5 days/week, ≤2 h/day of TV, and sleeping 9-11 h/night (ages 5-13 y) or 8-10 h/night (ages 14-18 y)...
May 30, 2017: Journal of Physical Activity & Health
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