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https://www.readbyqxmd.com/read/29785307/a-review-of-percutaneous-transluminal-angioplasty-in-hemodialysis-fistula
#1
REVIEW
Ioannis Bountouris, Georgia Kritikou, Nikolaos Degermetzoglou, Konstantinos Ioannis Avgerinos
The number of patients in dialysis increases every year. In this review, we will evaluate the role of percutaneous transluminal angioplasty (PTA) according to patency of arteriovenous fistula and grafts. The main indication of PΤΑ is stenosis > 50% or obstruction of the vascular lumen of an arteriovenous fistula and graft. It is usually performed under local anesthesia. The infection rate is as low as the number of complications. Fistula can be used in dialysis in the same day without the need for a central venous catheter...
2018: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/29785212/reduction-of-vascular-inflammation-ldl-c-or-both-for-the-protection-from-cardiovascular-events
#2
REVIEW
Andromachi Reklou, Michael Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos, Dimitris Patoulias, Vasilios G Athyros
Background: Low density lipoprotein cholesterol (LDL-C) and low grade arterial inflammation are key pathogenic factors for atherosclerosis and its manifestation, cardiovascular disease (CVD). Objective: In this narrative review we assessed if decreasing LDL-C levels or inflammation or both is more effective in reducing CVD events. Results: In the Scandinavian Simvastatin Survival Study (4S), all statin trials of the 90s' and the Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) the benefit came from the LDL-C reduction...
2018: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29785211/a-very-rare-cause-of-lower-limb-ischemia-in-young-people-popliteal-artery-entrapment
#3
Hasan Baki Altinsoy, Ozkan Alatas, Emjed Khalil, Kenan Abdurrahman Kara, Candan Cudi Okten, Omer Faruk Dogan
Background: Popliteal artery entrapment syndrome (PAES) is a very rare pathology that can cause lower extremity ischemia in healthy young people. Anomalous anatomic relationships between the popliteal artery (PA) and the surrounding musculo-tendinous structures cause PAES. We present 31 patients with PAES in 35 limbs that were treated surgically in our clinic within a 12-year period. Patients and Methods: From 2001 to 2015, 31 patients (mean age: 32 ± 7.4 years) underwent surgery for PAES...
2018: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29785139/blockage-of-store-operated-ca-2-entry-antagonizes-epstein-barr-virus-promoted-angiogenesis-by-inhibiting-ca-2-signaling-regulated-vegf-production-in-nasopharyngeal-carcinoma
#4
Jiaxiang Ye, Junqi Huang, Qian He, Weilin Zhao, Xiaoying Zhou, Zhe Zhang, Yongqiang Li, Jiazhang Wei, Jinyan Zhang
Background: Epstein-Barr virus (EBV) actively contributes to the pathological process of nasopharyngeal carcinoma (NPC) by enabling NPC cells to acquire various capacities required for their malignant biological actions. Our earlier works demonstrated that EBV-encoded latent membrane protein 1 (LMP1) enhanced vascular endothelial growth factor (VEGF)-mediated angiogenesis by boosting store-operated Ca2+ entry (SOCE) upon extracellular epidermal growth factor (EGF) stimulation. However, the antagonistic effects of SOCE blockage on EBV-promoted angiogenesis must be appropriately evaluated in vivo, and the global effect of EBV infection on the EGF-elicited cytosolic Ca2+ signaling, which regulates VEGF-mediated angiogenesis remains to be further clarified...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29783797/-neuroendocrine-carcinoma-of-cervix-a-clinicopathologic-study-of-82-cases
#5
M Feng, J Zou, Y Zhang, L Sun
Objective: To investigate the clinicopathological characteristics and prognostic factors of neuroendocrine carcinoma (NEC) of the cervix. Methods: Eight-two patients diagnosed as NEC of cervix from 2008 to 2016 at West China Second University Hospital were analyzed retrospectively including HE slide review, immunohistochemistry and HPV genotyping. Survival analysis was performed using Kaplan-Meier and Cox regression model. Results: The age of the patients ranged from 16 to 75 years with mean age of 43 years...
May 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29783029/comparison-of-stanford-b-aortic-dissection-patients-who-received-tevar-combined-with-or-without-sleep-apnea-syndrome
#6
Xin Li, Wenwu Cai, Ping Zhang, Kun Fang, Jieting Zhu, Chang Shu
BACKGROUND: Patients with Stanford B aortic dissection usually complicated with sleep apnea syndrome. This condition always threatens the patients' respiration situation. In this study, we collected and analysis data of patients' peri-operative managements of Thoracic Endovascular Aortic Repair (TEVAR) for Stanford B Aortic Dissection (AD) complicated with Sleep Apnea Syndrome (SAS). Comparison has been made between these SAS patients and those who without SAS. METHODS: Between June 2013 and June 2014, the clinical data and outcomes of the Stanford B AD patients in the department of vascular surgery in the Second Xiangya Hospital were retrospectively reviewed and studied...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29783002/a-stepwise-approach-to-laparoscopic-enucleation-and-excision-of-retroperitoneal-cysts
#7
Haider Jan, Tina Kapoor, Vishalli Ghai
STUDY OBJECTIVE: Technical video demonstrating a step by step approach to laparoscopic enucleation and excision of retroperitoneal cysts. DESIGN: Technical video (Canadian Task Force classification III). SETTING: Benign Gynecology Department at a University Hospital. INTERVENTION: Laparoscopic enucleation and excision of retroperitoneal cysts. CONCLUSION: Retroperitoneal cysts are rare lesions associated with numerous complications including compression on neighbouring organs, infection, rupture and malignant transformation...
May 18, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29782355/inhibition-of-vascular-endothelial-cell-leak-following-escherichia-coli-attachment-in-an-experimental-model-of-sepsis
#8
Tony M McHale, Carolina D Garciarena, Robert P Fagan, Stephen G J Smith, Ignacio Martin-Loches, Gerard F Curley, Fidelma Fitzpatrick, Steve W Kerrigan
OBJECTIVES: The vascular endothelium is a major target of sepsis-induced events, and endothelial activation accounts for much of the pathology of sepsis. Urinary tract infections and pneumonia caused by Escherichia coli are among of the most common infections causing sepsis in both community and hospital settings. Currently, there are no approved drugs on the market to treat the underlying pathophysiology of sepsis. The aim of this study is to elucidate the molecular mechanism by which E...
May 18, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29779947/intermittent-pili-mediated-forces-fluidize-neisseria-meningitidis-aggregates-promoting-vascular-colonization
#9
Daria Bonazzi, Valentina Lo Schiavo, Silke Machata, Ilyas Djafer-Cherif, Pierre Nivoit, Valeria Manriquez, Hirokazu Tanimoto, Julien Husson, Nelly Henry, Hugues Chaté, Raphael Voituriez, Guillaume Duménil
Neisseria meningitidis, a bacterium responsible for meningitis and septicemia, proliferates and eventually fills the lumen of blood capillaries with multicellular aggregates. The impact of this aggregation process and its specific properties are unknown. We first show that aggregative properties are necessary for efficient infection and study their underlying physical mechanisms. Micropipette aspiration and single-cell tracking unravel unique features of an atypical fluidized phase, with single-cell diffusion exceeding that of isolated cells...
May 15, 2018: Cell
https://www.readbyqxmd.com/read/29779317/-the-expression-of-klk7-in-pancreatic-cancer-and-the-effects-on-the-biological-behavior-of-pancreatic-cancer-cells
#10
S L Zheng, M Y Feng, G Yang, G B Xiong, L F Zheng, T P Zhang, Y P Zhao
Objective: To investigate the expression of KLK7 in pancreatic cancer and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of KLK7 protein in pancreatic cancer tissue microarray with 92 samples. Statistical analysis of the relationship between KLK7 and clinicopathological characteristics was finished. Pancreatic cancer cell lines were infected with lentiviuses in order to get cells with KLK7 stable overexpression.KLK7-siRNA was transfected into pancreatic cancer cells to knock down KLK7...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29779313/-curative-effect-analysis-of-bile-reinfusion-combined-with-enteral-nutrition-support-before-surgery-of-hilar-cholangiocarcinoma
#11
P Song, L Mao, X J Bian, T Zhou, Y Y Fan, J Zhang, M Xie, Y D Qiu
Objective: To investigate the clinical effect of bile reinfusion combined with enteral nutrition support before surgery for hilar cholangiocarcinoma. Methods: A retrospective analysis of patients with hilar cholangiocarcinoma who underwent surgical treatment at Nanjing Drum Tower Hospital Hepato-biliary-pancreatic Surgery Department from July 2010 to August 2017 was completed.A total of 52 cases were finally enrolled in our study.All the patients included, on the basis of whether they received preoperative drainage and bile reinfusion, were divided into non-drainage group( n =15) and drainage group( n =37)...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29777842/nationally-representative-readmission-factors-in-patients-with-claudication-and-critical-limb-ischemia
#12
Rennier A Martinez, Michelle Shnayder, Joshua Parreco, Lukas Gaffney, Marcus Eby, Nicholas Cortolillo, Michael Lopez, Jack Zeltzer
INTRODUCTION: Hospital readmissions are not only associated with increased mortality, morbidity and costs but also, with current healthcare reform, tied to significant financial and administrative penalties. Some studies show that patients undergoing vascular surgery may have higher than average readmission rates. The recently released Nationwide Readmission Database (NRD) is the most comprehensive national source of readmission data, gathering discharge information from 22 geographically dispersed states, accounting for 51...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777447/integra-%C3%A2-dermal-regeneration-template-and-split-thickness-skin-grafting-a-therapy-approach-to-correct-aplasia-cutis-congenita-and-epidermolysis-bullosa-in-carmi-syndrome
#13
Julian Trah, Christina Has, Ingrid Hausser, Heinz Kutzner, Konrad Reinshagen, Ingo Königs
The association of junctional epidermolysis bullosa with pyloric atresia (JEB-PA) and aplasia cutis congenita (ACC) was described by El Shafie et al. (J Pediatr Surg 14(4):446-449, 1979) and Carmi et al. (Am J Med Genet 11:319-328, 1982). Most patients die in the first weeks of life, and no curative treatment options are available so far. We describe a patient with JEB-PA and ACC (OMIM # 226730) who was treated for extensive areas of ACC by Integra® -Dermal Regeneration Template and split-thickness skin grafting (STSG)...
May 18, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29776888/iga-vasculitis-as-a-presentation-of-human-immunodeficiency-virus-infection
#14
Anahy M Brandy-García, Jorge Santos-Juanes, Silvia Suarez, Luis Caminal-Montero
IgA vasculitis is a small-vessel vasculitis mediated by immune complexes. In clinical terms, it is characterized by palpable purpura in the lower limbs, joint involvement in the form of arthralgia or arthritis, and gastrointestinal and renal involvement (this will mark a poorer prognosis in adults). Infectious processes, mainly in the upper respiratory tract, are frequently found to be triggers. On the other hand, human immunodeficiency virus (HIV) causes immune dysfunction, which triggers hypergammaglobulinemia and can trigger autoimmune disorders...
May 15, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29775656/peripheral-vascular-stent-infection-case-report-and-review-of-literature
#15
Greg H Whitcher, Daniel J Bertges, Mrinal Shukla
We describe a case of an infected popliteal artery stent with septic emboli presenting 6 years after peripheral vascular intervention for intermittent claudication. Management included resection of the stent and popliteal artery and revascularization by femoral-popliteal bypass with autogenous vein. This case demonstrates that peripheral stent infections can develop years after intervention. We performed an English language PUBMED literature review of arterial peripheral vascular stent infections on using the search term, "Non-coronary stent or stent graft infection from 1966 to present...
May 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29775486/peroxidasin-contributes-to-lung-host-defense-by-direct-binding-and-killing-of-gram-negative-bacteria
#16
Ruizheng Shi, Zehong Cao, Hong Li, Jochen Graw, Guogang Zhang, Victor J Thannickal, Guangjie Cheng
Innate immune recognition is classically mediated by the interaction of host pattern-recognition receptors and pathogen-associated molecular patterns; this triggers a series of downstream signaling events that facilitate killing and elimination of invading pathogens. In this report, we provide the first evidence that PXDN (also known as vascular peroxidase-1) directly binds to gram-negative bacteria and mediates bactericidal activity, thus, contributing to lung host defense. PXDN contains five leucine-rich repeats and four immunoglobulin domains, which allows for its interaction with lipopolysaccharide, a membrane component of gram-negative bacteria...
May 18, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29775011/-hyper-ige-syndromes
#17
REVIEW
Y Y He, B Liu, X P Xiao
A hyper-IgE syndrome is a rare immunodeficiesncy disease, often accompanied by high serum IgE. It often characterized by facial features, repeated skin infections, eczema and pulmonary infection, including autosomal dominant HIES (AD-HIES) and autosomal recessive HIES (AR-HIES). AR-HIES is caused by mutations in STAT3, which is presented as connective tissue, bone, vascular disease, and high brain white matter signal. AD-HIES is mainly caused by mutations in DOCK8 and TYK2, which is presented as severe viral infection and poor prognosis...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29772995/bilateral-spontaneous-quadriceps-tendon-ruptures-after-staged-bilateral-total-knee-arthroplasties-a-case-report
#18
Marine Coste, Jared M Newman, Neil V Shah, Ahmed M Eldib, Preston W Grieco, Aditya V Maheshwari
Quadriceps tendon ruptures are rare complications of total knee arthroplasty (TKA) and may be associated with preexisting tendon degeneration, vascular injuries during surgery, damage to the quadriceps tendon with over resection of the patella, or incomplete healing after a particular surgical approach. Moreover, postoperative causes include tissue necrosis due to component malalignment, trauma, and infection. Patient factors such as chronic systemic diseases, medications, increased body weight, and sedentary lifestyle could also be responsible...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29772041/endophthalmitis-associated-with-intravitreal-injections-of-anti-vegf-agents-at-a-tertiary-referral-center-in-house-and-referred-cases
#19
Nicolas A Yannuzzi, Ninel Z Gregori, Philip J Rosenfeld, Nidhi Relhan, Nimesh A Patel, Nancy Si, Darlene Miller, Sander R Dubovy, William E Smiddy, Stephen G Schwartz, Harry W Flynn
BACKGROUND AND OBJECTIVE: To report the incidence rates, causative organisms, and visual acuity (VA) outcomes in patients with endophthalmitis associated with intravitreal injection of anti-vascular endothelial growth factor inhibitors. PATIENTS AND METHODS: Retrospective case series between 2005 and 2017. RESULTS: The study included 39 eyes of 39 patients, including 27 (69%) referred and 12 (31%) institutional patients. The use of topical antibiotics after an injection was gradually phased out at the authors' institution, where the preinjection rate of all clinically suspected endophthalmitis was 0...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29771268/hiv-disease-is-associated-with-increased-biomarkers-of-endothelial-dysfunction-despite-viral-suppression-on-long-term-antiretroviral-therapy-in-botswana
#20
Mosepele Mosepele, Terence Mohammed, Lucy Mupfumi, Sikhulile Moyo, Kara Bennett, Shahin Lockman, Linda C Hemphill, Virginia A Triant
BACKGROUND: Untreated HIV infection is associated with increased biomarkers of endothelial dysfunction. However, the predictors and degree of endothelial dysfunction among virally suppressed HIV-infected adults on long-term antiretroviral therapy (ART) have not been well studied in sub-Saharan Africa (SSA). METHODS: We enrolled 112 HIV-infected adults with virological suppression on long-term ART and 84 HIV-uninfected controls in Botswana. We measured plasma levels of markers of endothelial injury [soluble vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and E-selectin] and plasma levels of biomarkers of inflammation [interleukin 6 (IL-6)] and monocyte activation (sCD163)...
May 14, 2018: Cardiovascular Journal of Africa
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