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https://www.readbyqxmd.com/read/29351716/effect-of-metformin-on-glycemic-control-in-patients-with-type-1-diabetes-a-meta-analysis-of-randomized-controlled-trials
#1
Haiyang Meng, Ailing Zhang, Yan Liang, Jie Hao, Xiaojian Zhang, Jingli Lu
BACKGROUND: For T1D patients, adding metformin to insulin therapies is thought to improve blood glucose levels, but current evidence does not support this clinical benefit. Additional data from large clinical trials are now available; therefore, we conducted a meta-analysis of studies on assessing the efficacy and adverse effects of metformin. METHODS: We searched the MEDLINE, EMBASE and Cochrane Library databases for data from randomized controlled trials (RCTs)...
January 19, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29351715/the-impact-of-migration-background-on-the-health-outcomes-of-preschool-children-linking-a-cross-sectional-survey-to-the-school-entrance-health-examination-database-in-bavaria-germany
#2
Thu Giang Le Thi, Annette Heißenhuber, Thomas Schneider, Rebekka Schulz, Caroline Eva Wella Herr, Uta Nennstiel-Ratzel, Gabriele Hölscher
AIM OF THE STUDY: This study investigated the impact of migration background on the health outcomes of preschool children from families of various social status levels. METHODS: During the school entrance health examination (Schuleingangsuntersuchung (SEU)) from October 2012 to August 2013, the parents of 5052 preschool children (62% response rate) participated in a cross-sectional health survey within the framework of health-monitoring units (Gesundheits-Monitoring-Einheiten (GME)) in Bavaria, Germany...
January 19, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29351709/-validation-of-the-screening-for-complex-ptsd-skptbs-revision
#3
Florence Dorr, Martin Sack, Jürgen Bengel
BACKGROUND: The aim was to develop further a screening instrument for complex posttraumatic stress disorder (cPTSD). The screening for cPTSD (SkPTBS) tests a) potential traumatic experiences, b) influential features and risk factors, and c) symptoms of cPTSD. The SkPTBS by Dorr et al. (2016) was revised according to the current ICD-11 criteria set proposal for cPTSD and is explored in its revised edition. METHOD: Impacts of long-lasting interpersonal trauma were tested in inpatients of psychosomatic rehabilitation and in patients consulting a university outpatient center for trauma therapy...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29351696/risk-of-primary-spontaneous-pneumothorax-according-to-chest-configuration
#4
Chul Hwan Park, MinDong Sung, Geun Dong Lee, Young Woo Do, Hee Min Park, Junu Kim, Jin Hur, Kyunghwa Han, Tae Hoon Kim, Jason Jungsik Song, Sungsoo Lee
BACKGROUND:  We compared the chest configurations of patients with primary spontaneous pneumothorax (PSP) and age-sex-matched controls to determine the presence of chest wall deformities in patients with PSP. METHODS:  We retrospectively enrolled 166 male patients with PSP (age, 18-19 years) and 85 age-sex-matched controls without PSP, who simultaneously underwent chest computed tomography (CT) and radiography at one of two institutes. After correcting for height, the following thoracic parameters were comparatively evaluated between the two groups: maximal internal transverse (T) and anteroposterior (W) diameters of the chest, maximal internal lung height (H), Haller index (T/W), and T/Height, T/H, W/Height, W/H, and H/Height ratios...
January 19, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29351695/reasons-for-failure-of-systemic-to-pulmonary-artery-shunts-in-neonates
#5
Keti Vitanova, Cornelius Leopold, Jelena Pabst von Ohain, Cordula Wolf, Elisabeth Beran, Rüdiger Lange, Julie Cleuziou
BACKGROUND:  Systemic-to-pulmonary artery shunt placement is an established palliative procedure for congenital heart disease. Although it is thought to be a simple operation, it is associated with significant morbidity and mortality. METHODS:  Data for all neonates who underwent surgery for a systemic-to-pulmonary artery shunt between 2000 and 2016 were reviewed. The study endpoints were shunt failure and shunt-related mortality. Shunt failure was defined as a shunt dysfunction because of thrombosis or stenosis requiring intervention or reoperation; shunt mortality was defined as death because of a shunt dysfunction...
January 19, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29351694/treatment-outcomes-for-right-sided-endocarditis-in-intravenous-drug-users-a-systematic-review-and-analysis-of-outcomes-in-a-tertiary-centre
#6
Karen Magsino, Rohan Sanjanwala, Brett Hiebert, Janet Rothney, Rizwan Manji, Rakesh Arora, Pallav Shah
BACKGROUND:  The increasing prevalence of intravenous drug users (IVDU) has resulted in higher incidence of right-sided infective endocarditis (RSIE). However, treatment guidelines for RSIE in IVDU are not well defined. The aim is to evaluate efficacy of different treatment strategies in reducing mortality and to describe treatment outcomes. METHODS:  We systematically reviewed the literature using PubMed, Cochrane, CENTRAL, OvidEMBASE, Web of Science, and Medline databases to include prospective studies that compare mortality rates among IVDU with RSIE receiving isolated medical treatment versus those receiving medical-surgical treatment...
January 19, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29351687/intraoperative-transpedicular-onyx-injection-to-reduce-vascularity-of-a-thoracic-hemangiopericytoma-after-unsuccessful-preoperative-endovascular-embolization-a-technical-report
#7
Hazem Mashaly, Zoe Zhang, Andrew Shaw, Patrick Youssef, Ehud Mendel
BACKGROUND AND IMPORTANCE: Hemangiopericytoma is a rare vascular tumor with central nervous system involvement representing only 1% of central nervous system tumors. They rarely affect the vertebral column. Complete surgical resection is the treatment of choice for hemangiopericytoma given their high rates of local recurrence. However, the high vascularity of such tumors with the risk of massive bleeding during surgery represents a significant challenge to surgeons. Therefore, preoperative endovascular embolization via the transarterial route has been advocated...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351683/novel-bilateral-extracavitary-approach-for-thoracolumbar-decompression
#8
Jeffrey P Mullin, Alvin Y Chan, Emily Bennett, Michael P Steinmetz
BACKGROUND: Bilateral extracavitary approach (BECA) is an option for decompression cases that require a more extended ventral approach. The clear advantage is increased accessibility to the most ventral aspects of the spine from a bilateral perspective. OBJECTIVE: To assess the safety and efficacy of thoracic and thoracolumbar decompression and/or reconstruction from BECA. METHODS: A retrospective chart review was performed reviewing all patients who underwent BECA for thoracolumbar decompression from 2003 to 2012 at our institution...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351677/use-of-risk-model-for-assessment-of-residents-perception-of-complexity-of-surgical-steps-example-of-modular-component-steps-of-lumbar-spinal-fusion-surgery
#9
Jeffrey S Raskin, Jesse J Liu, Katherine Holste, Sarah Brown, Fran Hardaway, Priscilla Pang, Ahmed M Raslan
BACKGROUND: Quality improvement projects increasingly emphasize standardization of surgical work flow to optimize operative room efficiency. Removing special cause variability resulting from nonsurgical waste is an obvious target; however, resident surgical education must be maintained, even in the setting of process improvement. OBJECTIVE: To describe the impact of resident-identified "risky" or "uncomfortable" procedural steps on operative time during transforaminal lumbar interbody fusion (TLIF)...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351673/the-barrow-neurological-institute-grading-scale-as-a-predictor-for-delayed-cerebral-ischemia-and-outcome-after-aneurysmal-subarachnoid-hemorrhage-data-from-a-nationwide-patient-registry-swiss-sos
#10
Marian Christoph Neidert, Nicolai Maldaner, Martin Nikolaus Stienen, Michel Roethlisberger, Daniel W Zumofen, Donato D'Alonzo, Serge Marbacher, Rodolfo Maduri, Isabel Charlotte Hostettler, Bawarjan Schatlo, Michel M Schneider, Martin A Seule, Daniel Schöni, Johannes Goldberg, Christian Fung, Marta Arrighi, Daniele Valsecchi, Philippe Bijlenga, Karl Schaller, Oliver Bozinov, Luca Regli, Jan-Karl Burkhardt
BACKGROUND: The Barrow Neurological Institute (BNI) scale is a novel quantitative scale measuring maximal subarachnoid hemorrhage (SAH) thickness to predict delayed cerebral ischemia (DCI). This scale could replace the Fisher score, which was traditionally used for DCI prediction. OBJECTIVE: To validate the BNI scale. METHODS: All patient data were obtained from the prospective aneurysmal SAH multicenter registry. In 1321 patients, demographic data, BNI scale, DCI, and modified Rankin Scale (mRS) score up to the 1-yr follow-up (1FU) were available for descriptive and univariate statistics...
January 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29351672/high-treatment-success-rate-among-multidrug-resistant-tuberculosis-patients-in-myanmar-2012-2014-a-retrospective-cohort-study
#11
Myat K Thu, Ajay M V Kumar, Kyaw T Soe, Saw Saw, Saw Thein, Zaw Mynit, Htet M W Maung, Si T Aung
Background: Since 2011, Myanmar has adopted domiciliary care for multidrug-resistant tuberculosis (MDR-TB) patients and implemented several patient-support measures such as community-based directly observed treatment, nutritional support and financial incentives for patients and providers. We assessed treatment outcomes among MDR-TB patients registered for treatment in the Yangon and Mandalay Regions of Myanmar during 2012-2014 and factors associated with unfavourable treatment outcomes...
January 17, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29351659/smoking-status-and-survival-among-a-national-cohort-of-lung-and-colorectal-cancer-patients
#12
Sandra J Japuntich, Pallavi Kumar, Jane Pendergast, Grelda Yazmin Juarez Caballero, Jennifer Malin, Robert Wallace, Elizabeth Chrischilles, Nancy L Keating, Elyse R Park
Introduction: The purpose of this study was to explore the association of smoking status and clinically relevant duration of smoking cessation with long-term survival after lung cancer (LC) or colorectal cancer (CRC) diagnosis. We compared survival of patients with LC and CRC who were never-smokers, long-term, medium-term, and short-term quitters, and current smokers around diagnosis. Methods: We studied 5,575 patients in Cancer Care Outcomes Research and Surveillance (CanCORS), a national, prospective observational cohort study, who provided smoking status information approximately 5 months after LC or CRC diagnosis...
January 17, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29351658/intensive-versus-conventional-blood-pressure-monitoring-in-a-general-practice-population-the-blood-pressure-reduction-in-danish-general-practice-trial-a-randomized-controlled-parallel-group-trial
#13
Pia Klarskov, Lia E Bang, Peter Schultz-Larsen, Hans Gregers Petersen, David Benee Olsen, Ronan M G Berg, Henrik Abrahamsen, Niels Wiinberg
Objective: To compare the effect of a conventional to an intensive blood pressure monitoring regimen on blood pressure in hypertensive patients in the general practice setting. Design: Randomized controlled parallel group trial with 12-month follow-up. Setting: One hundred and ten general practices in all regions of Denmark. Participants: One thousand forty-eight patients with essential hypertension. Intervention: Conventional blood pressure monitoring ('usual group') continued usual ad hoc blood pressure monitoring by office blood pressure measurements, while intensive blood pressure monitoring ('intensive group') supplemented this with frequent home blood pressure monitoring and 24-hour ambulatory blood pressure monitoring...
January 17, 2018: Family Practice
https://www.readbyqxmd.com/read/29351657/characterization-of-the-spatial-and-temporal-distribution-of-nipah-virus-spillover-events-in-bangladesh-2007-2013
#14
Maria C Cortes, Simon Cauchemez, Noemie Lefrancq, Stephen P Luby, M Jahangir Hossain, Hossain M S Sazzad, Mahmudur Rahman, Peter Daszak, Henrik Salje, Emily S Gurley
Nipah virus is a zoonotic virus, harbored by bats and lethal to humans. Bat to human spillovers occur every winter in Bangladesh. However, there is significant heterogeneity in the number of spillovers detected by district and year that remains unexplained. We analyzed data from all 57 spillovers from 2007-2013 and found that temperature differences explained 36% of the year-to-year variation in the total number of spillovers each winter while distance to surveillance hospitals explained 45% of spatial heterogeneity...
January 17, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29351648/transarterial-onyx-embolization-of-intracranial-dural-fistulas-a-prospective-cohort-systematic-review-and-meta-analysis
#15
Udi Sadeh-Gonike, Nicolas Magand, Xavier Armoiry, Roberto Riva, Paul Emile Labeyrie, Bernadette Lamy, Anne-Claire Lukaszewicz, Jean-Jacques Lehot, Francis Turjman, Benjamin Gory
BACKGROUND: Onyx is important embolic material in the endovascular treatment of intracranial dural arteriovenous fistula (DAVF). However, its impact on DAVF occlusion rates, morbidity, mortality, and complication rates is not fully examined. OBJECTIVE: To improve understanding of safety and effectiveness profiles associated with transarterial endovascular treatment using Onyx for intracranial DAVF. METHODS: We analyzed data from our prospective clinical registry and conducted a systematic review of all previous transarterial embolization studies using Onyx published between January 2005 and December 2015 in MEDLINE and EMBASE...
June 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29351646/effect-of-a-postpartum-training-program-on-prevalence-of-diastasis-recti-abdominis-in-postpartum-primiparous-women-a-randomized-controlled-trial
#16
Sandra L Gluppe, Gunvor Hilde, Merete K Tennfjord, Marie E Engh, Kari Bø
Background: Diastasis recti abdominis affects a significant number of women during the prenatal and postnatal period. Objective: The objective was to evaluate the effect of a postpartum training program on prevalence of diastasis recti abdominis. Design: The design was a secondary analysis of an assessor-masked randomized controlled trial. Methods: One hundred and seventy-five primiparous women (mean age 29.8±4.1) were randomized to an exercise or control group...
January 17, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29351645/dosimetry-during-percutaneous-coronary-interventions-of-chronic-total-occlusions
#17
Jérémie Dabin, Joren Maeremans, Danielle Berus, Werner Schoonjans, Giulia Tamborino, Jo Dens, Peter Kayaert
Percutaneous coronary interventions (PCI) of coronary chronic total occlusions (CTO) increase the risk of high radiation exposure for both the patient and the cardiologist. This study evaluated the maximum dose to the patients' skin (MSD) and the exposure of the cardiologists during CTO-PCI. Moreover, the efficiency of radioprotective drapes to reduce cardiologist exposure was assessed. Patient dose was measured during 31 procedures; dose to the cardiologist's extremities were measured during 65 procedures, among which 31 were performed with radioprotective drapes...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29351642/caregiver-provided-physical-therapy-home-programs-for-children-with-motor-delay-a-scoping-review
#18
Edward James R Gorgon
Background: Caregiver-provided physical therapy home programs (PTHP) play an important role in enhancing motor outcomes in pediatric patient populations. Purpose: This scoping review systematically mapped clinical trials of caregiver-provided PTHP that were aimed at enhancing motor outcomes in children who have or who are at risk for motor delay, with the purpose of (1) describing trial characteristics; (2) assessing methodologic quality, and (3) examining the reporting of caregiver-related components...
January 17, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29351636/effectiveness-of-respiratory-syncytial-virus-immunoprophylaxis-on-bronchiolitis-hospitalizations-among-high-risk-infants
#19
Pingsheng Wu, Gabriel J Escobar, Tebeb Gebretsadik, Kecia N Carroll, Sherian X Li, Eileen M Walsh, Edward F Mitchel, Chantel Sloan, William D Dupont, Chang Yu, Jeffrey R Horner, Tina V Hartert
We sought to determine the real-world effectiveness of respiratory syncytial virus (RSV) immunoprophylaxis in a population-based cohort to inform policy. The study population included infants born 1996-2008 and enrolled in Kaiser Permanente Northern California. During the RSV season (November-March), RSV immunoprophylaxis administration and the following 30 days were defined as RSV immunoprophylaxis protected period(s), and all other days as unprotected period(s). Bronchiolitis hospitalizations were determined using the International Classification of Diseases Ninth Revision codes during RSV season...
January 17, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29351632/presenteeism-in-academic-employees-occupational-and-individual-factors
#20
G Kinman, S Wray
Background: There is growing evidence that presenteeism can be damaging for individuals and organizations. It is, therefore, important to identify the prevalence of working while sick in different working environments and the factors that contribute to such behaviour. Aims: To examine the prevalence of self-reported presenteeism in academic staff working in UK universities and colleges and the extent to which job demands, control, support and work engagement are risk factors...
January 17, 2018: Occupational Medicine
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