keyword
MENU ▼
Read by QxMD icon Read
search

T cells

keyword
https://www.readbyqxmd.com/read/28239930/secondary-cutaneous-peripheral-t-cell-lymphoma-unspecified-with-generalized-benign-looking-dermatitis-a-possibly-distinct-peripheral-t-cell-lymphoma
#1
Woo Jin Lee, Hyun Ji Kang, Chong Hyun Won, Sung Eun Chang, Jee Ho Choi, Mi Woo Lee
BACKGROUND: Cutaneous lymphomas are a heterogeneous group of tumors with various clinical manifestations, histological features, and prognoses. METHODS: Among 425 cases of cutaneous lymphoma, we describe eight cases of peripheral T-cell lymphoma, unspecified, presenting with generalized benign-looking dermatitis. RESULTS: Our case series included eight cases of secondary cutaneous peripheral T-cell lymphoma, unspecified. The observed clinical morphology features included drug eruption-like generalized morbilliform maculopatches in two cases, generalized folliculitis-like papules in two cases, and generalized eczematous dermatitis-like papules and patches in four cases...
February 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28239926/documenting-dna-in-the-dust
#2
M T P Gilbert
I bought a robotic vacuum cleaner this summer and set it to work. Although my initial expectations were not high, my robot (christened Buddy) finished its cleaning cycle, and then insistently demanded that I empty its dust collection box. As I took the box out, my jaw dropped. I live in a modern house, we don't have pets, and I like to think that I keep it reasonably dust free. But, there was much dust in that box. And when I ran it again 2 days later, the same thing happened. And indeed, every 2 days, Buddy dutifully goes to work, and sucks up a similarly impressive quantity...
February 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28239912/verrucae-planae-within-previous-xenograft-sites-of-burn-wounds
#3
Olivia Chen, Michelle Vernali Pearlstein, Dean S Morrell, Sarah B Corley
Burn injuries are known to compromise host immune defenses through disruption of mucocutaneous barriers and suppression of cell-mediated immune responses, which may render patients with burn injuries susceptible to viral infections in the days to years after an initial insult. We report a case of verrucae planae developing as a secondary condition confined to former xenograft sites in a child, appearing more than 3.5 years after initial second-degree burn injuries. Only a few reports have previously described the development of verrucae in former burn sites, with most reporting latency to onset of verrucae appearance of months rather than years...
February 27, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28239901/molecular-prevalence-of-merkel-cell-polyomavirus-in-nonmelanoma-skin-cancer-in-a-brazilian-population
#4
T R Bellott, C F Baez, S G Almeida, M T Venceslau, M G Zalis, M A Guimarães, M C Rochael, F B Luz, R B Varella, J R Almeida
BACKGROUND: Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than Merkel cell carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on the development of these tumours and its prevalence in various populations. AIM: To assess the prevalence of MCPyV DNA in cases of nonmelanoma skin cancer (NMSC). METHODS: The prevalence of MCPyV DNA was assessed in 96 cases of NMSC in a Brazilian population comprising 76 subjects, and these results were correlated with epidemiological and demographical data...
February 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28239829/comparison-of-anterior-segment-parameter-values-obtained-with-scheimpflug-placido-topographer-optical-low-coherence-reflectometry-and-noncontact-specular-microscopy-in-morbid-obesity
#5
B Dogan, U Dogan, M K Erol, M Habibi, M T Oruc
OBJECTIVE: To investigate the measurement of anterior segment parameters using Sirius Scheimpflug-Placido topographer, Lenstar optical low coherence reflectometry (OLCR), and noncontact specular microscopy (SM) in morbidly obese and nonobese subjects. PATIENTS AND METHODS: Twenty-eight morbidly obese subjects (BMI ≥ 40; Group 1) and 28 age- sex-matched healthy nonobese subjects (BMI 18.50-24.99; Group 2) were included in this study. Anterior segment parameters were measured by Scheimpflug-Placido topographer and OLCR...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239819/mir-137-and-its-target-tgfa-modulate-cell-growth-and-tumorigenesis-of-non-small-cell-lung-cancer
#6
X Liu, L Chen, X-D Tian, T Zhang
OBJECTIVE: MiR-137 has been reported to serve as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the potential mechanism remains largely unclear. The present study aimed to explore the potential molecular mechanisms by which miR-137 regulated NSCLC. MATERIALS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to quantify the expression levels of miR-137 in NSCLC tissues and cell lines. Dual-luciferase reporter assay was employed to confirm the specificity of miR-137 target genes...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239798/effect-of-fibroblast-like-cells-of-mesenchymal-origin-of-cytotoxic-activity-of-lymphocytes-against-nk-sensitive-target-cells
#7
A Yu Lupatov, Ya S Kim, O A Bystrykh, I V Vakhrushev, S V Pavlovich, K N Yarygin, G T Sukhikh
We studied immunosuppressive properties of skin fibroblasts and mesenchymal stromal cells against NK cells. In vitro experiments showed that mesenchymal stromal cells isolated from human umbilical cord and human skin fibroblasts can considerably attenuate cytotoxic activity of NK cells against Jurkat cells sensitive to NK-mediated lysis. NK cells cultured in lymphocyte population exhibited higher cytotoxic activity than isolated NK cells. Mesenchymal stromal cells or fibroblasts added 1:1 to lymphocyte culture almost completely suppressed NK cell cytotoxicity...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239788/expression-of-surface-molecules-in-human-mesenchymal-stromal-cells-co-cultured-with-nucleated-umbilical-cord-blood-cells
#8
Yu A Romanov, E E Balashova, N E Volgina, N V Kabaeva, T N Dugina, G T Sukhikh
We studied the expression of different classes of surface molecules (CD13, CD29, CD40, CD44, CD54, CD71, CD73, CD80, CD86, CD90, CD105, CD106, CD146, HLA-I, and HLA-DR) in mesenchymal stromal cells from human umbilical cord and bone marrow during co-culturing with nucleated umbilical cord blood cells. Expression of the majority of surface markers in both types of mesenchymal stromal cells was stable and did not depend on the presence of the blood cells. Significant differences were found only for cell adhesion molecules CD54 (ICAM-1) and CD106 (VCAM-1) responsible for direct cell-cell contacts with leukocytes and only for bone marrow derived cells...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239783/effect-of-thp-1-cells-on-the-formation-of-vascular-tubes-by-endothelial-ea-hy926-cells-in-the-presence-of-placenta-secretory-products
#9
T Yu Lvova, K L Belyakova, S A Sel'kov, D I Sokolov
We studied the effect of THP-1 cells on the formation of vessel-like structures by endothelial cells in the presence of placenta-conditioned media. Addition of THP-1 cells to endothelial cells cultured in the presence of media conditioned by first-trimester placentas led to an increase in the length of cell tubes and reduced their number in comparison with endothelial cell monoculture. In the presence of media conditioned by third-trimester placentas, THP-1 cells did not affect the length and number of cell tubes formed by endothelial cells...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239749/interleukin-21-inhibits-cancer-mediated-foxp3-induction-in-na%C3%A3-ve-human-cd4-t-cells
#10
Vinodh Kannappan, Kate Butcher, Malgorzata Trela, Iain Nicholl, Weiguang Wang, Kesley Attridge
IL-21 is known to promote anti-tumour immunity due to its ability to promote T cell responses and counteract Treg-mediated suppression. It has also been shown to limit Treg frequencies during tumour-antigen stimulations. However, whether this represents inhibition of FOXP3 induction in naïve CD4 T cells or curtailed expansion of natural Treg remains unclear. Moreover, whether this effect is maintained in an environment of tumour-derived immunosuppressive factors is not known. Here, we show that in the context of a number of cancers, naïve CD45RA+ CD4 T cells are induced to express high levels of FOXP3, and that FOXP3 expression correlates with inhibition of T cell proliferation...
February 27, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28239687/protein-phosphatase-5-contributes-to-the-overexpression-of-epigenetically-regulated-t-lymphocyte-genes-in-patients-with-lupus
#11
D Patel, G Gorelik, B Richardson
OBJECTIVE: Lupus develops when genetically predisposed people encounter certain drugs or environmental agents causing oxidative stress such as infections and sun exposure, and then typically follows a chronic relapsing course with flares triggered by the exogenous stressors. Current evidence indicates that these environmental agents can trigger lupus flares by inhibiting the replication of DNA methylation patterns during mitosis in CD4(+) T cells, altering the expression of genes suppressed by this mechanism that convert normal "helper" cells into auto reactive cells which promote lupus flares...
December 2016: Lupus (Los Angel)
https://www.readbyqxmd.com/read/28239679/adenovirus-serotype-5-vaccine-vectors-trigger-il-27-dependent-inhibitory-cd4-t-cell-responses-that-impair-cd8-t-cell-function
#12
Rafael A Larocca, Nicholas M Provine, Malika Aid, M Justin Iampietro, Erica N Borducchi, Alexander Badamchi-Zadeh, Peter Abbink, David Ng'ang'a, Christine A Bricault, Eryn Blass, Pablo Penaloza-MacMaster, Kathryn E Stephenson, Dan H Barouch
Adenovirus serotype 5 (Ad5) vaccine vectors elicit robust CD8(+) T cell responses, but these responses typically exhibit a partially exhausted phenotype. However, the immunologic mechanism by which Ad5 vectors induce dysfunctional CD8(+) T cells has not previously been elucidated. Here we demonstrate that, following immunization of B6 mice, Ad5 vectors elicit antigen-specific IL-10(+)CD4(+) T cells with a distinct transcriptional profile in a dose-dependent fashion. In rhesus monkeys, we similarly observed upregulated expression of IL-10 and PD-1 by CD4(+) T cells following Ad5 vaccination...
November 2016: Science Immunology
https://www.readbyqxmd.com/read/28239678/bidirectional-intragraft-alloreactivity-drives-the-repopulation-of-human-intestinal-allografts-and-correlates-with-clinical-outcome
#13
Julien Zuber, Brittany Shonts, Sai-Ping Lau, Aleksandar Obradovic, Jianing Fu, Suxiao Yang, Marion Lambert, Shana Coley, Joshua Weiner, Joseph Thome, Susan DeWolf, Donna L Farber, Yufeng Shen, Sophie Caillat-Zucman, Govind Bhagat, Adam Griesemer, Mercedes Martinez, Tomoaki Kato, Megan Sykes
A paradigm in transplantation states that graft-infiltrating T cells are largely non-alloreactive "bystander" cells. However, the origin and specificity of allograft T cells over time has not been investigated in detail in animals or humans. Here, we use polychromatic flow cytometry and high throughput TCR sequencing of serial biopsies to show that gut-resident T cell turnover kinetics in human intestinal allografts are correlated with the balance between intra-graft host-vs-graft (HvG) and graft-vs-host (GvH) reactivities and with clinical outcomes...
October 2016: Science Immunology
https://www.readbyqxmd.com/read/28239658/loss-of-immune-homeostasis-dictates-shiv-rebound-after-stem-cell-transplantation
#14
Christopher W Peterson, Clarisse Benne, Patricia Polacino, Jasbir Kaur, Cristina E McAllister, Abdelali Filali-Mouhim, Willi Obenza, Tiffany A Pecor, Meei-Li Huang, Audrey Baldessari, Robert D Murnane, Ann E Woolfrey, Keith R Jerome, Shiu-Lok Hu, Nichole R Klatt, Stephen DeRosa, Rafick P Sékaly, Hans-Peter Kiem
The conditioning regimen used as part of the Berlin patient's hematopoietic cell transplant likely contributed to his eradication of HIV infection. We studied the impact of conditioning in simian-human immunodeficiency virus-infected (SHIV-infected) macaques suppressed by combination antiretroviral therapy (cART). The conditioning regimen resulted in a dramatic, but incomplete depletion of CD4(+) and CD8(+) T cells and CD20(+) B cells, increased T cell activation and exhaustion, and a significant loss of SHIV-specific Abs...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239657/tissue-resident-macrophages-can-contain-replication-competent-virus-in-antiretroviral-naive-siv-infected-asian-macaques
#15
Sarah R DiNapoli, Alexandra M Ortiz, Fan Wu, Kenta Matsuda, Homer L Twigg, Vanessa M Hirsch, Kenneth Knox, Jason M Brenchley
SIV DNA can be detected in lymphoid tissue-resident macrophages of chronically SIV-infected Asian macaques. These macrophages also contain evidence of recently phagocytosed SIV-infected CD4(+) T cells. Here, we examine whether these macrophages contain replication-competent virus, whether viral DNA can be detected in tissue-resident macrophages from antiretroviral (ARV) therapy-treated animals and humans, and how the viral sequences amplified from macrophages and contemporaneous CD4(+) T cells compare. In ARV-naive animals, we find that lymphoid tissue-resident macrophages contain replication-competent virus if they also contain viral DNA in ARV-naive Asian macaques...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239656/autoreactive-helper-t-cells-alleviate-the-need-for-intrinsic-tlr-signaling-in-autoreactive-b-cell-activation
#16
Josephine R Giles, Adriana Turqueti Neves, Ann Marshak-Rothstein, Mark J Shlomchik
T cells play a significant role in the pathogenesis of systemic autoimmune diseases, including systemic lupus erythematosus; however, there is relatively little information on the nature and specificity of autoreactive T cells. Identifying such cells has been technically difficult because they are likely to be rare and low affinity. Here, we report a method for identifying autoreactive T cell clones that recognize proteins contained in autoantibody immune complexes, providing direct evidence that functional autoreactive helper T cells exist in the periphery of normal mice...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239654/flow-virometric-sorting-and-analysis-of-hiv-quasispecies-from-plasma
#17
Thomas Musich, Jennifer C Jones, Brandon F Keele, Lisa M Miller Jenkins, Thorsten Demberg, Thomas S Uldrick, Robert Yarchoan, Marjorie Robert-Guroff
Flow cytometry is utilized extensively for cellular analysis, but technical limitations have prevented its routine application for characterizing virus. The recent introduction of nanoscale fluorescence-activated cytometric cell sorting now allows analysis of individual virions. Here, we demonstrate staining and sorting of infectious HIV. Fluorescent antibodies specific for cellular molecules found on budding virions were used to label CCR5-tropic Bal HIV and CXCR4-tropic NL4.3 HIV Env-expressing pseudovirions made in THP-1 cells (monocyte/macrophage) and H9 cells (T cells), respectively...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239647/enhanced-fcgr2a-and-fcgr3a-signaling-by-hiv-viremic-controller-igg
#18
Raymond A Alvarez, Ana M Maestre, Kenneth Law, Natasha D Durham, Maria Ines Barria, Akiko Ishii-Watabe, Minoru Tada, Manav Kapoor, Mathew T Hotta, Gabriela Rodriguez-Caprio, Daniel S Fierer, Ana Fernandez-Sesma, Viviana Simon, Benjamin K Chen
HIV-1 viremic controllers (VC) spontaneously control infection without antiretroviral treatment. Several studies indicate that IgG Abs from VCs induce enhanced responses from immune effector cells. Since signaling through Fc-γ receptors (FCGRs) modulate these Ab-driven responses, here we examine if enhanced FCGR activation is a common feature of IgG from VCs. Using an infected cell-based system, we observed that VC IgG stimulated greater FCGR2A and FCGR3A activation as compared with noncontrollers, independent of the magnitude of HIV-specific Ab binding or virus neutralization activities...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239619/evaluation-of-cross-presentation-in-bone-marrow-derived-dendritic-cells-in-vitro-and-splenic-dendritic-cells-ex-vivo-using-antigen-coated-beads
#19
Andrés Alloatti, Fiorella Kotsias, Eik Hoffmann, Sebastian Amigorena
Antigen presentation by MHC class I molecules, also referred to as cross-presentation, elicits cytotoxic immune responses. In particular, dendritic cells (DC) are the most proficient cross-presenting cells, since they have developed unique means to control phagocytic and degradative pathways. This protocol allows the evaluation of antigen cross-presentation both in vitro (by using bone marrow-derived DC) and ex vivo (by purifying CD8(+) DC from spleen after incorporation of particulate antigen) using ovalbumin (OVA)-coupled particles...
November 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28239502/immunooncology-can-the-right-chimeric-antigen-receptors-t-cell-design-be-made-to-cure-all-types-of-cancers-and-will-it-be-covered
#20
REVIEW
Regina Au
Immunooncology (IO) is the buzz word today and it has everyone doing IO research. If we look back at the history of cancer treatment, the survival rate was measured in months which, according to oncologists, was a lot back then because the mortality rate in most cancers was 100%. However, most traditional chemotherapies were not well tolerated because they would kill both cancerous and healthy cells, which lead to major side effects such as loss of hair, nausea and vomiting, and risk of infection. Survival was better but not much better depending on the type of cancer and the patient's own genetic and physiological make-up...
2017: Journal of Pharmaceutics
keyword
keyword
10360
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"