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Mesenchymal stem cell incontinence

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https://www.readbyqxmd.com/read/27855713/microrna-29-facilitates-transplantation-of-bone-marrow-derived-mesenchymal-stem-cells-to-alleviate-pelvic-floor-dysfunction-by-repressing-elastin
#1
Minfei Jin, Yuelin Wu, Jun Wang, Weiping Ye, Lei Wang, Peipei Yin, Wei Liu, Chenhao Pan, Xiaolin Hua
BACKGROUND: Pelvic floor dysfunction (PFD) is a condition affecting many women worldwide, with symptoms including stress urinary incontinence (SUI) and pelvic organ prolapse (POP). We have previously demonstrated stable elastin-expressing bone marrow-derived mesenchymal stem cells (BMSCs) attenuated PFD in rats, and aim to further study the effect of microRNA-29a-3p regulation on elastin expression and efficacy of BMSC transplantation therapy. METHODS: We inhibited endogenous microRNA-29a-3p in BMSCs and investigated its effect on elastin expression by RT-PCR and Western blot...
November 17, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27741564/the-anatomy-of-caprine-female-urethra-and-characteristics-of-muscle-and-bone-marrow-derived-caprine-cells-for-autologous-cell-therapy-testing
#2
A Burdzinska, B Dybowski, W Zarychta-Wisniewska, A Kulesza, R Zagozdzon, Z Gajewski, L Paczek
Cell therapy is emerging as an alternative treatment of stress urinary incontinence. However, many aspects of the procedure require further optimization. A large animal model is needed to reliably test cell delivery methods. In this study we aim to determine suitability of the goat as an experimental animal for testing intraurethral autologous cell transplantation in terms of urethral anatomy and cell culture parameters. The experiments were performed in 12 mature/aged female goats. Isolated caprine muscle derived cells (MDC) were myogenic in vitro and mesenchymal stem cells (MSC) population was able to differentiate into adipo-, osteo- and chondrogenic lineages...
October 14, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27631002/applications-of-chondrocyte-based-cartilage-engineering-an-overview
#3
REVIEW
Abdul-Rehman Phull, Seong-Hui Eo, Qamar Abbas, Madiha Ahmed, Song Ja Kim
Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and transcriptional factors regulate the mesenchymal stem cells (MSCs) differentiation to chondrocytes. The number of chondrocytes and dedifferentiation are the key limitations in subsequent clinical application of the chondrocytes. Different culture methods are being developed to overcome such issues. Using tissue engineering and cell based approaches, chondrocytes offer prominent therapeutic option specifically in orthopedics for cartilage repair and to treat ailments such as tracheal defects, facial reconstruction, and urinary incontinence...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27331440/glioproliferative-lesion-of-the-spinal-cord-as-a-complication-of-stem-cell-tourism
#4
LETTER
Aaron L Berkowitz, Michael B Miller, Saad A Mir, Daniel Cagney, Vamsidhar Chavakula, Indira Guleria, Ayal Aizer, Keith L Ligon, John H Chi
No abstract text is available yet for this article.
July 14, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27328811/local-injection-of-bone-marrow-progenitor-cells-for-the-treatment-of-anal-sphincter-injury-in-vitro-expanded-versus-minimally-manipulated-cells
#5
Benedetta Mazzanti, Bruno Lorenzi, Annalisa Borghini, Margherita Boieri, Lara Ballerini, Riccardo Saccardi, Elisabetta Weber, Federica Pessina
BACKGROUND: Anal incontinence is a disabling condition that adversely affects the quality of life of a large number of patients, mainly with anal sphincter lesions. In a previous experimental work, in-vitro expanded bone marrow (BM)-derived mesenchymal stem cells (MSC) were demonstrated to enhance sphincter healing after injury and primary repair in a rat preclinical model. In the present article we investigated whether unexpanded BM mononuclear cells (MNC) may also be effective. METHODS: Thirty-two rats, divided into groups, underwent sphincterotomy and repair (SR) with primary suture of anal sphincters plus intrasphincteric injection of saline (CTR), or of in-vitro expanded MSC, or of minimally manipulated MNC; moreover, the fourth group underwent sham operation...
2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27311602/regenerative-medicine-provides-alternative-strategies-for-the-treatment-of-anal-incontinence
#6
Søren Gräs, Cæcilie Krogsgaard Tolstrup, Gunnar Lose
INTRODUCTION AND HYPOTHESIS: Anal incontinence is a common disorder but current treatment modalities are not ideal and the development of new treatments is needed. The aim of this review was to identify the existing knowledge of regenerative medicine strategies in the form of cellular therapies or bioengineering as a treatment for anal incontinence caused by anal sphincter defects. METHODS: PubMed was searched for preclinical and clinical studies in English published from January 2005 to January 2016...
June 16, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27306130/regenerative-medicine-techniques-and-methods-of-administering-autologous-derived-stem-cells-in-urinary-incontinence
#7
Klaudia Stangel-Wojcikiewicz, Maciej Petko, Konrad Kobus, Marcin Majka, Tomasz Gołąbek, Piotr Chłosta, Antoni Basta
The aim of the work is to present regenerative medicine achievement as an alternative SUI treatment and the variety of injected cells type as well as injection techniques itself with the analysis of their quality and possible the mechanism in which they reduce urinary incontinence symptoms. For over a decade numerous authors declare use of different type of autologous mesenchymal-derived stem cells (AMDC) in male and female SUI. The leakage improvement reached 80%, despite the number of injected cells as well as the injection technique...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27247705/endometrial-mesenchymal-stem-cells-as-a-cell-based-therapy-for-pelvic-organ-prolapse
#8
REVIEW
Stuart J Emmerson, Caroline E Gargett
Pelvic organ prolapse (POP) occurs when the pelvic organs (bladder, bowel or uterus) herniate into the vagina, causing incontinence, voiding, bowel and sexual dysfunction, negatively impacting upon a woman's quality of life. POP affects 25% of all women and results from childbirth injury. For 19% of all women, surgical reconstructive surgery is required for treatment, often augmented with surgical mesh. The surgical treatment fails in up to 30% of cases or results in adverse effects, such as pain and mesh erosion into the bladder, bowel or vagina...
May 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/27141455/clinical-applications-of-low-intensity-pulsed-ultrasound-and-its-potential-role-in-urology
#9
REVIEW
Zhongcheng Xin, Guiting Lin, Hongen Lei, Tom F Lue, Yinglu Guo
Low-intensity pulsed ultrasound (LIPUS) is a form of ultrasound that delivered at a much lower intensity (<3 W/cm(2)) than traditional ultrasound energy and output in the mode of pulse wave, and it is typically used for therapeutic purpose in rehabilitation medicine. LIPUS has minimal thermal effects due to its low intensity and pulsed output mode, and its non-thermal effects which is normally claimed to induce therapeutic changes in tissues attract most researchers' attentions. LIPUS have been demonstrated to have a rage of biological effects on tissues, including promoting bone-fracture healing, accelerating soft-tissue regeneration, inhibiting inflammatory responses and so on...
April 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27097800/local-release-from-affinity-based-polymers-increases-urethral-concentration-of-the-stem-cell-chemokine-ccl7-in-rats
#10
Edgardo Rivera-Delgado, Zhina Sadeghi, Nick X Wang, Jonathan Kenyon, Sapna Satyanarayan, Michael Kavran, Chris Flask, Adonis Z Hijaz, Horst A von Recum
The protein chemokine (C-C motif) ligand 7 (CCL7) is significantly over-expressed in urethral and vaginal tissues immediately following vaginal distention in a rat model of stress urinary incontinence. Further evidence, in this scenario and other clinical scenarios, indicates CCL7 stimulates stem cell homing for regenerative repair. This CCL7 gradient is likely absent or compromised in the natural repair process of women who continue to suffer from SUI into advanced age. We evaluated the feasibility of locally providing this missing CCL7 gradient by means of an affinity-based implantable polymer...
April 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27048404/transplantation-of-bone-marrow-derived-mesenchymal-stem-cells-expressing-elastin-alleviates-pelvic-floor-dysfunction
#11
Minfei Jin, Ying Chen, Yun Zhou, Yan Mei, Wei Liu, Chenhao Pan, Xiaolin Hua
BACKGROUND: Pelvic floor dysfunction (PFD) is a group of clinical conditions including stress urinary incontinence (SUI) and pelvic organ prolapse (POP). The abnormality of collagen and elastin metabolism in pelvic connective tissues is implicated in SUI and POP. METHODS: To reconstitute the connective tissues with normal distribution of collagen and elastin, we transduced elastin to bone marrow-derived mesenchymal stem cells (BMSC). Elastin-expressing BMSCs were then differentiated to fibroblasts using bFGF, which produced collagen and elastin...
2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/26888731/treatment-of-faecal-incontinence-using-allogeneic-adipose-derived-mesenchymal-stem-cells-a-study-protocol-for-a-pilot-randomised-controlled-trial
#12
Eun Jung Park, Jeonghyun Kang, Seung Hyuk Baik
INTRODUCTION: Faecal incontinence is a distressing condition with recurrent uncontrolled passage of faecal material. Although faecal incontinence may cause psychological depression and social isolation, previous treatments have been limited. Recently, regenerative treatment has been developed using mesenchymal stem cells. Especially, there are possibilities that adipose-tissue-derived stem cells can be effective to treat a degenerated anal sphincter that is causing faecal incontinence...
2016: BMJ Open
https://www.readbyqxmd.com/read/26785911/smooth-muscle-precursor-cells-derived-from-human-pluripotent-stem-cells-for-treatment-of-stress-urinary-incontinence
#13
Zhe Wang, Yan Wen, Yan Hui Li, Yi Wei, Morgaine Green, Prachi Wani, Pengbo Zhang, Renee Reijo Pera, Bertha Chen
There is great interest in using stem cells (SC) to regenerate a deficient urethral sphincter in patients with urinary incontinence. The smooth muscle component of the sphincter is a significant contributor to sphincter function. However, current translational efforts for sphincter muscle restoration focus only on skeletal muscle regeneration because they rely on adult mesenchymal SC as cell source. These adult SC do not yield sufficient smooth muscle cells (SMCs) for transplantation. We may be able to overcome this limitation by using pluripotent stem cell (PSC) to derive SMCs...
March 15, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/26439006/delivery-of-human-mesenchymal-adipose-derived-stem-cells-restores-multiple-urological-dysfunctions-in-a-rat-model-mimicking-radical-prostatectomy-damages-through-tissue-specific-paracrine-mechanisms
#14
René Yiou, Meriem Mahrouf-Yorgov, Céline Trébeau, Marc Zanaty, Cécile Lecointe, Richard Souktani, Patricia Zadigue, Florence Figeac, Anne-Marie Rodriguez
Urinary incontinence (UI) and erectile dysfunction (ED) are the most common functional urological disorders and the main sequels of radical prostatectomy (RP) for prostate cancer. Mesenchymal stem cell (MSC) therapy holds promise for repairing tissue damage due to RP. Because animal studies accurately replicating post-RP clinical UI and ED are lacking, little is known about the mechanisms underlying the urological benefits of MSC in this setting. To determine whether and by which mechanisms MSC can repair damages to both striated urethral sphincter (SUS) and penis in the same animal, we delivered human multipotent adipose stem cells, used as MSC model, in an immunocompetent rat model replicating post-RP UI and ED...
February 2016: Stem Cells
https://www.readbyqxmd.com/read/26025492/bone-marrow-mesenchymal-stem-cell-therapy-for-voiding-dysfunction
#15
REVIEW
Alice Yu, Lysanne Campeau
Lower urinary tract symptoms can significantly impact quality of life. Current standard treatments are not always effective and are associated with complications and side effects. The discovery of stem cells led to research into cell-based therapies for treatment of disorders of voiding dysfunction. Bone marrow mesenchymal stem cells are particularly promising given their ability to differentiate into a variety of cell types. Recent studies have investigated bone marrow stem cells to treat a number of functional voiding pathologies including bladder outlet obstruction, neurogenic bladder, and stress urinary incontinence...
July 2015: Current Urology Reports
https://www.readbyqxmd.com/read/25911465/placental-mesenchymal-stromal-cells-rescue-ambulation-in-ovine-myelomeningocele
#16
Aijun Wang, Erin G Brown, Lee Lankford, Benjamin A Keller, Christopher D Pivetti, Nicole A Sitkin, Michael S Beattie, Jacqueline C Bresnahan, Diana L Farmer
UNLABELLED: Myelomeningocele (MMC)-commonly known as spina bifida-is a congenital birth defect that causes lifelong paralysis, incontinence, musculoskeletal deformities, and severe cognitive disabilities. The recent landmark Management of Myelomeningocele Study (MOMS) demonstrated for the first time in humans that in utero surgical repair of the MMC defect improves lower limb motor function, suggesting a capacity for improved neurologic outcomes in this disorder. However, functional recovery was incomplete, and 58% of the treated children were unable to walk independently at 30 months of age...
June 2015: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/25789845/cell-therapy-for-stress-urinary-incontinence
#17
REVIEW
Melanie L Hart, Ander Izeta, Bernardo Herrera-Imbroda, Bastian Amend, Jan E Brinchmann
Urinary incontinence (UI) is the involuntary loss of urine and is a common condition in middle-aged and elderly women and men. Stress urinary incontinence (SUI) is caused by leakage of urine when coughing, sneezing, laughing, lifting, and exercise, even standing leads to increased intra-abdominal pressure. Other types of UI also exist such as urge incontinence (also called overactive bladder), which is a strong and unexpected sudden urge to urinate, mixed forms of UI that result in symptoms of both urge and stress incontinence, and functional incontinence caused by reduced mobility, cognitive impairment, or neuromuscular limitations that impair mobility or dexterity...
August 2015: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/25642292/the-potential-role-of-stem-cells-in-the-treatment-of-urinary-incontinence
#18
REVIEW
Christine Tran, Margot S Damaser
Voiding dysfunction encompasses a wide range of urologic disorders including stress urinary incontinence and overactive bladder that have a detrimental impact on the quality of life of millions of men and women worldwide. In recent years, we have greatly expanded our understanding of the pathophysiology of these clinical conditions. However, current gold standard therapies often provide symptomatic relief without targeting the underlying etiology of disease development. Recently, the use of stem cells to halt disease progression and reverse underlying pathology has emerged as a promising method to restore normal voiding function...
February 2015: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/25608017/regeneration-of-degenerated-urinary-sphincter-muscles-improved-stem-cell-based-therapies-and-novel-imaging-technologies
#19
REVIEW
Bastian Amend, Martin Vaegler, Kerstin Fuchs, Julia G Mannheim, Susanne Will, Ulrich Kramer, Melanie L Hart, Wouter Feitz, Christopher Chapple, Arnulf Stenzl, Wilhelm K Aicher
Stress urinary incontinence (SUI) is a largely ousted but significant medical, social, and economic problem. Surveys suggest that nowadays approximately 10% of the male and 15% of the female population suffer from urinary incontinence at some stage in their lifetime. In women, two major etiologies contribute to SUI: degeneration of the urethral sphincter muscle controlling the closing mechanism of the bladder outflow and changes in lower pelvic organ position associated with degeneration of connective tissue or with mechanical stress, including obesity and load and tissue injury during pregnancy and delivery...
2015: Cell Transplantation
https://www.readbyqxmd.com/read/25453258/virus-integration-and-genome-influence-in-approaches-to-stem-cell-based-therapy-for-andro-urology
#20
REVIEW
Longkun Li, Deying Zhang, Peng Li, Margot Damaser, Yuanyuan Zhang
Despite the potential of stem cells in cell-based therapy, major limitations such as cell retention, ingrowth, and trans-differentiation after implantation remain. One technique for genetic modification of cells for tissue repair is the introduction of specific genes using molecular biology techniques, such as virus integration, to provide a gene that adds new functions to enhance cellular function, and to secrete trophic factors for recruiting resident cells to participate in tissue repair. Stem cells can be labeled to track cell survival, migration, and lineage...
March 2015: Advanced Drug Delivery Reviews
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