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Noise induce hearing loss

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https://www.readbyqxmd.com/read/28723602/tinnitus-anxiety-depression-and-substance-abuse-in-rock-musicians-a-norwegian-survey
#1
Carl Christian Lein Stormer, Tore Sorlie, Niels Christian Stenklev
OBJECTIVE: Rock musicians are known to have an increased prevalence of hearing loss and tinnitus. The aims of the present study were to examine the distribution of anxiety and depression symptoms among rock musicians with or without tinnitus and how these mental health indicators and internal locus of control influenced upon their tinnitus symptom concerns and the degree to which the tinnitus affected their lives. DESIGN: The study was a questionnairebased cross-sectional survey of subjects selected from a cohort of rock musicians...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28716314/safety-and-efficacy-of-ebselen-for-the-prevention-of-noise-induced-hearing-loss-a-randomised-double-blind-placebo-controlled-phase-2-trial
#2
Jonathan Kil, Edward Lobarinas, Christopher Spankovich, Scott K Griffiths, Patrick J Antonelli, Eric D Lynch, Colleen G Le Prell
BACKGROUND: Noise-induced hearing loss is a leading cause of occupational and recreational injury and disease, and a major determinant of age-related hearing loss. No therapeutic agent has been approved for the prevention or treatment of this disorder. In animal models, glutathione peroxidase 1 (GPx1) activity is reduced after acute noise exposure. Ebselen, a novel GPx1 mimic, has been shown to reduce both temporary and permanent noise-induced hearing loss in preclinical studies. We assessed the safety and efficacy of ebselen for the prevention of noise-induced hearing loss in young adults in a phase 2 clinical trial...
July 14, 2017: Lancet
https://www.readbyqxmd.com/read/28716312/ethical-considerations-in-noise-induced-hearing-loss-research
#3
Stéphane F Maison, Steven D Rauch
No abstract text is available yet for this article.
July 14, 2017: Lancet
https://www.readbyqxmd.com/read/28712672/noise-induced-cochlear-synaptopathy-in-rhesus-monkeys-macaca-mulatta
#4
M D Valero, J A Burton, S N Hauser, T A Hackett, R Ramachandran, M C Liberman
Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in mice can destroy up to ∼50% of synapses between auditory nerve fibers (ANFs) and inner hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the synaptopathy occurs first in high-threshold ANFs. However, the fiber loss likely impairs temporal processing and hearing-in-noise, a classic complaint of those with sensorineural hearing loss...
July 8, 2017: Hearing Research
https://www.readbyqxmd.com/read/28706081/brief-stimulus-exposure-fully-remediates-temporal-processing-deficits-induced-by-early-hearing-loss
#5
David B Green, Michelle M Mattingly, Yi Ye, Jennifer D Gay, Merri J Rosen
In childhood, partial hearing loss can produce prolonged deficits in speech perception and temporal processing. Early therapeutic interventions targeting temporal processing may improve later speech-related outcomes, however. Gap detection is a measure of auditory temporal resolution that relies on auditory cortex (ACx), and early auditory deprivation alters intrinsic and synaptic properties in ACx. Thus, early deprivation should induce deficits in gap detection, which should be reflected in ACx gap sensitivity...
July 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28705607/noise-induced-hearing-loss-induces-loudness-intolerance-in-a-rat-active-sound-avoidance-paradigm-asap
#6
Senthilvelan Manohar, Jaclyn Spoth, Kelly Radziwon, Benjamin D Auerbach, Richard Salvi
Hyperacusis is a loudness hypersensitivity disorder in which moderate-intensity sounds are perceived as extremely loud, aversive and/or painful. To assess the aversive nature of sounds, we developed an Active Sound Avoidance Paradigm (ASAP) in which rats altered their place preference in a Light/Dark shuttle box in response to sound. When no sound (NS) was present, rats spent more than 95% of the time in the Dark Box versus the transparent Light Box. However, when a 60 or 90 dB SPL noise (2-20 kHz, 2-8 kHz, or 16-20 kHz bandwidth) was presented in the Dark Box, the rats'' preference for the Dark Box significantly decreased...
July 8, 2017: Hearing Research
https://www.readbyqxmd.com/read/28704890/analysis-of-subway-interior-noise-at-peak-commuter-time
#7
Donguk Lee, Gibbeum Kim, Woojae Han
BACKGROUND AND OBJECTIVES: Although mass transit systems are convenient and efficient for urban people, little attention has been paid to the potential hearing hazard from their noise. The purpose of the current study was to measure and analyze levels of subway interior noise at peak commuter times and to provide information about commuters' daily dose of noise exposure. MATERIALS AND METHODS: To measure the subway interior noise, nine subway lines inside Seoul (i...
July 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28694336/magnified-neural-envelope-coding-predicts-deficits-in-speech-perception-in-noise
#8
Rebecca E Millman, Sven L Mattys, André D Gouws, Garreth Prendergast
Verbal communication in noisy backgrounds is challenging. Understanding speech in background noise that fluctuates in intensity over time is particularly difficult for hearing-impaired listeners with a sensorineural hearing loss (SNHL). The reduction in fast-acting cochlear compression associated with SNHL exaggerates the perceived fluctuations in intensity in amplitude-modulated sounds. SNHL-induced changes in the coding of amplitude-modulated sounds may have a detrimental effect on the ability of SNHL listeners to understand speech in the presence of modulated background noise...
July 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28690836/noise-induced-and-age-related-hearing-loss-%C3%A2-new-perspectives-and-potential-therapies
#9
REVIEW
M Charles Liberman
The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view. In noise-induced hearing loss, exposures causing only reversible threshold shifts (and no hair cell loss) nevertheless cause permanent loss of >50% of the synaptic connections between hair cells and the auditory nerve. Similarly, in age-related hearing loss, degeneration of cochlear synapses precedes both hair cell loss and threshold elevation...
2017: F1000Research
https://www.readbyqxmd.com/read/28685503/interventions-to-prevent-occupational-noise-induced-hearing-loss
#10
REVIEW
Christina Tikka, Jos H Verbeek, Erik Kateman, Thais C Morata, Wouter A Dreschler, Silvia Ferrite
BACKGROUND: This is the second update of a Cochrane Review originally published in 2009. Millions of workers worldwide are exposed to noise levels that increase their risk of hearing disorders. There is uncertainty about the effectiveness of hearing loss prevention interventions. OBJECTIVES: To assess the effectiveness of non-pharmaceutical interventions for preventing occupational noise exposure or occupational hearing loss compared to no intervention or alternative interventions...
July 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28651254/a-preliminary-study-of-a-spanish-graphic-novella-targeting-hearing-loss-prevention
#11
Mark Guiberson, Emily Wakefield
Purpose: This preliminary study developed a digital graphic novella targeting hearing protection beliefs of Spanish-speaking agricultural workers. Researchers used pretest-posttest interview surveys to establish if the novella had an immediate influence on the participants' beliefs about noise-induced hearing loss and usage of hearing protection devices. Method: Researchers developed a digital graphic novella directed to increase knowledge about noise-induced hearing loss and increase the proper use of hearing protection devices...
June 23, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28637591/salicylate-induced-frequency-map-reorganization-in-four-subfields-of-the-mouse-auditory-cortex
#12
Yasutaka Yanagawa, Kengo Takasu, Hisayuki Osanai, Takashi Tateno
Salicylate is the active ingredient in aspirin, and in high-doses it is used as an experimental tool to induce transient hearing loss, tinnitus, and hyperacusis. These salicylate-induced perceptual disturbances are associated with tonotopic-map reorganization and neural activity modulation, and such neural correlates have been examined in the central auditory pathway, including the auditory cortex (AC). Although previous studies have reported that salicylate induces increases in noise-burst-evoked neural responses and reorganization of tonotopic maps in the primary AC, little is known about the effects of salicylate on other frequency-organized AC subfields such as the anterior auditory, secondary auditory, and dorsomedial fields...
August 2017: Hearing Research
https://www.readbyqxmd.com/read/28635495/analysis-of-audiometric-notch-as-a-noise-induced-hearing-loss-phenotype-in-us-youth-data-from-the-national-health-and-nutrition-examination-survey-2005-2010
#13
Ishan S Bhatt, O'neil Guthrie
OBJECTIVE: Bilateral audiometric notch (BN) at 4000-6000 Hz was identified as a noise-induced hearing loss (NIHL) phenotype for genetic association analysis in college-aged musicians. This study analysed BN in a sample of US youth. DESIGN: Prevalence of the BN within the study sample was determined and logistic-regression analyses were performed to identify audiologic and other demographic factors associated with BN. Computer-simulated "flat" audiograms were used to estimate potential influence of false-positive rates in estimating the prevalence of the BN...
February 8, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28627704/matrix-metalloproteinase-2-and-9-contribute-to-functional-integrity-and-noise%C3%A2-induced-damage-to-the-blood-labyrinth-barrier
#14
Jun Wu, Weiju Han, Xingrui Chen, Weiwei Guo, Ke Liu, Ruoya Wang, Jishuai Zhang, Na Sai
The cochlear blood-labyrinth barrier (BLB), located in the stria vascularis, is critical for the homeostasis of cochlear solutes and ion transport. Significant disruption to the BLB occurs early during noise‑induced hearing loss. Matrix metalloproteinase (MMP)‑2 and ‑9 are important molecules known to be capable of degrading tight junction (TJ) proteins. The TJ proteins are important components of the extracellular matrix (ECM), required to maintain BLB integrity and permeability. Previous studies have demonstrated that MMP‑2 and ‑9, rich in healthy cochlea, serve an essential role in regulating the cochlear response to acoustic trauma...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28598950/drill-induced-cochlear-injury-during-otologic-surgery-intracochlear-pressure-evidence-of-acoustic-trauma
#15
Renee M Banakis Hartl, Jameson K Mattingly, Nathaniel T Greene, Nyssa F Farrell, Samuel P Gubbels, Daniel J Tollin
HYPOTHESIS: Drilling on the incus produces intracochlear pressure changes comparable to pressures created by high-intensity acoustic stimuli. BACKGROUND: New-onset sensorineural hearing loss (SNHL) following mastoid surgery can occur secondary to inadvertent drilling on the ossicular chain. To investigate this, we test the hypothesis that high sound pressure levels are generated when a high-speed drill contacts the incus. METHODS: Human cadaveric heads underwent mastoidectomy, and fiber-optic sensors were placed in scala tympani and vestibuli to measure intracochlear pressures (PIC)...
August 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28583912/noise-trauma-induced-behavioral-gap-detection-deficits-correlate-with-reorganization-of-excitatory-and-inhibitory-local-circuits-in-the-inferior-colliculus-and-are-prevented-by-acoustic-enrichment
#16
Joshua J Sturm, Ying-Xin Zhang-Hooks, Hannah Roos, Tuan Nguyen, Karl Kandler
Hearing loss leads to a host of cellular and synaptic changes in auditory brain areas that are thought to give rise to auditory perception deficits such as temporal processing impairments, hyperacusis, and tinnitus. However, little is known about possible changes in synaptic circuit connectivity that may underlie these hearing deficits. Here, we show that mild hearing loss as a result of brief noise exposure leads to a pronounced reorganization of local excitatory and inhibitory circuits in the mouse inferior colliculus...
June 28, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28562070/the-role-of-micrornas-in-environmental-risk-factors-noise-induced-hearing-loss-and-mental-stress
#17
Verónica Miguel, Julia Yue Cui, Lidia Daimiel, Cristina Espinosa-Díez, Carlos Fernández-Hernando, Terrance J Kavanagh, Santiago Lamas
SIGNIFICANCE: MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality of life are those of chemical nature (toxic chemicals, heavy metals, pollutants, and pesticides) as well as those related to everyday life such as exposure to noise or mental and psychosocial stress...
June 30, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28549396/molecular-mechanisms-underlying-the-protective-effects-of-hydrogen-saturated-saline-on-noise-induced-hearing-loss
#18
Liwei Chen, Mingkun Han, Yan Lu, Daishi Chen, Xuejun Sun, Shiming Yang, Wei Sun, Ning Yu, Suoqiang Zhai
OBJECTIVES: This study aimed to explore the molecular mechanism of the protective effects of hydrogen-saturated saline on NIHL. METHODS: Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily abdominal injections 3 d before and 1 h before noise exposure. ABR were tested to examine cochlear physiology changes. The changes of 8-hydroxy-desoxyguanosine (8-HOdG), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), intercellular cell adhesion molecule-1 (ICAM-1) and high mobility group box-1 protein (HMGB1) in the cochlea were also examined...
May 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28535812/current-insights-in-noise-induced-hearing-loss-a-literature-review-of-the-underlying-mechanism-pathophysiology-asymmetry-and-management-options
#19
REVIEW
Trung N Le, Louise V Straatman, Jane Lea, Brian Westerberg
BACKGROUND: Noise-induced hearing loss is one of the most common forms of sensorineural hearing loss, is a major health problem, is largely preventable and is probably more widespread than revealed by conventional pure tone threshold testing. Noise-induced damage to the cochlea is traditionally considered to be associated with symmetrical mild to moderate hearing loss with associated tinnitus; however, there is a significant number of patients with asymmetrical thresholds and, depending on the exposure, severe to profound hearing loss as well...
May 23, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28532971/clinical-and-audiological-characteristics-of-1000hz-audiometric-notch-patients
#20
Hyun-Min Lee, Seok-Hyun Kim, Jae-Hwan Jung, Se-Joon Oh, Soo-Keun Kong, Il-Woo Lee
PURPOSE: Among the hearing loss patients, we can confirm that the hearing loss of the specific frequency decreases, such as the 2000Hz notch in otosclerosis and the 4000Hz notch (c5-dip) in noise-induced hearing loss. The 1000Hz notch (c3-dip), however, is rarely studied. We fortuitously encountered a group of patients with a 1kHz hearing loss and report it with a review of the literature. METHODS: Otological history, audiogram, diagnosis, occupation, and history of noise exposure were reviewed from charts and telephone interview, and compared between c3-dip and c5-dip patients (n=98)...
April 1, 2017: American Journal of Otolaryngology
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