keyword
https://read.qxmd.com/read/36969247/differentiation-related-genes-in-tumor-associated-macrophages-as-potential-prognostic-biomarkers-in-non-small-cell-lung-cancer
#21
JOURNAL ARTICLE
Zhaoxun Li, Bin Zhou, Xinsheng Zhu, Fujun Yang, Kaiqi Jin, Jie Dai, Yuming Zhu, Xiao Song, Gening Jiang
BACKGROUND: The purpose of this study was to evaluate the role of differentiation-related genes (DRGs) in tumor-associated macrophages (TAMs) in non-small cell lung cancer (NSCLC). METHODS: Single cell RNA-seq (scRNA-seq) data from GEO and bulk RNA-seq data from TCGA were analyzed to identify DRGs using trajectory method. Functional gene analysis was carried out by GO/KEGG enrichment analysis. The mRNA and protein expression in human tissue were analyzed by HPA and GEPIA databases...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36796456/multi-omic-approach-associates-blood-methylome-with-bronchodilator-drug-response-in-pediatric-asthma
#22
JOURNAL ARTICLE
Javier Perez-Garcia, Esther Herrera-Luis, Annie Li, Angel C Y Mak, Scott Huntsman, Sam S Oh, Jennifer R Elhawary, Celeste Eng, Kenneth B Beckman, Donglei Hu, Fabian Lorenzo-Diaz, Michael A Lenoir, Jose Rodriguez-Santana, Noah Zaitlen, Jesús Villar, Luisa N Borrell, Esteban G Burchard, Maria Pino-Yanes
BACKGROUND: Albuterol is the drug most widely used as asthma treatment among African Americans despite having a lower bronchodilator drug response (BDR) than other populations. Although BDR is affected by gene and environmental factors, the influence of DNA methylation (DNAm) is unknown. OBJECTIVE: This study aims to identify epigenetic markers in whole blood associated with BDR, study their functional consequences by multi-omic integration, and assess their clinical applicability in admixed populations with a high asthma burden...
February 14, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/36764282/fibrinogen-like-protein-2-in-inflammatory-diseases-a-future-therapeutic-target
#23
REVIEW
Li Fu, Zheng Liu, Yang Liu
Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen family, exists as a membrane-bound protein with immune-associated coagulation activity and a soluble form possessing immunosuppressive functions. The immunomodulatory role of FGL2 is evident in fibrin deposition-associated inflammatory diseases and cancer, suggesting that FGL2 expression could be exploited as a disease biomarker and a therapeutic target. Recently, in vitro studies and knockout and transgenic animal FGL2 models have been used by us and others to reveal the involvement of FGL2 in the pathogenesis of various inflammatory diseases...
February 8, 2023: International Immunopharmacology
https://read.qxmd.com/read/36759517/fgl2-targeting-t-cells-exhibit-antitumor-effects-on-glioblastoma-and-recruit-tumor-specific-brain-resident-memory-t-cells
#24
JOURNAL ARTICLE
Qingnan Zhao, Jiemiao Hu, Lingyuan Kong, Shan Jiang, Xiangjun Tian, Jing Wang, Rintaro Hashizume, Zhiliang Jia, Natalie Wall Fowlkes, Jun Yan, Xueqing Xia, Sofia F Yi, Long Hoang Dao, David Masopust, Amy B Heimberger, Shulin Li
Although tissue-resident memory T (TRM ) cells specific for previously encountered pathogens have been characterized, the induction and recruitment of brain TRM cells following immune therapy has not been observed in the context of glioblastoma. Here, we show that T cells expressing fibrinogen-like 2 (FGL2)-specific single-chain variable fragments (T-αFGL2) can induce tumor-specific CD8+ TRM cells that prevent glioblastoma recurrence. These CD8+ TRM cells display a highly expanded T cell receptor repertoire distinct from that found in peripheral tissue...
February 10, 2023: Nature Communications
https://read.qxmd.com/read/36755239/identification-of-key-biomarkers-and-immune-infiltration-in-the-thoracic-acute-aortic-dissection-by-bioinformatics-analysis
#25
JOURNAL ARTICLE
Jun Luo, Haoming Shi, Haoyu Ran, Cheng Zhang, Qingchen Wu, Yue Shao
BACKGROUND: Thoracic acute aortic dissection (TAAD), one of the most fatal cardiovascular diseases, leads to sudden death, however, its mechanism remains unclear. METHODS: Three Gene Expression Omnibus datasets were employed to detect differentially expressed genes (DEGs). A similar function and co-expression network was identified by weighted gene co-expression network analysis. The least absolute shrinkage and selection operator, random forest, and support vector machines-recursive feature elimination were utilized to filter diagnostic TAAD markers, and then screened markers were validated by quantitative real-time PCR and another independent dataset...
February 8, 2023: BMC Cardiovascular Disorders
https://read.qxmd.com/read/36671474/assessment-of-fibrinogen-like-2-fgl2-in-human-chronic-kidney-disease-through-transcriptomics-data-analysis
#26
JOURNAL ARTICLE
Sara Denicolò, Viji Nair, Johannes Leierer, Michael Rudnicki, Matthias Kretzler, Gert Mayer, Wenjun Ju, Paul Perco
Fibrinogen-like 2 (FGL2) was recently found to be associated with fibrosis in a mouse model of kidney damage and was proposed as a potential therapeutic target in chronic kidney disease (CKD). We assessed the association of renal FGL2 mRNA expression with the disease outcome in two independent CKD cohorts (NEPTUNE and Innsbruck CKD cohort) using Kaplan Meier survival analysis. The regulation of FGL2 in kidney biopsies of CKD patients as compared to healthy controls was further assessed in 13 human CKD transcriptomics datasets...
December 31, 2022: Biomolecules
https://read.qxmd.com/read/36639424/mass-spectrometry-analysis-of-gut-tissue-in-acute-siv-infection-in-rhesus-macaques-identifies-early-proteome-alterations-preceding-the-interferon-inflammatory-response
#27
JOURNAL ARTICLE
A R Berard, T Hensley-McBain, L Noël-Romas, K Birse, M Abou, G Westmacott, S McCorrister, J Smedley, Nichole R Klatt, Adam D Burgener
HIV infection damages the gut mucosa leading to chronic immune activation, increased morbidities and mortality, and antiretroviral therapies, do not completely ameliorate mucosal dysfunction. Understanding early molecular changes in acute infection may identify new biomarkers underlying gut dysfunction. Here we utilized a proteomics approach, coupled with flow cytometry, to characterize early molecular and immunological alterations during acute SIV infection in gut tissue of rhesus macaques. Gut tissue biopsies were obtained at 2 times pre-infection and 4 times post-infection from 6 macaques...
January 13, 2023: Scientific Reports
https://read.qxmd.com/read/36508913/expression-of-fibrinogen-like-protein-2-fgl2-on-toll-like-receptor-9-tlr9-expression-in-autoimmune-myelitis
#28
JOURNAL ARTICLE
Wenjun Shao, Yue Huang, Lili Wang, Penghui Li, Yan Jia, Jiewen Zhang
Toll-like receptor 9 (TLR9) can participate in the signal transduction of activated immune cells and induce myelitis and other autoimmune diseases. The effector molecule fibrin-like protein 2 (Fgl2) plays a role in regulating the body's autoimmune signaling pathway. They both have the conditions for the treatment of this disease target. The objective of this work was to investigate the effect of Fgl2 on the expression of DNA receptor TLR9 in autoimmune myelitis. 140 rats were randomly divided into a normal control group, an autoimmune myelitis group, a low-dose Fgl2 group, a middle-dose Fgl2 group, a higher-dose Fgl2 group, a high-dose Fgl2 group, and a methylprednisolone group...
December 9, 2022: International Immunopharmacology
https://read.qxmd.com/read/36470485/in-silico-analysis-of-genomic-landscape-of-sars-cov-2-and-its-variant-of-concerns-delta-and-omicron-reveals-changes-in-the-coding-potential-of-mirnas-and-their-target-genes
#29
JOURNAL ARTICLE
Sandeep Saini, Savi Khurana, Dikshant Saini, Saru Rajput, Chander Jyoti Thakur, Jeevisha Singh, Akanksha Jaswal, Yogesh Kapoor, Varinder Kumar, Avneet Saini
COVID-19 related morbidities and mortalities are still continued due to the emergence of new variants of SARS-CoV-2. In the last few years, viral miRNAs have been the centre of study to understand the disease pathophysiology. In this work, we aimed to predict the change in coding potential of the viral miRNAs in SARS-CoV-2's VOCs, Delta and Omicron compared to the Reference (Wuhan origin) strain using bioinformatics tools. After ab-intio based screening by the Vmir tool and validation, we retrieved 22, 6, and 6 pre-miRNAs for Reference, Delta, and Omicron...
December 2, 2022: Gene
https://read.qxmd.com/read/36313679/targeting-fgl2-in-glioma-immunosuppression-and-malignant-progression
#30
REVIEW
Xiaoyu Ma, Hongtao Zhu, Lidong Cheng, Xin Chen, Kai Shu, Suojun Zhang
Glioblastoma (GBM) is the most malignant type of glioma with the worst prognosis. Traditional therapies (surgery combined with radiotherapy and chemotherapy) have limited therapeutic effects. As a novel therapy emerging in recent years, immunotherapy is increasingly used in glioblastoma (GBM), so we expect to discover more effective immune targets. FGL2, a member of the thrombospondin family, plays an essential role in regulating the activity of immune cells and tumor cells in GBM. Elucidating the role of FGL2 in GBM can help improve immunotherapy efficacy and design treatment protocols...
2022: Frontiers in Oncology
https://read.qxmd.com/read/36300695/the-distinctive-role-of-membrane-fibrinogen-like-protein-2-in-the-liver-stage-of-rodent-malaria-infections
#31
JOURNAL ARTICLE
Shiming Jiao, Nie Tan, Chengyu Zhu, Yong Fu, Kun Zhang, Yan Ding, Wenyue Xu
AIMS: Viral infection often induce the expression of murine fibrinogen-like protein 2 (mFGL2) triggering immune coagulation, which causes severe liver pathogenesis via increased fibrin deposition and thrombosis in the microvasculature. We aimed to investigate the role of mFGL2 in the liver stage of malaria infections. METHODS AND RESULTS: We reveal that infection with malaria sporozoites also induces increased expression of mFGL2 and that this expression is primarily located within the liver Kupffer and endothelial cells...
October 27, 2022: Parasite Immunology
https://read.qxmd.com/read/36243222/a-homozygous-truncating-mutation-of-fgl2-is-associated-with-immune-dysregulation
#32
JOURNAL ARTICLE
Erin Janssen, Mohammad F Alosaimi, Anas M Alazami, Abdullah Alsuliman, Ayodele Alaiya, Bandar Al-Saud, Hamoud Al-Mousa, Tariq Jassim Al-Zaid, Emma Smith, Craig D Platt, Hibah Alruwaili, Sarah Albanyan, Sulaiman M Al-Mayouf, Raif S Geha
BACKGROUND: The type II transmembrane protein fibrinogen-like protein 2 (FGL2) plays critical roles in hemostasis and immune regulation. The C-terminal immunoregulatory domain of FGL2 can be secreted and is a mediator of regulatory T (Treg) cell suppression. Fgl2-/- mice develop autoantibodies and glomerulonephritis and have impaired Treg cell function. OBJECTIVE: Our aim was to identify the genetic underpinning and immune function in a patient with childhood onset of leukocytoclastic vasculitis, systemic inflammation, and autoantibodies...
October 13, 2022: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/36201506/a-microfluidics-based-method-for-isolation-and-visualization-of-cells-based-on-receptor-ligand-interactions
#33
JOURNAL ARTICLE
Long Dao, Qingnan Zhao, Jiemiao Hu, Xueqing Xia, Qing Yang, Shulin Li
Receptor-ligand binding has been analyzed at the protein level using isothermal titration calorimetry and surface plasmon resonance and at the cellular level using interaction-associated downstream gene induction/suppression. However, no currently available technique can characterize this interaction directly through visualization. In addition, all available assays require a large pool of cells; no assay capable of analyzing receptor-ligand interactions at the single-cell level is publicly available. Here, we describe a new microfluidic chip-based technique for analyzing and visualizing these interactions at the single-cell level...
2022: PloS One
https://read.qxmd.com/read/36085259/fibrinogen-like-protein-2-its-biological-function-across-cell-types-and-the-potential-to-serve-as-an-immunotherapy-target-for-brain-tumors
#34
REVIEW
Sheng Zhang, Ganesh Rao, Amy Heimberger, Shulin Li
Brain tumors are among the 10 leading causes of cancer-related death and present unique treatment challenges due to their critical location, genetic heterogeneity, and the blood-brain barrier. Recent advances in targeted immunotherapy and immune checkpoint blocking therapy provide alternative therapeutic strategies for brain tumors. Fibrinogen-like protein 2 (FGL2), which induces transformation from low-grade glioma to high-grade glioblastoma, is a type II membrane protein that is highly expressed in both host immune cells and tumor cells...
September 2, 2022: Cytokine & Growth Factor Reviews
https://read.qxmd.com/read/35926777/fgl2-mcoln3-autophagy-axis-triggered-neutrophil-extracellular-traps-exacerbate-liver-injury-in-fulminant-viral-hepatitis
#35
JOURNAL ARTICLE
Xitang Li, Qiang Gao, Wenhui Wu, Suping Hai, Junjian Hu, Jie You, Da Huang, Hongwu Wang, Di Wu, Meifang Han, Dong Xi, Weiming Yan, Tao Chen, Xiaoping Luo, Qin Ning, Xiaojing Wang
BACKGROUND & AIMS: Fulminant viral hepatitis (FVH) is a life-threatening disease, but its pathogenesis is not fully understood. Neutrophil extracellular traps (NETs) were an unrecognized link between inflammation and coagulation, which are 2 main features of FVH. Here, we investigated the role and mechanism of NETs in the pathogenesis of FVH. METHODS: A mouse model of FVH was established by murine hepatitis virus strain-3 infection. Liver leukocytes of infected or uninfected mice were used for single-cell RNA sequencing and whole-transcriptome sequencing...
2022: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/35767958/development-of-allergen-specific-ige-in-a-food-allergy-model-requires-precisely-timed-b-cell-stimulation-and-is-inhibited-by-fgl2
#36
JOURNAL ARTICLE
Qiang Chen, Markus Xie, Hong Liu, Alexander L Dent
Immunoglobulin E (IgE) responses are a central feature of allergic disease. Using a well-established food-allergy model in mice, we show that two sensitizations with cognate B cell antigen (Ag) and adjuvant 7 days apart promotes optimal development of IgE+ germinal center (GC) B cells and high-affinity IgE production. Intervals of 3 or 14 days between Ag sensitizations lead to loss of IgE+ GC B cells and an undetectable IgE response. The immunosuppressive factors Fgl2 and CD39 are down-regulated in T follicular helper (TFH) cells under optimal IgE-sensitization conditions...
June 28, 2022: Cell Reports
https://read.qxmd.com/read/35749999/mir-146b-suppresses-lps-induced-m1-macrophage-polarization-via-inhibiting-the-fgl2-activated-nf-%C3%AE%C2%BAb-mapk-signaling-pathway-in-inflammatory-bowel-disease
#37
JOURNAL ARTICLE
Yang Pan, Dan Wang, Fan Liu
OBJECTIVES: M1 macrophage polarization and phenotype in Inflammatory Bowel Disease (IBD) are common biological responses. METHOD: Herein, IBD mice models were constructed and macrophages were derived. RESULTS: It was discovered that microRNA-146b (miR-146b) was downregulated in IBD mice and Lipopolysaccharide (LPS)-induced macrophages. Moreover, the inhibitory role of overexpressed miR-146b in reducing the inflammation level and blocking M1 macrophage polarization was confirmed...
2022: Clinics
https://read.qxmd.com/read/35656152/exploring-the-genetic-associations-between-the-use-of-statins-and-alzheimer-s-disease
#38
JOURNAL ARTICLE
Jibeom Lee, Suhyeon Park, Yumin Kim, Hyun Min Kim, Chang-Myung Oh
Objective: Alzheimer's disease (AD) is the most common cause of dementia. The statins have shown beneficial effects on cognitive functions and reduced the risk of dementia development. However, the exact mechanisms of statin effects in AD are not yet fully understood. In this study, we aimed to explore the underlying mechanisms of statin on AD. Methods: We downloaded AD blood dataset (GSE63060) and statin-related blood gene expression dataset (GSE86216). Then we performed gene expression analysis of each dataset and compared blood gene expressions between AD patients and statin-treated patients...
May 2022: Journal of lipid and atherosclerosis
https://read.qxmd.com/read/35602471/identification-and-validation-of-immune-molecular-subtypes-and-immune-landscape-based-on-colon-cancer-cohort
#39
JOURNAL ARTICLE
Wenqian Qi, Qian Zhang
Background: The incidence and mortality rates of colon adenocarcinoma (COAD), which is the fourth most diagnosed cancer worldwide, are high. A subset of patients with COAD has shown promising responses to immunotherapy. However, the percentage of patients with COAD benefiting from immunotherapy is unclear. Therefore, gaining a better understanding of the immune milieu of colon cancer could aid in the development of immunotherapy and suitable combination strategies. Methods: In this study, gene expression profiles and clinical follow-up data were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and molecular subtypes were identified using the ConsensusClusterPlus package in R...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35536524/overexpression-of-mir-17-predicts-adverse-prognosis-and-disease-recurrence-for-acute-myeloid-leukemia
#40
JOURNAL ARTICLE
Yang Cao, Yue Liu, Limei Shang, Huijuan Chen, Yanhua Yue, Weimin Dong, Yanting Guo, Haonan Yang, Xiaojun Yang, Yan Liu, Weiying Gu, Xiaoying Zhang
BACKGROUND: The clinical significance of miR-17 in patients with acute myeloid leukemia (AML) remains unknown. METHODS: Real-time quantitative reverse transcription-polymerase chain reaction (qPCR) was performed to detect the miR-17 expression in 115 de novo AML patients, 31 patients at complete remission (CR) time, 8 patients at relapse time and 30 normal controls. RESULTS: MiR-17 was upregulated in de novo AML compared with normal controls...
July 2022: International Journal of Clinical Oncology
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