Javier Perez-Garcia, Esther Herrera-Luis, Annie Li, Angel C Y Mak, Scott Huntsman, Sam S Oh, Jennifer R Elhawary, Celeste Eng, Kenneth B Beckman, Donglei Hu, Fabian Lorenzo-Diaz, Michael A Lenoir, Jose Rodriguez-Santana, Noah Zaitlen, Jesús Villar, Luisa N Borrell, Esteban G Burchard, Maria Pino-Yanes
BACKGROUND: Albuterol is the drug most widely used as asthma treatment among African Americans despite having a lower bronchodilator drug response (BDR) than other populations. Although BDR is affected by gene and environmental factors, the influence of DNA methylation (DNAm) is unknown. OBJECTIVE: This study aims to identify epigenetic markers in whole blood associated with BDR, study their functional consequences by multi-omic integration, and assess their clinical applicability in admixed populations with a high asthma burden...
February 14, 2023: Journal of Allergy and Clinical Immunology