Kristianne J C Galpin, Galaxia M Rodriguez, Vincent Maranda, David P Cook, Elizabeth Macdonald, Humaira Murshed, Shan Zhao, Curtis W McCloskey, Andrzej Chruscinski, Gary A Levy, Michele Ardolino, Barbara C Vanderhyden
The tumour microenvironment is infiltrated by immunosuppressive cells, such as regulatory T cells (Tregs), which contribute to tumour escape and impede immunotherapy outcomes. Soluble fibrinogen-like protein 2 (sFGL2), a Treg effector protein, inhibits immune cell populations, via receptors FcγRIIB and FcγRIII, leading to downregulation of CD86 in antigen presenting cells and limiting T cell activation. Increased FGL2 expression is associated with tumour progression and poor survival in several different cancers, such as glioblastoma multiforme, lung, renal, liver, colorectal, and prostate cancer...
January 8, 2024: Scientific Reports