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https://www.readbyqxmd.com/read/28713999/elevated-fibrinogen%C3%A2-like-protein-2-in-tnbs%C3%A2-induced-colitis-mice-association-with-th17-and-regulatory-t-cells
#1
Haihua Lin, Renpin Chen, Xuepei Jiang, Xiaoli Wu, Xielin Huang, Xiuli Dong, Xu Yang, Xiuqing Lin, Xin Chen, Xiangrong Chen, Zhiming Huang
The etiology and pathogenesis of inflammatory bowel disease (IBD) is complex and remains to be completely elucidated. Numerous cytokines are associated with the initiation and development of IBD. Fibrinogen‑like protein 2 (FGL2), an immunosuppressive cytokine expressed by regulatory cluster of differentiation (CD)4+ T (Treg) cells, has been identified to be important for immunomodulatory activity in the inflammatory state. Therefore, the present study investigated the expression of FGL2 and interleukin (IL)‑17 in trinitro‑benzene‑sulfonic acid (TNBS)‑induced colitis mice to identify the function of FGL2, based on the effector CD4+ T helper (Th)17/Treg balance, in IBD...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28687661/a-systems-vaccinology-approach-reveals-temporal-transcriptomic-changes-of-immune-responses-to-the-yellow-fever-17d-vaccine
#2
Jue Hou, Shuhui Wang, Manxue Jia, Dan Li, Ying Liu, Zhengpeng Li, Hong Zhu, Huifang Xu, Meiping Sun, Li Lu, Zhinan Zhou, Hong Peng, Qichen Zhang, Shihong Fu, Guodong Liang, Lena Yao, Xuesong Yu, Lindsay N Carpp, Yunda Huang, Julie McElrath, Steve Self, Yiming Shao
In this study, we used a systems vaccinology approach to identify temporal changes in immune response signatures to the yellow fever (YF)-17D vaccine, with the aim of comprehensively characterizing immune responses associated with protective immunity. We conducted a cohort study in which 21 healthy subjects in China were administered one dose of the YF-17D vaccine; PBMCs were collected at 0 h and then at 4 h and days 1, 2, 3, 5, 7, 14, 28, 84, and 168 postvaccination, and analyzed by transcriptional profiling and immunological assays...
July 7, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28656005/stroma-derived-fibrinogen-like-protein-2-activates-cancer-associated-fibroblasts-to-promote-tumor-growth-in-lung-cancer
#3
Ying Zhu, Longhui Zhang, Haoran Zha, Fei Yang, Chunyan Hu, Lin Chen, Bo Guo, Bo Zhu
Fibrinogen-like protein 2 (Fgl2), a member of the fibrinogen super family, is a pleiotropic cytokine that impacts diverse cellular functions. Previous studies have shown that tumor cell-derived Fgl2 promotes tumorigenesis and metastasis in immune-deficient mice, and it also functions as an immune-suppressive modulator in glioblastoma multiform (GMB). This study aimed to evaluate whether and how tumor stroma-derived Fgl2 affects tumorigenesis and tumor progression. We established the syngeneic transplantable Lewis lung carcinoma (LLC) model in Fgl2-knock-out (Fgl2-KO) mice and we found that deficiency of host Fgl2 is associated with reduced growth of syngeneic LLC tumors...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28494352/il-33-protects-murine-viral-fulminant-hepatitis-by-targeting-coagulation-hallmark-protein-fgl2-fibroleukin-expression
#4
Haijing Yu, Yang Liu, Jiaquan Huang, Hongwu Wang, Weiming Yan, Dong Xi, Guanxin Shen, Xiaoping Luo, Qin Ning
Fulminant hepatitis (FH) is characterized by rapid liver failure and high mortality. The pathogenesis of viral FH includes virus-induced immune activation, inflammation, and subsequent hepatic apoptosis and necrosis. However, the mechanisms that underlie FH progression are unclear. IL-33 is a member of the IL-1-related cytokines, considered to be an "alarmin" that participates in various diseases, but its precise role in the coagulation of FH is not very clear. In our study, we found that IL-33 is significantly elevated in mice infected with murine hepatitis virus strain 3 (MHV-3)...
May 8, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28487604/overexpression-of-fibrinogen-like-protein-2-protects-against-t-cell-induced-colitis
#5
Agata Bartczak, Jianhua Zhang, Oyedele Adeyi, Achiya Amir, David Grant, Reginald Gorczynski, Nazia Selzner, Andrzej Chruscinski, Gary A Levy
AIM: To determine the effect of overexpression of fibrinogen-like protein 2 (FGL2) on regulatory T cell (Treg) and effector T (Teff) cell function on T cell-induced colitis in Rag1(-/-) mice. METHODS: Treg and Teff cells from fgl2(-/-), fgl2(+/+), and fgl2(Tg) mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1(-/-) mice...
April 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28336906/identification-and-evaluation-of-new-immunoregulatory-genes-in-mesenchymal-stromal-cells-of-different-origins-comparison-of-normal-and-inflammatory-conditions
#6
COMPARATIVE STUDY
Mohammad Fayyad-Kazan, Mehdi Najar, Hussein Fayyad-Kazan, Gordana Raicevic, Laurence Lagneaux
BACKGROUND Mesenchymal stromal cells (MSCs) possess potent immunomodulatory properties that increase their value as a cell-based therapeutic tool for managing various immune-based disorders. Over the past years, accumulated results from trials using MSCs-based therapy have shown substantial contradictions. Although the reasons underlying these discrepancies are still not completely understood, it is well known that the immunomodulatory activities mediated by distinct MSCs differ in a manner dependent on their tissue origin and adequate response to inflammation priming...
March 24, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28063478/developmental-expression-of-b-cell-molecules-in-equine-lymphoid-tissues
#7
J M B Prieto, R L Tallmadge, M J B Felippe
Identification and classification of B cell subpopulations has been shown to be challenging and inconsistent among different species. Our study tested aspects of ontogeny, phenotype, tissue distribution, and function of equine CD5(hi) B cells, which represented a greater proportion of B cells early in development and in the peritoneal cavity. CD5(hi) and CD5(lo) B cells differentially expressed B cell markers (CD2, CD21, IgM) measured using flow cytometry, but similar mRNA expression of signature genes (DGKA, FGL2, PAX5, IGHM, IL10) measured using quantitative RT-PCR...
January 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27815440/identification-of-novel-cd4-t-cell-subsets-in-the-target-tissue-of-sj%C3%A3-gren-s-syndrome-and-their-differential-regulation-by-the-lymphotoxin-light-signaling-axis
#8
Scott Haskett, Jian Ding, Wei Zhang, Alice Thai, Patrick Cullen, Shanqin Xu, Britta Petersen, Galina Kuznetsov, Luke Jandreski, Stefan Hamann, Taylor L Reynolds, Norm Allaire, Timothy S Zheng, Michael Mingueneau
Despite being one of the most common rheumatologic diseases, there is still no disease-modifying drug for primary Sjögren's syndrome (pSS). Advancing our knowledge of the target tissue has been limited by the low dimensionality of histology techniques and the small size of human salivary gland biopsies. In this study, we took advantage of a molecularly validated mouse model of pSS to characterize tissue-infiltrating CD4(+) T cells and their regulation by the lymphotoxin/LIGHT signaling axis. Novel cell subsets were identified by combining highly dimensional flow and mass cytometry with transcriptomic analyses...
November 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27732889/two-fibrinogen-like-proteins-fgl1-and-fgl2-are-disulfide-linked-subunits-of-oligomers-that-specifically-bind-nonviable-spermatozoa
#9
Subir K Nagdas, Virginia P Winfrey, Gary E Olson
Nevertheless, a nonviable sperm population is present in the cauda epididymidis of many species. Degenerating spermatozoa release enzymes that could have detrimental effects on the viability of neighboring cells, and they are source of autoantigens that induce an autoimmune response if they escape the blood-epididymis barrier. Does the epididymis have specialized protective mechanism(s) to segregate the viable sperm population from defective spermatozoa? Previously, we identified a fibrinogen-like protein-2 (fgl2) that specifically binds to and polymerizes into a cocoon-like complex coating defective spermatozoa and sperm fragments...
October 9, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27163335/adenovirus-mediated-artificial-microrna-against-human-fibrinogen-like-protein-2-inhibits-hepatocellular-carcinoma-growth
#10
Ming Wang, Junhui Liu, Dong Xi, Xiaoping Luo, Qin Ning
BACKGROUND: Human fibrinogen-like protein 2 (hFGL2) is overexpressed in various human solid tumors and is associated with tumor growth, invasion and angiogenesis of hepatocellular carcinoma (HCC) LM6 cells. In the present study, an adenoviral vector expressing an artificial microRNA (miRNA) against hfgl2 (Ad-hfgl2-miRNA) was used to evaluate the effect of FGL2 knockdown on cell proliferation and tumor growth of HCCLM6 xenografts. METHODS: Ad-hfgl2-miRNA was constructed and its effect on hFGL2 expression and cell proliferation was analyzed...
July 2016: Journal of Gene Medicine
https://www.readbyqxmd.com/read/27050058/coagulation-gene-expression-profiling-in-infants-with-necrotizing-enterocolitis
#11
Stefano Giuliani, Yew-Wei Tan, Dongling Zheng, Evmorfia Petropoulou, Ali Sohail, Sarah Bradley, Justin Richards, Nigel Kennea, Yalda Jamshidi
OBJECTIVES: Coagulopathy and mesenteric thrombosis are common in premature neonates with necrotizing enterocolitis (NEC). This pilot study aimed to investigate the hypothesis that there are changes in the gene expression related to the coagulation and anticoagulation systems in NEC. METHODS: Consecutive neonates (n = 11) with NEC (Bell stages 2-3) were recruited. Two comparison groups, matched for birth weight and corrected gestational age, were selected based on the absence of inflammation and coagulopathy (healthy control, n = 10), or the presence of a confirmed blood infection (sepsis control, n = 12)...
December 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26718313/overexpression-of-fibrinogen-like-protein-2-promotes-tolerance-in-a-fully-mismatched-murine-model-of-heart-transplantation
#12
A Bartczak, A Chruscinski, M Mendicino, H Liu, J Zhang, W He, A Z Amir, A Nguyen, R Khattar, H Sadozai, C G Lobe, O Adeyi, M J Phillips, L Zhang, R M Gorczynski, D Grant, G A Levy
Fibrinogen-like protein 2 (FGL2) is an immunomodulatory protein that is expressed by regulatory T cells (Tregs). The objective of this study was to determine if recombinant FGL2 (rFGL2) treatment or constitutive FGL2 overexpression could promote transplant tolerance in mice. Although rFGL2 treatment prevented rejection of fully mismatched cardiac allografts, all grafts were rejected after stopping treatment. Next, we generated FGL2 transgenic mice (fgl2(Tg) ) that ubiquitously overexpressed FGL2. These mice developed normally and had no evidence of the autoimmune glomerulonephritis seen in fgl2(-/-) mice...
June 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/26522304/blood-ph-in-coronary-artery-microthrombosis-of-rats
#13
Kuai-Fa Fang, Zhu-Jun Chen, Meng Liu, Ping-Sheng Wu, Da-Zhi Yu
OBJECTIVE: To study the mechanism and significance of pH change in the coronary artery microthrombosis of rats. METHODS: After the sodium laurate-induced model of coronary artery microthrombosis of rats was constructed, the vascular endothelial cells were separated and then cultured in the mediums with different pH values for 24 h. Enzyme linked immunosorbent assay was used to detect the content of von Willebrand factor (vWF) in the medium; while the real-time PCR and western blot assay were used to detect the expression of fibrinogen-like protein 2 (FGL2) at the mRNA and protein level...
October 2015: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/26482204/sodium-tanshinone-iia-sulfonate-ameliorates-experimental-coronary-no-reflow-phenomenon-through-down-regulation-of-fgl2
#14
Rui Long, Ya You, Wenzhu Li, Nan Jin, Shiyuan Huang, Ting Li, Kun Liu, Zhaohui Wang
AIMS: The effects of sodium tanshinone IIA sulfonate (STS) on coronary no-reflow (CNR) relevant to microvascular obstruction (MVO) remain unknown. Studies had shown that fibrinogen-like protein 2 (FGL2) expressed in microvascular endothelial cells (MECs) is a key mediator in MVO. Thus, we aimed to elucidate the roles of STS in CNR and relations between STS and FGL2. MAIN METHODS: Myocardial ischemia/reperfusion was selected to represent CNR model. The no-reflow zone and infarct area were assessed using Thioflavin S and TTC staining, and cardiac functional parameters were detected using echocardiography...
December 1, 2015: Life Sciences
https://www.readbyqxmd.com/read/26367131/the-nlrp3-inflammasome-and-il-1%C3%AE-accelerate-immunologically-mediated-pathology-in-experimental-viral-fulminant-hepatitis
#15
Sheng Guo, Chengying Yang, Bo Diao, Xiaoyong Huang, Meihua Jin, Lili Chen, Weiming Yan, Qin Ning, Lixin Zheng, Yuzhang Wu, Yongwen Chen
Viral fulminant hepatitis (FH) is a severe disease with high mortality resulting from excessive inflammation in the infected liver. Clinical interventions have been inefficient due to the lack of knowledge for inflammatory pathogenesis in the virus-infected liver. We show that wild-type mice infected with murine hepatitis virus strain-3 (MHV-3), a model for viral FH, manifest with severe disease and high mortality in association with a significant elevation in IL-1β expression in the serum and liver. Whereas, the viral infection in IL-1β receptor-I deficient (IL-1R1-/-) or IL-1R antagonist (IL-1Ra) treated mice, show reductions in virus replication, disease progress and mortality...
September 2015: PLoS Pathogens
https://www.readbyqxmd.com/read/26362649/gene-expression-meta-analysis-reveals-immune-response-convergence-on-the-ifn%C3%AE-stat1-irf1-axis-and-adaptive-immune-resistance-mechanisms-in-lymphoma
#16
Matthew A Care, David R Westhead, Reuben M Tooze
BACKGROUND: Cancers adapt to immune-surveillance through evasion. Immune responses against carcinoma and melanoma converge on cytotoxic effectors and IFNγ-STAT1-IRF1 signalling. Local IFN-driven immune checkpoint expression can mediate feedback inhibition and adaptive immune resistance. Whether such coupled immune polarization and adaptive resistance is generalisable to lymphoid malignancies is incompletely defined. The host response in diffuse large B-cell lymphoma (DLBCL), the commonest aggressive lymphoid malignancy, provides an empirical model...
September 11, 2015: Genome Medicine
https://www.readbyqxmd.com/read/26260407/susceptibility-versus-resistance-in-alveolar-echinococcosis-larval-infection-with-echinococcus-multilocularis
#17
REVIEW
Bruno Gottstein, Junhua Wang, Ghalia Boubaker, Irina Marinova, Markus Spiliotis, Norbert Müller, Andrew Hemphill
Epidemiological studies have demonstrated that the majority of human individuals exposed to infection with Echinococcus spp. eggs exhibit resistance to disease as shown by either seroconversion to parasite--specific antigens, and/or the presence of 'dying out' or 'aborted' metacestodes, not including hereby those individuals who putatively got infected but did not seroconvert and who subsequently allowed no development of the pathogen. For those individuals where infection leads to disease, the developing parasite is partially controlled by host immunity...
October 30, 2015: Veterinary Parasitology
https://www.readbyqxmd.com/read/26241231/role-of-regulatory-t-cells-treg-and-the-treg-effector-molecule-fibrinogen-like-protein-2-in-alloimmunity-and-autoimmunity
#18
Andrzej Chruscinski, Hassan Sadozai, Vanessa Rojas-Luengas, Agata Bartczak, Ramzi Khattar, Nazia Selzner, Gary A Levy
CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) are critical to the maintenance of immune tolerance. Treg are known to utilize a number of molecular pathways to control immune responses and maintain immune homeostasis. Fibrinogen-like protein 2 (FGL2) has been identified by a number of investigators as an important immunosuppressive effector of Treg, which exerts its immunoregulatory activity by binding to inhibitory FcγRIIB receptors expressed on antigen-presenting cells including dendritic cells, endothelial cells, and B cells...
July 30, 2015: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/26182381/fibrinogen-like-protein-2-gene-silencing-inhibits-cardiomyocytes-apoptosis-improves-heart-function-of-streptozotocin-induced-diabetes-rats-and-the-molecular-mechanism-involved
#19
Zheng Zhenzhong, Yu Yafa, Liang Jin
Fibrinogen-like protein 2 (Fgl2) is involved in apoptosis, angiogenesis and inflammatory response. Diabetes is closely associated with apoptosis, angiogenesis and coagulation. So it allowed us to assume that Fgl2 plays an important role during the process of diabetic cardiomyopathy (DCM). In the present study, we test that the feasibility of Fgl2 as a therapeutic target for the treatment of DCM and its possible molecular mechanism involved. We found that Fgl2 gene silencing inhibits apoptosis and improves heart function of streptozotocin (STZ)-induced diabetes rats, the possible mechanism maybe that Fgl2 gene silencing reduces the tumour necrosis factor (TNF)±levels, decreases the expression of B-cell lymphoma-2 (bcl2), bcl-2-associated X (bax), toll-like receptors 4 (TLR4) and p38 mitogen-activated protein kinase (MAPK)...
May 20, 2015: Bioscience Reports
https://www.readbyqxmd.com/read/26161303/physiological-functions-and-clinical-implications-of-fibrinogen-like-2-a-review
#20
Genyan Yang, W Craig Hooper
Fibrinogen-like 2 (FGL2) encompasses a transmembrane (mFGL2) and a soluble (sFGL2) form with differential tertiary structure and biological activities. Typically, mFGL2 functions as prothrombinase that is capable of initiating coagulation in tissue without activation of the blood clotting cascade, whereas sFGL2 largely acts as an immunosuppressor that can repress proliferation of alloreactive T lymphocytes and maturation of bone marrow dendritic cells. Protein sequences of FGL2 exhibit evolutionary conservation across wide variety of species, especially at the carboxyl terminus that contains fibrinogen related domain (FRED)...
August 25, 2013: World Journal of Clinical Infectious Diseases
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