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micafungin in acute myeloid leukaemia

A Vena, E Bouza, A Álvarez-Uría, J Gayoso, P Martín-Rabadán, F Cajuste, J Guinea, J Gómez Castellá, R Alonso, P Munoz
OBJECTIVES: To investigate the performance of the routine serum galactomannan (sGM) assay in the diagnosis of invasive aspergillosis (IA) in high-risk haematology patients receiving prophylaxis with micafungin. METHODS: Retrospective study including all haematological patients who received prophylaxis with micafungin during high-risk IA episodes (neutropenic patients after chemotherapy for acute myeloid leukaemia/myelodysplastic syndrome; allogeneic haematopoietic stem-cell transplantation during early neutropenic phase or graft-versus-host disease requiring high prednisone doses) and for whom at least one sGM result was available...
December 2017: Clinical Microbiology and Infection
Fabio Miglietta, Antonietta Vella, Maria Letizia Faneschi, Giambattista Lobreglio, Adriana Rizzo, Claudio Palumbo, Carla Palumbo, Nicola Di Renzo, Maria Pizzolante
Emerging fungal pathogens, such as Geotrichum capitatum, are often associated with poor prognosis and represent a new challenge in modern medicine. Invasive Geotrichum capitatum infection is rare and has been reported exclusively in patients who showed signs of severe immunodeficiency, particularly those affected by haematological malignancies. The optimal therapy against systemic geotricosis has not yet been identified due to limited data about its antifungal susceptibility. The use of several therapeutic strategies and the low number of cases treated does not allow identification of specific therapeutic protocols...
June 2015: Le Infezioni in Medicina
Daniela Tacke, Dieter Buchheidt, Meinolf Karthaus, Stefan W Krause, Georg Maschmeyer, Silke Neumann, Helmut Ostermann, Olaf Penack, Christina Rieger, Markus Ruhnke, Michael Sandherr, Katharina E Schweer, Andrew J Ullmann, Oliver A Cornely
Invasive fungal infections cause substantial morbidity and mortality in immunocompromised patients, particularly in those with haematological malignancies and recipients of allogeneic haematopoietic stem cell transplantation. Difficulties in diagnosing invasive fungal infections and subsequent delays in treatment initiation lead to unfavourable outcomes and emphasise the importance of prophylaxis. Since the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology in 2009, results of 14 additional clinical studies have been published comprising 2,899 patients and initiating this update...
September 2014: Annals of Hematology
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