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extra medullary acute myeloid leukaemia

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https://www.readbyqxmd.com/read/25250110/proptosis-and-facial-palsy-as-an-unusual-clinical-presentation-of-acute-myeloid-leukemia
#1
Dhaneshor Sharma Takhenchangbam, Rajesh Singh Laishram, Tomcha Singh Thoudem, Akoijam Sunita, Lanu Tiameren Imchen
Simultaneous proptosis and facial palsy as the clinical presentation of childhoodAcute Myeloid Leukaemia (AML) is very rare. To date, no case have beenreported anywhere to the best of our knowledge. Extra medullary leukemic deposits or Granulocytic Sarcoma (GS) is a rare manifestation in about 3% of childhood AML, 9.3% of GS manifested as orbit deposits causing proptosis in one or both eyes. CNS infiltration or acute otomastoiditis subsequent to leukemic infiltration of the temporal bone may be implicated with facial paralysis...
2013: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/25150243/granulocytic-sarcoma-chloroma-presenting-as-colo-colic-intussusception-in-a-16-year-old-boy-an-unusual-presentation
#2
Saurabh Gupta, Inderjit Chawla, Vishwajeet Singh, Karnail Singh
A 16-year-old boy presented with intestinal obstruction with left lumbar mass. On evaluation with ultrasonography and contrast-enhanced CT of abdomen he was found to have left colo-colic intussusception. On exploratory laparotomy he was found to have invagination of necrosed distal transverse colon and splenic flexure with omentum into descending colon with enlarged mesenteric lymph nodes for which left hemicolectomy was performed. Histopathology and immunohistochemistry was suggestive of submucosal infiltration by immature myeloid precursors with few metamyelocytes and occasional eosinophils and the cells showed cytoplasmic granular positivity with myeloperoxidase stain suggestive of granulocytic sarcoma (chloroma-extra-medullary manifestation of acute myeloid leukaemia)...
2014: BMJ Case Reports
https://www.readbyqxmd.com/read/24086883/granulocytic-sarcoma-presenting-as-an-orbital-mass-report-of-two-cases
#3
Brijesh Thakur, Kachnar Varma, Vatsala Misra, Smita Chauhan
Granulocytic sarcoma is a rare variant of a myeloid malignancy, which shows an extra-medullary tumour mass which is composed of myeloblasts and myeloid precursors with varying degrees of differentiation. It occurs most commonly in bone, periosteum, soft tissue, lymph nodes, and skin; although it can occur anywhere throughout the body. Here, we are reporting two cases of orbital granulocytic sarcoma in children, which presented clinically with proptosis and periorbital swellings, which were first diagnosed by Fine Needle Aspiration Cytology (FNAC)...
August 2013: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/23372230/chloroma-of-perianal-region-masquerading-as-perianal-abscess
#4
Rajeev Sen, Sunita Singh, Mahapatra S Qury, Sanjay Marwah, Garima Aggarwal, Shyam Singla
Chloroma, also called granulocytic sarcoma (GS) or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but its appearance may precede the onset of leukaemia. The presence of a chloroma is certainly a sign of poor prognosis. We report a case of chloroma in a middle aged female without a prior history of leukemia in the perianal skin region with clinical diagnosis of perianal abscess. When there is no concomitant leukaemia, diagnosis of chloroma may be difficult...
January 2013: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/16450777/maxillo-ethmoidal-chloroma-in-acute-myeloid-leukaemia-case-report
#5
E Ferri, C Minotto, F Ianniello, S Cavaleri, E Armato, P Capuzzo
Chloroma, also called Granulocytic Sarcoma or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myelo-proliferative disorders but its appearance may precede the onset of leukaemia. Chloroma may be found in several extracranial sites. Involvement of the head and neck region is uncommon. Differential diagnosis is often difficult and includes acute lymphoblastic leukaemia, large cell NHL, lymphoblastic lymphoma and Ewing's sarcoma. The case is presented of a maxillo-ethmoidal chloroma occurring in a case of poor prognosis acute myeloid leukaemia, emphasizing the clinical and cyto-histological features and problems concerning differential diagnosis...
June 2005: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/16263587/heart-and-muscle-involvement-by-extra-medullary-myeloid-leukemia-a-case-report-and-review-of-the-literature
#6
REVIEW
E Jost, J Lorenzen, P Haage, G Bos, D Beelen, O Galm, G Gehbauer, R Osieka
Extra-medullary myeloid tumours (EMT) have been described after curative treatment for acute myeloid leukaemia (AML) in increasing numbers after allogeneic stem cell transplantation. The sites of manifestations are ubiquitous and the discovery is most frequently guided by symptoms reported by the patient or by findings on clinical examination. This study reports a case of EMT in muscles and the heart 1.5 years after allogeneic transplantation for an AML with t(8;21)(q22;23) who achieved a complete remission by use of an idarubicine-based combination chemotherapy...
December 2005: Leukemia & Lymphoma
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