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nodular lymphocyte predominance hodgkin lymphoma

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https://www.readbyqxmd.com/read/27895166/t-cell-rich-lymphoid-infiltrates-with-large-b-cells-a-review-of-key-entities-and-diagnostic-approach
#1
REVIEW
Chee Leong Cheng, Simon O'Connor
Accurate diagnostic interpretation of a lymphoid population composed predominantly of small T cells, together with smaller numbers of large B cells, with or without a nodular architecture, is a common problem faced by the histopathologist. The differential diagnosis of this histological pattern is wide, ranging from reactive conditions such as drug reactions and viral infections, through borderline entities such as immunodeficiency-related lymphoproliferative disorders to lymphomas. The latter includes entities where the large B cells are primarily neoplastic (classical and nodular lymphocyte-predominant Hodgkin lymphomas and T cell/histiocyte-rich large B cell lymphoma) as well as T cell lymphomas such as angioimmunoblastic T cell lymphoma where the large B cells represent an epiphenomenon and may or may not be neoplastic...
November 28, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27888658/a-case-of-composite-classical-and-nodular-lymphocyte-predominant-hodgkin-lymphoma-with-progression-to-diffuse-large-b-cell-non-hodgkin-lymphoma-diagnostic-difficulty-in-fine-needle-aspiration-cytology
#2
Dilip K Das, Zafar A Sheikh, Mariam H Al-Shama'a, Bency John, Abdulla M S Alawi, Thamradeen A Junaid
A small percentage of nodular lymphocytic predominant Hodgkin lymphoma (NLPHL) progresses to diffuse large B-cell lymphoma (DLBCL). There have also been rare reports of gray zone lymphoma with features intermediate between classical Hodgkin lymphoma (CHL) and DLBCL. We report a very rare case of composite lymphoma (CHL and NLPHL) progressing to DLBCL, and highlight the diagnostic difficulty faced during its fine-needle aspiration (FNA) cytology diagnosis. A 65-year-old woman presented with a right axillary swelling which was subjected to FNA cytology...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27861371/chronic-lymphocytic-inflammation-with-pontine-perivascular-enhancement-responsive-to-steroids-clippers-with-intracranial-epstein-barr-virus-infection-a-case-report
#3
Yue Ma, Xiaolong Sun, Wen Li, Yi Li, Tao Kang, Xiai Yang, Wen Jiang
BACKGROUND: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder in the central nervous system (CNS) with distinct clinical, radiological, and pathological features. The pathophysiology of CLIPPERS still remains unclear and the reports are quite few. Although the radiological lesions were reported to be located predominantly in the pons, brachium pontis, and cerebellum, other adjacent structures such as the white matter and spinal cord were very recently reported as involved regions in CLIPPERS...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27816718/atypical-variants-of-nodular-lymphocyte-predominant-hodgkin-lymphoma-show-low-microvessel-density-and-vessels-of-distention-type
#4
Victoria Scheidt, Martin-Leo Hansmann, Bianca Schuhmacher, Claudia Döring, Sylvia Hartmann
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) presents different histopathologic growth patterns, including atypical forms showing overlapping histopathologic and clinical features with T cell/histiocyte rich large B cell lymphoma (THRLBCL). As growth patterns are associated with vessel distribution, the aim of the present study was to compare angiogenesis in different NLPHL patterns with THRLBCL as well as other lymphomas. Atypical variants of NLPHL and THRLBCL (n=10 per group) both showed a low microvessel density (MVD, 1...
November 2, 2016: Human Pathology
https://www.readbyqxmd.com/read/27708232/a-strong-host-response-and-lack-of-myc-expression-are-characteristic-for-diffuse-large-b-cell-lymphoma-transformed-from-nodular-lymphocyte-predominant-hodgkin-lymphoma
#5
Bianca Schuhmacher, Benjamin Rengstl, Claudia Döring, Julia Bein, Sebastian Newrzela, Uta Brunnberg, Hans Michael Kvasnicka, Martine Vornanen, Ralf Küppers, Martin-Leo Hansmann, Sylvia Hartmann
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an indolent lymphoma, but can transform into diffuse large B cell lymphoma (DLBCL), showing a more aggressive clinical behavior. Little is known about these cases on the molecular level. Therefore, the aim of the present study was to characterize DLBCL transformed from NLPHL (LP-DLBCL) by gene expression profiling (GEP). GEP revealed an inflammatory signature pinpointing to a specific host response. In a coculture model resembling this host response, DEV tumor cells showed an impaired growth behavior...
September 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27697411/management-of-early-stage-hodgkin-lymphoma-a-practice-guideline
#6
J Herst, M Crump, F G Baldassarre, J MacEachern, J Sussman, D Hodgson, M C Cheung
In the past, treatment for patients with early-stage Hodgkin lymphoma consisted mainly of radiotherapy. Now, chemotherapy alone and chemoradiotherapy are treatment options. These guidelines aim to provide recommendations on the optimal management of early-stage Hodgkin lymphoma. We conducted a systematic review searching MEDLINE, EMBASE, the Cochrane Library and other literature sources from 2003 to 2015, and applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Two authors independently reviewed and selected studies, and appraised the evidence quality...
September 30, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27688147/bleomycin-induced-skin-toxicity-is-it-always-flagellate-erythema
#7
Shailendra Prasad Verma, Arunkumar Subbiah, Vinod Kolar Vishwanath, Tarun Kumar Dutta
Bleomycin-induced skin toxicity is a rare and unique complication. We report a 35-year-old man with nodular lymphocytic predominant Hodgkin's lymphoma, stage IVB, who was started on adriamycin, bleomycin, vinblastin and dacarbazine (ABVD) chemotherapy. He developed pruritic hyperpigmented, patchy skin lesions on the neck, back, chest and thighs after IA cycle of ABVD chemotherapy. Lesions were not typical flagellate rash but hyperpigmented, patchy and mildly pruritic lesions over the trunk and proximal extremities...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27644653/clinico-hematological-findings-for-classical-hodgkin-s-lymphoma-an-institutional-experience
#8
Sadia Sultan, Syed Mohammed Irfan, Saira Parveen, Saif Ali
BACKGROUND: Classical Hodgkin's lymphoma (cHL) is a B-cell lymphoid neoplasm characterized by a distinctive biological behavior with potentially curable disease characteristics. It is an uncommon hematological malignancy which primarily affects younger individuals. The rationale of this study was to determine its clinico-hematological profile along with stage strati cation in Pakistani patients. MATERIALS AND METHODS: In this descriptive study, adult patients with Hodgkin's lymphoma were enrolled from January 2010 to December 2014...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27532537/an-unusual-clinical-and-pathological-presentation-of-a-nodular-lymphocyte-predominant-hodgkin-lymphoma-poppema-lennert-lymphoma
#9
Sarra Ben Rejeb, Amen Dhaoui, Dorra Ben Ghachem, Taieb Jomni, Maher Abouda, Maher Abouda, S Turki, Khadija Bellil
No abstract text is available yet for this article.
February 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27496311/nodular-lymphocyte-predominant-hodgkin-lymphoma
#10
REVIEW
Kerry J Savage, Anja Mottok, Michelle Fanale
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma with distinct clinicopathologic features. It is typified by the presence of lymphocyte predominant (LP) cells, which are CD20(+) but CD15(-) and CD30(-) and are found scattered amongst small B lymphocytes arranged in a nodular pattern. Despite frequent and often late or multiple relapses, the prognosis of NLPHL is very favorable. There is an inherent risk of secondary aggressive non-Hodgkin lymphoma (NHL) and studies support that risk is highest in those with splenic involvement at presentation...
July 2016: Seminars in Hematology
https://www.readbyqxmd.com/read/27496304/hodgkin-lymphoma-pathology-and-biology
#11
REVIEW
Stephan Mathas, Sylvia Hartmann, Ralf Küppers
The Hodgkin and Reed-Sternberg (HRS) tumor cells of classical Hodgkin lymphoma (HL), as well as the lymphocyte predominant (LP) cells of nodular lymphocyte predominant HL (NLPHL), are derived from mature B cells. However, HRS cells have largely lost their B-cell phenotype and show a very unusual expression of many markers of other hematopoietic cell lineages, which aids in the differential diagnosis between classical HL (cHL) and NLPHL and distinguishes cHL from all other hematopoietic malignancies. The bi- or multinucleated Reed-Sternberg cells most likely derive from the mononuclear Hodgkin cells through a process of incomplete cytokinesis...
July 2016: Seminars in Hematology
https://www.readbyqxmd.com/read/27312067/peripheral-t-cell-lymphomas-of-follicular-helper-t-cell-type-frequently-display-an-aberrant-cd3-dim-cd4-population-by-flow-cytometry-an-important-clue-to-the-diagnosis-of-a-hodgkin-lymphoma-mimic
#12
Mir Alikhan, Joo Y Song, Aliyah R Sohani, Julien Moroch, Anne Plonquet, Amy S Duffield, Michael J Borowitz, Liuyan Jiang, Carlos Bueso-Ramos, Kedar Inamdar, Madhu P Menon, Sandeep Gurbuxani, Ernest Chan, Sonali M Smith, Alina Nicolae, Elaine S Jaffe, Philippe Gaulard, Girish Venkataraman
Nodal follicular helper T-cell-derived lymphoproliferations (specifically the less common peripheral T-cell lymphomas of follicular type) exhibit a spectrum of histologic features that may mimic reactive hyperplasia or Hodgkin lymphoma. Even though angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma of follicular type share a common biologic origin from follicular helper T-cells and their morphology has been well characterized, flow cytometry of peripheral T-cell lymphomas of follicular type has not been widely discussed as a tool for identifying this reactive hyperplasia/Hodgkin lymphoma mimic...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27247366/an-immunohistochemical-survey-of-snare-proteins-shows-distinct-patterns-of-expression-in-hematolymphoid-neoplasia
#13
Rekha Bhat, Pritish K Bhattacharyya, Howard Ratech
OBJECTIVES: Five proteins from the soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) complex family were studied in normal hematopoietic cells in bone marrow; normal lymphocytes at different stages of maturation and differentiation in bone marrow, thymus, tonsil, and lymph node; malignant lymphomas; and leukemias. METHODS: Sixty-eight reactive and 380 hematopoietic and lymphoid neoplasms were immunohistochemically stained for syntaxin 7 (STX7), vesicle-associated membrane proteins (VAMP2, VAMP7, VAMP8), and synaptosomal-associated protein 23 (SNAP23)...
May 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27221964/nf-%C3%AE%C2%BAb-deregulation-in-hodgkin-lymphoma
#14
Marc A Weniger, Ralf Küppers
Hodgkin and Reed/Sternberg (HRS) cells in classical Hodgkin lymphoma (HL) show constitutive activity of both the canonical and non-canonical NF-κB signaling pathways. The central pathogenetic role of this activity is indicated from studies with HL cell lines, which undergo apoptosis upon NF-κB inhibition. Multiple factors contribute to the strong NF-κB activity of HRS cells. This includes interaction with other cells in the lymphoma microenvironment through CD30, CD40, BCMA and other receptors, but also recurrent somatic genetic lesions in various factors of the NF-κB pathway, including destructive mutations in negative regulators of NF-κB signaling (e...
August 2016: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/27194138/-if-rt-alone-remains-gold-standard-for-stage%C3%A2-ia-nodular-lymphocyte-predominant-hodgkin-lymphoma
#15
Karoline Pilz, Christina Jentsch, Mechthild Krause
No abstract text is available yet for this article.
June 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27185197/phase-ii-trial-of-ofatumumab-plus-eshap-o-eshap-as-salvage-treatment-for-patients-with-relapsed-or-refractory-classical-hodgkin-lymphoma-after-first-line-chemotherapy
#16
Carmen Martínez, Antonio Díaz-López, Mercedes Rodriguez-Calvillo, Ramón García-Sanz, María José Terol, Elena Pérez-Ceballos, Maria J Jiménez, Alberto Cantalapiedra, Eva Domingo-Domenech, María José Rodriguez, Antonia Sampol, Manuel Espeso, Francisco-Javier López, Javier Briones, Juan F García, Anna Sureda
The management of recurrent/refractory (R/R) Hodgkin lymphoma (HL) remains challenging. Previously published data have shown some efficacy of rituximab in this setting. The purpose of this phase II trial was to investigate the activity of ofatumumab in combination with etoposide, steroids, cytarabine and cisplatin (O-ESHAP) in 62 patients with R/R classical HL. Treatment consisted of ESHAP plus ofatumumab 1000 mg on days 1 and 8 of the first cycle and day 1 of the second and third cycles. O-ESHAP was well tolerated with only 3% of patients requiring treatment discontinuation because of adverse events...
September 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27133958/progressive-transformation-of-germinal-centers-single-center-experience-of-33-turkish-patients
#17
REVIEW
Melda Cömert Özkan, Nazan Özsan, Mine Hekimgil, Güray Saydam, Mahmut Töbü
Progressive transformation of germinal centers (PTGCs) is a benign disease of the lymph nodes that is rarely associated with Hodgkin disease. We reviewed the clinical and pathologic features of PTGCs and the relationship of PTGCs with lymphoid neoplasia in an adult population. The data from 33 patients who were diagnosed with PTCGs were retrospectively analyzed. Of the 33 PTGC patients, 48.5% were men and 51.5% were women, with a mean age of 43.8 years at diagnosis. Most of the enlarged and excised lymph nodes were cervical and axillary...
August 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27069706/papillary-thyroid-cancer-in-a-child-with-progressive-transformation-of-germinal-centers
#18
Suresh Mohan, Bradley DeNardo, Dariusz Stachurski, Jennifer Greene Welch, Jan C Groblewski
Objectives. To describe the presentation and management of a child with Progressive Transformation of Germinal Centers (PTGC), an uncommon condition characterized by significant persistent lymphadenopathy, who developed papillary thyroid carcinoma and to explore and review potential links between PTGC and neoplastic processes in the head and neck. Methods. Case presentation and literature review are used. Results. A 10-year-old female presented with a right parotid mass and cervical lymphadenopathy. Multiple biopsies revealed PTGC without malignancy...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27045512/evaluation-of-the-diagnostic-and-prognostic-value-of-pdl1-expression-in-hodgkin-and-b-cell-lymphomas
#19
Thomas Menter, Andrea Bodmer-Haecki, Stephan Dirnhofer, Alexandar Tzankov
Activation of the programmed death 1 (PD1)/PD1 ligand (PDL1) pathway is important for tumor cells to escape from immune control. The clinical efficacy of therapeutic modulation of the PD1-PDL1 pathway has been recently shown in classical Hodgkin lymphoma (cHL), but little is known about the frequency and diagnostic and prognostic importance of PDL1 expression in lymphomas. The available anti-PDL1 antibody clones E1L3N and SP142 were compared, and a large cohort of Hodgkin lymphomas (n=280) and B-cell lymphomas (n=619) was examined for PDL1 using E1L3N...
August 2016: Human Pathology
https://www.readbyqxmd.com/read/27015240/nodular-lymphocyte-predominant-hodgkin-lymphoma-presenting-with-unilateral-orbital-involvement
#20
Pradeep Mettu, Megan Griffith, Sophia Yohe, Andrew R Harrison
A 40-year-old Caucasian woman presented to her general ophthalmologist for swelling of the left upper eyelid that began approximately 6 months before. CT scan of the orbits with and without contrast demonstrated homogenous enhancement of the left lacrimal gland. Examination was notable for left hypoglobus and proptosis. The patient underwent left lateral orbitotomy with biopsy of the mass and frozen section analysis showed lymphoid infiltrates. Subsequent histopathologic diagnosis was consistent with nodular lymphocyte predominant Hodgkin lymphoma, a rare subtype of Hodgkin lymphoma that has only once been previously reported in the orbit...
March 24, 2016: Ophthalmic Plastic and Reconstructive Surgery
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