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https://www.readbyqxmd.com/read/29470850/identification-and-functional-analysis-of-a-novel-g310d-variant-in-the-insulin-like-growth-factor-1-receptor-igf1r-gene-that-associates-with-type-2-diabetes-in-american-indians
#1
Yunhua L Muller, Graham Skelton, Paolo Piaggi, Peng Chen, Anup Nair, Sayuko Kobes, Wen-Chi Hsueh, William C Knowler, Robert L Hanson, Leslie J Baier, Clifton Bogardus
AIMS: Insulin-like growth factor 1 receptor (IGF1R) is involved in cell growth and glucose homeostasis. In the current study, the IGF1R locus was analyzed as a candidate gene for type 2 diabetes (T2D) in American Indians. MATERIALS AND METHODS: Whole genome sequence data from 335 American Indians identified 3 novel missense variants in IGF1R. The associations of IGF1R variants with T2D, age of T2D onset and birth weight were analyzed in a population based sample of 7701 American Indians...
February 22, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29422042/scoping-out-the-literature-on-mobile-needle-and-syringe-programs-review-of-service-delivery-and-client-characteristics-operation-utilization-referrals-and-impact
#2
REVIEW
Carol Strike, Miroslav Miskovic
BACKGROUND: Needle and syringe program (NSP) service delivery models encompass fixed sites, mobile services, vending machines, pharmacies, peer NSPs, street outreach, and inter-organizational agreements to add NSP services to other programs. For programs seeking to implement or improve mobile services, access to a synthesis of the evidence related to mobile services is beneficial, but lacking. METHODS: We used a scoping study method to search MEDLINE, PSYCHInfo, Embase, Scopus, and Sociological for relevant literature...
February 8, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29366725/performance-of-the-2012-systemic-lupus-international-collaborating-clinics-classification-criteria-versus-the-1997-american-college-of-rheumatology-classification-criteria-in-adult-and-juvenile-systemic-lupus-erythematosus-a-systematic-review-and-meta-analysis
#3
REVIEW
Esther A R Hartman, Annet van Royen-Kerkhof, Johannes W G Jacobs, Paco M J Welsing, Ruth D E Fritsch-Stork
OBJECTIVE: To evaluate the performance in classifying systemic lupus erythematosus by the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC'12), versus the revised American College of Rheumatology criteria from 1997 (ACR'97) in adult and juvenile SLE patients. METHODS: A systematic literature search was conducted in PubMed and Embase for studies comparing SLICC'12 and ACR'97 with clinical diagnosis. A meta-analysis was performed to estimate the sensitivity and specificity of SLICC'12 and ACR'97...
January 21, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29361978/use-of-david-algorithms-for-clustering-custom-annotated-gene-lists-in-a-non-model-organism-rainbow-trout
#4
Hao Ma, Guangtu Gao, Gregory M Weber
OBJECTIVE: The DAVID gene functional classification tool requires adaptations for use in non-model species and there is little available information to guide selection of a kappa score. Our objective was to develop an R-script that allows custom gene identifiers and novel annotation information to be incorporated into analyses, then use such data to evaluate the number of differentially expressed genes (DEGs) in a comparison based on kappa score selection. RESULTS: Using an R-script we developed and multiple data sets ranging from 555 to 3340 annotated DEGs from a study in rainbow trout, we found the percentage of DEGs harbored within a module and the number of genes shared among multiple modules decreased with increasing kappa score regardless of the number of DEGs in the comparison...
January 23, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29353440/healthy-lifestyle-promotion-in-primary-schools-through-the-board-game-kaledo-a-pilot-cluster-randomized-trial
#5
Emanuela Viggiano, Alessandro Viggiano, Anna Di Costanzo, Adela Viggiano, Andrea Viggiano, Eleonora Andreozzi, Vincenzo Romano, Claudia Vicidomini, Daniela Di Tuoro, Giuliana Gargano, Lucia Incarnato, Celeste Fevola, Pietro Volta, Caterina Tolomeo, Giuseppina Scianni, Caterina Santangelo, Maria Apicella, Roberta Battista, Maddalena Raia, Ilaria Valentino, Marianna Palumbo, Giovanni Messina, Antonietta Messina, Marcellino Monda, Bruno De Luca, Salvatore Amaro
The board game Kaledo was proven to be effective in improving nutrition knowledge and in modifying dietary behavior in students attending middle and high school. The present pilot study aims to reproduce these results in younger students (7-11 years old) attending primary school. A total of 1313 children from ten schools were recruited to participate in the present study. Participants were randomized into two groups: (1) the treatment group which consisted of playing Kaledo over 20 sessions and (2) the no intervention group...
January 20, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29304505/leaching-and-geochemical-behavior-of-fired-bricks-containing-coal-wastes
#6
Yassine Taha, Mostafa Benzaazoua, Mohamed Edahbi, Mohammed Mansori, Rachid Hakkou
High amounts of mine wastes are continuously produced by the mining industry all over the world. Recycling possibility of some wastes in fired brick making has been investigated and showed promising results. However, little attention is given to the leaching behavior of mine wastes based fired bricks. The objective of this paper is to evaluate the geochemical behavior of fired bricks containing different types of coal wastes. The leachates were analyzed for their concentration of As, Ba, Cd, Co, Cr, Cu, Mo, Ni, Pb, Zn and sulfates using different leaching tests; namely Tank Leaching tests (NEN 7375), Toxicity Characteristic Leaching Procedure (TCLP) and pH dependence test (EPA, 1313)...
January 2, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29278577/evaluation-of-a-dedicated-tobacco-cessation-support-service-for-thoracic-cancer-center-patients
#7
Katharine A Amato, Mary E Reid, Heather M Ochs-Balcom, Gary A Giovino, Maansi Bansal-Travers, Graham W Warren, Martin C Mahoney, Andrew J Hyland
CONTEXT: Cancer patients' continued tobacco use results in poorer therapeutic outcomes including decreased quality of life and survival. OBJECTIVE: To assess reach and impact of a free, opt-out, telephone-based tobacco cessation program for thoracic cancer center patients. DESIGN: Observational study. SETTING: Comprehensive Cancer Center in Western New York. PARTICIPANTS: Current or recent (within past 30 days) tobacco-using thoracic cancer center patients referred to a tobacco cessation support service between October 2010 and October 2012 at a Comprehensive Cancer Center (n = 942/1313 referrals were eligible for cessation support)...
December 22, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29242815/fracture-strength-of-veneered-translucent-zirconium-dioxide-crowns-with-different-porcelain-thicknesses
#8
Fahad Bakitian, Przemek Seweryniak, Evaggelia Papia, Christel Larsson, Per Vult von Steyern
Objective: To evaluate fracture strength of veneered translucent zirconium dioxide crowns designed with different porcelain layer thicknesses. Materials and Methods: Sixty crowns, divided into six groups of 10, were used in this study. Groups were divided according to different thicknesses of porcelain veneer on translucent zirconium dioxide cores of equal thickness (0.5 mm). Porcelain thicknesses were 2.5, 2.0, 1.0, 0.8, 0.5 and 0.3 mm. Crowns were artificially aged before loaded to fracture. Determination of fracture mode was performed using light microscope...
2017: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/29240230/lc-ms-ms-profiling-of-polyphenol-enriched-leaf-stem-and-root-extracts-of-korean-humulus-japonicus-siebold-zucc-and-determination-of-their-antioxidant-effects
#9
Jin Young Choi, Kebede Taye Desta, Soo Jung Lee, Yun-Hi Kim, Sung Chul Shin, Gon-Sup Kim, Sung Joong Lee, Jae-Han Shim, Ahmet Hacımüftüo, A M Abd El-Aty
Polyphenols from ethyl acetate extracts from the leaves, stems, and roots of Korean Humulus japonicus were comprehensively profiled using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). A total of 36 polyphenols were detected, of which 26 were structurally characterized based on their [M-H]- peak, MS/MS fragmentation pattern, UV-Vis absorption, and published data. Validation data provided satisfactory results for the evaluated parameters. The determination coefficients (R2 ) exceeded or equal to 0...
December 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29169877/cetuximab-plus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-versus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-in-advanced-nsclc-swog-s0819-a-randomised-phase-3-study
#10
Roy S Herbst, Mary W Redman, Edward S Kim, Thomas J Semrad, Lyudmila Bazhenova, Gregory Masters, Kurt Oettel, Perry Guaglianone, Christopher Reynolds, Anand Karnad, Susanne M Arnold, Marileila Varella-Garcia, James Moon, Philip C Mack, Charles D Blanke, Fred R Hirsch, Karen Kelly, David R Gandara
BACKGROUND: EGFR antibodies have shown promise in patients with advanced non-small-cell lung cancer (NSCLC), particularly with squamous cell histology. We hypothesised that EGFR copy number by fluorescence in-situ hybridisation (FISH) can identify patients most likely to benefit from these drugs combined with chemotherapy and we aimed to explore the activity of cetuximab with chemotherapy in patients with advanced NSCLC who are EGFR FISH-positive. METHODS: We did this open-label, phase 3 study (SWOG S0819) at 277 sites in the USA and Mexico...
November 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29159547/correction-to-current-methodologies-and-implications-of-phase-identification-of-the-vertical-jump-a-systematic-review-and-meta-analysis
#11
Alexander Neale Eagles, Mark Gregory Leigh Sayers, Matthew Bousson, Dale Ingham Lovell
Pages 1313-5, table 1, column 1: The cell entries in the 'Reference' column, which previously read.
November 21, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29158614/evaluation-of-the-external-and-internal-workload-in-female-futsal-players
#12
Marco Beato, Giuseppe Coratella, Federico Schena, Andrew T Hulton
Match analysis technology has been extensively used in football, but there is limited literature on its use in futsal. Despite its increased popularity, the female futsal game model has never been quantified. The aim of this study was to quantify locomotor and mechanical activities performed during a non-competitive female futsal match, measuring the differences between the first and second half. Sixteen female futsal players of the Italian 2(nd) division were enrolled (age 27±5 years, height 1.65±0.09 m, body weight 56...
September 2017: Biology of Sport
https://www.readbyqxmd.com/read/29155404/carbohydrate-source-affects-the-synthesis-of-silver-nanoparticles-by-lactobacillus-plantarum-1449-and-lactobacillus-ruminis-1313
#13
María de Lourdes Reyes-Escogido, David Meneses-Rodríguez, Rodolfo Guardado-Mendoza
Strains of Lactobacillus have been used for the synthesis of metallic nanoparticles. Since the carbohydrate source could influence the yield and size of the synthesised nanoparticles, the authors evaluated the potential of Lactobacillus plantarum 1449 and Lactobacillus ruminis 1313 to produce silver nanoparticles (AgNPs) using three carbohydrate sources and AgNO3. The presence of AgNO3 in the medium extended the duration of the acceleration and logarithmic phases of the two strains independently of the carbohydrate source used but did not inhibit their growth...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29138130/check-and-report-ebola-care-hotline-the-user-perspective-of-an-innovative-tool-for-postarrival-monitoring-of-ebola-in-the-united-states
#14
Ilana Olin McCarthy, Abbey E Wojno, Heather A Joseph, Scott Teesdale
BACKGROUND: The response to the 2014-2016 Ebola epidemic included an unprecedented effort from federal, state, and local public health authorities to monitor the health of travelers entering the United States from countries with Ebola outbreaks. The Check and Report Ebola (CARE) Hotline, a novel approach to monitoring, was designed to enable travelers to report their health status daily to an interactive voice recognition (IVR) system. The system was tested with 70 Centers for Disease Control and Prevention (CDC) federal employees returning from deployments in outbreak countries...
November 14, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29127335/early-diverging-lineages-within-cryptomycota-and-chytridiomycota-dominate-the-fungal-communities-in-ice-covered-lakes-of-the-mcmurdo-dry-valleys-antarctica
#15
Keilor Rojas-Jimenez, Christian Wurzbacher, Elizabeth Charlotte Bourne, Amy Chiuchiolo, John C Priscu, Hans-Peter Grossart
Antarctic ice-covered lakes are exceptional sites for studying the ecology of aquatic fungi under conditions of minimal human disturbance. In this study, we explored the diversity and community composition of fungi in five permanently covered lake basins located in the Taylor and Miers Valleys of Antarctica. Based on analysis of the 18S rRNA sequences, we showed that fungal taxa represented between 0.93% and 60.32% of the eukaryotic sequences. Cryptomycota and Chytridiomycota dominated the fungal communities in all lakes; however, members of Ascomycota, Basidiomycota, Zygomycota, and Blastocladiomycota were also present...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117658/treatment-of-postherpetic-neuralgia-with-5-topical-lidocaine-plaster-%C3%A2-experience-from-a-small-county-hospital-case-report
#16
Maša Kontić, Višnja Vičić-Hudorović, Narcis Hudorović
Postherpetic neuralgia (PHN) characterized by chronic neuropathic pain is a common complication of herpes zoster. We investigated the efficacy, safety and cost of treating refractory chronic neuropathic pain with 5% topical lidocaine plaster (TLP) in a female patient attending pain unit at a small county hospital. An 80-year-old female diagnosed with PHN presented with severe left intercostal allodynia and hyperalgesia up to the root of the fourth to tenth thoracic dermatome. We administered the well established first- and second-line specific medications for PHN, but treatment regimens were not efficient...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29111510/cation-tautomerism-twinning-and-disorder-in-the-triclinic-and-monoclinic-forms-of-4-amino-5-chloro-2-6-dimethylpyrimidinium-5-chloro-2-hydroxybenzoate-and-a-new-disordered-refinement-of-2-amino-4-6-dimethoxypyrimidin-1-ium-thiophene-2-carboxylate
#17
Ammaiyappan Rajam, P Thomas Muthiah, Ray J Butcher, Jerry P Jasinski, Christopher Glidewell
Pyrimidines are important compounds in biology and medicine, and the aminopyrimidine fragment can be identified in three of the four bases in DNA. The targeted drug action of pharmaceuticals containing this functionality is likely to depend heavily on molecular recognition processes involving hydrogen bonding. Crystallization of an equimolar mixture of 4-amino-5-chloro-2,6-dimethylpyrimidine and 5-chloro-2-hydroxybenzoic acid yielded two forms of the 1:1 salt, C6H9ClN3(+)·C7H4ClO3(-), each containing a different tautomeric form of the cation...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29104181/evaluation-of-newborn-sickle-cell-screening-programme-in-england-2010-2016
#18
Allison Streetly, Rupa Sisodia, Moira Dick, Radoslav Latinovic, Kirsty Hounsell, Elizabeth Dormandy
OBJECTIVE: To evaluate England's NHS newborn sickle cell screening programme performance in children up to the age of 5 years. DESIGN: Cohort of resident infants with sickle cell disease (SCD) born between 1 September 2010 and 31 August 2015 and followed until August 2016. PARTICIPANTS: 1317 infants with SCD were notified to the study from all centres in England and 1313 (99%) were followed up. INTERVENTIONS: Early enrolment in clinical follow-up, parental education and routine penicillin prophylaxis...
November 5, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29103677/enhanced-protection-against-fmdv-in-cattle-after-prime-boost-vaccination-based-on-mucosal-and-inactivated-fmd-vaccine
#19
Manar E Khalifa, Ayman H El-Deeb, Sayed M Zeidan, Hussein A Hussein, Hany I Abu-El-Naga
Improved immunization and control strategies and platforms are greatly needed for foot and mouth disease virus (FMDV) and mucosal vaccines propose an effective strategy for the control FMDV by blocking viral entry. In this study, several immunization strategies, using two FMDV vaccine formulations, including Montanide ISA 206 oil-based FMD inactivated vaccine and Montanide IMS 1313 VG N PR-based concentrated semi-purified FMD mucosal vaccine, were applied. Results of intranasal immunization with the prepared FMD mucosal vaccine, given once or twice, induced IgA levels in both nasal and salivary secretions besides a high response of lymphocyte proliferation with protection levels reaching 20% and 40%, respectively, in a challenge trial in cattle...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28973520/longitudinal-hemodynamics-of-transcatheter-and-surgical-aortic-valves-in-the-partner-trial
#20
Pamela S Douglas, Martin B Leon, Michael J Mack, Lars G Svensson, John G Webb, Rebecca T Hahn, Philippe Pibarot, Neil J Weissman, D Craig Miller, Samir Kapadia, Howard C Herrmann, Susheel K Kodali, Raj R Makkar, Vinod H Thourani, Stamatios Lerakis, Ashley M Lowry, Jeevanantham Rajeswaran, Matthew T Finn, Maria C Alu, Craig R Smith, Eugene H Blackstone
Importance: Use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis is growing rapidly. However, to our knowledge, the durability of these prostheses is incompletely defined. Objective: To determine the midterm hemodynamic performance of balloon-expandable transcatheter heart valves. Design, Setting, and Participants: In this study, we analyzed core laboratory-generated data from echocardiograms of all patients enrolled in the Placement of Aortic Transcatheter Valves (PARTNER) 1 Trial with successful TAVR or surgical AVR (SAVR) obtained preimplantation and at 7 days, 1 and 6 months, and 1, 2, 3, 4, and 5 years postimplantation...
November 1, 2017: JAMA Cardiology
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