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https://www.readbyqxmd.com/read/29169877/cetuximab-plus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-versus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-in-advanced-nsclc-swog-s0819-a-randomised-phase-3-study
#1
Roy S Herbst, Mary W Redman, Edward S Kim, Thomas J Semrad, Lyudmila Bazhenova, Gregory Masters, Kurt Oettel, Perry Guaglianone, Christopher Reynolds, Anand Karnad, Susanne M Arnold, Marileila Varella-Garcia, James Moon, Philip C Mack, Charles D Blanke, Fred R Hirsch, Karen Kelly, David R Gandara
BACKGROUND: EGFR antibodies have shown promise in patients with advanced non-small-cell lung cancer (NSCLC), particularly with squamous cell histology. We hypothesised that EGFR copy number by fluorescence in-situ hybridisation (FISH) can identify patients most likely to benefit from these drugs combined with chemotherapy and we aimed to explore the activity of cetuximab with chemotherapy in patients with advanced NSCLC who are EGFR FISH-positive. METHODS: We did this open-label, phase 3 study (SWOG S0819) at 277 sites in the USA and Mexico...
November 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29159547/correction-to-current-methodologies-and-implications-of-phase-identification-of-the-vertical-jump-a-systematic-review-and-meta-analysis
#2
Alexander Neale Eagles, Mark Gregory Leigh Sayers, Matthew Bousson, Dale Ingham Lovell
Pages 1313-5, table 1, column 1: The cell entries in the 'Reference' column, which previously read.
November 21, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29158614/evaluation-of-the-external-and-internal-workload-in-female-futsal-players
#3
Marco Beato, Giuseppe Coratella, Federico Schena, Andrew T Hulton
Match analysis technology has been extensively used in football, but there is limited literature on its use in futsal. Despite its increased popularity, the female futsal game model has never been quantified. The aim of this study was to quantify locomotor and mechanical activities performed during a non-competitive female futsal match, measuring the differences between the first and second half. Sixteen female futsal players of the Italian 2(nd) division were enrolled (age 27±5 years, height 1.65±0.09 m, body weight 56...
September 2017: Biology of Sport
https://www.readbyqxmd.com/read/29155404/carbohydrate-source-affects-the-synthesis-of-silver-nanoparticles-by-lactobacillus-plantarum-1449-and-lactobacillus-ruminis-1313
#4
María de Lourdes Reyes-Escogido, David Meneses-Rodríguez, Rodolfo Guardado-Mendoza
Strains of Lactobacillus have been used for the synthesis of metallic nanoparticles. Since the carbohydrate source could influence the yield and size of the synthesised nanoparticles, the authors evaluated the potential of Lactobacillus plantarum 1449 and Lactobacillus ruminis 1313 to produce silver nanoparticles (AgNPs) using three carbohydrate sources and AgNO3. The presence of AgNO3 in the medium extended the duration of the acceleration and logarithmic phases of the two strains independently of the carbohydrate source used but did not inhibit their growth...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29138130/check-and-report-ebola-care-hotline-the-user-perspective-of-an-innovative-tool-for-postarrival-monitoring-of-ebola-in-the-united-states
#5
Ilana Olin McCarthy, Abbey E Wojno, Heather A Joseph, Scott Teesdale
BACKGROUND: The response to the 2014-2016 Ebola epidemic included an unprecedented effort from federal, state, and local public health authorities to monitor the health of travelers entering the United States from countries with Ebola outbreaks. The Check and Report Ebola (CARE) Hotline, a novel approach to monitoring, was designed to enable travelers to report their health status daily to an interactive voice recognition (IVR) system. The system was tested with 70 Centers for Disease Control and Prevention (CDC) federal employees returning from deployments in outbreak countries...
November 14, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29127335/early-diverging-lineages-within-cryptomycota-and-chytridiomycota-dominate-the-fungal-communities-in-ice-covered-lakes-of-the-mcmurdo-dry-valleys-antarctica
#6
Keilor Rojas-Jimenez, Christian Wurzbacher, Elizabeth Charlotte Bourne, Amy Chiuchiolo, John C Priscu, Hans-Peter Grossart
Antarctic ice-covered lakes are exceptional sites for studying the ecology of aquatic fungi under conditions of minimal human disturbance. In this study, we explored the diversity and community composition of fungi in five permanently covered lake basins located in the Taylor and Miers Valleys of Antarctica. Based on analysis of the 18S rRNA sequences, we showed that fungal taxa represented between 0.93% and 60.32% of the eukaryotic sequences. Cryptomycota and Chytridiomycota dominated the fungal communities in all lakes; however, members of Ascomycota, Basidiomycota, Zygomycota, and Blastocladiomycota were also present...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117658/treatment-of-postherpetic-neuralgia-with-5-topical-lidocaine-plaster-%C3%A2-experience-from-a-small-county-hospital-case-report
#7
Maša Kontić, Višnja Vičić-Hudorović, Narcis Hudorović
Postherpetic neuralgia (PHN) characterized by chronic neuropathic pain is a common complication of herpes zoster. We investigated the efficacy, safety and cost of treating refractory chronic neuropathic pain with 5% topical lidocaine plaster (TLP) in a female patient attending pain unit at a small county hospital. An 80-year-old female diagnosed with PHN presented with severe left intercostal allodynia and hyperalgesia up to the root of the fourth to tenth thoracic dermatome. We administered the well established first- and second-line specific medications for PHN, but treatment regimens were not efficient...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29111510/cation-tautomerism-twinning-and-disorder-in-the-triclinic-and-monoclinic-forms-of-4-amino-5-chloro-2-6-dimethylpyrimidinium-5-chloro-2-hydroxybenzoate-and-a-new-disordered-refinement-of-2-amino-4-6-dimethoxypyrimidin-1-ium-thiophene-2-carboxylate
#8
Ammaiyappan Rajam, P Thomas Muthiah, Ray J Butcher, Jerry P Jasinski, Christopher Glidewell
Pyrimidines are important compounds in biology and medicine, and the aminopyrimidine fragment can be identified in three of the four bases in DNA. The targeted drug action of pharmaceuticals containing this functionality is likely to depend heavily on molecular recognition processes involving hydrogen bonding. Crystallization of an equimolar mixture of 4-amino-5-chloro-2,6-dimethylpyrimidine and 5-chloro-2-hydroxybenzoic acid yielded two forms of the 1:1 salt, C6H9ClN3(+)·C7H4ClO3(-), each containing a different tautomeric form of the cation...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29104181/evaluation-of-newborn-sickle-cell-screening-programme-in-england-2010-2016
#9
Allison Streetly, Rupa Sisodia, Moira Dick, Radoslav Latinovic, Kirsty Hounsell, Elizabeth Dormandy
OBJECTIVE: To evaluate England's NHS newborn sickle cell screening programme performance in children up to the age of 5 years. DESIGN: Cohort of resident infants with sickle cell disease (SCD) born between 1 September 2010 and 31 August 2015 and followed until August 2016. PARTICIPANTS: 1317 infants with SCD were notified to the study from all centres in England and 1313 (99%) were followed up. INTERVENTIONS: Early enrolment in clinical follow-up, parental education and routine penicillin prophylaxis...
November 5, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29103677/enhanced-protection-against-fmdv-in-cattle-after-prime-boost-vaccination-based-on-mucosal-and-inactivated-fmd-vaccine
#10
Manar E Khalifa, Ayman H El-Deeb, Sayed M Zeidan, Hussein A Hussein, Hany I Abu-El-Naga
Improved immunization and control strategies and platforms are greatly needed for foot and mouth disease virus (FMDV) and mucosal vaccines propose an effective strategy for the control FMDV by blocking viral entry. In this study, several immunization strategies, using two FMDV vaccine formulations, including Montanide ISA 206 oil-based FMD inactivated vaccine and Montanide IMS 1313 VG N PR-based concentrated semi-purified FMD mucosal vaccine, were applied. Results of intranasal immunization with the prepared FMD mucosal vaccine, given once or twice, induced IgA levels in both nasal and salivary secretions besides a high response of lymphocyte proliferation with protection levels reaching 20% and 40%, respectively, in a challenge trial in cattle...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28973520/longitudinal-hemodynamics-of-transcatheter-and-surgical-aortic-valves-in-the-partner-trial
#11
Pamela S Douglas, Martin B Leon, Michael J Mack, Lars G Svensson, John G Webb, Rebecca T Hahn, Philippe Pibarot, Neil J Weissman, D Craig Miller, Samir Kapadia, Howard C Herrmann, Susheel K Kodali, Raj R Makkar, Vinod H Thourani, Stamatios Lerakis, Ashley M Lowry, Jeevanantham Rajeswaran, Matthew T Finn, Maria C Alu, Craig R Smith, Eugene H Blackstone
Importance: Use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis is growing rapidly. However, to our knowledge, the durability of these prostheses is incompletely defined. Objective: To determine the midterm hemodynamic performance of balloon-expandable transcatheter heart valves. Design, Setting, and Participants: In this study, we analyzed core laboratory-generated data from echocardiograms of all patients enrolled in the Placement of Aortic Transcatheter Valves (PARTNER) 1 Trial with successful TAVR or surgical AVR (SAVR) obtained preimplantation and at 7 days, 1 and 6 months, and 1, 2, 3, 4, and 5 years postimplantation...
November 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28963152/appropriate-hinge-position-for-prevention-of-unstable-lateral-hinge-fracture-in-open-wedge-high-tibial-osteotomy
#12
R Nakamura, N Komatsu, K Fujita, K Kuroda, M Takahashi, R Omi, Y Katsuki, H Tsuchiya
AIMS: Open wedge high tibial osteotomy (OWHTO) for medial-compartment osteoarthritis of the knee can be complicated by intra-operative lateral hinge fracture (LHF). We aimed to establish the relationship between hinge position and fracture types, and suggest an appropriate hinge position to reduce the risk of this complication. PATIENTS AND METHODS: Consecutive patients undergoing OWHTO were evaluated on coronal multiplanar reconstruction CT images. Hinge positions were divided into five zones in our new classification, by their relationship to the proximal tibiofibular joint (PTFJ)...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28932263/how-does-cellulosome-composition-influence-deconstruction-of-lignocellulosic-substrates-in-clostridium-ruminiclostridium-thermocellum-dsm-1313
#13
Shahar Yoav, Yoav Barak, Melina Shamshoum, Ilya Borovok, Raphael Lamed, Bareket Dassa, Yitzhak Hadar, Ely Morag, Edward A Bayer
BACKGROUND: Bioethanol production processes involve enzymatic hydrolysis of pretreated lignocellulosic biomass into fermentable sugars. Due to the relatively high cost of enzyme production, the development of potent and cost-effective cellulolytic cocktails is critical for increasing the cost-effectiveness of bioethanol production. In this context, the multi-protein cellulolytic complex of Clostridium (Ruminiclostridium) thermocellum, the cellulosome, was studied here. C. thermocellum is known to assemble cellulosomes of various subunit (enzyme) compositions, in response to the available carbon source...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28880931/restrictive-intraoperative-fluid-optimisation-algorithm-improves-outcomes-in-patients-undergoing-pancreaticoduodenectomy-a-prospective-multicentre-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Laurence Weinberg, Damian Ianno, Leonid Churilov, Ian Chao, Nick Scurrah, Clive Rachbuch, Jonathan Banting, Vijaragavan Muralidharan, David Story, Rinaldo Bellomo, Chris Christophi, Mehrdad Nikfarjam
We aimed to evaluate perioperative outcomes in patients undergoing pancreaticoduodenectomy with or without a cardiac output goal directed therapy (GDT) algorithm. We conducted a multicentre randomised controlled trial in four high volume hepatobiliary-pancreatic surgery centres. We evaluated whether the additional impact of a intraoperative fluid optimisation algorithm would influence the amount of fluid delivered, reduce fluid related complications, and improve length of hospital stay. Fifty-two consecutive adult patients were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28859869/conservatism-predicts-lapses-from-vegetarian-vegan-diets-to-meat-consumption-through-lower-social-justice-concerns-and-social-support
#15
Gordon Hodson, Megan Earle
Lapses from vegetarian and vegan (i.e., veg*n) food choices to meat consumption are very common, suggesting that sustaining veg*nism is challenging. But little is known about why people return to eating animals after initially deciding to avoid meat consumption. Several potential explanatory factors include personal inconvenience, meat cravings, awkwardness in social settings, or health/nutrition concerns. Here we test the degree to which political ideology predicts lapsing to meat consumption. Past research demonstrates that political ideology predicts present levels of meat consumption, whereby those higher in right-wing ideologies eat more animals, even after controlling for their hedonistic liking of meat (e...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/28845052/should-breast-cancer-surgery-be-done-in-an-outpatient-setting-health-economics-from-the-perspective-of-service-providers
#16
Margaret Formago, Michael G Schrauder, Claudia Rauh, Carolin C Hack, Sebastian M Jud, Thomas Hildebrandt, Rüdiger Schulz-Wendtland, S Frentz, S Graubert, Matthias W Beckmann, Michael P Lux
INTRODUCTION: The care of patients with breast cancer is extremely complex and requires interdisciplinary care in certified facilities. These specialized facilities provide numerous services without being correspondingly remunerated. The question whether breast cancer surgery should be performed in an outpatient setting to reduce costs is increasingly being debated. This study compares inpatient surgical treatment with a model of the same surgery performed on an outpatient basis to examine the potential financial impact...
August 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28806113/-hungarian-diet-and-nutritional-status-survey-the-otap2014-study-v-vitamin-intake-of-the-hungarian-population
#17
Erzsébet Schreiberné Molnár, Zsuzsanna Nagy-Lőrincz, Barbara Nagy, Márta Bakacs, Orsolya Kis, Eszter Sarkadi Nagy, Éva Martos
INTRODUCTION AND AIM: The Hungarian Diet and Nutritional Status Survey was implemented on a sub-sample of the European Health Interview Survey. In this paper, the authors present the data on the vitamin intake of the Hungarian population. METHOD: The survey represents the vitamin intake of the Hungarian non-institutionalised adult population of 18 years and older. There are significant differences between men's and women's vitamin intake. RESULTS: The intake of all water-soluble vitamins except for vitamin C is higher in men than in women, and the difference between the genders regarding the intake of vitamin E and D is significant...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28768222/metal-leachability-from-coal-combustion-residuals-under-different-phs-and-liquid-solid-ratios
#18
Evandro B da Silva, Shiwei Li, Letúzia M de Oliveira, Julia Gress, Xiaoling Dong, Ann C Wilkie, Timothy Townsend, Lena Q Ma
Coal combustion residuals (CCRs) contain variable amounts of trace metals, which can negatively impact the environment. We analyzed metal concentrations and leachability of CCRs from seven coal-fired power plants from Florida. The purpose of this study was to characterize and assess metal leachability in representative CCRs samples from coal-fired power plants, including As, Ba, Cd, Cr, Pb, and Se. The specific objectives were to: (1) measure metal leachability under different pH conditions and liquid-to-solid ratios using USEPA Leaching Environmental Assessment Framework (LEAF) Methods 1313 and 1316, and (2) compare their leachability with those obtained by the Synthetic Precipitation Leaching Procedure (SPLP)...
July 13, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28747607/safety-and-effectiveness-of-certolizumab-pegol-in-patients-with-rheumatoid-arthritis-interim-analysis-of-post-marketing-surveillance
#19
Hideto Kameda, Keiichiro Nishida, Toshihiro Nannki, Akira Watanabe, Yukiya Oshima, Shigaki Momohara
Objective: To evaluate the safety and effectiveness of certolizumab pegol (CZP) in a real-world setting among Japanese patients with rheumatoid arthritis. METHODS: Post-marketing surveillance data from 2,579 patients treated with CZP were analyzed. Adverse events (AEs) observed during the 24-week CZP treatment period were recorded. Disease activity was evaluated using DAS28-ESR and DAS28-CRP at baseline, Week 12, Week 24, or at withdrawal. RESULTS: The total period of exposure to CZP was 1313...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28721648/recall-of-prenatal-counselling-among-obese-and-overweight-women-from-a-canadian-population-a-population-based-study
#20
Angela E Vinturache, Anika Winn, Suzanne C Tough
Objective The objective of this study was to evaluate the recall of prenatal counselling received among overweight and obese women in primary care settings. Methods A sample of 1996 women with singleton, term deliveries and pre-pregnancy BMI >18.5 kg/m(2) were identified from the All Our Babies pregnancy cohort. Information on socio-demographic characteristics and women's experiences with prenatal counselling on nutrition, vitamin and mineral supplements, exercise, weight gain, employment, alcohol and drug use, and smoking during pregnancy were collected through questionnaires administered at <25 weeks and 34-36 weeks gestation...
November 2017: Maternal and Child Health Journal
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