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https://www.readbyqxmd.com/read/29161276/association-between-diabetes-mellitus-and-active-tuberculosis-a-systematic-review-and-meta-analysis
#1
Rami H Al-Rifai, Fiona Pearson, Julia A Critchley, Laith J Abu-Raddad
The burgeoning epidemic of diabetes mellitus (DM) is one of the major global health challenges. We systematically reviewed the published literature to provide a summary estimate of the association between DM and active tuberculosis (TB). We searched Medline and EMBASE databases for studies reporting adjusted estimates on the TB-DM association published before December 22, 2015, with no restrictions on region and language. In the meta-analysis, adjusted estimates were pooled using a DerSimonian-Laird random-effects model, according to study design...
2017: PloS One
https://www.readbyqxmd.com/read/29155151/hba1c-monitoring-interval-in-patients-on-treatment-for-stable-type-2-diabetes-a-ten-year-retrospective-open-cohort-study
#2
Sachiko Ohde, Gautam A Deshpande, Hiroshi Yokomichi, Osamu Takahashi, Tsuguya Fukui, Zentaro Yamagata
[Aims] This study aims to suggest an informative interval for HbA1c in DM patients with stable glycemic control, based on test characteristics of the HbA1C assay using the signal-to-noise ratio method. [Methods] This was a retrospective, open cohort study. Data were collected between January 2005 to December 2014 at a tertiary-level community hospital in Japan. All adult patients aged under 75 years, with stable glycemic control on a first pharmaceutical regimen for Type II diabetes, and at least two HbA1c measurements after they achieved glycemic stability, were included in the analysis...
November 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29154506/evaluation-of-major-and-minor-lower-extremity-amputation-in-diabetic-foot-patients
#3
Fırat Ozan, Kaan Gürbüz, İlhami Çelik, Zehra Beştepe Dursun, Erdal Uzun
Background/aim: We evaluated the existing risk factors with clinical results in patients who underwent major and minor amputation of the lower extremity as a result of diabetic foot ulcers (DFUs). Materials and methods: We retrospectively studied 107 patients who had undergone lower extremity amputation. The patients were divided into minor (Group 1, n = 75) and major (Group 2, n = 32) amputation groups. On clinical evaluation, the type of surgery performed, smoking history, comorbidities, duration of diabetes mellitus (DM) diagnosis, duration of DFU presence, peripheral neuropathy, peripheral arterial disease, results of deep tissue culture, length of hospitalization, and blood parameters were investigated...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29146610/association-between-stroke-risk-and-metformin-use-in-hemodialysis-patients-with-diabetes-mellitus-a-nested-case-control-study
#4
Li-Nien Chien, Chu-Lin Chou, His-Hsien Chen, Chih-Chin Kao, Yen-Chung Lin, Yueh-Lin Wu, Jin-Shuen Chen, Li-Ying Chen, Te-Chao Fang
BACKGROUND: Metformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (DM). The benefits of metformin for stroke have not been examined in hemodialysis patients with DM. METHODS AND RESULTS: Using the National Health Insurance Research Database, we identified 17 760 patients with DM and new-onset hemodialysis between 2001 and 2013. Of these, 1898 patients hospitalized for either ischemic or hemorrhagic stroke were matched to 7592 control patients according to sex, age, and year of initial hemodialysis therapy by using incidence sampling...
November 16, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29145217/association-of-female-sex-and-heart-rate-with-increased-arterial-stiffness-in-patients-with-type-2-diabetes-mellitus
#5
Min Kyung Kang, Jae Myung Yu, Kwang Jin Chun, Jaehuk Choi, Seonghoon Choi, Namho Lee, Jung Rae Cho
OBJECTIVE: This study aimed to evaluate the factors associated with increased arterial stiffness (IAS) measured by pulse wave velocity (PWV) and its clinical implications in patients with type 2 diabetes mellitus (DM). METHODS: This was an observational, cross-sectional study. The ankle-brachial PWV was used to measure arterial stiffness, and 310 patients (mean age, 49±9 years; 180 men) with type 2 DM were divided into two groups according to the results of PWV: Group 1 (IAS; n=214) and Group 2 (normal arterial stiffness; n=96)...
November 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29145148/honokiol-protects-pancreatic-%C3%AE-cell-against-high-glucose-and-intermittent-hypoxia-induced-injury-by-activating-nrf2-are-pathway-in-vitro-and-in-vivo
#6
Chen-Guang Li, Chang-Lin Ni, Min Yang, Yun-Zhao Tang, Zhu Li, Yan-Juan Zhu, Zhen-Huan Jiang, Bei Sun, Chun-Jun Li
Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with glucose intolerance, insulin resistance and type 2 diabetes mellitus (T2DM). Although several studies have revealed that intermittent hypoxia (IH) in OSAHS may further aggravate pancreatic β cell damage and promote the evolution of type 2 diabetes (T2DM) by increasing oxidative stress, the underlying mechanisms are unclear. Honokiol, a potent radical scavenger, has been demonstrated to ameliorate oxidative stress in many cases. The present study aimed to explore the potential mechanism of IH and diabetes synergistically damage and destruct the pancreatic β cell, examine the effects of honokiol on ameliorating pancreatic β cell injury in this context and explore the mechanism of such effects...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29142574/frequency-of-type-2-diabetes-mellitus-in-nephropathic-patients-and-comparison-of-mean-magnesium-levels-in-nephropathic-patients-with-and-without-type-2-diabetes-mellitus
#7
Mariam Azeem, Adil Iqbal, Nasir Farooq Butt, Fawad Ahmad Randhawa, Uzma Malik
Objective: The objective of this study was to determine the frequency of Type 2 diabetes mellitus (T2DM) in patients with nephropathy (i.e. Chronic Kidney Disease Stage 1 to 3) and to compare the mean magnesium levels in diabetic nephropathic patients and non-diabetic nephropathic patients. Methods: This cross-sectional study was conducted in department of Medicine, Mayo Hospital Lahore from August 2014 to February 2015. Using non-probability purposive sampling 200 nephropathic (Chronic Kidney Disease Stage 1 to 3) patients were selected...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29137017/prognostic-value-of-glucose-metabolism-for-non-st-segment-elevation-infarction-patients-with-diabetes-mellitus-and-single-concomitant-chronic-total-occlusion-following-primary-percutaneous-coronary-intervention
#8
Zhi Xing, Lei Zhang, Zhiqiang Liu, Pengyi He, Yuchun Yang, Muhuyati Wulasihan
Glucose metabolism status may play a predictive role in the severity of the complications among patients with type 2 diabetes mellitus (DM). However, few studies have focused on the prognostic value of glycosylated hemoglobin (HbA1c) and Homeostatic Model Assessment 2 for Insulin Resistance (HOMA2-IR) in patients with DM, non-ST-segment elevation infarction (NSTEMI), and single concomitant chronic total occlusion (CTO) following primary percutaneous coronary intervention (PCI). Short- and long-term prognostic value of HbA1c and HOMA2-IR in patients with DM with NSTEMI and single CTO who received primary percutaneous transluminal coronary intervention (pPCI)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137012/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-diabetic-peripheral-neuropathy-in-type-2-diabetes-mellitus
#9
Tingting Xu, Zihua Weng, Chu Pei, Siyuan Yu, Yating Chen, Wenjie Guo, Xingzuo Wang, Peng Luo, Jia Sun
To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.A total of 557 newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, including 397 T2DM patients without complication (DM group) as well as 160 T2DM patients complicated with DPN (DPN group). Student t test, Mann-Whitney U test, or χ test was applied to the data of the 2 groups, including the levels of neutrophils and lymphocytes as well as the NLR values of peripheral blood and other biochemistry indexes; Pearson correlation analysis was used to calculate the correlation of NLR and detected factors; risk factors of DPN were estimated via logistic regression analysis and multivariate analysis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135987/determining-the-optimal-screening-interval-for-type-2-diabetes-mellitus-using-a-risk-prediction-model
#10
Andrei Brateanu, Thomas Barwacz, Lei Kou, Sihe Wang, Anita D Misra-Hebert, Bo Hu, Abhishek Deshpande, Nana Kobaivanova, Michael B Rothberg
BACKGROUND: Progression to diabetes mellitus (DM) is variable and the screening time interval not well defined. The American Diabetes Association and US Preventive Services Task Force suggest screening every 3 years, but evidence is limited. The objective of the study was to develop a model to predict the probability of developing DM and suggest a risk-based screening interval. METHODS: We included non-diabetic adult patients screened for DM in the Cleveland Clinic Health System if they had at least two measurements of glycated hemoglobin (HbA1c), an initial one less than 6...
2017: PloS One
https://www.readbyqxmd.com/read/29135090/gene-expression-profiling-demonstrates-wnt-%C3%AE-catenin-pathway-genes-alteration-in-mexican-patients-with-colorectal-cancer-and-diabetes-mellitus
#11
Laura Ivonne Wence-Chavez, Ulises Palomares-Chacon, Juan Pablo Flores-Gutierrez, Luis Felipe Jave-Suarez, Adriana Del Carmen Aguilar-Lemarroy, Patricio Barros-Nunez, Silvia Esperanza Flores-Martinez, Jose Sanchez-Corona, Monica Alejandra Rosales-Reynoso
PURPOSE: Several studies have shown a strong association between diabetes mellitus (DM) and increased risk of colorectal cancer (CRC). The fundamental mechanisms that support this association are not entirely understood; however, it is believed that hyperinsulinemia and hyperglycemia may be involved. Some proposed mechanisms include upregulation of mitogenic signaling pathways like MAPK, PI3K, mTOR, and WNT, which are involved in cell proliferation, growth, and cancer cell survival. The purpose of this study was to evaluate the gene expression profile and identify differently expressed genes involved in mitogenic pathways in CRC patients with and without DM...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29133026/levels-of-adhesion-molecules-in-peripheral-blood-correlat-with-stages-of-diabetic-retinopathy-and-may-serve-as-bio-markers-for-microvascular-complications
#12
Arnon Blum, Nina Pastukh, Dorina Socea, Hanin Jabaly
BACKGROUND: Proliferative diabetic retinopathy is a devastating complication of diabetes mellitus, developing within 15 years in 50% of patients with type 1 diabetes mellitus (DM) and in 10% of patients with type 2 DM. The correlation between levels of inflammatory markers in the peripheral blood and retinopathy staging has not been studied yet, and the purpose of this prospective study was to find a possible association between inflammation and staging of diabetic retinopathy. METHODS: A prospective (pilot) study that measured level of adhesion molecules in the peripheral blood of 10 healthy subjects and 30 patients with type 2 diabetes mellitus...
November 10, 2017: Cytokine
https://www.readbyqxmd.com/read/29125636/very-tight-versus-tight-control-which-should-be-the-criteria-for-pharmacologic-therapy-dose-adjustment-in-diabetes-in-pregnancy-evidence-from-randomized-controlled-trials
#13
Claudia Caissutti, Gabriele Saccone, Andrea Ciardulli, Vincenzo Berghella
INTRODUCTION: There is inconclusive evidence from randomized controlled trials (RCTs) to support any specific criteria for pharmacologic therapy dose adjustment in diabetes in pregnancy. Our objective was to analyze the criteria for dose adjustment of pharmacologic treatment for diabetes mellitus (DM) in pregnancy. MATERIAL AND METHODS: Data sources: MEDLINE, OVID and Cochrane Library were searched from their inception to September 2017. Selection criteria included all trials of DM in pregnancy managed by oral hypoglycemic agents or insulin reporting criteria for pharmacologic therapy dose adjustment...
November 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29125137/red-blood-cell-distribution-width-relative-lymphocyte-count-and-type-2-diabetes-mellitus-predict-all-cause-mortality-in-patients-with-advanced-heart-failure
#14
Bożena Szyguła-Jurkiewicz, Łukasz Siedlecki, Łukasz Pyka, Ewa Romuk, Piotr Przybyłowski, Mariusz Gąsior
INTRODUCTION    Early identification of patients with advanced heart failure (HF) who are at a higher risk for poor outcome is an important element of patient management, both from the medical and the economic point of view. OBJECTIVES    In the present study, we sought to determine the association between hematologic parameters assessed on admission and within the 3-year mortality period in patients consecutively admitted with advanced HF.  We also investigated the association between baseline demographic and clinical data and mortality...
November 9, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29124870/defining-a-hba1c-value-that-predicts-increased-risk-of-penile-implant-infection
#15
Mohamad Habous, Raanan Tal, Tarek Soliman, Alaa Tealab, Mohammed Nassar, Zenhom Mekawi, Saad Mahmoud, Osama Abdelwahab, Mohamed Elkhouly, Hatem Kamr, Abdallah Remeah, Saleh Binsaleh, David Ralph, John Mulhall
OBJECTIVES: To explore the association between HbA1C level and penile implant infection rates and to define a cut-off value that predicted implant infection. PATIENTS AND METHODS: A multi center prospective study included all patients undergoing penile implant surgery between 2009-15. Preoperative, perioperative and postoperative management were identical for the entire cohort. Univariate analysis was performed to define predictors of implant infection. HbA1c levels were analyzed as a continuous variable and sequential analysis was conducted utilizing 0...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29122892/subclinical-first-trimester-renal-abnormalities-are-associated-with-preeclampsia-in-normoalbuminuric-women-with-type-1-diabetes
#16
Clare B Kelly, Michelle B Hookham, Jeremy Y Yu, Alicia J Jenkins, Alison J Nankervis, Kristian F Hanssen, Satish K Garg, James A Scardo, Samar M Hammad, M Kathryn Menard, Christopher E Aston, Timothy J Lyons
OBJECTIVE: This study was conducted to determine the utility of tubular (urinary/plasma neutrophil gelatinase-associated lipocalin [NGAL] and urinary kidney injury molecule 1 [KIM-1]) and glomerular (estimated glomerular filtration rate [eGFR]) biomarkers in predicting preeclampsia (PE) in pregnant women with type 1 diabetes mellitus (T1DM) who were free of microalbuminuria and hypertension at the first trimester. RESEARCH DESIGN AND METHODS: This was a prospective study of T1DM pregnancy...
November 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29121924/impact-of-overweight-on-left-ventricular-function-in-type-2-diabetes-mellitus
#17
Makiko Suto, Hidekazu Tanaka, Yasuhide Mochizuki, Jun Mukai, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Sano, Hiroyuki Shimoura, Junichi Ooka, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa, Ken-Ichi Hirata
BACKGROUND: Coexistence of left ventricular (LV) longitudinal myocardial systolic dysfunction with LV diastolic dysfunction could lead to heart failure with preserved ejection fraction (HFpEF). Diabetes mellitus (DM) is known as a significant factor associated with HFpEF. Although the mechanisms of DM-related LV myocardial injury are complex, it has been postulated that overweight contributes to the development of LV myocardial injury in type 2 diabetes mellitus (T2DM) patients. However, the precise impact of overweight on LV longitudinal myocardial systolic function in T2DM patients remains unclear...
November 9, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29121498/cardiac-involvement-in-myotonic-dystrophy-the-role-of-troponins-and-n-terminal-pro-b-type-natriuretic-peptide
#18
Rea Valaperta, Claudia De Siena, Rosanna Cardani, Fortunata Lombardia, Edina Cenko, Benedetta Rampoldi, Barbara Fossati, Elisa Brigonzi, Roberta Rigolini, Paola Gaia, Giovanni Meola, Elena Costa, Raffaele Bugiardini
BACKGROUND AND AIMS: Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are dominant inherited muscular dystrophies with multiple systemic involvement, often producing cardiac injury. This study sought to determine the clinical significance of elevated high sensitivity cardiac troponin T and I (hs-cTnT and hs-cTnI), and N-terminal pro B-type natriuretic peptide (NT-pro-BNP) in this population. METHODS: Sixty DM patients (35 men and 25 women; mean age: 45.1 years, range: 12-73 years) underwent clinical cardiac investigations and measurements of serum hs-cTnT, hs-cTnI, creatine kinase (CK), and NT-proBNP...
October 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29118510/foveal-neovascularization-in-a-patient-with-type-2-diabetes-mellitus
#19
Anisha Seth, Basudeb Ghosh, Vishaal Bhambhwani, Anika Gupta, Usha K Raina
Retinal neovascularization in Diabetes mellitus (DM) is commonly seen at the optic disc and mid-periphery. It is rare at the fovea as the fovea is an avascular zone and there are very few case reports of foveal neovascularization in Type 1 DM. We report a case of unilateral foveal neovascularization in Type 2 DM.
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29115461/histone-deacetylase-inhibition-of-cardiac-autophagy-in-rats-on-a-high%C3%A2-fat-diet-with-low%C3%A2-dose-streptozotocin-induced-type-2-diabetes-mellitus
#20
Ting-I Lee, Kuan-Jen Bai, Yao-Chang Chen, Ting-Wei Lee, Cheng-Chih Chung, Wen-Chih Tsai, Shin-Yi Tsao, Yu-Hsun Kao
Autophagy serves a role in preserving cellular homeostasis. Diabetes mellitus (DM) impairs cardiac autophagy and is associated with an accumulation of cytotoxic proteins that may provoke apoptosis and damage cardiomyocytes. Histone deacetylase (HDAC) inhibitors attenuate cardiac fibrosis and inflammation, and improve cardiomyopathy resulting from DM. However, the effect of HDAC inhibition on autophagy in DM cardiomyopathy has not been investigated. The purpose of the present study was to evaluate whether HDAC inhibition modulates cardiac autophagy and to investigate the potential mechanisms in type 2 DM (T2DM) hearts...
October 26, 2017: Molecular Medicine Reports
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