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https://www.readbyqxmd.com/read/27897261/diabetes-onset-at-31-45-years-of-age-is-associated-with-an-increased-risk-of-diabetic-retinopathy-in-type-2-diabetes
#1
Wenjun Zou, Lisha Ni, Qianyi Lu, Chen Zou, Minjie Zhao, Xun Xu, Haibing Chen, Zhi Zheng
This hospital-based, cross-sectional study investigated the effect of age of diabetes onset on the development of diabetic retinopathy (DR) among Chinese type 2 diabetes mellitus (DM) patients. A total of 5,214 patients with type 2 DM who were referred to the Department of Ophthalmology at the Shanghai First People's Hospital from 2009 to 2013 was eligible for inclusion. Diabetic retinopathy status was classified using the grading system of the Early Treatment Diabetic Retinopathy Study (ETDRS). Logistic and hierarchical regression analyses were used to identify independent variables affecting the development of DR...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896491/clusters-of-cognitive-impairment-among-different-phenotypes-of-myotonic-dystrophy-type-1-and-type-2
#2
Stojan Peric, Vidosava Rakocevic Stojanovic, Gorana Mandic Stojmenovic, Vera Ilic, Masa Kovacevic, Aleksandra Parojcic, Jovan Pesovic, Milija Mijajlovic, Dusanka Savic-Pavicevic, Giovanni Meola
Neuropsychological examinations in myotonic dystrophy (DM) patients show a great variability of results from a condition of intellectual disability to the subtle cognitive impairments. It is unclear if different clusters of neuropsychological deficits appear in different phenotypes of DM, or if there are patients with no cognitive deficit at all. The aim of this study is to assess cognitive impairments among patients with different phenotypes of DM type 1 (DM1) and type 2 (DM2), and to potentially define cognitive clusters in these disorders...
November 28, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27893687/spontaneous-and-transient-predinner-hyperglycemia-in-some-patients-with-diabetes-dusk-phenomenon
#3
Wei Li, Si-Na Du, Min-Jia Shi, Zhan-Zhan Sun
Blood glucose fluctuations have higher risk than absolute blood glucose level in diabetic chronic complications. At present, "dawn phenomenon" is well known by clinicians, but "dusk phenomenon" has not been recognized. This study explored the objective existence of "dusk phenomenon" (spontaneous and transient predinner hyperglycemia) and its clinical significance.The data of 54 patients with diabetes, who received routine insulin pump therapy between December 2010 and October 2012 in our hospital, were retrospectively analyzed...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27893660/salivary-lactate-dehydrogenase-and-aminotransferases-in-diabetic-patients
#4
Barbara Malicka, Katarzyna Skoskiewicz-Malinowska, Urszula Kaczmarek
Diabetes mellitus (DM) is a group of metabolic diseases resulting from impaired insulin secretion and/or action. DM is characterized by hyperglycemia that can lead to the dysfunction or damage of organs, including the salivary glands.The aim of this study was to compare the levels of salivary lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic patients.The study was approved by the Bioethics Committee of Wroclaw Medical University (Poland). The study comprised 90 adults of both sexes, aged 21 to 57 years...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27890243/effect-of-combination-cholesterol-lowering-therapy-and-triglyceride-lowering-therapy-on-medical-costs-in-patients-with-type-2-diabetes-mellitus
#5
Gregory A Nichols, Kristi Reynolds, Temitope Olufade, Teresa M Kimes, Maureen O'Keeffe-Rosetti, Daniel S Sapp, Deborah Anzalone, Stephen P Fortmann
High triglyceride (TG) levels among patients with type 2 diabetes mellitus (DM) are associated with higher medical costs. We analyzed the economic impact of TG-lowering therapies and whether the association between medical costs and therapy differed according to TG reduction. We conducted an observational cohort study of 184,932 patients with diabetes mellitus who had a TG measurement between January 2012 and June 2013 and a second TG measurement 3 to 15 months later. We identified 4 therapy groups (statin monotherapy, TG-specific monotherapy, statin/TG-specific combination therapy, or no therapy) and stratified those groups by percent change in TG (increased ≥5%, change of ≤4...
November 4, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27889840/five-to-thirteen-year-results-of-a-cemented-dual-mobility-socket-to-treat-recurrent-dislocation
#6
Moussa Hamadouche, Mickael Ropars, Camille Rodaix, Thierry Musset, François Gaucher, David Biau, Jean Pierre Courpied, Denis Huten
PURPOSE: Dual mobility (DM) socket has been associated with a low rate of dislocation following both primary and revision total hip arthroplasty (THA). However, little is known about the long-term efficiency of DM in the treatment of THA instability. The purpose of this retrospective study was to evaluate the outcome of a cemented DM socket to treat recurrent dislocation after a minimum of five year follow-up. METHODS: The series included 51 patients with a mean age of 71...
November 26, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27889125/analysis-of-pasture-supplementation-strategies-by-means-of-a-mechanistic-model-of-ruminal-digestion-and-metabolism-in-the-dairy-cow
#7
J P McNamara, M J Auldist, L C Marett, P J Moate, W J Wales
Effective pasture supplementation is critical to the efficiency of resource management in milk production. We understand a great deal about ruminal and metabolic processes in dairy cattle that control efficiency but we need to improve our ability to predict effects of practical feeding strategies based on the basic biological processes of the cow. Therefore, a large-scale pasture supplementation study was used to explore the details of both practical management and the underlying biological principles and processes involved...
November 23, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27888609/effects-of-lorcaserin-on-pre-existing-valvulopathy-a-pooled-analysis-of-phase-3-trials
#8
Neil J Weissman, Steven R Smith, Randi Fain, Nancy Hall, William R Shanahan
OBJECTIVE: To evaluate the effects of lorcaserin in patients with pre-existing Food and Drug Administration (FDA)-defined valvulopathy. METHODS: This is a pooled, post hoc analysis of three Phase 3 studies. BLOOM and BLOSSOM patients were 18 to 65 years of age without diabetes and with a body mass index (BMI) of 27 to 29.9 kg/m(2) and ≥1 weight-related comorbidity or a BMI of 30 to 45 kg/m(2) . BLOOM-DM patients had a BMI of 27 to 45 kg/m(2) and type 2 diabetes...
November 26, 2016: Obesity
https://www.readbyqxmd.com/read/27888412/diabetes-screening-in-overweight-and-obese-children-and-adolescents-choosing-the-right-test
#9
Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr
: Type 2 diabetes can occur without any symptoms, and health problems associated with the disease are serious. Screening tests allowing an early diagnosis are desirable. However, optimal screening tests for diabetes in obese youth are discussed controversially. We performed an observational multicenter analysis including 4848 (2668 female) overweight and obese children aged 7 to 17 years without previously known diabetes. Using HbA1c and OGTT as diagnostic criteria, 2.4% (n = 115, 55 female) could be classified as having diabetes...
November 25, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27887655/fracture-risk-and-healthcare-resource-utilization-and-costs-among-osteoporosis-patients-with-type-2-diabetes-mellitus-and-without-diabetes-mellitus-in-japan-retrospective-analysis-of-a-hospital-claims-database
#10
Masayo Sato, Wenyu Ye, Tomoko Sugihara, Yoshitaka Isaka
BACKGROUND: Osteoporosis, osteoporosis-related fractures, and diabetes are considerable health burdens in Japan. Diabetes in patients with osteoporosis has been reported to be associated with increased fracture risk. This retrospective analysis of a Japanese hospital claims database investigated the real-world effect of type 2 diabetes mellitus (T2DM) on the incidence of clinical fractures, costs, and healthcare resource utilization in patients with osteoporosis and a subgroup of patients prescribed raloxifene...
November 25, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27887576/carotid-arterial-wall-inflammation-in-peripheral-artery-disease-is-augmented-by-type-2-diabetes-a-cross-sectional-study
#11
Sophie J Bernelot Moens, Robert M Stoekenbroek, Fleur M van der Valk, Simone L Verweij, Mark J W Koelemay, Hein J Verberne, Max Nieuwdorp, Erik S G Stroes
BACKGROUND: Patients with peripheral artery disease (PAD) are at increased risk of secondary events, which is exaggerated in the presence of type 2 diabetes mellitus. Diabetes is associated with a systemic pro-inflammatory state. We therefore investigated the cumulative impact of PAD and type 2 diabetes on carotid arterial wall inflammation. As recent data suggest a detrimental role of exogenous insulin on cardiovascular disease, we also included a group of insulin users. RESULTS: (18)F-fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG PET/CT) imaging showed increased carotid arterial wall inflammation, assessed as target-to-background ratio (TBR), in PAD patients without diabetes (PAD-only: n = 11, 1...
November 25, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27884740/effect-of-mechanical-debridement-with-adjunct-antimicrobial-photodynamic-therapy-in-the-treatment-of-peri-implant-diseases-in-type-2-diabetic-smokers-and-non-smokers
#12
Tariq Abduljabbar
OBJECTIVE: The aim of the present 6-month follow-up study was to assess the effect of mechanical debridement (MD) with adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of peri-implant diseases in type-2 diabetic smokers and non-smokers. METHODS: Patients were divided into 2 groups: (a) Group-1: type-2 diabetic smokers; and (b) Group-2: type-2 diabetic non-smokers. In both groups, hemoglobin A1c (HbA1c) levels and peri-implant bleeding on probing (BOP) and probing depth (PD) ≥4mm were measured at baseline and after 6 months of follow-up...
November 21, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27884659/relationship-between-plasma-glycation-with-membrane-modification-oxidative-stress-and-expression-of-glucose-trasporter-1-in-type-2-diabetes-patients-with-vascular-complications
#13
Krishna A Adeshara, Arundhati G Diwan, Tejashri R Jagtap, Komal Advani, Aisha Siddiqui, Rashmi S Tupe
BACKGROUND OF STUDY: Enhanced protein glycation in diabetes causes irreversible cellular damage through membrane modifications. Erythrocytes are persistently exposed to plasma glycated proteins; however, little are known about its consequences on membrane. Aim of this study was to examine the relationship between plasma protein glycation with erythrocyte membrane modifications in type 2 diabetes patients with and without vascular complications. METHOD: We recruited 60 healthy controls, 85 type 2 diabetic mellitus (DM) and 75 type 2 diabetic patients with complications (DMC)...
October 17, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27884155/long-chain-polyunsaturated-fatty-acids-lcpufas-and-nordihydroguaiaretic-acid-ndga-modulate-metabolic-and-inflammatory-markers-in-a-spontaneous-type-2-diabetes-mellitus-model-stillman-salgado-rats
#14
Alejandro Dain, Gaston Repossi, Gustavo T Diaz-Gerevini, Jairam Vanamala, Undurti N Das, Aldo R Eynard
BACKGROUND: Diabetes mellitus (DM) is a complex disease with alterations in metabolic and inflammatory markers. Stillman Salgado rats (eSS) spontaneously develop type 2 DM by middle age showing progressive impairment of glucose tolerance with hyperglycemia, hypertriglyceridemia and hyperinsulinemia. We analyzed the effects of supplementation of ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) with or without nordihydroguaiaretic acid (NDGA) added, an antioxidant and lipoxygenase inhibitor, on metabolic and inflammatory parameters in eSS rats to evaluate whether they can delay development and/or prevent progression of DM...
November 25, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27882817/h2s-improves-renal-fibrosis-in-stz-induced-diabetic-rats-by-ameliorating-tgf-%C3%AE-1-expression
#15
Yan Li, Lin Li, Ou Zeng, Jun Mao Liu, Jun Yang
Nephropathy develops in many patients with type 1 diabetes mellitus (T1DM). However, the specific mechanisms and therapies remain unclear. For this purpose we investigated the effects of hydrogen sulfide (H2S) on renal fibrosis in streptozotocin (STZ) induced diabetic rats and its underlying mechanisms. Experimental rats were randomly divided into four groups: Control group (normal rats), DM group (diabetes rats), DM + NaHS group [diabetes rats treated with sodium hydrosulfide (NaHS)], and NaHS group (normal rats treated with NaHS)...
November 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27877108/cerebral-ketone-body-oxidation-is-facilitated-by-a-high-fat-diet-enriched-with-advanced-glycation-end-products-in-normal-and-diabetic-rats
#16
Adriano M de Assis, Jussemara S da Silva, Anderson Rech, Aline Longoni, Yasmine Nonose, Cendrine Repond, Matheus A de Bittencourt Pasquali, José C F Moreira, Diogo O Souza, Luc Pellerin
Diabetes mellitus (DM) causes important modifications in the availability and use of different energy substrates in various organs and tissues. Similarly, dietary manipulations such as high fat diets also affect systemic energy metabolism. However, how the brain adapts to these situations remains unclear. To investigate these issues, control and alloxan-induced type I diabetic rats were fed either a standard or a high fat diet enriched with advanced glycation end products (AGEs) (HAGE diet). The HAGE diet increased their levels of blood ketone bodies, and this effect was exacerbated by DM induction...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27876036/diabetes-screening-intervals-based-on-risk-stratification
#17
Sachiko Ohde, Emily McFadden, Gautam A Deshpande, Hiroshi Yokomichi, Osamu Takahashi, Tsuguya Fukui, Rafael Perera, Zentaro Yamagata
BACKGROUND: Guidelines for frequency of Type 2 diabetes mellitus (DM) screening remain unclear, with proposed screening intervals typically based on expert opinion. This study aims to demonstrate that HbA1c screening intervals may differ substantially when considering individual risk for diabetes. METHODS: This was a multi-institutional retrospective open cohort study. Data were collected between April 1999 to March 2014 from one urban and one rural cohort in Japan...
November 22, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27870711/the-effect-of-metformin-on-oncological-outcomes-in-patients-with-cervical-cancer-with-type-2-diabetes-mellitus
#18
Jitti Hanprasertpong, Ingporn Jiamset, Alan Geater, Thanarpan Peerawong, Wikanda Hemman, Sasima Kornsilp
OBJECTIVE: The aim of this study was to evaluate any association between metformin use and oncological outcomes of cervical cancer in patients with type 2 diabetes mellitus (DM). METHODS: We retrospectively identified 248 patients with cervical cancer with type 2 DM who received primary treatment between 2004 and 2015. The clinicopathological characteristics and oncological outcomes were collected and analyzed. The patients were then separated into metformin use (n = 118) or non-metformin use (n = 130) groups...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27868170/protein-kinases-mechanisms-and-downstream-targets-in-inflammation-mediated-obesity-and-insulin-resistance
#19
REVIEW
Kalyana C Nandipati, Saravanan Subramanian, Devendra K Agrawal
Obesity-induced low-grade inflammation (metaflammation) impairs insulin receptor signaling. This has been implicated in the development of insulin resistance. Insulin signaling in the target tissues is mediated by stress kinases such as p38 mitogen-activated protein kinase, c-Jun NH2-terminal kinase, inhibitor of NF-kB kinase complex β (IKKβ), AMP-activated protein kinase, protein kinase C, Rho-associated coiled-coil containing protein kinase, and RNA-activated protein kinase. Most of these kinases phosphorylate several key regulators in glucose homeostasis...
November 21, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27867429/correlation-between-diastolic-function-and-endothelial-function-in-patients-with-type-2-diabetes-and-hypertension
#20
Ricardo Bedirian, Mario Fritsch Neves, Wille Oigman, Ronaldo Altenburg Odebrecht Curi Gismondi, Cesar Romaro Pozzobon, Marcia Cristina Boaventura Ladeira, Marcia Bueno Castier
BACKGROUND: Endothelial dysfunction may be involved in the pathophysiology of cardiac abnormalities in patients with diabetes mellitus (DM). A correlation between endothelial dysfunction and diastolic dysfunction in patients with type 1 DM has been demonstrated, but this relationship has not been well investigated in type 2 DM. OBJECTIVE: Compare groups of patients with type 2 DM and hypertension with and without diastolic dysfunction using endothelial function indexes, and to assess whether correlations exist between the diastolic function and the endothelial function indexes...
2016: Open Cardiovascular Medicine Journal
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