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Yaniv Levi, Ayyaz Sultan, Mistre Alemayehu, Sabrina Wall, Shahar Lavi
BACKGROUND: Coronary no-reflow during primary percutaneous coronary intervention (PPCI) is a predictor of poorer cardiovascular outcome. Both endothelial dysfunction and no-reflow involves abnormal vascular function and hemostasis. Our aim was to assess the association between endothelial dysfunction and no reflow during primary PCI. METHODS: Thirty consecutive patients with ST elevation myocardial infarction (STEMI) and normal flow during primary PCI were compared to 19 consecutive patients who had no reflow...
September 3, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Ioanna Xanthopoulou, Chrysoula Vogiatzi, Theodora Bampouri, Athina Chasapi, Ilianna Bei, Periklis Davlouros, George Hahalis, Dimitrios Alexopoulos
BACKGROUND: Ticagrelor may exert pleiotropic actions, beyond platelet inhibition, which are possibly adenosine-mediated. It has been suggested that in patients with coronary artery disease (CAD) ticagrelor may influence endothelial function. OBJECTIVE: We aimed to assess the possibility of endothelial function deterioration following ticagrelor treatment cessation. METHODS: This was a prospective, observational study, in stable CAD patients with prior percutaneous coronary intervention (PCI) for acute coronary syndrome manifested 1 year earlier, under ticagrelor maintenance dose (90 mg bid) and due to discontinue ticagrelor...
June 24, 2016: Current Vascular Pharmacology
K Mu, Y Zhang, D Y Niu, Y Ye, W L Yan
OBJECTIVE: To investigate the distribution of peripheral arterial stiffness, endothelial function and their correlations with cardiovascular risk factors in the 7-17 year-olds. METHODS: Normal weight and obese subjects aged 7-17 years with completed data on questionnaires, anthropometric and blood biochemical tests, were recruited from a cross-sectional population-based study on childhood hypertension in Minhang district of Shanghai. Automatic waveform analyzer (BP-203RPE-I) and Endopat 2000 were used to measure the arterial stiffness...
June 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
A Meeme, G A Buga, M Mammen, A Namugowa
OBJECTIVES: The EndoPAT method has been used as a non-invasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia. METHODS: Two hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine...
May 19, 2016: Cardiovascular Journal of Africa
Masaaki Sagara, Kunihiro Suzuki, Chie Aoki, Seiichi Tanaka, Isao Taguchi, Teruo Inoue, Yoshimasa Aso
BACKGROUND: The aim of the present study was to elucidate the effect of teneligliptin on oxidative stress and endothelial function in Japanese patients with type 2 diabetes and chronic kidney disease (CKD). METHODS: Forty-five patients with type 2 diabetes and CKD who received sitagliptin for at least 12 months were randomized to either continue sitagliptin (n = 23) or switch to teneligliptin (n = 22) for 24 weeks. The following parameters were evaluated at baseline and after 24 weeks of treatment with continued sitagliptin or teneligliptin: blood pressure, haemoglobin A1c (HbA1c), estimated glomerular filtration rate (eGFR), urinary albumin excretion, endothelial function by reactive hyperaemia index (RHI; EndoPAT(®) system), reactive oxygen metabolites (ROMs) measured by the d-ROMS test, 8-hydroxy-2'-deoxyguanosine, urinary liver-type fatty acid binding protein (L-FABP), and urinary 8-isoprostane...
2016: Cardiovascular Diabetology
Tomas Kovarnik, Stepan Jerabek, Zhi Chen, Andreas Wahle, Ling Zhang, Gabriela Dostalova, Hana Skalicka, Ales Kral, Jan Horak, Milan Sonka, Ales Linhart
BACKGROUND AND AIM: To study relationships between endothelial dysfunction (ED) and coronary atherosclerosis derived from intravascular ultrasound (IVUS) and virtual histology (VH). METHODS: ED was examined by EndoPAT system (Itamar Medical) in 56 patients who underwent IVUS and VH (Volcano corp.). Reactive Hyperemia Index (RHI) < 2 was used for definition of ED. IVUS sequences were divided into 5mm-long non-overlapping and adjacent vessel segments. Plaque phenotype was determined for each frame and 5 mm vessel segment was labeled according to highest frame score (from 0 for "no lesion" to 5 for "TCFA")...
May 10, 2016: Kardiologia Polska
Helena U Westergren, Sara Svedlund, Remi A Momo, Juuso I Blomster, Karin Wåhlander, Erika Rehnström, Peter J Greasley, Regina Fritsche-Danielson, Jan Oscarsson, Li-Ming Gan
BACKGROUND: Patients with angina-like symptoms without myocardial perfusion scintigram (MPS)-verified abnormality may still be at risk for cardiovascular events. We hypothesized that insulin resistance could play a role in this population even without diagnosed diabetes. We further explored physiological and blood biomarkers, as well as global gene expression patterns that could be closely related to impaired glucose homeostasis to deepen our mechanistic understanding. METHODS: A total of 365 non-diabetic patients with suspected myocardial ischemia referred to MPS were enrolled and followed up regarding event-free survival with a median time of 5...
2016: Cardiovascular Diabetology
Sara Hazim, Peter J Curtis, Manuel Y Schär, Luisa M Ostertag, Colin D Kay, Anne-Marie Minihane, Aedín Cassidy
BACKGROUND: There is much speculation with regard to the potential cardioprotective benefits of equol, a microbial-derived metabolite of the isoflavone daidzein, which is produced in the large intestine after soy intake in 30% of Western populations. Although cross-sectional and retrospective data support favorable associations between the equol producer (EP) phenotype and cardiometabolic health, few studies have prospectively recruited EPs to confirm this association. OBJECTIVE: The aim was to determine whether the acute vascular benefits of isoflavones differ according to EP phenotype and subsequently investigate the effect of providing commercially produced S-(-)equol to non-EPs...
March 2016: American Journal of Clinical Nutrition
Margarida Sarmento-Dias, Carla Santos-Araújo, Rui Poínhos, Bruno Oliveira, Isabell Soares Silva, Liliana Simões Silva, Maria João Sousa, Flora Correia, Manuel Pestana
AIMS: Cardiovascular (CV) events are the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD), including those patients on peritoneal dialysis (PD). Fibroblast growth factor 23 (FGF23) has been associated with left ventricular hypertrophy (LVH) and mortality in patients with CKD. However, the role of FGF23 in uremic vasculopathy remains unclear. In this study, we aimed to assess the relationship between FGF23 and LVH, endothelial dysfunction, vascular calcification, and arterial stiffness in 48 stable PD patients...
March 2016: Clinical Nephrology
Elena Venturi, Silvia Pinnola, Carmela Morizzo, Beatrice Boldrini, Monica Rossi, Silvia Trifirò, Domenico Tricò, Andrea Natali
OBJECTIVE: To evaluate the characteristics and the determinants of ED, as measured by PAT. METHODS: We measured basal and post-ischemic digital pulse amplitude (EndoPAT(®)) in a mixed outpatient population of 206 diabetic and 101 non-diabetic subjects, of whom 50% with clinically manifest CVD, undergoing to an extensive clinical, biochemical, and vascular phenotype characterization. RESULTS: The major characteristics of ED (tertile 1 vs 3), in addition to lower post-ischemic vasodilatory reserve (34 vs 203%), were a 3-fold higher baseline pulse amplitude and a delayed (60 second) peak response...
April 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Jong Kyou Kwon, Joo Yong Lee, Hae Do Jung, Cheol Kyu Oh, Young Deuk Choi, Kang Su Cho
PURPOSE: To evaluate the association of self-reported erectile function and endothelial function using the EndoPAT device. MATERIALS AND METHODS: We prospectively enrolled 76 men (age≥40 years) after obtaining a complete medical history and a self-reported questionnaire (International Index of Erectile Function-5 [IIEF-5], SEP Q2, Q3). Endothelial function was noninvasively measured with an EndoPAT 2000, recorded as the reactive hyperemia index (RHI), and analyzed according to the patients' baseline characteristics...
December 2015: World Journal of Men's Health
Andres Guerra, Bavana V Rangan, Ameka Coleman, Hao Xu, Anna Kotsia, Georgios Christopoulos, Alan Sosa, Howard Chao, Henry Han, Guthbudeen Abdurrahim, Michele Roesle, James A de Lemos, Darren K McGuire, Milton Packer, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: Thirty-eight patients with intermediate (30%-60% diameter stenosis) saphenous vein graft lesions were randomized to extended-release niacin (ER-niacin) or placebo for 12 months. We sought to evaluate the impact of ER-niacin on carotid intima media thickness (CIMT), endothelial function, and endothelial progenitor cell (EPC) mobilization. METHODS: Carotid B-mode ultrasound was used to image the common and internal carotid arteries, at baseline and at 12 months after enrollment...
December 2015: Journal of Invasive Cardiology
Alexandra Gerstgrasser, Sigrid Röchter, Dirk Dressler, Christiane Schön, Claudia Reule, Sybille Buchwald-Werner
Mangifera indica fruit preparation (Careless™) activates the evolutionary conserved metabolic sensors sirtuin 1 and adenosine monophosphate-activated protein kinase, which have been identified as playing a key role in microcirculation and endothelial function. Here, an acute effect of a single dose of 100 mg or 300 mg Careless™ on microcirculation was investigated in a randomized, double-blind, crossover pilot study in ten healthy women to determine the effective dosage. Microcirculation and endothelial function were assessed by the Oxygen-to-see system and pulse amplitude tonometry (EndoPAT™), respectively...
March 2016: Planta Medica
Luciene da Silva Araújo, Julia Freitas Rodrigues Fernandes, Márcia Regina Simas Torres Klein, Antonio Felipe Sanjuliani
OBJECTIVES: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease (CVD). Several of the proposed mechanisms for the development of CVD in OSA are similar to those proposed for the increased risk of CVD in obesity, so that it is difficult to determine the influence of OSA on these pathogenic mechanisms in obese individuals. The aim of this study was to evaluate the relationship of OSA with endothelial function, oxidative stress, inflammatory biomarkers, metabolic profile, sympathetic nervous system activity, and blood pressure (BP) in obese individuals...
November 2015: Nutrition
Christian Jung, Karl Drummer, Peter Oelzner, Hans R Figulla, Joachim Boettcher, Marcus Franz, Stefan Betge, Martin Foerster, Gunter Wolf, Alexander Pfeil
UNLABELLED: Systemic sclerosis (SSc) is a systemic, autoimmune connective tissue disease characterized by vasculopathy and microvascular changes. Fluorescence Optical Imaging (FOI) is a technique used to assess inflammation in patients with arthritis; in this study FOI is used to quantify inflammation in the hand. Endothelial Microparticle (EMP) can reflect damage or activation of the endothelium but also actively modulate processes of inflammation, coagulation and vascular function. The aim of the present study was to quantify EMP and FOI, to determine an association between these microparticles and inflammation and to endothelial function...
2015: Clinical Hemorheology and Microcirculation
Verena Brüll, Constanze Burak, Birgit Stoffel-Wagner, Siegfried Wolffram, Georg Nickenig, Cornelius Müller, Peter Langguth, Birgit Alteheld, Rolf Fimmers, Stefanie Naaf, Benno F Zimmermann, Peter Stehle, Sarah Egert
The polyphenol quercetin may prevent CVD due to its antihypertensive and vasorelaxant properties. We investigated the effects of quercetin after regular intake on blood pressure (BP) in overweight-to-obese patients with pre-hypertension and stage I hypertension. In addition, the potential mechanisms responsible for the hypothesised effect of quercetin on BP were explored. Subjects (n 70) were randomised to receive 162 mg/d quercetin from onion skin extract powder or placebo in a double-blinded, placebo-controlled cross-over trial with 6-week treatment periods separated by a 6-week washout period...
October 28, 2015: British Journal of Nutrition
Maria Daniel, Christina Ekenbäck, Stefan Agewall, Elin B Brolin, Kenneth Caidahl, Kerstin Cederlund, Olov Collste, Lars Eurenius, Mats Frick, Shams Younis-Hassan, Loghman Henareh, Tomas Jernberg, Karin Malmqvist, Jonas Spaak, Peder Sörensson, Claes Hofman-Bang, Per Tornvall
Myocardial Infarction with normal coronary arteries (MINCA) is common with a prevalence of 1% to 12% of all myocardial infarctions. The pathogenic mechanisms of MINCA are still unknown, but endothelial dysfunction has been suggested as a possible cause. To investigate risk factors and markers for MINCA, we conducted a case-control study. Considering the reported low prevalence of classical risk factors for coronary heart disease (CHD) in some but not all studies, our hypothesis was that endothelial function and intima-media thickness (IMT) were better, respectively lower, than CHD controls...
September 15, 2015: American Journal of Cardiology
Jia Shen, Joseph C Poole, Matthew L Topel, Aurelian Bidulescu, Alanna A Morris, Riyaz S Patel, Jose G Binongo, Sandra B Dunbar, Lawrence Phillips, Viola Vaccarino, Gary H Gibbons, Arshed A Quyyumi
CONTEXT: The diagnosis of metabolic syndrome (MetS) identifies individuals at risk for developing diabetes and cardiovascular disease. African Americans (AAs) have high rates of cardiovascular disease and subclinical vascular disease including arterial stiffness and microvascular dysfunction but have relatively low rates of MetS. OBJECTIVE: The objective of the study was to evaluate the relationship between MetS and vascular function in a biracial cohort with the hypothesis that the diagnosis of MetS underestimates subclinical vascular disease in AAs...
November 2015: Journal of Clinical Endocrinology and Metabolism
Michael Bestawros, Takondwa Chidumayo, Meridith Blevins, Ashley Canipe, Jay Bala, Paul Kelly, Suzanne Filteau, Bryan E Shepherd, Douglas C Heimburger, John R Koethe
INTRODUCTION: Persistent systemic inflammation is associated with mortality among undernourished, HIV-infected adults starting antiretroviral therapy (ART) in sub-Saharan Africa, but the etiology of these deaths is not well understood. We hypothesized that greater systemic inflammation is accompanied by cardiovascular dysfunction over the first 12 weeks of ART. METHODS: In a prospective cohort of 33 undernourished (body mass index <18.5 kg/m(2)) Zambian adults starting ART, we measured C-reactive protein (CRP), tumor necrosis factor-α receptor 1 (TNF-α R1), and soluble CD163 and CD14 at baseline and 12 weeks...
March 2015: Journal of AIDS & Clinical Research
Lisa C Hudgins, Vidhya Annavajjhala, Arzu Kovanlikaya, Maura D Frank, Aliza Solomon, Thomas S Parker, Rubin S Cooper
BACKGROUND: Digital tonometry is designed to non-invasively screen for endothelial dysfunction by the detection of impaired flow-induced reactive hyperaemia in the fingertip. We determined whether digital reactive hyperaemia correlated with risk factors for atherosclerosis in two groups of children at increased risk for endothelial dysfunction. METHODS: A total of 15 obese children and 23 non-obese, dyslipidaemic children, 8-21 years of age, were enrolled, and their medical histories, anthropometric measurements, carotid wall thickness by means of ultrasonography, and fasting blood samples for cardiovascular risk factors were obtained...
March 2016: Cardiology in the Young
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